Exploring the complexities of rice iron toxicity: Paradoxes, mechanisms, and strategic deliberations.

Iron (Fe) toxicity in rice presents a paradox: excessive soil Fe in tropical flooded soils reduces yields by 15-30 %, yet edible grains remain Fe-deficient, worsening global "hidden hunger", which affects 1.72 billion people. This paradox arises from inefficient Fe translocation from roots to grains and complex research landscapes: field, pot, and hydroponic studies yield conflicting tolerance rankings, hindering mechanistic insights.

Ion toxicity in waterlogged soils: mechanisms of root response and adaptive strategies.

Waterlogging poses a significant global threat to agriculture by inducing ion toxicities (e.g. Fe², Mn², NH ) in roots due to soil redox changes.

Design and Characterization of Curcumin-Modified Polyurethane Material with Good Mechanical, Shape-Memory, pH-Responsive, and Biocompatible Properties.

In the context of critical challenges in curcumin-modified polyurethane synthesis-including limited curcumin bioavailability and suboptimal biodegradability/biocompatibility-a novel polyurethane material (Cur-PU) with good mechanical, shape memory, pH-responsive, and biocompatibility was synthesized via a one-pot, two-step synthetic protocol in which HO-PCL-OH served as the soft segment and curcumin was employed as the chain extender. The experimental results demonstrate that with the increase in Cur units, the crystallinity of the Cur-PU material decreases from 32.6% to 5.

USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma.

Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options. Temozolomide (TMZ), a first-line chemotherapeutic agent, often proves ineffective due to resistance and toxicity associated with overexpressed O-methylguanine-DNA-methyltransferase (MGMT). In this study, we identified ubiquitin-specific protease 7 (USP7) as a nuclear regulator of MGMT stability and TMZ resistance.

Asymmetric waveguide and compressively strained quantum well-enabled high-power, polarization-dependent 850 nm gain chip.

The development of high-power gain chips is crucial for advancing hybrid-integrated narrow-linewidth lasers, which face power limitations in emerging applications such as quantum sensing and atomic cooling. This study designed a high-power GaAs-based gain chip based on an asymmetric waveguide and compressively strained quantum wells for the 850 nm wavelength band. By applying the epitaxial structure and low-loss waveguide, a record continuous-wave output power of 114.

Cerebrospinal fluid changes may be related to sigmoid sinus wall dehiscence-pulsatile tinnitus coexisting with normal intracranial pressure.

BackgroundIntracranial pressure is closely associated with pulsatile tinnitus (PT) caused by sigmoid sinus wall dehiscence (SSWD). Cerebrospinal fluid (CSF) plays a key role in regulating intracranial pressure; however, CSF alterations have not been reported in SSWD-PT patients.PurposeTo evaluate cardiac-driven CSF flow dynamics and volume changes in SSWD-PT patients with normal intracranial pressure.

Propofol lessens renal ischemia/reperfusion-acute lung injury by preventing mTOR-induced Pyroptosis.

Background And Aims: Acute lung injury (ALI) is one of the significant pathophysiological features of renal ischemia/reperfusion (rI/R) and is the chief reason for rI/R-mediated numerous organ failures. Pyroptosis is a lethal pathogenesis of ALI in rI/R, and precise, actual treatments are deficient. While propofol (Pro) has been revealed to have anti-apoptosis and anti-necroptosis properties, it remains uncertain whether it inhibits Pyroptosis to ameliorate rI/R-induced ALI.

Phenotypic Evaluation and Genome-Wide Association Mapping for Bacterial Leaf Streak Resistance in a Worldwide Cultivated Emmer Wheat Collection.

Bacterial leaf streak (BLS), caused by the bacterial pathogen pv. (Xtu), is an important disease affecting wheat production worldwide. Recently, the Northern Great Plains of the USA-a key region for durum wheat and hard red spring wheat-has reported an increased prevalence and severity of BLS.

A New Design Methodology of Asphalt Mixture Dynamic Modulus Based on Pavement Response.

The design of asphalt mixture has, for a long time, been an empirical and proof process, causing the mismatch between material design and pavement structure design. To enhance the rationality of asphalt pavement design, this study seeks a path to bridge the gap between asphalt mixture modulus and structural behavior. Firstly, pavement models with different base rigidities, including cement concrete base, cement-treated granular base, and granular base, were constructed to calculate the pavement responses under different dynamic modulus master curve parameters.

Gastric cardiac leiomyoma complicated with massive gastrointestinal bleeding: A rare case report.

Rationale: We report a rare case of gastric cardiac leiomyoma with massive gastrointestinal bleeding as the first symptom that presented. This is the first case of this rare condition occurring in a patient younger than 20 years old. Positive results could not be obtained by routine biopsy, and the diagnosis was finally confirmed by endoscopic ultrasound-guided fine-needle aspiration biopsy.

The Establishment of 3D Polarity-Reversed Organoids From Human Endometrial Tissue as a Model for Infection-Induced Endometritis.

Endometritis is a prevalent gynecological condition, often resulting from bacterial infections, which poses significant risks to women's reproductive health, including recurrent pregnancy loss, spontaneous abortion, and intrauterine adhesions. While conventional in vitro models have provided valuable insights into the pathogenesis of bacterial-induced endometritis, they often fail to replicate the complex cellular architecture and microenvironment of the endometrium due to species-specific differences and variations in the menstrual cycle. In this study, we present a novel organoid-based culture system that establishes a bacterial-induced endometritis model using endometrial organoids derived from primary epithelial cells.

Decorated high-dispersity Fe(OH) nanoparticles on NiZn LDH nanosheets towards enhanced alkaline oxygen evolution reaction.

The creation of efficient, earth-abundant electrocatalysts is crucial to address the sluggish kinetics of the oxygen evolution reaction (OER). In this study, a straightforward immersion technique is employed to fabricate a NiZnFe LDH composite by embedding Fe(OH) nanoparticles onto NiZn LDH nanosheets. The optimized NiZnFe LDH catalyst exhibits an overpotential of just 191 mV at 10 mA cm, significantly outperforming traditional OER catalysts.

Self-Supervised Optimization of RF Data Coherence for Improving Breast Reflection UCT Reconstruction.

The reflection ultrasound computed tomography (UCT) is gaining prominence as an essential instrument for breast cancer screening. However, reflection UCT quality is often compromised by the variability in sound speed across breast tissue. Traditionally, reflection UCT utilizes the delay-and-sum (DAS) algorithm, where the time of flight (TOF) significantly affects the coherence of the reflected radio frequency (RF) data, based on an oversimplified assumption of uniform sound speed.

Accuracy of Dual-layer Detector Spectral CT in Localizing Cholesteatoma: An Advanced Imaging Perspective.

Rationale And Objectives: Accurate early localization of temporal bone cholesteatoma is essential for determining the most appropriate surgical approach. Dual-layer detector spectral CT (DLCT) with multi-parameter spectral imaging has significantly improved soft tissue resolution. This study aims to investigate the value of dual-layer detector spectral CT multimodal parameters in the localization diagnosis of cholesteatoma of the temporal bone.

A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III clinical trial to assess the efficacy and safety of Yuping Tongqiao tablets in the treatment of persistent allergic rhinitis.

Ethnopharmacological Relevance: Yuping Tongqiao Tablets is a classic traditional Chinese medicine (TCM) formula commonly employed in China for managing various ailments, especially allergic conditions. Clinical reports indicate its potential as an effective treatment for persistent allergic rhinitis. Nevertheless, there remains a dearth of placebo-controlled studies to definitively establish its safety and efficacy.

Anomalous pH-Dependence of Ru for Hydrogen Electrochemistry.

The essence of the classic pH-dependent catalytic behavior of Pt toward hydrogen electrochemistry has been debated for decades. In stark contrast, Ru represents a unique exception by exhibiting intrinsically anomalous pH dependence among Pt-group metals, significantly challenging the universal validity of the existing mechanistic system derived from classic pH effects. To decode the chemical essence beneath the unique anomalous pH dependence, refined multidimensional structural characterizations and electrical transport spectroscopic studies reveal that the electron delocalization on Ru surface enables strong oxophilicity and unique pH-dependent coverage of OH*, essentially different from the H*-dominated Pt surface.

Identification of a novel genetic locus conferring virulence in the wheat tan spot pathogen Pyrenophora tritici-repentis.

The ascomycete Pyrenophora tritici-repentis (Ptr) is the causal agent of tan spot, a common and economically important wheat disease worldwide. Three necrotrophic effectors (NEs), known as Ptr ToxA, Ptr ToxB, and Ptr ToxC, have been identified from the fungal pathogen as major virulence factors. The race 2 isolate 86-124 which produces Ptr ToxA is capable of causing disease on wheat lines that is insensitive to Ptr ToxA, suggesting the use of additional NEs during the infection.

Machine Learning-Based Identification of Children With Intermittent Exotropia Using Multiple Resting-State Functional Magnetic Resonance Imaging Features.

Objective: To investigate the performance of machine learning (ML) methods based on resting-state functional magnetic resonance imaging (rs-fMRI) parameters in distinguishing children with intermittent exotropia (IXT) from healthy controls (HCs).

Method: Forty-one IXT children and 36 HCs were recruited. The amplitude of low-frequency fluctuations (ALFF), fractional ALFF (fALFF) in the slow-4 and slow-5 bands, and regional homogeneity (ReHo) were calculated.

From non-coding RNAs to cancer regulators: The fascinating world of micropeptides.

Micropeptides are commonly identified as peptides encoded by non-coding RNAs (ncRNAs). In the short open reading frame (sORF) of ncRNAs, there is a base sequence encoding functional micropeptides, which is of great significance in the biological field. Recently, micropeptides regulate diverse processes, including mitochondrial metabolism, calcium transport, mRNA splicing, signal transduction, myocyte fusion, and cellular senescence, regulating the homeostasis of the internal environment and cancer's incidence and progression.

Prediction of lymph node metastasis in stage I-III colon cancer patients younger than 40 years.

Aims: Developing a clinical model to predict the individual risk of lymph node metastasis (LNM) in young colon cancer (CC) patients may address an unmet clinical need.

Methods: A total of 2,360 CC patients under 40 years old were extracted from the SEER database and randomly divided into development and validation cohorts. Risk factors for LNM were identified by using a logistic regression model.

Probiotics reduce the recurrence of asymptomatic bacterial vaginosis in Chinese women.

Asymptomatic Bacterial Vaginosis(aBV)increases the risk of acquiring multiple sexually transmitted diseases, HPV, gynecologic complications and adverse reproductive outcomes, and is speculated to affect 10 ~ 35% of women. Without intervention, a significant proportion of aBV would progress. Metronidazole is the most widely used treatment for aBV, yet the main challenge has always been the high rate of recurrence.

Comparative analysis of organoid, air-liquid interface, and direct infection models for studying pathogen-host interactions in endometrial tissue.

The endometrium is a critical component of female reproductive health. Endometritis can significantly affect women's health, leading to complications such as infertility, pregnancy failure, and intrauterine adhesions. Therefore, establishing a reliable and effective model of endometritis is essential for advancing research in female reproductive health.

Detection method of subgrade settlement for the road of ART in coastal tidal flat area based on Vehicle-mounted binocular stereo vision technology.

To address the problem present in current subgrade settlement detection methods, this paper proposes a nondestructive intelligent and dynamic detection method for subgrade settlement based on vehicle-mounted binocular stereo vision technology. This method aims to achieve all season, the whole road, long-term detection of subgrade settlement for Road of ART (Autonomous rail Rapid Transit) in coastal tidal flat areas. Firstly, improved Schneider encoding is adopted as the marker for subgrade settlement monitoring points.

COLEC10: A potential tumor suppressor and prognostic biomarker in hepatocellular carcinoma through modulation of EMT and PI3K-AKT pathways.

Hepatocellular carcinoma (HCC) is a cancer with poor prognosis, underscoring the urgent need for enhanced detection and management. This study aimed to investigate the role of Collectin Subfamily Member 10 (COLEC10) in HCC, which was revealed to be associated with various diseases. Bioinformatics tools, including GEO, cBioPortal, and TCGA, were used to identify differentially expressed genes.