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The design of asphalt mixture has, for a long time, been an empirical and proof process, causing the mismatch between material design and pavement structure design. To enhance the rationality of asphalt pavement design, this study seeks a path to bridge the gap between asphalt mixture modulus and structural behavior. Firstly, pavement models with different base rigidities, including cement concrete base, cement-treated granular base, and granular base, were constructed to calculate the pavement responses under different dynamic modulus master curve parameters. The influence of master curve parameters on critical pavement responses was identified by the response surface method (RSM). Furthermore, a Whale Optimization Algorithm-Back Propagation (WOA-BP) artificial-neural-network-based pavement response prediction model was established. Then, a database mapping over 100 thousand pavement responses and dynamic modulus master curve parameters was built for determining the dynamic modulus master curve parameters by optimizing the pavement responses. The results show that the impacts of dynamic modulus master curve parameters on critical pavement responses depend on pavement structures. In general, parameter has the greatest impact, followed by , while the effects of and are relatively small. The Artificial Neural Network (ANN) performance prediction model, optimized by the WOA algorithm, has a high accuracy. The methodology for determining the dynamic modulus master curve parameter based on the critical response of pavement was successfully implemented. The findings can bridge the gap between material design and structure design of asphalt pavement and provide a basis for more accurate and reasonable asphalt pavement design.
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http://dx.doi.org/10.3390/ma18133184 | DOI Listing |
Colloids Surf B Biointerfaces
September 2025
Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Via De Sanctis, Campobasso, 86100, Italy. Electronic address:
Four different biomedical patches were bioprinted using nanocomposite hydrogels of sodium alginate/gelatin, sodium alginate/gelatin/indocyanine green freely dispersed, sodium alginate/gelatin/empty liposomes and sodium alginate/gelatin/indocyanine green loaded liposomes. Quasi-static and dynamic nanoindentations of the patch surfaces were performed to examine the effect of the single component on the mechanical response. The combination of results suggests that the mechanical structure of the gels is strongly influenced by crosslinking and the liposomes incorporating dye.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States of America.
Gaucher Disease (GD) is a rare genetic disorder characterized by a deficiency in the enzyme glucocerebrosidase, leading to the accumulation of glucosylceramide in various cells, including red blood cells (RBCs). This accumulation results in altered biomechanical properties and rheological behavior of RBCs, which may play an important role in blood rheology and the development of bone infarcts, avascular necrosis (AVN) and other bone diseases associated with GD. In this study, dissipative particle dynamics (DPD) simulations are employed to investigate the biomechanics and rheology of blood and RBCs in GD under various flow conditions.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Martin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.
Programmable self-assembly has recently enabled the creation of complex structures through precise control of the interparticle interactions and the particle geometries. Targeting ever more structurally complex, dynamic, and functional assemblies necessitates going beyond the design of the structure itself, to the measurement and control of the local flexibility of the intersubunit connections and its impact on the collective mechanics of the entire assembly. In this study, we demonstrate a method to infer the mechanical properties of multisubunit assemblies using cryogenic electron microscopy (cryo-EM) and RELION's multi-body refinement.
View Article and Find Full Text PDFJ Food Sci
September 2025
College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, Anhui, China.
The growing consumer interest in functional and health-oriented foods prompted the incorporation of tartary buckwheat sprout flour (TBSF) into food production. The addition of TBSF enhanced the nutritional value of noodles. Research has shown that as the proportion of TBSF increased, both the water absorption rate and thermal stability of the dough improved, while formation time decreased and dough aging was inhibited.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
September 2025
Department of Chemical System Engineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
The effect of shape and size of embolic agents on embolization phenomena has been discussed clinically for transcatheter arterial chemoembolization (TACE). We numerically discussed the unique embolization behavior of new deformable toroidal microparticles in blood vessels by computational fluid dynamics simulations. We employed an Eulerian-Eulerian (full Eulerian) fluid-structure interaction (FSI) method to analyze the flow and deformation behaviors of a deformable torus in a cylindrical pipe.
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