[Clinical research of Zhuangdan Yanshi Decoction combined with dapoxetine hydrochloride in the treatment of premature ejaculation with cholestasis and phlegm disturbance syndrome].

Objective: To investigate the clinical efficacy of Zhuangdan Yanshi Decoction combined with dapoxetine hydrochloride in the treatment of premature ejaculation with cholestasis and phlegm disturbance.

Methods: A total of 120 patients diagnosed with premature ejaculation and treated in the Andrology Outpatient Department of Shaanxi Provincial Hospital of Traditional Chinese Medicine from March to December in 2022 were selected and randomly divided into treatment group and control group, with 60 cases in each group. The incubation period of intravaginal ejaculation (IELT), the Diagnostic Scale of Premature Ejaculation (PEDT), the Premature Ejaculation Assessment Scale (PEP), the 5-item Sexual Function Evaluation of Chinese Premature Ejaculation Patients (CIPE-5) and the improvement of traditional Chinese medicine symptom scores were compared before and after the treatment.

Hardening-off under fluctuating light enhances the photosystem I resistance to excessive fluctuating light in Enhalus acoroides.

Seagrass meadows of Enhalus acoroides are rapidly declining. Transplanting artificially cultured seedlings is considered an efficient method of seagrass restoration. However, excessive fluctuating light (eFL) in the wild is highly likely to be a major threat to the survival of transplanted seedlings of E.

Stereodivergent Synthesis of Enantioenriched Organoboron Compounds with Carbon/Boron Dual Stereocenters via Rh(I)/Cu(I)-Catalyzed Enantioselective Desymmetrization of B-H Insertions.

Despite notable progress in the study of chiral boron compounds, research on tetracoordinate chiral boron species remains limited. Achieving a configurationally stable boron stereocenter typically requires stabilizing the tetrahedral structure of the boron atom with suitable Lewis bases. Moreover, due to the high reactivity of borane complexes and the limited methods for their modification, designing and synthesizing tetracoordinate chiral boron compounds with stable stereocenters presents considerable challenges.

Development and application of a novel tumor habitat analysis technique based on dynamical modeling.

Background: Oropharyngeal cancer (OPC) exhibits varying responses to chemoradiation therapy, making treatment outcome prediction challenging. Traditional imaging-based methods often fail to capture the spatial heterogeneity within tumors, which influences treatment resistance and disease progression. Advances in modeling techniques allow for more nuanced analysis of this heterogeneity, identifying distinct tumor regions, or habitats, that drive patient outcomes.

Asymmetric waveguide and compressively strained quantum well-enabled high-power, polarization-dependent 850 nm gain chip.

The development of high-power gain chips is crucial for advancing hybrid-integrated narrow-linewidth lasers, which face power limitations in emerging applications such as quantum sensing and atomic cooling. This study designed a high-power GaAs-based gain chip based on an asymmetric waveguide and compressively strained quantum wells for the 850 nm wavelength band. By applying the epitaxial structure and low-loss waveguide, a record continuous-wave output power of 114.

Programmable waveguide mesh photonic integrated circuits based on thin-film lithium niobate.

Programmable photonics chips based on a versatile structure are crucial for the next generation of advanced photonics systems. In this paper, we designed a programmable photonics chip with a hexagonal waveguide mesh consisting of longitudinally parallel arranged tunable basic units based on thin-film lithium niobate. We fabricated a waveguide mesh on a chip with an effective area of 5.

Analysis of a photonics-assisted multi-path interference cancellation system based on the combination of the digital domain and analog domain.

In this paper, a photonics-assisted multi-path interference (MI) cancellation system based on the combination of the digital domain and analog domain is proposed and demonstrated. The cancellation in the photonics-assisted analog domain avoids oversaturation of the analog-to-digital converter (ADC) signal at the input while the adaptive feedback control in the digital domain can also compensate for the optical path's undesirable factors, thus making MI cancellation in the best state all the time. Initially, the differences in MI cancellation between small-signal and large-signal modulations are analyzed.

Viral-community-induced antibiotic resistance gene regulation throughout the process of sewage sludge composting and its subsequent application to a phosphate mining wasteland: A three-year, large-scale field study.

The application of sewage sludge compost to phosphate mining wastelands improves soil quality, and provides a viable solution for sludge disposal. However, attention must be paid to antibiotic resistance genes (ARGs) in sewage sludge. Based on a large-scale field study, we comprehensively profiled the antibiotic resistome throughout the process of sewage sludge composting and its subsequent application to a phosphate mining wasteland.

Single-faceted IrO monolayer enabling high-performing proton exchange membrane water electrolysis beyond 10,000 h stability at 1.5 A cm.

Both commercial and laboratory-synthesized IrO catalysts typically possess rutile-type structures with multiple facets. Theoretical results predict the (101) facet is the most energetically favorable for oxygen evolution reaction owing to its lowest energy barrier. Achieving monolayer thickness while exposing this desired facet is a significant opportunity for IrO.

Broadband flat thin-film lithium niobate electro-optic frequency comb generator fabricated with photolithography.

Flat electro-optic frequency combs, as coherent spectral sequences with equidistant distribution, exhibit significant potential in high-capacity optical communication and reconfigurable microwave photonics. This study develops a monolithically integrated, fully packaged electro-optic comb device on a thin-film lithium niobate (TFLN) platform using an efficient photolithography scheme, overcoming the size and loss constraints of traditional discrete cascaded components. The synergistic interaction between cascaded amplitude modulator (AM) and three phase modulators (PMs) balances the optimization between comb-line count and flatness.

Solvent Engineering and Metal-Doping Dual Effects Enable Morphology Precise Controlled MOF-based Electrocatalysts for Highly Efficient Oxygen Evolution Reaction.

Designing economically viable electrocatalysts with superior activity for the oxygen evolution reaction (OER) represents a critical challenge in advancing practical water electrolysis systems for renewable hydrogen generation. In this work, CoFe-MOF(W) with a layered structure is created through synergistic modulation of a dual-regulation mechanism combining solvent engineering with metal doping, exhibiting superior electrocatalytic performance, requiring merely 276 mV overpotential to reach a current density of 10 mA cm while demonstrating fast kinetics with a 55 mV dec Tafel slope. The experimental results indicated that the solvent engineering facilitated the inducing unsaturated coordination states that tailored morphology and exposed more active sites, meanwhile, Fe-doping modulated the electronic structure of Co sites while introducing multimetal synergy for enhanced charge transfer, resulting in superior OER performance.

Polarization-insensitive 90° optical hybrid on the thin-film lithium niobate platform.

We propose a simple polarization-insensitive 90° optical hybrid on the thin-film lithium niobate (TFLN) platform. The design comprises one 1 × 2 multimode interference (MMI) coupler, three 2 × 2 MMI couplers, and crossing waveguides, effectively reducing the excitation of higher-order modes. By optimizing the length of the 2 × 2 MMI to balance the beat length difference between transverse electric (TE) and transverse magnetic (TM) modes, polarization-insensitive transmission across the entire C-band was achieved.

OsFT coordinates photosynthetic stability and carotenoid metabolism to regulate tillering in rice.

Introduction: Photosynthesis and tillering number have been essential components determining grain yield in rice. However, the genetic mechanism of carotenoid biosynthesis pathway, which is one of the photosynthetic pigments of rice, affecting tillering of rice is rarely studied.

Objective: This study elucidates the roles of OsFT in photosynthesis and carotenoid biosynthesis, and the synergistic regulation of rice tillering by SL and ABA, providing a theoretical basis for breeding high-yielding, drought-resistant rice varieties.

Aging Population and Lacking Sanitation Governance: Global Challenges in Alleviating Deaths from Unsafe Rural Sanitation.

With the rapid pace of global urbanization, health risks faced by rural communities are often overlooked. Deaths Attributable to Unsafe Sanitation in Rural areas (DAUSRs) are influenced by demographic factors, disease mortality rates, and environmental sanitation conditions. However, most studies have been limited in scope and scale and lack a comprehensive evaluation framework for global DAUSRs.

Transition between germination and dormancy for non-motile cells of Haematococcus pluvialis: dependence on nitrogen availability through metabolic flux of amino acids and nucleotides.

The slow growth and time-consuming cultivation process of Haematococcus pluvialis hinder its large-scale production. Germination of red, non-motile cells presents a novel strategy to improve cultivation efficiency; however, the underlying metabolic adaptations remain poorly understood. This study reveals the regulatory role of nitrogen in the dormancy-to-germination transition.

The Alternative Oxidase Pathway Participates in Seagrass Seedling Establishment by Regulating Photosynthetic and Respiratory Metabolism.

The roles of the alternative oxidase (AOX) pathway in plant physiology and metabolism are of increasing interest. AOX was found to regulate the growth of Enhalus acoroides seedlings, but its specific mechanism and physiological significance are unclear. In this study, the roles of the AOX pathway during E.

Bridging conservation gaps under climate change at multiple scales to protect 30% of Earth's surface by 2030.

The 30×30 commitment outlined in the Kunming-Montreal Global Biodiversity Framework (KM-GBF) offers a critical opportunity for enhancing global biodiversity conservation. However, KM-GBF's efforts to address climate change impacts remain limited. We developed 1-km-resolution hotspot maps for climate change vulnerability with the exposure-sensitivity-adaptation framework, species distribution for 4 terrestrial vertebrate taxa, and carbon stock capacity including organic and biomass carbon, for 2030.

Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function.

Label-free optical imaging and sensing of single nanoparticles are vital for fundamental research, disease diagnosis, and nanomaterial studies. Surface plasmon resonance microscopy (SPRM) is a label-free detection technology which is widely used in the detection of single nanoparticles. However, conventional SPRM suffers from poor spatial resolution, a limited field-of-view, system complexity, and high operating costs.

Low cost small scale recycling aluminium cans for energy conservation and environmental sustainability.

A smart, low-cost small-scale aluminium (Al) beverage cans recycling technology is needed to solve the problem of abandoned cans around the world. In this research, a small-scale Al recycling system which is clean, safe, sustainable, easy to use and low cost, has been developed. It uses natural solar energy as the power source, a smart induction furnace to quickly melt the Al cans and two filters to purify the generated gas during the melting.

Modulating Reaction Kinetics Using an Electrolytic Method to Achieve Efficient Vehicle Identification Number Reappearance.

Vehicle identification number (VIN) reappearance technology is an important means of vehicle traceability in various criminal cases. However, with the advancement of metallurgical techniques, the corrosion resistance of metal becomes stronger, and the traditional chemical etching reappearance method gradually fails. In order to break through the dilemma of traditional methods, this study establishes an electrochemical corrosion system by introducing the corrosion inhibitor hexamethylenetetramine (HMTA) to precisely regulate the electrochemical dissolution kinetics.

Advances and challenges in identifying precursors of memory CD4 T cells.

Memory T (T) cells play critical roles in protective immunity and immunopathology, and their generation and maintenance have attracted a lot of interests. In recent decades, informative investigations into CD8 T cell precursors have greatly enhanced our understanding of fate decision during CD8 T cell differentiation. Yet, much less is known about the generation of CD4 T cells and their precursors.

Comprehensive metabolomics study identifies SN-38 organ specific toxicity in mice.

SN-38 (7-ethyl-10-hydroxycamptothecin), the active metabolite of irinotecan, is a crucial anticancer agent frequently studied in drug delivery systems. Irinotecan (CPT-11) is used to treat various solid tumors but is associated with adverse effects such as nausea, vomiting, diarrhea, and steatohepatitis. However, the precise biochemical pathways underlying these side effects remain unclear.

Progress in silicon-based reconfigurable and programmable all-optical signal processing chips.

Taking the advantage of ultrafast optical linear and nonlinear effects, all-optical signal processing (AOSP) enables manipulation, regeneration, and computing of information directly in optical domain without resorting to electronics. As a promising photonic integration platform, silicon-on-insulator (SOI) has the advantage of complementary metal oxide semiconductor (CMOS) compatibility, low-loss, compact size as well as large optical nonlinearities. In this paper, we review the recent progress in the project granted to develop silicon-based reconfigurable AOSP chips, which aims to combine the merits of AOSP and silicon photonics to solve the unsustainable cost and energy challenges in future communication and big data applications.

Synthesis of Aviation Fuel Range Alkanes Through Hydrodeoxygenation of Lignocellulose Derived C Aldol Condensate Catalyzed by Ni-NbO/ZrP Catalysts.

The hydrodeoxygenation (HDO) of lignocellulose-based furan compounds holds significant potential for the synthesis of aviation fuel. However, challenges such as high catalyst costs and low yields persist. This study proposes a two-step strategy, involving pre-hydrogenation followed by HDO, to convert the C condensation product derived from furfural and levulinic acid into hydrocarbons within the aviation fuel range.

A Novel Method for Rapid Measurement of Facial Blood Oxygen Saturation Using a Snapshot Multispectral Imager.

Blood oxygen saturation measuring is crucial for the diagnosis of disease severity. Despite the great efforts in non-contact vital signs monitoring by image photoplethysmography (IPPG) technology, the high-efficiency acquisition of transient image data is still challenging and generally requires complicated data processing processes. In this paper, we demonstrated a novel method for rapid measurement of blood oxygen saturation.