U-shaped association between ultra-processed food intake and overactive bladder in US adults: a national cross-sectional study.

Background: The association between ultra-processed food (UPF) intake and overactive bladder (OAB) remains unclear. This study aimed to investigate the relationship between UPF consumption and the risk of OAB in U.S.

Technological Advances in Anti-hair Loss and Hair Regrowth Cosmeceuticals: Mechanistic Breakthroughs and Industrial Prospects Driven by Multidisciplinary Collaborative Innovation.

In light of the escalating global prevalence of hair loss, there is an imperative to explore strategies for the prevention and promotion of hair growth. This article reviews the current situation, challenges, innovations, and prospects of cosmetics that promote anti-hair loss and hair growth. Firstly, the physiological and pathological mechanisms of hair loss, including androgenetic alopecia, telogen effluvium, and alopecia areata, as well as the influence of genetic, environmental, and lifestyle factors, are explored.

Targeting HDAC and PARP Enhances STING-Dependent Antitumor Immunity in STING-Deficient Tumor.

The stimulator of interferon genes (STING)-mediated innate immune pathway plays an important role in tumor immunosurveillance. STING deficiency in tumors impairs the interferon response; however, the underlying mechanism remains unclear. Here, it is demonstrated that histone deacetylase (HDAC) suppresses STING expression by reducing H3K9 acetylation at the STING promoter.

Epilobieae genomes and the evolution of Myrtales.

Unlabelled: The order Myrtales, one of the most species-rich lineage within the Superrosidae clade, with the majority of its species distributed across five families: Myrtaceae, Melastomataceae, Lythraceae, Onagraceae, and Combretaceae. Despite the ecological and economic importance of the Myrtales, its phylogenetic relationships remain unresolved, with previous studies yielding inconsistent results based on gene fragments and plastid genomes. Genomic data, particularly single-copy/low-copy nuclear genes, provide valuable insights for resolving these phylogenetic relationships.

Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis.

Modified Qianghuo Shengshi decoction (MQSD), a TCM formula, is clinically used for osteoarthritis (OA) symptom relief. Its exact molecular actions, however, are not fully understood. This investigation seeks to elucidate the molecular mechanisms by which MQSD impedes OA progression.

Aging Population and Lacking Sanitation Governance: Global Challenges in Alleviating Deaths from Unsafe Rural Sanitation.

With the rapid pace of global urbanization, health risks faced by rural communities are often overlooked. Deaths Attributable to Unsafe Sanitation in Rural areas (DAUSRs) are influenced by demographic factors, disease mortality rates, and environmental sanitation conditions. However, most studies have been limited in scope and scale and lack a comprehensive evaluation framework for global DAUSRs.

Learning curves in endoscopic thyroidectomy: A literature review of different surgical approaches.

Objective: This review analyzes the learning curves of various endoscopic thyroidectomy approaches, aiming to guide surgeons in improving training efficiency, reducing learning time, and enhancing surgical safety and outcomes.

Methods: A literature search in PubMed and Web of Science for studies published from January 2014 to April 2024 on the learning curves of endoscopic thyroidectomy was conducted. Studies involving human subjects with specific case data were included; duplicates, non-English publications, animal studies, reviews, and unrelated thyroid conditions were excluded.

Efficient terahertz radiation generation from air plasma with mid- and near-infrared three-color femtosecond pulses.

We report on the generation of the terahertz (THz) radiation from air plasma driven by a three-color femtosecond field with the fundamental pulse in the near- (1700 nm and 800 nm) and mid-infrared (3900 nm) ranges. With an inline optical setup for three-color pulse generation and relative phase control, we observed that the THz pulse energy can be enhanced up to 6 times compared with the conventional two-color excitation scheme, dependent on the incident fundamental pulse energy. The polarization of the enhanced THz pulse was found to be elliptical, with the second and third harmonics components of the three-color pump also being elliptically polarized.

In vivo keratotomy by mid-infrared femtosecond laser resonant with amide vibrational mode.

Background: Laser keratotomy, a corneal incision technique for vision correction, has advanced with near-infrared (NIR) femtosecond (fs) lasers-ultrashort pulsed light sources in the near-infrared spectrum. However, NIR femtosecond lasers encounter challenges such as postoperative astigmatism due to scattering by edematous tissues, and endothelial cells distortion by mechanical impact.

Methods: The mid-infrared (MIR) femtosecond lasers at a central wavelength of 6.

Nanobody based immunoassay for detection of aquatic virus: Giant salamander iridovirus.

Aquatic viruses cause devastating diseases in aquaculture, severely limiting production and resulting in significant economic losses. The giant salamander iridovirus (GSIV), a member of the genus Ranavirus, is the only virus reported to infect giant salamanders, posing a severe threat to the farming industry. Currently, there are no effective strategies available for its control.

Nanobody-Based Immunoassays for the Detection of Food Hazards-A Review.

Food safety remains a significant global challenge that affects human health. Various hazards, including microbiological and chemical threats, can compromise food safety throughout the supply chain. To address food safety issues and ensure public health, it is necessary to adopt rapid, accurate, and highly specific detection methods.

Survival analysis between different treatment strategies of mixed adenoneuroendocrine carcinoma (MANEC): a population-based study.

Background: Mixed adenoneuroendocrine carcinoma (MANEC) is rare and heterogeneous. Currently, there is no concise treatment standard for MANEC. This study aimed to explore the prognostic impact of different treatment methods in MANEC.

Accuracy of machine learning in diagnosing microsatellite instability in gastric cancer: A systematic review and meta-analysis.

Background: Significant challenges persist in the early identification of microsatellite instability (MSI) within current clinical practice. In recent years, with the growing utilization of machine learning (ML) in the diagnosis and management of gastric cancer (GC), numerous researchers have explored the effectiveness of ML methodologies in detecting MSI. Nevertheless, the predictive value of these approaches still lacks comprehensive evidence.

Different patterns of bacterioplankton in response to inorganic and organic phosphorus inputs in freshwater lakes - a microcosmic study.

Phosphorus (P) is a limiting factor in fresh waters and is also the main cause of water eutrophication and deterioration, However, the practical effect of elevated P level on bacterioplankton is less evaluated. In this study, we investigated the bacterioplankton in a 96 hours microcosm experiment with P additions in two forms (organic/inorganic P, OP/IP) and three levels (final conc., 0.

Assessing the predictive value of pre- and post-operative inflammatory markers in patients undergoing total knee arthroplasty.

Background And Objective: Total Knee Arthroplasty (TKA) has proven highly effective in improving quality of life for patients with severe knee conditions. Despite advancements, surgical complications such as periprosthetic joint infections (PJIs) pose risks. The potential predictive value of pre- and post-operative inflammatory markers like neutrophil-to-lymphocyte ratio (NLR), D-dimer, and albumin levels on surgical outcomes is garnering attention.

Perfluorooctanoic acid effect and microbial mechanism to methane production in anaerobic digestion.

Perfluorooctanoic acid (PFOA) as emerging pollutants was largely produced and stable in nature environment. Its fate and effect to the wasted sludge digestion process and corresponding microbial mechanism was rarely reported. This study investigated the different dose of PFOA to the wasted sludge digestion process, where the methane yield and microbial mechanism was illustrated.

Carbon storage through China's planted forest expansion.

China's extensive planted forests play a crucial role in carbon storage, vital for climate change mitigation. However, the complex spatiotemporal dynamics of China's planted forest area and its carbon storage remain uncaptured. Here we reveal such changes in China's planted forests from 1990 to 2020 using satellite and field data.

Wireless sequential dual light delivery for programmed PDT in vivo.

Using photodynamic therapy (PDT) to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of light. Polymeric nanocarriers are widely used for photosensitizer delivery, while the self-quenching of the encapsulated photosensitizers would impair the PDT efficacy. Furthermore, the generated short-lived reactive oxygen spieces (ROS) can hardly diffuse out of nanocarriers, resulting in low PDT efficacy.

Formation and non-covalent interactions of binary and ternary complexes based on β-casein, Lentinus edodes mycelia polysaccharide, and taxifolin.

Polyphenols, polysaccharides, and proteins are essential nutrients and functional substances present in food, and when present together these components often interact with each other to influence their structure and function. Proteins and polysaccharides are also excellent carrier materials for polyphenols. In this context, this study investigated the non-covalent interactions between taxifolin (TAX), Lentinus edodes mycelia polysaccharide (LMP), and β-casein (β-CN).

Bifunctional HDAC and DNMT inhibitor induces viral mimicry activates the innate immune response in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a unique breast cancer subtype characterized by a lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. Since TNBC lacks ER, PR, and HER2, there are currently no drugs that specifically target TNBC. Therefore, the development of new drugs or effective treatment strategies to target TNBC has become an urgent clinical need.

A national-scale assessment of land subsidence in China's major cities.

China's massive wave of urbanization may be threatened by land subsidence. Using a spaceborne synthetic aperture radar interferometry technique, we provided a systematic assessment of land subsidence in all of China's major cities from 2015 to 2022. Of the examined urban lands, 45% are subsiding faster than 3 millimeters per year, and 16% are subsiding faster than 10 millimeters per year, affecting 29 and 7% of the urban population, respectively.

Potential causal association between leisure sedentary behaviors and osteoporosis: A two-sample Mendelian randomization analysis.

Previous observational studies have observed a correlation between sedentary behavior and osteoporosis. However, conclusions from these studies have been contradictory. To explore the potential causal relationship between sedentary behavior and osteoporosis, we conducted a Mendelian randomization analysis.

Application status and optimization suggestions of tumor organoids and CAR-T cell co-culture models.

Tumor organoids, especially patient-derived organoids (PDOs) exhibit marked similarities in histopathological morphology, genomic alterations, and specific marker expression profiles to those of primary tumour tissues. They are applied in various fields including drug screening, gene editing, and identification of oncogenes. However, CAR-T therapy in the treatment of solid tumours is still at an exploratory stage.