Tunable Multistate Mechanoresistance in a Single-Molecule Junction Incorporating Energy-Dissipative Structures.

Mechanoresponsive molecular devices are capable of exhibiting dynamic responses to external mechanical stimuli, enabling applications in smart materials, nano-devices, and flexible electronics. However, energy conversion induced by mechanical stimuli requires efficient energy dissipation mechanisms. Traditional methods often involve bond breaking or incomplete energy release, which can lead to device failure during continuous operations.

Quantifying Bite Forces for Solid Foods: Implications for Patients Postmandibular Reconstruction.

Background: Bite forces required to masticate different food consistencies remain unknown, complicating dietary guidelines following mandibular reconstruction. This study quantifies the forces required for solid foods and estimates safe bite limits postreconstruction.

Methods: Twenty food items were prepared according to IDDSI Levels 5 through 7b.

Fracture patterns and outcomes in children and adolescents aged 5-19 years with type 1 diabetes: Analysis of data from the US nationwide inpatient sample, 2005-2020.

Background: Despite the high prevalence of type 1 diabetes mellitus (T1DM) and fractures in pediatric populations, little is known about fracture patterns and T1DM-specific outcomes. This study aimed to investigate differences in fracture patterns and T1DM-specific outcomes between children and adolescents with/without T1DM.

Methods: This retrospective observational study assessed differences in fracture patterns and outcomes among hospitalized children and adolescents (ages 5-19) with and without T1DM using the United State (US) Nationwide Inpatient Sample (NIS).

Is CXCR4-targeted Ga-pentixafor PET/CT a reliable AVS-free modality for surgical decision-making and prognostic prediction in primary aldosteronism with bilateral adrenal lesions?

Background: For patients diagnosed with primary aldosteronism (PA) accompanied by bilateral adrenal lesions, identifying optimal candidates for surgical intervention remains a significant clinical challenge. Although adrenal venous sampling (AVS) is currently the gold standard for lateralizing aldosterone hypersecretion, its technical complexity, invasiveness, and interpretive difficulties restrict its widespread adoption. In this study, we aimed to investigate the clinical application of Ga-pentixafor positron emission tomography/computed tomography (PET/CT) as a non-invasive imaging modality in AVS-free surgical decision-making for PA patients with bilateral adrenal lesions.

Investigation into Ultrasonic Oscillation-Assisted Nickel Electroplating onto a Diamond Surface.

At present, there are some challenging issues for diamond electroplating devices, such as poor particle-cathode contact uniformity, low conductivity, inefficient deposition, and complex disassembly/cleaning process of the device. To overcome these issues, an ultrasonic oscillation-assisted nickel electroplating device is innovatively designed and presented in this paper. The device features: (1) innovative architecture enabling rapid disassembly; (2) ultrasonic enhancement of diamond particle mobility (frequency × amplitude); (3) optimized electrical contact interfaces.

Clinical and genetic features of older patients with pheochromocytomas and paragangliomas: A multicenter retrospective study.

Purpose: The genetic background and catecholamine phenotype of pheochromocytomas and paragangliomas (PPGLs) influence the age at diagnosis. However, few studies have systematically investigated clinical features of older patients with PPGLs. This study was based on one of the largest PPGL cohorts in China and aimed to summarize the clinical and genetic characteristics of older PPGL patients, especially concerning intraoperative hemodynamics and genetic background.

Palladium-catalyzed aromatic C-H alkylation of 1-naphthylamines with dichloroalkanes and its application in fused polycyclic amine synthesis.

Herein, we report a palladium-catalyzed aromatic C-H bond alkylation reaction of 1-naphthylamines at the C8 site with dichloroalkanes as alkylating agents. DFT calculation demonstrates the distinctive advantage of the separated dichloroalkanes in the reaction by stabilizing the key intermediate C-H⋯N or C-H⋯π interaction induced by the additional Cl atom. In addition to the specific alkylation site selectivity in the naphthyl ring, the products provided by the current C-H alkylation protocol display important applications in the construction of fused polycyclic amines a one-step treatment.

Thulium versus holmium: Which is safer for the removal of entombed stents?

Introduction: Removal of entombed ureteral stents can be technically challenging, particularly if the stent were to fragment during removal. The purpose of this study was to compare the therapeutic suitability of the thulium fiber laser (TFL) and the holmium laser (HL) in the treatment of entombed stents.

Methods: In this benchtop study, first, the time taken for each laser to transect the stent was recorded in 10 experiments/laser.

Rock Solid Measurements: A Comparison of Three Methods of Kidney Stone Volume Assessment.

Renal stone volume is an important variable for treatment selection and predicting surgical outcomes. However, the standardized and optimal method for stone volume assessment has not been identified. The purpose of this study was to evaluate and compare three methods of volume assessment: the scalene ellipsoid formula, three-dimensional (3D) slicer, and Enterprise Imaging.

Dual-Pronged Attack: Biomimetic Multi-Functional MOFs for Rheumatoid Arthritis Therapy via Inhibiting Synovial Hyperplasia and Improving Immune Microenvironment.

Fibroblast-like synoviocytes (FLSs) and synovial macrophages (SMs) contribute significantly to the occurrence and development of rheumatoid arthritis (RA). Although therapeutic strategies targeting FLSs or SMs have achieved certain results, monotherapy often fails to effectively alleviate synovitis. By loading methotrexate (MTX) and glucose oxidase (GOx) in the zinc imidazole framework-8 (ZIF-8) and incorporating with the platinum nanoparticles (Pt NPs) and macrophage membranes, multifunctional probe mZPMG NPs were prepared.

Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems.

Brain organoid technology has revolutionized the ability to model human neurodevelopment in vitro. However, current techniques remain limited by their reliance on simplified endothelial cell populations. Multi-Region Brain Organoids (MRBOs) are engineered that integrate cerebral, mid/hindbrain, and complex endothelial organoids into one structure.

Depressive Symptoms and Osteoporosis in Middle-Aged and Older Adults: A Cross-Sectional Analysis of NHANES and HRS Data.

Background & Aims: Depression and osteoporosis are common among middle-aged and older adults, both impacting morbidity and quality of life. Their shared risk factors suggest a potential link, but this relationship remains underexplored. This study aimed to assess the association between depressive symptoms and osteoporosis in two large cohorts: the National Health and Nutrition Examination Survey (NHANES, 2005-2010) and Health and Retirement Study (HRS, 2012).

Optimization and Experimental Analysis of Electroless Nickel Plating on the Diamond Surface.

Coating diamond particle surfaces with a layer of high-temperature resistant nickel, which possesses weldability, effectively enhances the bonding strength between diamond particles and substrates in pre-grinding tools. This improves their stability and strength at high temperatures, thereby enhancing the performance, lifespan, and efficiency of grinding tools. This paper explores the electroless nickel plating process on diamond surfaces, analyzes the working principle of electroless nickel plating on diamond surfaces, and proposes the use of 2 g/L AgNO solution and 2 g/L AgNO + 10 mL/L NH·HO solution as Pd-free activating solutions.

Impact of first ambulation time on unilateral biportal endoscopy in lumbar disc herniation: a systematic review and meta-analysis.

Background: This study aimed to evaluate the effect of early versus late postoperative ambulation on clinical outcomes and complications following unilateral biportal endoscopy (UBE) for lumbar disc herniation (LDH).

Methods: A systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines. PubMed, Embase, Web of Science, and Cochrane Library were searched up to February 2025.

The microbiologist's guide to metaproteomics.

Metaproteomics is an emerging approach for studying microbiomes, offering the ability to characterize proteins that underpin microbial functionality within diverse ecosystems. As the primary catalytic and structural components of microbiomes, proteins provide unique insights into the active processes and ecological roles of microbial communities. By integrating metaproteomics with other omics disciplines, researchers can gain a comprehensive understanding of microbial ecology, interactions, and functional dynamics.

Potential of C-X-C-Chemokine-Receptor-Type-4-Directed PET/CT Using [¹⁸F]AlF-NOTA-QHY-04 in Identifying Molecular Subtypes of Small Cell Lung Cancer.

Objective: Molecular subtyping of small-cell lung cancer (SCLC) has major implications for prognostic relevance and treatment guidance. This study aimed to explore the feasibility of a novel tracer targeting C-X-C-chemokine-receptor-type-4 (CXCR4) for distinguishing different SCLC subtypes.

Materials And Methods: Thirty-five patients with pathologically confirmed SCLC were enrolled in this prospective study.

2D layered BP/group-IV monochalcogenide van der Waals heterostructures for photovoltaics: electronic structure, band alignment, and carrier dynamics.

van der Waals heterostructures, composed of two-dimensional materials, have emerged as a promising platform for optoelectronic and photovoltaic applications. In this study, we constructed four vdW heterostructures, including BP/GeS, BP/GeSe, BP/SnS, and BP/SnSe, using BP and group-IV monochalcogenides as building blocks and investigated their potential for photovoltaic applications. First-principles calculations reveal that BP forms type II heterostructures with GeSe, SnS, and SnSe, while the BP/GeS system exhibits type I band alignment due to interfacial charge transfer.

An Electric Molecular Faraday Cage.

Faraday cages are essential tools for protecting conducting materials from unwanted electromagnetic radiation by redistributing charges around the cage's exterior. When integrated into nanoscale molecular circuits, particularly those with well-defined inner cavity structures, Faraday cages isolate guest molecules from external influences, thereby improving device stability and performance. The design of molecular Faraday cages involves the intersection of molecular electronics and supramolecular chemistry with the goal of safeguarding internal molecules from harmful substances.

Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection.

The gut microbiome's pivotal role in health and disease is well established. SARS-CoV-2 infection often causes gastrointestinal symptoms and is associated with changes of the microbiome in both human and animal studies. While hamsters serve as important animal models for coronavirus research, there exists a notable void in the functional characterization of their microbiomes with metaproteomics.

[Regulatory effect of electroacupuncture at "Neiguan" (PC6) on mitochondrial autophagy during the ischemia and reperfusion phases in rats with myocardial ischemia-reperfusion injury].

Objective: To investigate the regulatory effect of electroacupuncture (EA) at "Neiguan" (PC6) on mitochondrial autophagy in rats with myocardial ischemia-reperfusion injury (MIRI) at different phases (ischemia and reperfusion phases), and to explore the bidirectional regulatory effects of EA at "Neiguan" (PC6) and its potential mechanism.

Methods: Forty-five male SD rats were randomly divided into 6 groups according to the random number table method, namely, sham-operation group (=9), model-A group (=6), model-B group (=9), EA-A1 group (=6), EA-B1 group (=6), and EA-B2 group (=9). Except the rats in the sham-operation group, the MIRI model was established in the other groups with the physical ligation and tube pushing method.

Inhibition of Mitochondrial-Associated Protein MAGMAS Resensitizes Chemoresistant Prostate Cancer Cells to Docetaxel.

Background/objectives: Metastatic prostate cancer (PCa) is the leading cause of cancer-related deaths and a major contributor to cancer mortality in men. Most patients with metastatic PCa eventually develop metastatic castration-resistant prostate cancer (mCRPC), characterized by resistance to treatment with androgen-deprivation therapy, and often later the development of resistance to other types of agents. MAGMAS, a 13.

PCAFA-Net: A Physically Guided Network for Underwater Image Enhancement with Frequency-Spatial Attention.

Underwater images frequently experience degradation, including color shifts, blurred details, and reduced contrast, primarily caused by light scattering and the challenging underwater conditions. The conventional methods based on physical models have proven insufficient for effectively addressing diverse underwater conditions, while deep learning approaches are limited by the quantity and diversity of data, making it challenging to perform well in unknown environments. Furthermore, these methods typically fail to fully exploit the spectral differences between clear and degraded images and do not capture critical information in the frequency domain, limiting further improvements in enhancement performance.

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy.

In clinical practice, surgical removal of tumors often leaves behind small tumors and circulating tumor cells, increasing the risk of metastasis and recurrence, which seriously affects treatment outcomes. Immunotherapy activates the immune system to monitor and inhibit tumor metastasis and recurrence long-term. However, inflammatory microenvironments at surgical sites lead to immunosuppressive tumor-associated macrophages (TAMs), causing immune evasion.

Efficacy of novel regimens targeting oxidative phosphorylation in .

in both replicating and non-replicating states relies on oxidative phosphorylation (OxPhos) to generate ATP for its growth and survival. Our research delved into the efficacy of novel regimens targeting the OxPhos pathway in murine models. The combination of bedaquiline, clofazimine, pyrazinamide, alongside telacebec, and SQ109 was investigated against both wild-type H37Rv and an mutant with cross-resistance between bedaquiline and clofazimine.