Bimetallic FeNi-ZSM-5-catalyzed pyrolysis of photovoltaic waste: Selective and high-yield aromatic valorization for circular resource recovery.

Catalytic pyrolysis, an efficient thermochemical process, offers a promising pathway to valorize thermoset photovoltaic backsheets (TPV) into high-value chemicals. This study investigates the ex situ catalytic pyrolysis of TPV using two acidic catalysts, ZSM-5 and FeNi-ZSM-5, under varied operational conditions, with a focus on product distribution and process efficiency. The catalytic intervention significantly enhanced pyrolysis performance.

Synergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models.

Background: Stress is a prevalent mental health concern that often emerges in late adolescence or early adulthood. Since 2007, the Food and Drug Administration (FDA) has not approved any novel anxiolytic pharmaceuticals, leading to increased interest in nutritional supplements as alternative therapies for stress management.

Purpose: Building on our previous study, this work aims to investigate the synergistic effects of Theanine (Th) and Walnut Peptide (WP) on stress mitigation and cognitive enhancement.

Needs Analysis of Supportive Care for Postoperative Wound Rehabilitation in Anal Fistula Patients Based on the Kano Model.

Objective: To qualitatively analyze the supportive care needs (including health education and nursing care) of anal fistula patients after fistulotomy using the Kano model.

Methods: A total of 183 anal fistula patients who underwent fistulotomy from December 2021 to December 2023 were selected via cluster sampling. Sociodemographic data were collected, and a self-designed questionnaire based on the Kano model (validated through two rounds of expert consultation and referring to the related literature) was used to assess patients' supportive care needs.

Is CXCR4-targeted Ga-pentixafor PET/CT a reliable AVS-free modality for surgical decision-making and prognostic prediction in primary aldosteronism with bilateral adrenal lesions?

Background: For patients diagnosed with primary aldosteronism (PA) accompanied by bilateral adrenal lesions, identifying optimal candidates for surgical intervention remains a significant clinical challenge. Although adrenal venous sampling (AVS) is currently the gold standard for lateralizing aldosterone hypersecretion, its technical complexity, invasiveness, and interpretive difficulties restrict its widespread adoption. In this study, we aimed to investigate the clinical application of Ga-pentixafor positron emission tomography/computed tomography (PET/CT) as a non-invasive imaging modality in AVS-free surgical decision-making for PA patients with bilateral adrenal lesions.

Characteristics of Varicella Breakthrough Cases in Jinhua City, 2016-2024.

: Varicella remains a prevalent vaccine-preventable disease, but breakthrough infections are increasingly reported. However, long-term, population-based studies investigating the temporal and demographic characteristics of breakthrough varicella remain limited. : This retrospective study analyzed surveillance data from Jinhua City, China, from 2016 to 2024.

Engineered Biomimetic Nanovesicles Derived From Bone Marrow Stromal Cells With Innate Homing Capability for Targeted Delivery.

Precise delivery of pharmaceuticals administered to bone marrow for various bone diseases is challenging, given the bone marrow-blood barrier (MBB). Bone marrow stromal cells (BMSCs) derived from bone marrow can naturally infiltrate the MBB and home to bone tissue. Here, biomimetic nanovesicles (namely mNVs) engineered with the extracted cell membrane from BMSCs are reported for homing delivery of different core nanomedicines to bone marrow.

Case Report: Compound heterozygous variants in cause complex syndactyly with oligodactyly, renal artery variation, and facial scar.

Background: The gene, a member of the basic helix-loop-helix (bHLH) family of transcription factors, plays a critical role in limb development. Mutations in have been associated with various limb malformations, including syndactyly and split-hand/foot malformation. This study aimed to identify and characterize novel variants in a fetus with complex limb and renal abnormalities, providing further insights into the genetic basis of developmental disorders.

Fine particulate matter contributes to the development of atherosclerosis via miR-3529-3p encapsulated in extracellular vesicles.

Exposure to fine particulate matter (PM) has been closely correlated with cardiovascular morbidity and mortality. The present study elucidates the mechanism by which PM induces vascular endothelial injury and accelerates atherosclerosis through alveolar macrophage-derived extracellular vesicles (AMs-EVs). Utilizing ApoE mice and in vitro models, it was demonstrated that PM exposure provokes pulmonary inflammation and M1 macrophage polarization, thereby augmenting the release of AMs-EVs.

Diamond-Inspired DNA Hydrogel Based on Tetrahedral Framework Nucleic Acids for Burn Wound Healing.

Burn wounds frequently pose high risks of a prolonged healing process and even death due to the persistent reactive oxygen species (ROS)-mediated inflammatory cascade. There is an urgent requirement for advanced dressings modulating the immune microenvironment surrounding the wound. DNA hydrogels have been preliminarily investigated in tissue regeneration due to their excellent permeability, editability, and biocompatibility.

ATF2-mediated Transcriptional Activation of USP4 Stabilizes KMT2A Protein and Promotes Trophoblast Dysfunction.

Preeclampsia (PE) is a severe and prevalent complication of pregnancy, characterized by insufficient trophoblast invasion, placental hypoxia, and systemic inflammation, which collectively represent the central pathological mechanisms underlying the disease. The molecular mechanism involving activating transcription factor 2 (ATF2), ubiquitin-specific peptidase 4 (USP4), and lysine methyltransferase 2 A (KMT2A) in hypoxia/reoxygenation (H/R)-treated trophoblast cells (HTR-8/SVneo) is explored, aiming to provide a novel theoretical basis for therapeutic strategies against PE. An in vitro H/R model was established using HTR-8/SVneo trophoblast cells to simulate PE pathophysiology.

A multimodal deep learning radiomics model for predicting degenerative meniscus tear after arthroscopy.

Background: Degenerative meniscus tears are often accompanied by varying degrees of osteoarthritis, making the prognostic outcome of arthroscopic partial meniscectomy (APM) difficult to predict. Our research objective is to develop and validate a multimodal deep learning radiology (MDLR) model based on the integration of multimodal data using deep learning radiology (DLR) scores from preoperative magnetic resonance imaging (MRI) images and clinical variables.

Materials And Methods: From February 2020 to February 2022, 452 eligible patients with degenerative meniscus tear who underwent APM were retrospectively enrolled in cohorts.

Advances in microneedle technology for skin wound healing: integrating nanomaterials and intelligent drug delivery systems.

Recent clinical challenges in wound healing, particularly chronic non-healing wounds such as diabetic ulcers and burn injuries, highlight the limitations of current treatments in achieving rapid healing, infection control, and scar reduction. The integration of nanomaterials with microneedle technology-an emerging platform for transdermal drug delivery and microenvironment regulation-offers significant advantages in addressing these challenges. By incorporating functional nanomaterials such as nanonzymes, metal nanoparticles, and antimicrobial nanostructures, microneedle platforms enhance local hemostasis, infection suppression, inflammation regulation, angiogenesis, and tissue regeneration.

Robust Antiferromagnetism of the 2H-FeSiN Monolayer with Correlation and Strain Effects.

A new class of Janus two-dimensional materials, MAN (M = V, Nb, Ta; A = Si, Ge), has recently been theoretically proposed, exhibiting the absence of magnetic ordering. However, the fundamental origin of this nonmagnetic behavior remains unresolved. In this work, we employ first-principles calculations to predict a new Janus 2D antiferromagnetic material, 2H-FeSiN.

Higher risk of gastrointestinal stenosis and obstruction in clozapine-treated individuals with schizophrenia: a pharmacovigilance study based on the FDA adverse event reporting system database.

Background: Clozapine, the most effective antipsychotic for treatment-resistant schizophrenia, is associated with severe adverse drug reactions (ADRs), including gastrointestinal stenosis and obstruction (GSO). Despite its efficacy, clozapine's anticholinergic properties impair gastrointestinal motility, leading to underrecognized yet life-threatening complications. This study investigates the risk of GSO in clozapine-treated individuals using real-world pharmacovigilance data.

Amelioration of hypercholesterolemia by Lactiplantibacillus plantarum GLPL02 via regulating intestinal flora and cholesterol metabolism.

Background: In recent years, hypercholesterolemia has become one of the important risk factors for death around the world. Lactic acid bacteria (LAB), especially Lactiplantibacillus plantarum, exhibit strain-specific property of cholesterol-lowering activity. However, the metabolic mechanism involved in lipid-lowering capacity and regulation of intestinal flora of L.

CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted Cancer.

CDKN2A/MTAP co-deletion occurs frequently in non-small cell lung cancer and other solid tumors, including glioblastoma and pancreatic ductal adenocarcinoma. Lung cancer remains the leading cause of cancer-related mortality, and fewer than 15% of glioblastoma or pancreatic cancer patients survive 5 years, underscoring the need for more effective therapies. PRMT5 is a synthetic-lethal dependency in MTAP-null tumors and an attractive therapeutic target for CDKN2A/MTAP-deleted cancers.

The hidden toll of air pollution: mental health effects on middle-aged and older adults.

Objective: Depressive disorders are increasingly recognized as a major public health challenge, especially in aging societies. This study aims to explore the impact of air pollution on the mental health of middle-aged and older adults, with a particular focus on identifying the vulnerable subgroups and underlying mechanisms.

Methods: We employ micro-level data to empirically examine how exposure to fine particulate matter (PM2.

DNA Tetrahedron Functionalized Microneedles Blocking IL-6 to Promote Skin Wound Healing.

Excessive secretion of Interleukin-6 (IL-6) is a critical barrier to the healing of inflammatory wounds. Previous attempts aimed to overcome this challenge by using antibodies to neutralize IL-6. However, the immunogenicity of an antibody may trigger antidrug antibody formation, resulting in reduced therapeutic efficacy and possible adverse reactions.

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis.

Hyperactive enzymes drive the pathology of several diseases, and classically, "occupancy-driven" drugs (e.g., active site or allosteric inhibitors) are used to target these enzymes.

Ablation of macrophage transcriptional factor FoxO1 protects against ischemia-reperfusion injury-induced acute kidney injury.

Acute kidney injury (AKI) has high morbidity and mortality, but effective clinical drugs and management are lacking. Previous studies have suggested that macrophages play a crucial role in the inflammatory response to AKI and may serve as potential therapeutic targets. Emerging evidence has highlighted the importance of forkhead box protein O1 (FoxO1) in mediating macrophage activation and polarization in various diseases, but the specific mechanisms by which FoxO1 regulates macrophages during AKI remain unclear.

Intratumoral Bacterial-Targeted Cascade-Responsive Sonoafterglow Nanoprobes for Immune Reprogramming and Visualization in Glioblastoma.

Bacteria within glioblastoma (GBM) promote tumor progression and immunosuppression, while current treatments face challenges such as poor blood-brain barrier (BBB) penetration and immunosuppressive macrophages. To overcome these, we developed cascade-responsive sonoafterglow nanoprobes for bacteria-targeting, immune reprogramming, and imaging. These nanoprobes, incorporating a sonoafterglow pro-substrate, sonosensitizer, and maltodextrin, selectively targeted bacteria via the ATP-binding cassette sugar transporter pathway.