Treatment of advanced cervical cancer with Cinobufacini and Paclitaxel-Cisplatin combination: A meta-analysis.

Background: Standard treatments for advanced cervical cancer, such as paclitaxel-cisplatin combination (TP) chemotherapy, are often limited by reduced efficacy and significant toxicity. Cinobufacini (Huachansu), a traditional Chinese medicine, has demonstrated potential in enhancing the effectiveness of conventional cancer therapies.

Methods: A systematic search of Web of Science, PubMed, Cochrane, Embase, China National Knowledge Infrastructure, and other databases was conducted up to July 30, 2024.

Identifying Tipping Points during Healthy Brain Aging through Single-Nucleus Transcriptomic Analysis.

Brain aging significantly impairs cognitive and behavioral functions. While some nonlinear aging studies have identified age-specific aging peaks at certain ages, the influence of different cell types on brain aging fluctuations across the lifespan remains unclear. This study, approaching from the interdisciplinary perspective of brain aging and systems dynamics, extends the nonlinear aging analysis to the cellular level, using single-cell transcriptomic data to analyze 45 healthy elderly brain samples aged 29-94 years.

Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis.

Background: Pulmonary fibrosis (PF) is a progressive and fatal lung disease with limited treatment options. Targeting the underlying inflammatory and cell death mechanisms holds promise for developing novel therapies. Rottlerin, a natural polyphenolic compound with known anti-inflammatory properties, has not been explored as a potential treatment option for PF.

Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation.

Ischemic heart disease lacks optimal therapies targeting post-infarction inflammation and remodeling. The role of TCA cycle metabolites in modulating macrophage-driven cardiac inflammation remains unclear. This study hypothesized that AKG supplementation attenuates cardiac dysfunction by regulating macrophage activation via TCA cycle replenishment and FTO-dependent epigenetic mechanisms.

Reversible ALKBH5 cytosolic aggregation accelerates cellular senescence.

Cellular senescence is the major hallmark and therapeutic target of aging and age-related diseases. The role of ALKBH5, one of the main m6A demethylases, in cellular senescence emerges however remains contentious. Herein, we show the reversible ALKBH5 aggregation in cytoplasm promotes cellular senescence.

CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted Cancer.

CDKN2A/MTAP co-deletion occurs frequently in non-small cell lung cancer and other solid tumors, including glioblastoma and pancreatic ductal adenocarcinoma. Lung cancer remains the leading cause of cancer-related mortality, and fewer than 15% of glioblastoma or pancreatic cancer patients survive 5 years, underscoring the need for more effective therapies. PRMT5 is a synthetic-lethal dependency in MTAP-null tumors and an attractive therapeutic target for CDKN2A/MTAP-deleted cancers.

Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathway.

Fibroblast‑like synoviocytes (FLSs) are the primary drivers of synovial tissue hyperplasia in rheumatoid arthritis (RA). Activation of the tumor necrosis factor‑like weak inducer of apoptosis (TWEAK)/fibroblast growth factor‑inducible immediate‑early response protein 14 (Fn14) pathway significantly contributes to the pathogenesis of RA. Kirenol (Kir), a compound with anti‑inflammatory and antirheumatic properties, has an unclear mechanism of action.

Anti-citrullinated histone H3 immunoglobulin G: new antibodies highly correlate with anti-neutrophil extracellular traps antibodies and thrombosis in antiphospholipid syndrome.

Background: Neutrophil extracellular traps (NETs) are involved in the development of thrombosis. Discovering anti-NETs antibodies has provided new understanding of how NETs and thrombotic processes are connected. However, these antibodies are currently only recognized as a diverse group, with their exact makeup still unknown.

Corilagin alleviates radiation enteritis through caspase-1/gasdermin D-dependent pyroptosis by targeting aldo-keto reductase family 1 member C2 via glutathione metabolism.

Radiation enteritis, caused by radiation therapy for abdominopelvic malignancies, inhibits local tumor control and seriously affects the quality of life of patients. Therefore, effective strategies to mitigate radiation enteritis are urgently needed. Corilagin, a natural ellagitannin found in plants, exhibits antioxidant, anti-inflammatory, and antitumor effects.

RTA-408 overcomes cisplatin-resistant lung cancer by inhibiting WWP1-mediated NCOA4 ubiquitination to induce ferritinophagy and ferroptosis.

Worldwide, pulmonary carcinoma remains the predominant cause of cancer-induced fatalities. Cisplatin (DDP) is a platinum-containing cell cycle-non-specific chemotherapeutic agent and serves as the first-line treatment for non-small cell lung cancer (NSCLC). However, NSCLC cells gradually develop resistance to cisplatin during treatment, reducing drug sensitivity and leading to a significant decrease in the effect of chemotherapy or even treatment failure.

Transition of cellular senescence to pyroptosis mediates recurrence of small cell lung cancer after chemotherapy.

Chemotherapy-induced different cell fates play crucial roles in cancer treatment outcomes; however, the cross-talk between the cell fates during cancer recurrence remains unclear. Here, we found that the transition from cellular senescence to pyroptosis promoted small cell lung cancer (SCLC) recurrence after cisplatin and etoposide treatment. Parts of the senescent SCLC cells induced by chemotherapy showed positive cytoplasmic chromatin fragments (CCFs), and CCFs activated the ubiquitin-editing enzyme A20, which stabilized NLRP3 through its deubiquitinating activity, resulting in senescent cells undergoing pyroptosis.

Platinum-zinc oxide as a super signal amplifier for ultrasensitive electrochemical immunodetection of CEA.

Electrochemical immunosensors are essential for disease screening, diagnosis, treatment and monitoring. In this study, a novel sandwich-type electrochemical immunosensor has been constructed for the sensitive detection of tumor marker carcinoembryonic antigen (CEA) based on platinum‑zinc oxide (Pt-ZnO) nanoparticles as a signal amplification platform. Pt-ZnO has outstanding peroxidase-like activity that enables efficient catalysis of the HO reaction, leading to effective amplification of the current signal through numerous electron transfers.

Association of multimorbidity with biological age acceleration in acute ischemic stroke patients: a cross-sectional study.

Background: Multimorbidity may influence biological aging, particularly in acute ischemic stroke (AIS) patients with high comorbidity burden. However, evidence on associations between multimorbidity and biological aging in AIS remains limited, with unclear differential impacts of specific multimorbidity clusters. This study evaluated latent multimorbidity patterns in AIS patients and quantified relationships between multimorbidity and biological age (BA) acceleration.

Leaf economic strategies drive global variation in phosphorus stimulation of terrestrial plant production.

Plant biomass and its allocation are fundamental for understanding biospheric matter production. However, the impacts of atmospheric phosphorus (P) deposition on species-specific biomass and its allocation in global terrestrial plants remain unclear. By synthesizing 5548 observations of plant biomass and its allocation related to P addition worldwide, we find that P addition increases plant biomass by an average of 35% globally.

Probiotic-Enhanced Porous Bio-Hybrids with Inflammatory Targeting, ROS Scavenging, and Long-Term Drug Release for Ulcerative Colitis Treatment.

Functional porous materials hold significant promise for biomedical applications owing to their high surface area and customizable pore architectures. However, the complex gastrointestinal environment poses considerable challenges for conventional nanomaterials in achieving targeted accumulation and controlled drug release. Herein, a kind of novel probiotic-enhanced porous bio-hybrids (E-xPAM@ASA) is designed via bio-hybridization of 5-aminosalicylic acid-loaded hairy microporous nanospheres (xPAM@ASA) with probiotic Escherichia coli Nissle 1917.

Comparative study and relevant exploration on methods for establishing unfractionated heparin therapeutic range (HTR) based on APTT.

Background: Building heparin therapeutic range (HTR) to monitoring unfractionated heparin (UFH) is important, while the two methods for establishing HTR exhibit discrepancies and yield different HTR results. The manifestations and underlying factors contributing to these discrepancies remain areas of uncertainty.

Methods: APTT, anti-Xa activity, and various coagulation factors, as well as FIB and AT, were measured in ex vivo samples from 41 patients receiving UFH treatment.

Augmentation of [F]-C-SNAT4 PET imaging of apoptosis after radiotherapy using a cold mixing strategy.

Background: Positron Emission Tomography (PET) imaging can monitor cancer treatment response by non-invasively detecting apoptosis in vivo. Signal-to-noise (SNR) remains one of the critical barriers to approval for clinical use. We have previously developed a PET tracer [18 F]-C-SNAT4 for imaging capase-3 activity in apoptotic tumors induced by chemo- and immunotherapy.

The effect of anthocyanin extract from Lycium ruthenicum Murray on intestinal barrier function in Bamei ternary pigs.

The intestinal barrier is a critical defense against external pathogens and plays a central role in immune regulation and nutrient absorption. Oxidative stress and chronic inflammation in high-altitude environments can exacerbate the damage to the intestinal barrier in Baimei ternary pigs. Anthocyanin extract of Lycium ruthenicum Murray (AEL), has garnered widespread attention due to its rich anthocyanin flavonoid content, which exhibits antioxidant and anti-inflammatory properties.

Postpancreatectomy acute pancreatitis in pancreaticoduodenectomy and distal pancreatectomy: a retrospective cohort study on risk factors and clinical outcomes.

Background: Postpancreatectomy acute pancreatitis (PPAP) is a severe complication that can occur following pancreaticoduodenectomy (PD) or distal pancreatectomy (DP). Specific studies focus on the difference of PPAP in PD and DP are lacking.

Methods: Patients who underwent PD or DP between 2019 and 2024 were retrospectively reviewed.

Association between healthy eating Index-2020 and anxiety: Insights from NHANES highlighting fruit and vegetable intake.

Background: Anxiety is a prevalent mental health issue globally, and diet has been increasingly recognized as a potential influencing factor. This study investigates the association between the Healthy Eating Index-2020 (HEI-2020) and anxiety in a nationally representative U.S.

Epidemiological trends and serological profiles of respiratory pathogens in Guangzhou: an 11-year retrospective study from 2013 to 2023.

Background: Respiratory pathogens pose significant public health challenges globally, particularly in densely populated urban areas. This study aimed to analyze the epidemiological trends of multiple respiratory pathogens in Guangzhou, China, from 2013 to 2023, and investigate associated serological profiles to inform clinical management and public health interventions.

Methods: We conducted a retrospective analysis of 96,927 cases with suspected respiratory infections (SRIs) (defined by fever >37.

Polymer Brush-Based Asymmetric Porous Patch with Excellent Anti-Bacterial and Anti-Contamination Properties Enables Infectious Abdominal Wall Defect Repair.

Well-integration of multiple bioactive components into a biological patch without damaging its cellular matrix structure is crucial for infectious abdominal wall defect repair but remains challenging. Herein, a novel asymmetric biological composite patch (bPVA/SIS-NP) is developed by in situ introducing zwitterionic polyvinyl alcohol molecular brush (bPVA) hydrogel to a cationic small intestinal submucosal decellularized matrix (SIS) via a self-induced phase separation based united strategy. Due to its high hydrogen bonding crosslinking and strong mechanical interlocking with SIS-NP layer, bPVA layer can maintain stable anti-contamination and the corresponding anti-adhesion properties in the contaminated environment.

ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.

Abnormal lipid metabolism in microglia leads to the formation of pathological lipid droplets (LDs), a phenomenon also observed in neurodegenerative diseases such as Alzheimer's disease (AD). The abnormal accumulation of LDs disrupts normal cellular function and exacerbates the pathological process of AD. ATP11B is a P4-ATPase and the expression of changes in the brain of patients with AD and diseases of lipid metabolism.

PAMAM-Based DNA Fluorescence Nanoprobe for Rapid Whole Cellular APE1 Detection and Imaging.

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/ref-1, APE1), a vital protein for DNA repair and cellular redox regulation, is frequently overexpressed in tumor cells, underscoring the importance of developing sensitive detection methods for early cancer diagnosis. However, the rapid detection and visualization of nuclear APE1 in tumor cells are still challenging. In this study, we successfully developed a novel DNA fluorescent nanoprobe based on polyamidoamine (PAMAM) for the rapid detection of cytoplasmic and nuclear APE1.