Leadership Roles, Care Models, and Effectiveness of Advanced Practice Nurse-Led Multidisciplinary Teams: A Scoping Review.

Aim: This review aimed to delineate the leadership roles, care models, and effectiveness of advanced practice nurse (APN)-led multidisciplinary teams in healthcare settings.

Background: Emerging international evidence suggests leadership constitutes a core characteristic of APN roles. Despite expanding involvement of advanced practice nurses in leading advanced and sustainable care within multidisciplinary teams, the current understanding of such care models is limited.

Identifying Tipping Points during Healthy Brain Aging through Single-Nucleus Transcriptomic Analysis.

Brain aging significantly impairs cognitive and behavioral functions. While some nonlinear aging studies have identified age-specific aging peaks at certain ages, the influence of different cell types on brain aging fluctuations across the lifespan remains unclear. This study, approaching from the interdisciplinary perspective of brain aging and systems dynamics, extends the nonlinear aging analysis to the cellular level, using single-cell transcriptomic data to analyze 45 healthy elderly brain samples aged 29-94 years.

Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation.

Stroke significantly alters microglial immune status beyond the traditional M1/M2 classification. We analyzed single-cell RNA sequencing data from the striatum of hemorrhagic, ischemic, and control mice, revealing activation of mitochondrial autophagy and assembly processes after stroke. Gene Ontology functional enrichment analysis indicated that stroke-associated genes predominantly regulate mitochondrial maintenance, with leucyl-tRNA synthetase 2 (Lars2) markedly upregulated in post-stroke microglia.

Machine learning prediction of coal workers' pneumoconiosis classification based on few-shot clinical data.

Objective: Aiming at the problems of the long incubation period, insufficient early diagnosis, and lack of treatment methods of coal workers' pneumoconiosis (CWP), the objective of this study is to accurately predict the CWP staging based on machine learning (ML) methods and small-sample clinical data.

Methods: The study included a comparative analysis of clinical data from 202 healthy individuals and 81 CWP patients at general Hospital of Xuzhou Mining Group. Firstly, various oversampling techniques were employed to address the issue of data imbalance.

Molecularly imprinted polymers based enrichment and separation for trace analysis in capillary electrophoresis.

Capillary electrophoresis (CE) is well known for its high resolution, rapidity, low sample and reagent consumption, and ability to simply change separation modes, and has been widely used for separation and detection of various analytes important for many fields. One major limitation is the concentration limits of detection, which can be further worsened in complex samples with a significant matrix component. Molecularly imprinted polymers (MIPs) based solid-phase extraction (SPE) and stationary phases (SPs) enjoy great popularity in CE, owing to the recognition specificity, physical robustness, thermal stability, as well as low cost and easy preparation of MIPs.

Postoperative Movement-evoked Pain Trajectories in Abdominal Surgery Patients: A Retrospective Study.

Purpose: This study aimed to characterize the early postoperative movement-evoked pain (MEP) trajectories in patients undergoing major abdominal surgery and to explore factors that may influence MEP trajectories.

Design: A single-center, retrospective analysis.

Methods: This retrospective study was conducted on 268 patients who underwent major abdominal surgery at a university hospital in China.

Molecularly Imprinted SERS Plasmonic Sensor for the Detection of Malachite Green.

Malachite green (MG) is a highly toxic dye commonly used in industries and aquaculture, leading to significant environmental contamination and health hazards. Therefore, sensitive and selective detection of MG in real samples is urgently needed. This study presents the development of a molecularly imprinted surface-enhanced Raman spectroscopy (MI-SERS) plasmonic sensor for the rapid and sensitive detection of MG.

Recent advances in molecular-imprinting-based solid-phase microextraction for determination of pharmaceutical residues.

Pharmaceutical residues usually exist in various complicated matrices at trace levels, but pose potential threats to human health and ecological environment. Recognition and determination of the residues are important and urgent. Therefore, efficient sample pretreatment techniques become a research hotspot for the sensitive and precise determination by chromatography and mass spectrometry.

Case Report: CASPR2-associated autoimmune encephalitis with NF155 Antibody-positive autoimmune nodopathies: a rare case with hyponatremia onset.

Objectives: This case report aims to highlight the atypical presentation and management of a patient diagnosed with CASPR2-associated autoimmune encephalitis and NF155 antibody-positive autoimmune nodopathies (AN), initially presenting with limb weakness and hyponatremia.

Methods: The patient was identified through clinical evaluation and diagnostic testing including serum and cerebrospinal fluid analysis, neuroimaging, and nerve conduction studies.

Results: The patient exhibited limb weakness, hyponatremia, cognitive abnormalities, and peripheral nerve involvement.

Predictive value of bedside diaphragmatic ultrasonography for extubation success in critically ill patients after general anaesthesia: A meta-analysis with trial sequential analysis (TSA).

Background And Aims: Accurate prediction of extubation success is crucial in critical care to avoid complications from premature or prolonged mechanical ventilation. Bedside diaphragmatic ultrasonography has emerged as a promising tool for assessing extubation readiness, but its effectiveness requires further validation. This meta-analysis evaluates the effectiveness of this method and uses trial sequential analysis (TSA) to assess evidence reliability and identify the need for further research.

Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection.

CASK, a MAGUK family scaffold protein, regulates gene expression as a transcription co-activator in neurons. However, the mechanism of CASK nucleus translocation and the regulatory function of CASK in myeloid cells remains unclear. Here, we investigated its role in H5N1-infected macrophages.

Barriers and facilitators to the implementation of guidelines for venous thromboembolism prevention and management: A mixed-methods systematic review.

Background: Evidence-based venous thromboembolism prevention and management is a priority for global health services. Low adoption of venous thromboembolism guidelines can result in compromised patient outcomes. Understanding clinicians' and patients' perceptions of barriers to and facilitators for guideline implementation and mapping identified barriers and facilitators to the Consolidated Framework for Implementation Research may inform theoretical interventions to improve guideline adoption rates.

Effectiveness of neuromuscular electrical stimulation on venous thromboprophylaxis in surgical patients: A systematic review and meta-analysis.

Background And Purpose: The effectiveness of neuromuscular electrical stimulation (NMES) for venous thromboprophylaxis is still debatable. This systematic review and meta-analysis evaluated the effectiveness and safety of NMES among surgical patients undergoing elective surgery.

Methods: Randomized controlled trials (RCTs) and quasi-experimental studies were retrieved from PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL, Wanfang, China National Knowledge Infrastructure and Chinese Biomedical Database from their inception to February 1st, 2024.

Psychometric evaluation of patient-reported experience measures for peri-anesthesia care: A systematic review based on COSMIN guidelines.

Background: Patient Reported Experience Measures (PREM) have become a critical component in assessing healthcare quality from the patient's perspective. Accurate and reproducible assessment tools are essential for generating robust and reliable results for evaluating peri-anesthesia patient experiences, identifying associated factors, and assessing the impact of healthcare interventions. However, there is currently no systematic review that consolidates all existing peri-anesthesia PREMs and evaluates their psychometric properties.

Clinical Impact of Operating Room Nursing Pathways on Hospitalization Duration and Consciousness Status in Patients Undergoing Emergency Craniocerebral Injury Surgery.

Background: Craniocerebral injuries carry high disability and mortality rates. In clinical practice, timely determination of the condition and immediate rescue interventions are crucial for patients with emergency craniocerebral injuries. Nurses play a pivotal role in providing proactive nursing services to save patients' lives.

Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite.

Tumors employ various strategies to evade immune surveillance. Central nervous system (CNS) has multiple features to restrain immune response. Whether tumors and CNS share similar programs of immunosuppression is elusive.

Causal associations between modifiable risk factors and isolated REM sleep behavior disorder: a mendelian randomization study.

Objectives: This Mendelian randomization (MR) study identified modifiable risk factors for isolated rapid eye movement sleep behavior disorder (iRBD).

Methods: Genome-wide association study (GWAS) datasets for 29 modifiable risk factors for iRBD in discovery and replication stages were used. GWAS data for iRBD cases were obtained from the International RBD Study Group.

High mobility group box 1 promotes endometriosis under hypoxia by regulating inflammation and autophagy in vitro and in vivo.

Background: Endometriosis is a chronic disease. Our previous study identified a positive correlation between high mobility group box 1 (HMGB1) and endometriosis, and HMGB1 and inflammation. However, the precise roles of HMGB1 in endometriosis are not fully elucidated.

The gene polymorphisms of eNOS and MTHFR modulates the development of preeclampsia in Han population.

We explored the effects of the endothelial nitric oxide synthase (eNOS) gene -786 T > C and 894 G > T locus polymorphisms and the methylenetetrahydrofolate reductase (MTHFR) gene 1298 A > C and 677 C > T locus polymorphisms on preeclampsia (PE) in pregnant women in Quanzhou area and provide reliable and stable predictors PE. This study included 160 normal pregnant women (normal control group) and 160 women with preeclampsia (PE group). Polymorphisms in eNOS gene and MTHFR were analyzed by the polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) technique.

Deciphering prognostic indicators in AQP4-IgG-seropositive neuromyelitis optica spectrum disorder: An integrative review of demographic and laboratory factors.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a group of inflammatory diseases affecting the central nervous system, characterized by optic neuritis and myelitis. The complex nature of NMOSD and varied patient response necessitates personalized treatment and efficient patient stratification strategies.

Objective: To provide a comprehensive review of recent advances in clinical and biomarker research related to aquaporin-4 (AQP4)-immunoglobulin G (IgG)-seropositive NMOSD prognosis and identify key areas for future research.

Are Physical Sunscreens Safe for Marine Life? A Study on a Coral-Zooxanthellae Symbiotic System.

Limited toxic and ecological studies were focused on physical sunscreen that is considered to have "safer performance", in which nanosize zinc oxide (nZnO) and nanosize titanium dioxide (nTiO) generally are added as ultraviolet filters. Herein, the common button coral sp. was newly used to assess the toxic effects and underlying mechanisms of physical sunscreen.

A radiomics-clinical combined nomogram-based on non-enhanced CT for discriminating the risk stratification in GISTs.

Purpose: To discriminate the risk stratification in gastrointestinal stromal tumors (GISTs) by preoperatively constructing a model of nonenhanced computed tomography (NECT).

Methods: A total of 111 GISTs patients (77 in the training group and 34 in the validation Group) from two hospitals between 2015 and 2022 were collected retrospectively. One thousand and thirty-seven radiomics features were extracted from non-contract CT images, and the optimal radiomics signature was determined by univariate analysis and LASSO regression.