Comprehensive dosimetric comparison of halcyon 3.0 versus truebeam for breast cancer volumetric modulated arc therapy plans.

Background: Breast cancer is the foremost malignancy threatening female health. This study aimed to compare the dosimetric performance of Halcyon 3.0 and TrueBeam in Volumetric Modulated Arc Therapy (VMAT) planning for breast cancer.

The First Reported Case of Infant Soft Tissues Infection Caused by : A Case Report and Literature Review.

. predominantly , are recognized respiratory pathogens, while soft tissue infections caused by non-pneumophila species remain exceptionally rare. We present the first documented case of  soft tissue infection in an infant worldwide.

Dual VEGF-Targeting Strategy Via AAV2-Delivered sFLT-1 and shVEGF for Retinal Neovascularization Therapy.

Purpose: Retinal neovascular diseases, often associated with elevated vascular endothelial growth factor (VEGF) levels, are major causes of blindness. Current therapies lack sustained efficacy and safety. This study aimed to evaluate the effectiveness of an adeno-associated virus 2 (AAV2)-based gene therapy vector carrying soluble fms-like tyrosine kinase-1 (sFLT-1) and short hairpin RNA targeting VEGF (shVEGF) in treating retinal neovascularization.

Functional Zoning for Integrated Management of Transboundary Lake Basins from a Sustainable Development Perspective: A Case Study of Lake Victoria in East Africa.

From the perspective of sustainable development, multi-objective collaborative governance plays a vital role in the integrated management of transboundary lake basin systems. However, regionally differentiated governance solutions, based on the systematic identification of spatial use functions within the basin, remain undefined. Based on an analysis of regional evolution patterns, this study establishes a coupled zoning framework to identify conflict types and synergetic relationships while quantifying the characteristics of the three spatial use functions: agricultural production, urban development, and ecological conservation.

Study on the effect of sustained -release icariin-loaded Graphene oxide-hydrogel composite scaffold on bone defect repair.

In orthopedic treatment, long-term nonunion of bone defects has always been a significant issue. As bone graft materials, tetra-armed polyethylene glycol (Tetra-PEG) hydrogel scaffolds are anticipated to address this issue due to their extracellular matrix (ECM)-like structure. However, poor osteoinductivity and cell adhesion after implantation restricted its clinical application in bone tissue engineering.

Triptonide stabilizes BIM to enhance oxaliplatin-induced ferroptosis and apoptosis in colorectal cancer.

Oxaliplatin (OXA) is a common chemotherapeutic agent for advanced colorectal cancer. However, its effectiveness is limited by drug resistance, highlighting the need for combination therapies. In this study, Triptonide (TN), a diterpenoid compound is used to enhance the sensitivity of OXA, and the underlying mechanisms are investigated.

Defence induction and identification of key genes associated with Lymantria dispar oral secretions in Populus davidiana × P. bolleana on the basis of transcriptome and hormone levels.

In the constant battle with herbivorous insects, plants have evolved sophisticated recognition and adaptation mechanisms to fight insect attacks. Insect infestation is a major challenge in poplar afforestation production. In this study, we mimicked insect feeding by applying insect oral secretions (OS) to the leaf mechanical wounds of Populus davidiana × P.

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.

Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our research demonstrates that sepsis could induce the migration of IL-7R CD8 γδ T17 cells from the small intestine to the meninges, where they secrete IL-17A, impairing mitochondrial function in microglia and activating the cGAS-STING-C1q pathway in male mice.

Cas12a-CHA dual-amplified fluorescent aptasensor for sensitive detection of ochratoxin A.

Ochratoxin A (OTA), a mycotoxin commonly found in food products, poses significant health risks due to its carcinogenic and immunotoxic properties. The development of sensitive and specific detection methods for OTA is therefore essential. In this study, we developed a fluorescence aptasensor for sensitive and selective detection of OTA in complex food matrices.

The Potential Mechanisms of Banxia Xiexin Decoction in Treating Chronic Colitis: Insights from UPLC-Q-TOF-MS/MS and Network Pharmacology Studies.

Introduction: Banxia Xiexin Decoction (BXD)is commonly used to treat a variety of gastrointestinal disorders, including Chronic Colitis (CC), due to its anti-inflammatory, antibacterial, and intestinal flora-regulating effects. However, CC is a chronic intestinal immunologic disease whose exact pathogenesis is unknown. Thus, more studies are needed to clarify the mechanism of action of BXD for CC treatment.

Chloroquine and hydroxychloroquine-related ocular adverse events in SLE treatment: a real-world disproportionality analysis based on FDA adverse event reporting system (FAERS).

Objective: This study aimed to evaluate the risk of adverse events associated with chloroquine (CQ) and hydroxychloroquine (HCQ) in patients with systemic lupus erythematosus (SLE), using data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS).

Risk factors for identifying pulmonary aspergillosis in pediatric patients.

Objectives: This study aimed to identify the independent risk factors and develop a predictive model for pulmonary aspergillosis (PA) in pediatric populations.

Methods: This retrospective study compromised 97 pediatric patients with pulmonary infections (38 PA cases and 59 non-PA cases) at Children's Hospital Affiliated to Shandong University between January 2020 and October 2024. Multivariate binary logistic regression was used to identify PA-associated risk factors.

Correction: Evaluating the impact of metabolic syndrome on aging in US adults: a cross-sectional study from NHANES.

[This corrects the article DOI: 10.3389/fpubh.2025.

The improved prediction value of neutrophil to lymphocyte ratio to pneumonia severity scores for mortality in the older people with community-acquired pneumonia.

Objective: We aimed to evaluate whether there is a linear relationship between neutrophil to lymphocyte ratio (NLR) and adverse outcomes in the older hospitalised patients with community-acquired pneumonia (CAP). The performance of adding NLR to current pneumonia severity scores, including CURB-65, CRB-65, A-DROP and SMART-COP, in predicting 30-day mortality was also investigated.

Methods: This is a secondary analysis based on an existing dataset of an older cohort of CAP, including 812 patients.

Relationship between early musical training and detection of binaural gap based on interaural correlation change.

Introduction: The auditory fusion of binaural sounds and the perceived auditory image are determined by the similarities of the sounds at the two ears. Sensitivity to the change in interaural correlation, a measure of interaural similarity, is crucial to extract target sound from noisy background. Although musicians have been found to perform better than non-musicians in various types of auditory processing tasks such as frequency discrimination or temporal resolution, the relationship between musical training and the interaural correlation processing remains poorly understood.

Single-cell RNA sequencing: new insights for pulmonary endothelial cells.

Pulmonary endothelial cells (PECs) are indispensable for sustaining lung microenvironmental homeostasis and exert significant influence across a spectrum of pulmonary pathologies. Single-cell RNA sequencing (scRNA-seq) has fundamentally transformed conventional paradigms surrounding PECs, unveiling novel perspectives on their roles in both physiological and pathological lung conditions. This technology provides critical insights into the phenotypic diversity and distinct molecular signatures of PECs, underscoring their substantial heterogeneity in structure, function and gene expression, which is contingent upon their spatial localization within the lung microenvironment.

Downregulation of UDP-glucose 6-dehydrogenase predicts adverse outcomes in patients with colorectal cancer and promotes tumorigenesis.

UDP-glucose 6-dehydrogenase (UGDH) is the key enzyme of glucuronic acid metabolism and a key mediator in several cancer developmental signaling pathways. However, the expression and function of UGDH in colorectal cancer (CRC) are unclear. Bioinformatics analysis was conducted to research the expression, diagnosis, prognosis, functional enrichment, genetic alterations, and immune characteristics of UGDH in CRC.

Evaluating the impact of metabolic syndrome on aging in US adults: a cross-sectional study from NHANES.

Objective: As the global population ages, promoting healthy aging has become increasingly important. Although metabolic syndrome (MetS) is associated with aging, current research evidence remains insufficient.

Methods: Data from the 1999-2010 National Health and Nutrition Examination Survey (NHANES) were used for analysis.

BpWRKY6 regulates insect resistance by affecting jasmonic acid and terpenoid synthesis in Betula platyphylla.

Forest pests and diseases pose serious threats to the sustainable development of forestry. Plants have developed effective resistance mechanisms through long-term evolution. Jasmonic acid and terpenoids play important roles in the defence response of plants against insects.

Global, regional, and national burdens of rheumatoid arthritis among people aged 60 years and older from 1990 to 2021: a trend analysis for the Global Burden of Disease Study 2021.

Background: Rheumatoid arthritis (RA) poses a significant global health burden, especially among individuals aged 60 and older. This study analyzes RA burden trends using 2021 Global Burden of Disease (GBD) data.

Methods: Utilizing the GBD 2021 data, we extracted detailed metric on RA incidence, prevalence, mortality, and disability-adjusted life years (DALYs) specifically for those aged 60 and above.

Nanohole-in-microsphere array (NiMA): An ultrasensitive digital-SERS tool for serum diagnosis of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a serious chronic systemic autoimmune disease leading to joint destruction for progressive disability. Accurate non-invasive diagnosis of RA in the early stages is vital to timely precision treatment. The advancements of surface-enhanced Raman spectroscopy (SERS) in label-free liquid biopsy for noninvasive diagnosis have been witnessed in the past decade.

Bacterial Epidemiology and Antimicrobial Resistance in Children in Shandong Province, China, 2017-2022: A Multicentre Retrospective Study.

Introduction: Bacterial antimicrobial resistance is becoming increasingly serious, but there are very limited studies in children. Shandong Province Pediatric bacterial & fungal Antimicrobial Resistance Surveillance System (SPARSS) program was established in 2017 to monitor and analyze the trends of bacterial epidemiology and antimicrobial resistance in children. Clinical bacterial isolates were collected from 59 tertiary hospital in Shandong Province China during 2017 to 2022.

PSMB10 maintains the stemness of chemotherapeutic drug-resistant leukemia cells by inhibiting senescence and cytotoxic T lymphocyte-mediated killing in a ubiquitinated degradation manner.

Background: Drug resistance and relapse are still major challenges in acute myeloid leukemia (AML) because of the inability to effectively eradicate leukemia stem cells (LSCs). Senescence induction combined with immune killing may offer promising strategies for LSC eradication. However, whether and how drug-resistant LSCs retain stemness via senescence and immune regulation remains unknown.

Matrix-bound EGF promotes malignant phenotypes of breast cancer organoids in the biomimetic ECM of alginate.

As multiple malignant phenotypes appear during cancer progression, it is essential to recognize the possible mechanisms from original to metastatic states. However, both two-dimensional monolayer cell culture and in vivo animal models have their inherent limitations, such as lack of proper cell-ECM interactions and uncontrollable variables. By their heterogeneous simulation of tumor processes, 3D organoids can better recapitulate real tumor characteristics and more realistic responses to distinct factors.

AuAg-Modified Porous Silicon Nanowires for Dual-Mode Interferometric and SERS-Based Bacterial Detection.

In this study, a novel approach for simultaneous interferometric and surface-enhanced Raman spectroscopy (SERS) detection of bacteria utilizing porous silicon nanowires (pSi NWs) modified with silver and gold nanoparticles is reported. The pSi NWs were fabricated through gold-assisted chemical etching of p-type, single-crystal silicon wafers with a (100) crystallographic orientation and resistivity between 1 and 5 mΩ·cm. Following etching, the nanowires' surfaces were modified with silver, then gold nanoparticles by reduction from their respective salts in the presence of 5 M HF.