The U-Shaped Relationship Between Serum Bicarbonate Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study of MIMIC-IV Database.

Background: The elevated mortality rate associated with sepsis is a primary global health concern. The correlation between bicarbonate levels and mortality risk in sepsis remains unclear.

Method: A retrospective cohort study was conducted using data from the MIMIC-IV database, including 12 744 adult sepsis patients.

Drug-coated balloon angioplasty versus conventional angioplasty for symptomatic non-acute intracranial artery occlusion.

Background And Objective: Non-acute intracranial artery occlusion (ICAO) is an important cause of recurrent ischemic stroke despite aggressive medical treatment. Conventional angioplasty has high incidences of perioperative complications and restenosis in treating these patients. Drug-coated balloon (DCB) treatment has shown superiority in preventing restenosis.

Ryanodine Receptor Inhibition with Dantrolene Prevents Ventricular Tachycardia Induction in Patients with Structural Heart Disease - A Randomized Controlled Trial.

Despite clinical need, no new drugs for treating ventricular tachycardia (VT) have emerged for over 20 years. In structural heart disease, posttranslational modifications render intracellular ryanodine receptor-2 (RyR2) calcium release channels leaky, which increases VT risk. Treatment with dantrolene, an RyR2 inhibitor, prevents VT in animal models.

Therapeutic restoration of mitochondria-endoplasmic reticulum cross talk for osteoarthritis.

Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondrocyte homeostasis and whether such processes can be explored as therapeutic targets for osteoarthritis remain unclear.

A Multimodal Strategy for Quality Control and Botanical Origin Traceability of Codonopsis Radix based on HPLC Fingerprints With Chemometric Analysis.

Codonopsis Radix (CR) is widely used in the food and pharmaceutical industries. However, the existence of three botanical origins in CR makes it challenging to ensure the quality of CR in the market. In this study, a method was developed to identify and analyze CR from different botanical origins, and their signature components were quantitatively compared.

C2H2 Zinc Finger Proteins GIS2 and ZFP8 Regulate Trichome Development via Hormone Signaling in Arabidopsis.

Trichomes are specialized epidermal structures that protect plants from environmental stresses, regulated by transcription factors integrating hormonal and environmental cues. This study investigates the roles of two C2H2 zinc finger proteins, and , in regulating trichome patterning in . Using dexamethasone-inducible overexpression lines, transcriptomic profiling, and chromatin immunoprecipitation, we identified 142 - and 138 -associated candidate genes involved in sterol metabolism, senescence, and stress responses.

Duration of diabetes, glycemic control and intracranial atherosclerotic plaque vulnerability.

Background: Intracranial vulnerable plaque, characterized by intraplaque hemorrhage (IPH), surface irregularity, positive remodeling, and plaque enhancement, is associated with cerebrovascular events. History of diabetes mellitus (DM) was reported to be a potential predictor of plaque vulnerability, but the predictive value of DM-related variables for it is still uncertain. The purpose of this study was to investigate the association of diabetes duration and glycemic control with symptomatic plaque vulnerability, in comparison to non-diabetic patients.

Cellulose nanocrystals reinforced polyvinyl alcohol hydrogel with thermal, mechanical, and ionic responsive behavior.

Conventional polyvinyl alcohol (PVA) hydrogels with isotropic polymer networks usually lack selective responses to external stimuli, which significantly limits their applications in smart devices. In this work, a series of double network (DN) composite PVA hydrogels reinforced with cellulose nanocrystal (CNC) were prepared by in situ photopolymerization of functional monomers and freeze-thawing (F-T). The incorporation of CNC and the DN structure resulted in the high tensile strength of the hydrogel (1.

Non-Heme Tri-Iron(II) Complex as a Precursor for Dioxygen Activation and Oxygen Reduction Reaction Catalysis.

Nonheme iron catalysts are attractive for bioinspired aerobic oxidations and oxygenations, as well as for the oxygen reduction reaction (ORR), although their potential in ORR remains largely underexploited. This study presents a rare example of such a system, displaying O activation activity and ORR catalytic selectivity toward HO generation. The triiron(II) complex [FeL](BF), where L is a thiolate-containing N3S donor bis(2-pyridylmethyl)amine derivative, was fully characterized in the solid state and in MeCN solution, where it dissociates into the mononuclear solvent adduct [FeL(MeCN)].

Disrupted Alternative Splicing of RAB11FIP3 Contributes to Diabetic Foot Ulcer Dysfunction.

Dysregulation of alternative splicing (AS) has been associated with various complications of diabetes, yet its role in the pathogenesis of diabetic foot ulcers (DFUs) and its involvement in metabolic memory (MM) remain unclear. In this study, we identified specific AS events in RAB11FIP3, notably the full-length (RAB11FIP3-FL) isoform and exon 6 exclusion (RAB11FIP3-Δ6). We found that RAB11FIP3 (FL/Δ6) ratio is significantly elevated in patients with MM and DFUs.

Muscone attenuates myocardial infarction by regulating ferroptosis of cardiomyocytes through Nrf2/system Xc-/GPX4 signaling pathway.

Acute myocardial infarction (MI) is among the diseases with the highest incidences and seriously threatens public health worldwide, with the present clinical treatment methods presenting considerable risks. Ferroptosis, characterized by iron dependence and intracellular oxidative accumulation, is a type of programmed cell death that has opened new avenues for treating MI. Muscone is one of the major active monomers of musk, which can improve ventricular remodeling after MI and myocardial ischemia-reperfusion injury.

Meta-Analysis of the Effect of Aerobic Exercise Combined with Respiratory Training on Stable Chronic Obstructive Pulmonary Disease.

The purpose of this study was to conduct a meta-analysis of the effects of aerobic exercise combined with respiratory training on patients with stable chronic obstructive pulmonary disease (COPD). The data of randomized controlled trials on the effects of aerobic exercise combined with respiratory training on patients with stable COPD published up to March 2024 were retrieved from six electronic databases (PubMed, Web of Science, Cochrane Library, Embase, CNKI and China Science and Technology Journal Database). The risk of bias and quality of evidence were assessed using the Cochrane Collaboration tool, and the Physiotherapy Evidence Database (PEDro) Scale approach, respectively.

Defence induction and identification of key genes associated with Lymantria dispar oral secretions in Populus davidiana × P. bolleana on the basis of transcriptome and hormone levels.

In the constant battle with herbivorous insects, plants have evolved sophisticated recognition and adaptation mechanisms to fight insect attacks. Insect infestation is a major challenge in poplar afforestation production. In this study, we mimicked insect feeding by applying insect oral secretions (OS) to the leaf mechanical wounds of Populus davidiana × P.

2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial.

Background: Inflammation is a common mechanism for atrial fibrillation (AF). 2-Hydroxybenzylamine (2-HOBA) is a novel therapeutic that scavenges isolevuglandins-a downstream mediator of inflammation and oxidative stress. 2-HOBA is safe and reduces AF in mice, prompting a first-in-human pilot clinical trial.

Serial Cross-Sectional Human Biomonitoring Analysis of Pesticide Exposure Patterns and Their Association with Lipid Metabolism Biomarkers: The Mediating Role of Liver Function.

Continuous low-level exposure to pesticides is inevitable in daily life. Previous studies have demonstrated the adverse effects of pesticide exposure on lipid metabolism. However, population studies have focused primarily on individual pesticides and have short-term fluctuations, and the animal experiments used doses far higher than those exposed by the general population.

Nanocolumn Floating Gates Induced by the Supramolecular Blending Strategy for Highly Improved Charge Trapping Capacity.

Nonvolatile organic field-effect transistor (OFET) memory devices have attracted extensive attention due to their advantages such as lightweightedness and nonvolatile readout. With the increasing demand for storage capacity and efficiency, it is extremely important to design high-capacity and stable OFET memory devices. Here, we propose a universal and convenient supramolecular blended strategy to conveniently prepare in situ the uniform size-tunable nanocolumn (NC) structures and further improve the charge capture ability in organic field-effect transistor (OFET) memory.

Immunogenicity of monovalent and multivalent subunit vaccines against SARS-CoV-2 variants in mice with divergent vaccination history.

There are challenges in selecting SARS-CoV-2 vaccine compositions, primarily due to divergent infection or vaccination history and immunological biases toward previous strains. In this study, we evaluated humoral immune responses induced by variant-based monovalent vaccines as booster shots in mice previously vaccinated with an ancestral strain-based vaccine with or without Omicron BA.5 exposure.

NOACs for VTE prevention in patients with lower limb fracture: a systematic review and meta-analysis.

Background: Novel oral anticoagulants (NOACs), including rivaroxaban, apixaban, edoxaban and dabigatran, are increasingly used for orthopaedic surgery patients. The aim of this study was to evaluate the efficacy and safety of NOACs in preventing venous thromboembolism (VTE) among patients with lower limb fractures.

Materials And Methods: This meta-analysis included randomized controlled trials (RCTs).

Mannose Oligosaccharide-Conjugated In Situ Pore-Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes severe cartilage erosion in joints. Current treatments are limited in accessing a 3D platform that not only supports chondrocyte recovery and new cartilage matrix formation but also effectively modulates the inflammatory environment, particularly through macrophage regulation and extracellular vesicle (EV)-mediated functions. Here, an injectable hydrogel is developed incorporating mannose oligosaccharide (MOS)-modified chondroitin sulfate and hyaluronic.

Semi-permeable polymer vesicle-based prooxidative and lactate-depleting nanoreactors with sustained activity against pancreatic cancer.

Polymer vesicles, also known as polymersomes, consist of polymer membranes enclosing an aqueous core and have attracted significant interest for biomedical applications. The aqueous core is particularly advantageous for encapsulating and stabilizing fragile cargo, such as proteins, to maintain long-term activity. Among these, enzyme-encapsulated polymersomes function as therapeutic nanoreactors and have gained increasing attention in recent years, especially for cancer treatment.

Relationship of the oxidative balance score with the risk of frailty and mortality in patients with asthma: a mediation analysis of NHANES.

Background: The high risk of frailty in patients with asthma is of increasing concern. Oxidative stress is an important mechanism in the pathogenesis of asthma, and the oxidative balance score (OBS) is a new index reflecting the state of oxidative homeostasis in the body that integrates dietary and physical activity factors. However, the relationship between the OBS and risk of frailty in patients with asthma remains unclear.

Multiphysics coupling analysis and structure optimization of flux switching permanent magnet linear motors.

This paper presents a comprehensive framework for thermal-electrical-vibration coupling analysis and lightweight structure optimization of high power density flux-switching permanent magnet linear motors (FSPMLMs). A multi-physics finite element model integrating electromagnetic, thermal, and structural fields is established to investigate the complex interactions between these domains under high power density operation. The electromagnetic-thermal coupling analysis reveals nonlinear temperature rise patterns with distinctive hotspots in winding regions, while the electromagnetic-vibration coupling identifies critical correlations between thrust fluctuations and structural responses.

Enhancing Neuroprotection Through Exercise: The Synergistic Effects of Bioactive Plant Compounds Via the CREB-BDNF Signaling Pathway.

The hippocampus, a vital brain region, orchestrates numerous critical functions including memory, learning, stress response, and emotional regulation. Structural changes in the hippocampus due to prolonged stress exposure can precipitate cognitive decline and behavioral deficits. Recent studies have illuminated the restorative influence of physical fitness on the hippocampus; notably, exercise enhances memory, learning, hippocampal architecture, neurogenesis, and synaptic plasticity.

Paramagnetic rim lesions in early multiple sclerosis: a 7 Tesla imaging study.

Paramagnetic rim lesions (PRL) are considered biomarkers of chronic active lesions (CAL) in multiple sclerosis. The chronological relationship between CAL and disease severity in multiple sclerosis is not fully defined. In this cross-sectional, prospective study, we investigate the relationship between PRL and clinical/radiological measures of disease severity at the time of diagnosis of multiple sclerosis, clinically isolated syndrome, or radiologically isolated syndrome.

Heterologous expression of PsnCHS7 gene in Populus davidiana × P. bolleana to improve resistance of Lymantria dispar.

Flavonoids are essential for combating stress and diseases. Chalcone synthase (CHS) plays a crucial role in the production of flavonoids associated with insect resistance in plants. To gain insight into the function of the CHS gene in plant defense, the PsnCHS7 of Populus simonii × P.