Intelligent Adolescent Idiopathic Scoliosis Detection Method Based on Three-Dimensional Measurements.

Adolescent Idiopathic Scoliosis (AIS) is a prevalent latent disorder among adolescents. Early detection and screening are crucial for preventing the progression of deformities. Current assessment methods for spinal curvature rely on X-ray imaging to measure the Cobb angle and detect scoliosis.

Design and Optimization of Intelligent High-Altitude Operation Safety System Based on Sensor Fusion.

In the field of high-altitude operations, the frequent occurrence of fall accidents is usually closely related to safety measures such as the incorrect use of safety locks and the wrong installation of safety belts. At present, the manual inspection method cannot achieve real-time monitoring of the safety status of the operators and is prone to serious consequences due to human negligence. This paper designs a new type of high-altitude operation safety device based on the STM32F103 microcontroller.

C2H2 Zinc Finger Proteins GIS2 and ZFP8 Regulate Trichome Development via Hormone Signaling in Arabidopsis.

Trichomes are specialized epidermal structures that protect plants from environmental stresses, regulated by transcription factors integrating hormonal and environmental cues. This study investigates the roles of two C2H2 zinc finger proteins, and , in regulating trichome patterning in . Using dexamethasone-inducible overexpression lines, transcriptomic profiling, and chromatin immunoprecipitation, we identified 142 - and 138 -associated candidate genes involved in sterol metabolism, senescence, and stress responses.

Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: the role of astrocyte-mediated mitochondrial transfer.

Background: Ischemic stroke significantly threatens human health, and current treatments remain limited, necessitating novel strategies. Mitochondrial transfer between neurons represents a crucial endogenous neuroprotective mechanism.

Objective: This study investigated whether electroacupuncture enhances mitochondrial transfer from astrocytes to damaged neurons during acute cerebral ischemia, promoting neuroprotection.

Cohesin variants and meiotic timing shape chromosome segregation accuracy.

The frequency of aneuploid gamete formation increases with maternal age, yet the effects of genetic variants on meiotic chromosome segregation accuracy during aging remain poorly understood. Using the multicellular organism Caenorhabditis elegans, we investigate the impact of mutations in the conserved cohesin complex on age-associated meiotic errors. Point mutations in the head domain of the cohesin component SMC-1, which alter local hydrophobicity, cause meiotic defects that vary with age.

Nanoarchitectonics of cobalt/nitrogen-doped carbon with an unbalanced double primitive bicontinuous motif for efficient electrocatalysis.

In virtue of the smooth mass transfer and unique physical properties enabled by the special three-dimensional (3D) interconnected network, bicontinuous porous functional materials have received extensive attention in catalysis, energy conversion, and cargo delivery. However, endowing materials with meticulous inner bicontinuous geometries and achieving precise control over the pore structures remain a huge challenge. Herein, we report a facile heterogeneous interface-induced topological phase transition method to obtain unbalanced double primitive architectural cobalt/nitrogen-doped (Co/N-doped) carbon particles.

The Transcription Factor Enhances Drought Tolerance in Rice.

Drought represents a prevalent abiotic stress in terrestrial plants, frequently impairing crop growth and yield. In this paper, we characterized the functional role of , a member of the NAC transcription factor family, in drought tolerance. was predominantly localized in both the cytoplasm and nucleus, with its expression being markedly induced under drought conditions.

Dynamic SAS-6 phosphorylation aids centrosome duplication and elimination in C. elegans oogenesis.

In most metazoans, centrosome elimination during oogenesis ensures accurate centriole inheritance in the zygote, yet the molecular mechanisms remain poorly understood. Here, we reveal a critical role for controlled SAS-6 phosphorylation in centrosome dynamics during oogenesis. Centrioles disassemble during late meiotic prophase, while the cartwheel protein SAS-6 exhibits dynamic behavior in early meiotic prophase.

Improving the Thermal and Mechanical Properties of Polycarbonate via the Copolymerization of Tetramethylbisphenol A with Bisphenol A.

Polycarbonate is a widely used engineering plastic. However, synthesis procedures using phosgene produce toxic gases that cause environmental pollution. It is important to improve the performance of polycarbonate by using a green and safe process.

WFDC3 identified as a prognostic and immune biomarker in pancreatic cancer.

The whey acidic protein four-disulfide core (WFDC) family comprises key modulators of tumor initiation and progression, offering significant potential for diagnostic, prognostic, and therapeutic applications. However, the specific role of WFDCs in the oncogenesis of pancreatic cancer (pancreatic adenocarcinoma [PAAD]) remains incompletely understood. To address this, we conducted an initial investigation using comprehensive bioinformatic analyses to evaluate WFDCs expression patterns across multiple tumor types, with a focus on PAAD.

GIS mediates GA signaling to directly target the expression of SPL15 to regulate trichome development in Arabidopsis thaliana.

Trichome development in Arabidopsis thaliana is regulated by a complex network of genetic and hormonal signaling pathways. GA/DELLA/GISs and miR156/SPLs are the two main regulatory modules regulating trichome initiation in A. thaliana.

Carbohydrate flow during grain filling: Phytohormonal regulation and genetic control in rice (Oryza sativa).

Both the filling and development of grain are key processes determining agriculture production and reproductive growth in rice. The processes of grain filling and endosperm development are crucial for the accumulation of major storage compounds in rice grains. This requires extensive remobilization of carbon reserves from source to sink and the precise regulation of sucrose-to-starch conversion.

A Facile Micelle-Assisted Self-Assembly Method to Covalent Organic Framework Helical Nanoarchitectures.

We present a micelle-assisted self-assembly strategy for synthesizing covalent organic framework (COF) helical hollow nanoribbons by using achiral monomers and surfactants. The process involves polymerization of nanowires within rod-like micelle cores, followed by their attachment to form helical nanoribbons and solvothermal crystallization to create hollow COF architectures. This method allows for the controllable synthesis of COF helical nanostructures with tunable pitch and morphology and can be extended to other COF helical architectures by variation of the amine monomer.

"Crystallinity Wave"-Driven Synthesis of Hollow Multi-Shell Covalent Organic Frameworks for Enhanced Supercapacitors.

Hollow multi-shell covalent organic frameworks (COFs) with abundant modular interfaces, high loading capacity, and various microenvironments are expected to hold great potential for chemical separation, heterogeneous catalysis, and energy storage/conversion. However, the synthetic methodology of COF hollow multi-shell nanoarchitectures has not been established. Herein, we demonstrate an ingenious "crystallinity wave"-induced regional difference ripening strategy to synthesize a series of hollow multi-shell COF particles with controllable shell numbers and shell thickness.

Nitrate reductase-dependent nitric oxide production mediates nitrate-conferred salt tolerance in rice seedlings.

Soil salinity is a destructive environmental factor that inhibits plant growth and crop yield. Applying nitrogen fertilizer is a practical method to enhance salt tolerance. However, the underlying mechanisms remain largely unknown.

Digitally Programmable Microphase Separation in Polymer Network Generates Microstructure Pattern.

Polymers with microstructure patterns are crucial to many applications, such as separation, optics, electronics, metamaterials, etc. However, introducing microstructure patterns with diverse morphologies and feature sizes ranging from nanometers to micrometers into large-area polymers remains a significant challenge. Here, we design a material system that enables digital programming microphase separation in a polymer network to generate microstructure patterns.

Protective effect of ascorbic acid against renal injury induced by 3-chloropropane-1,2-diol-dipalmitate in rats.

3-monochloropropane-1,2-diol esters (3-MCPDE) are a group of contaminants which are mainly formed during heat processing of edible oil and fat-based foods. The kidney is the primary target organ for the toxic effects of 3-MCPDE. 3-MCPD-di-palmitate exists in a variety of oils and fats, and is the most common and relatively high proportion of 3-MCPDE.

Cohesin ring gates are specialized for meiotic cell division.

Cohesin is a ring complex closed with structural maintenance of chromosome 1 (SMC-1), SMC-3, and a kleisin subunit, mediating sister chromatid cohesion in mitosis and meiosis. Kleisin N- and C-terminal domains interact with SMC-3 and SMC-1, forming two distinct cohesin gates. Whether these gates are specialized for mitosis and meiosis remains elusive.

A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study.

Benign prostatic hyperplasia (BPH) as a common geriatric disease in urology, the incidence and prevalence are rapidly increasing with the aging society, prompting an urgent need for effective prevention and treatment of BPH. However, limited therapeutic efficacy and higher risk of complications result in the treatment of BPH remaining challenging. The unclear pathogenic mechanism also hampers further exploration of therapeutic approaches for BPH.

Nanoarchitectonics of ultrafine molybdenum carbide nanocrystals into three-dimensional nitrogen-doped carbon framework for capacitive deionization.

Molybdenum carbide (MoC) has emerged as a promising material for capacitive deionization (CDI), but the poor electrochemical kinetics in conventional MoC owing to the bulk structure and low electric conductivity limit its CDI performance. To address this challenge, herein, we develop a novel strategy to synthesize ultrafine MoC nanocrystals that are embedded within a three-dimensional nitrogen-doped carbon framework (NC/MoC). This synthesis method involves the space-confined pyrolysis of molybdate precursors within metal-organic frameworks (MOFs).

Elevated Cancer-Associated Hyaluronan Correlates With Diagnosis and Lymph Node Metastasis of Papillary Thyroid Cancer.

The glycosaminoglycan hyaluronan (HA) plays an important role in tumor progression. However, its biological and clinical significance in papillary thyroid cancer (PTC) remains unknown. Immunohistochemistry was performed to examine HA expression in tissues from PTC patients.