Facile engineering bifunctional rhodium‑nickel metallene catalyst for urea-assisted hydrogen production.

Integration of the hydrogen evolution reaction (HER) and urea oxidation reaction (UOR) is a prospective strategy for energy-efficient hydrogen generation. However, developing highly effective dual functional catalysts for both HER and UOR is still challenging. Herein, two-dimensional rhodium‑nickel (RhNi) metallene with a wrinkled nanosheet structure is prepared by a feasible two-step hydrothermal approach, which provides numerous catalytically active centers and accelerates the charge transfer during the reaction.

Transcriptome Analysis of Tear-Derived Extracellular Vesicles as Biomarkers for Diabetic Retinopathy.

Diabetic retinopathy (DR) represents the predominant etiology of visual impairment and blindness on a global scale. At present, there is still a dearth of robust biomarkers for DR, which substantially limits its diagnosis, particularly at an early stage. Tears, owing to their inherent proximity to the ocular microenvironment, offer a unique advantage as a source of potential biomarkers for retinal pathologies.

Quantitative Susceptibility Mapping in the Assessment of Single and Repeated Closed Mild Traumatic Brain Injury.

Introduction: Repeated mild traumatic brain injury(mTBI) is one of the important causes of long-term neurological damage in military personnel and athletes. However, it is difficult to make a clear diagnosis of mild traumatic brain injury. This study aimed to analyze the characteristics of changes in magnetic susceptibility values after repeated mTBI by using quantitative susceptibility mapping(QSM).

Development and Characterization of a Murine Lung Adenocarcinoma Cell Line With High Thoracic Pleural Metastatic Potential.

Background/aim: Pleural metastasis and malignant pleural effusion (MPE) are common complications of lung adenocarcinoma. Patients with MPE have poor outcomes, with overall survival ranging from 5 to 11.4 months.

Exploring the role of hyperreflective walls as a biomarker for the management of cystoid macular edema.

Aim: To investigate the prevalence and clinical implications of hyperreflective walls (HRW) in foveal cystoid spaces in patients with cystoid macular edema (CME) caused by retinal diseases and noninfectious uveitis (NIU).

Methods: This retrospective cross-sectional study included 443 eyes with CME secondary to diabetic macular edema (DME), retinal vein occlusion (RVO), retinitis pigmentosa (RP), neovascular age-related macular degeneration (nAMD), and NIU. Demographic data, HRW features, and other spectral domain optical coherence tomography (SD-OCT) biomarkers were analyzed.

Single amino acid substitution at position 614 in SARS-CoV-2 Spike Protein alters viral assembly and infectivity.

The emergence of SARS-CoV-2 has posed a substantial global public - health threat and has led to the emergence of diverse variant strains. A prevalent mutation, D614G, is commonly detected in the spike glycoprotein (S) of successive SARS- CoV-2 variants, which enhances viral infectivity. Here, the objective was to examine the influence of mutations on the synthesis and processing of the S protein, virus assembly, and infectivity.

Muscle strength and mass as predictors of pancreatic cancer: insights from the UK biobank.

Background: While sarcopenia is associated with adverse pancreatic cancer (PC) outcomes, prospective evidence linking muscle health to PC risk remains limited. This study aimed to prospectively investigate the associations of grip strength and muscle mass with incident PC risk in the UK Biobank cohort.

Methods: Among 363,693 UK Biobank participants, grip strength (kg) and bioelectrical impedance analysis (BIA)-derived muscle mass (weight-normalized) were measured.

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Glioblastoma multiforme (GBM) shows profound inter- and intratumoral heterogeneity, but differences across ancestries remain understudied. We assemble the largest cohort of GBMs from East Asian patients (EAS-GBM) and perform genomic and transcriptomic analyses. Transcriptomic clustering reveals distinct EAS-GBM molecular subtypes-proliferative (PL), neurosynaptic (NS), metabolic (MB), and immunomodulatory (IM)-based on activated biological pathways.

An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing.

Energy restriction is closely related to cellular senescence and species longevity. Here, based on the structure and function of ATP synthase, a key enzyme for energy generation, we develop energy metabolism-engaged nanomedicines (EM-eNMs) to rejuvenate aged stromal/stem cells, and help to prevent skeletal ageing. We show that EM-eNMs infiltrate the mitochondria of aged bone marrow mesenchymal stromal/stem cells (BMMSCs), driving mitochondrial fission, mitophagy, glycolysis and maintaining BMMSC stemness and multifunction.

Copper single-atom-based flexible aptamer biochip for simultaneous monitoring of bladder cancer-related bacteria.

R apid and accurate detection of pathogenic bacteria is crucial for disease diagnosis in clinical practice. The infection of Escherichia coli (E. coli) and Staphylococcus aureus (S.

Antibody-positive pharyngeal-cervical-brachial variant superimposed on a paraparetic variant of Guillain-Barré syndrome: A case report.

Rationale: Guillain-Barré syndrome (GBS) is a self-limiting immune-mediated neuropathy, pharyngeal-cervical-brachial (PCB) and paraparetic variants are rare variants of GBS spectrum disorders, and there are no reports of their coexistence.

Patient Concerns: The patient had an episodic course with progressive exacerbation, with frequent episodes of weakness and soreness in both lower limbs as the main complaints, and presented with dysphagia in this occurrence.

Diagnoses: The patient was diagnosed with a case of GBS presenting features of both PCB and paraparetic variants.

Yttrium Contenting Compositionally Complex Medium-Entropy Li-Garnet Electrolyte with Improved Ionic Conductivity.

The compositionally complex medium/high-entropy design concept can greatly expand the categories and affect the properties of the materials. With such a designing concept, a medium-entropy Li-garnet electrolyte with appropriate yttrium content (formula LiLaZrNbTaHfYO) shows a record-high ionic conductivity of ∼5.7 × 10 S/cm, the highest reported for any single-site substituted high/medium-entropy Li-garnet.

An Automated Micro-Immunobeads-Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease.

The anticipated rise in the prevalence of Alzheimer's disease (AD) under global demographic shifts necessitates the development of universally accessible screening and diagnostic tools, of which blood tests hold the promise. However, the widespread adoption of blood tests remains impeded by the lack of analytically validated biomarkers and accessible decentralized platforms. Here, the study presents a portable and automated micro-immunobeads-based electromagnetic operation system, termed MEMOs, targeting potential AD blood biomarker exosome-bound Aβ42 (Exo-Aβ42), for automated blood testing of AD.

Cortical activation and functional connectivity in patients with chronic insomnia based on working memory tasks: a multi-channel near-infrared spectroscopy study.

Background: Working memory (WM) impairment has been found in patients with insomnia, and the frontotemporal region plays a central role in working memory. Therefore, changes in functional connectivity in the frontotemporal region may play an important role in WM impairment in patients of chronic insomnia, but little is known about the neural processes associated with WM dysfunction in patients with chronic insomnia. This study used functional near-infrared spectroscopy (fNIRS) to investigate differences in cortical activation and functional connectivity during a WM task between patients with chronic insomnia and healthy controls (HCs).

Transcriptomic Profiling of Buds Unveils Insights into Floral Initiation in Tea-Oil Tree ( 'changlin53').

Flowering is a key agronomic trait that directly influences the yield of the tea-oil tree (). Floral initiation, which precedes flower bud differentiation, represents a critical developmental stage affecting the flowering outcomes. However, the molecular mechanisms underlying floral initiation in remain poorly understood.

Potential-driven reaction order transitions of water oxidation on hematite photoanodes.

Understanding the potential-dependent kinetics of photoelectrochemical (PEC) reactions is crucial for advancing the catalytic applications, particularly for water oxidation. This dependency arises because the accumulation of photogenerated charges, directly influenced by the applied potential, fundamentally dictates the intrinsic limitation of slow charge transfer rates. In this study, we investigated the water oxidation on hematite photoanodes with {012} facets exposed, analyzing the reaction kinetics under light and dark conditions.

Discovery and biochemical characterization of prenyltransferases in the biosynthetic pathway of hericenones from Hericium erinaceus.

Hericenones, neurotrophic meroterpenoids from the medicinal mushroom Hericium erinaceus, exhibit remarkable nerve growth factor-enhancing properties with therapeutic potential for neurodegenerative disorders. Biosynthesis of these compounds requires prenyltransferase (PT)-mediated geranylation of orsellinic acid (OA, 1), though the fungal enzymes catalyzing this pivotal step remain uncharacterised. Through comprehensive genome mining of H.

Heparin administration at first medical contact vs immediately before primary percutaneous coronary intervention: the HELP-PCI trial.

Background And Aims: The beneficial effect of pre-treatment with unfractionated heparin (UFH) at first medical contact (FMC) before primary percutaneous coronary intervention (PPCI) in all-comers with ST-elevation myocardial infarction (STEMI) remains uncertain.

Methods: HELP-PCI was an investigator-initiated, randomized controlled trial conducted at 36 clinical centres in China. Patients with STEMI presenting ≤12 h after symptom onset undergoing PPCI were randomly assigned (1:1) to intravenous administration with UFH (100 U/kg) at FMC or in the Cath Lab through a catheter sheath.

Comparative effects of different loads of aerobic exercise on lipid metabolism in MASLD rats: a perspective from the gut-liver axis.

Objective: Exercise training has been shown to be effective in ameliorating obesity-related diseases, but the therapeutic effects of different loads of exercise on metabolic dysfunction-associated steatotic liver disease (MASLD) as well as the underlying mechanisms by which exercise is based on the enterohepatic axis and thus alleviates MASLD are still unclear. Therefore, the present study aimed to clarify the optimal exercise load for improving MASLD and to reveal its molecular mechanisms in the treatment of metabolic-associated fatty liver disease (MASLD) in the context of the enterohepatic axis.

Methods: Forty male rats were randomly divided into two groups: NFD ( = 8) and HFD ( = 32).

Generalizable Seizure Prediction with LLMs: Converting EEG to Textual Representations.

Seizure prediction through scalp electroencephalogram (EEG) holds considerable practical potential. The primary challenge faced by existing algorithms lies in the individual heterogeneity, which hinders the generalizability of models to new patients. Additionally, inconsistencies in channel settings across various epilepsy centers further limit the applicability of models to diverse datasets.

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination.

The DNA damage response plays a pivotal role in ovarian aging. Breast cancer susceptibility gene 2 (BRCA2), which participates in homologous recombination (HR), is a key regulator of natural menopause. Rare BRCA2 variants have been identified in patients with premature ovarian insufficiency (POI).

Puerarin alleviates cerebral ischemia/reperfusion (CIR)-induced neurocyte oxidative stress and apoptosis via DNA demethylation-mediated PI3K/Akt activation.

Background: Cerebral ischemia stroke (CIS) is a multifactorial and heterogeneous neurological disorder characterized by high mortality rate and longterm cognitive deficits. Puerarin (Pue) exhibits neuroprotective properties against cerebral ischemia/reperfusion (CIR) injury.

Methods: The DNA demethylation-mediated neuroprotective effects of Pue were investigated in vivo using TTC staining, H&E staining, and TUNEL assays.

MCAM interacts with integrin β1 to promote EGFR-TKI resistance in lung adenocarcinoma through the JAK3 signalling pathway.

Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have exhibited remarkable efficacy against EGFR-mutated lung cancer. However, the majority of patients receiving EGFR-TKIs face a grim prognosis due to acquired drug resistance. Melanoma cell adhesion molecule (MCAM), a highly glycosylated type I transmembrane protein belonging to the immunoglobulin superfamily, is upregulated in EGFR-TKI-resistant EGFR-mutant lung adenocarcinoma.

GeneSurfer enables transcriptome-wide exploration and annotation of gene co-expression modules in 3D spatial transcriptomics data.

Gene co-expression provides crucial insights into biological functions, however, there is a lack of exploratory analysis tools for localized gene co-expression in large-scale datasets. We present GeneSurfer, an interactive interface designed to explore localized transcriptome-wide gene co-expression patterns in the 3D spatial domain. Key features of GeneSurfer include transcriptome-wide gene filtering and gene clustering based on spatial local co-expression within transcriptomically similar cells, multi-slice 3D rendering of average expression of gene clusters, and on-the-fly Gene Ontology term annotation of co-expressed gene sets.