Static magnetic field enhances biogenic Mn (II) oxidation in magnetite sand filtration to strengthen the removal of emerging contaminants in groundwater.

Oligotrophic groundwater limits biodegradation in sand filtration, illuminating the pathway of the in-situ production of oxidatively active Mn oxide (MnOx) to remove emerging contaminants (ECs). Based on the Mn(II) removal filter, increased production of chemical MnOx (CheMnOx) for EC removal could be realized by increasing biogenic MnOx (BioMnOx) as the Mn active film to stimulate autocatalytic Mn(II) oxidation. However, progress in exogenously enhancing biogenic Mn(II) oxidation is limited.

Preoperative Assessment of Extraprostatic Extension in Prostate Cancer Using an Interpretable Tabular Prior-Data Fitted Network-Based Radiomics Model From MRI.

Background: MRI assessment for extraprostatic extension (EPE) of prostate cancer (PCa) is challenging due to limited accuracy and interobserver agreement.

Purpose: To develop an interpretable Tabular Prior-data Fitted Network (TabPFN)-based radiomics model to evaluate EPE using MRI and explore its integration with radiologists' assessments.

Study Type: Retrospective.

Trophic transfer of CeO nanoparticles from clamworm to juvenile turbot and related changes in fish flesh quality.

Engineered nanoparticles (ENPs) accumulate in marine sediments and exhibit adverse effects on benthic organisms. However, the effect of ENPs on marine benthic food chains is largely unknown. Herein, we investigated the trophic transfer and transformation of CeO ENPs within a simulated marine benthic food chain from clamworm () to turbot (), as well as their effects on fish flesh quality.

Resident Preferences for Telemedicine Services in China in the Digital Health Era: Mixed Methods Study.

Background: In the digital health era, telemedicine has become a key driver of health care reform and innovation globally. Understanding the factors influencing residents' choices of telemedicine services is crucial for optimizing service design, enhancing user experience, and developing effective policy measures.

Objective: This study aims to explore the key factors influencing Chinese residents' choices of telemedicine services, including consultation fee, physician qualifications, appointment waiting time, scope of services, privacy protection, and service hours.

Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells.

Introduction: Lenvatinib resistance remains a major challenge in hepatocellular carcinoma (HCC) treatment, highlighting the need for novel therapeutic strategies. Cuproptosis, a copper-dependent form of cell death, has been increasingly implicated in cancer progression. Quercetin, a naturally occurring bioactive flavonol known to modulate mitochondrial metabolism and multiple oncogenic signaling pathways, has emerged as a potential sensitizer.

JA Regulates Caffeine Biosynthesis in Tea Leaf for Resistance Against Fungal Infection and Antagonises With GA to Balance the Defence-Growth Trade-Off via CsDELLA-JAZ-MYC2-MYB184-TCS1 Module.

Caffeine is a defensive alkaloid primarily accumulated in tea leaves to defend against pathogens. But the regulatory mechanism for caffeine biosynthesis in response to fungal infection and the trade-off between specialised metabolite and plant growth remain elusive. Here, we report that jasmonic acid (JA)-regulated CsMYB184 is the key for caffeine biosynthesis in tea leaves.

Exogenous Mitochondrial Pretreatment Enhances the Therapeutic Effect of UC-MSCs on NAFLD in Type 2 Diabetic Mice by Mediating Mitochondrial Transfer.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease and is a comorbidity in type 2 diabetes (T2D) mellitus. Mesenchymal stem cell (MSC) is emerging as a potential therapeutic strategy for diabetes and NAFLD through mitochondrial transfer initiated by signaling from injured recipient cells. Thus, in this study, we investigated whether exogenous mitochondrial preconditioning of MSCs could exert superior effects on NAFLD and explore the role of MSCs-mediated mitochondrial transfer into hepatocyte.

Genetic variants of LncRNA associated with splicing regulation and their impact on ovarian cancer development.

Ovarian cancer (OC) is a highly lethal gynecologic malignancy that lacks reliable early biomarkers. Numerous long non-coding RNAs (lncRNAs) have been found to play critical regulatory roles in OC, yet the mechanisms underlying most of them remain unclear. Recently, lncRNAs have emerged as key regulators of RNA splicing, while splicing dysregulation is widespread and plays critical roles in cancer.

The Mechanical Reinforcing Mechanism and Self-Healing Properties of Biomimetic Hybrid Cement Composites via In-Situ Polymerization.

Addressing the inherent brittleness of cement to mitigate infrastructure failures stemming from cracking is imperative. To accomplish both early crack resistance and subsequent self-healing capabilities, a biomimetic microstructure composed of a sodium polyacrylate (CSPA) network interwoven with hydration products was developed. The calcium-enriched polymer network formed via in situ polymerization of sodium acrylate (ANa) can enhance the mechanical properties of cement and achieve efficient self-healing of cracks.

GAH-TNet: A Graph Attention-Based Hierarchical Temporal Network for EEG Motor Imagery Decoding.

Background: Brain-computer interfaces (BCIs) based on motor imagery (MI) offer promising solutions for motor rehabilitation and communication. However, electroencephalography (EEG) signals are often characterized by low signal-to-noise ratios, strong non-stationarity, and significant inter-subject variability, which pose significant challenges for accurate decoding. Existing methods often struggle to simultaneously model the spatial interactions between EEG channels, the local fine-grained features within signals, and global semantic patterns.

STIL-TA: A new model of traffic flow forecasting based on spatiotemporal interactive learning and temporal attention.

Accurate traffic flow forecasting plays a critical role in alleviating urban road congestion. Despite the success of existing models (e.g.

Molecular profiles of the great obstetrical syndromes reveal common features and dynamic changes in early pregnancy.

Background: The great obstetrical syndromes (GOS) encompass a spectrum of pregnancy-related complications that are the major determinants of maternal and neonatal mortality. Although shared placental pathology underlies these complications, knowledge of the molecular commonalities before clinical presentation remains incomplete.

Methods: In this case-control study nested within the prospective Shanghai Birth Cohort, we investigated the molecular characteristics underlying GOS conditions in the pre-symptomatic phase using serum samples from 203 nulliparas who subsequently developed GOS and 181 controls.

PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy.

Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults, yet its pathogenesis remains incompletely understood. The retinal pigment epithelium (RPE) plays a vital role in maintaining retinal homeostasis. In this study, the expression of senescence marker protein p16 is observed to be upregulated in the RPE of early DR mouse models.

Single Atom-Substituted Chalcogenides with Anion Vacancy Bonded on Graphene Nanotubes for Achieving "1+1+1>3" Synergistic Enhanced Sodium Storage.

Developing distinctive composite anodes with multiple active components is critical for enhancing the charge storage capability of sodium-ion hybrid capacitors (SIHCs). Herein, In single atom-substituted SnS with moderate sulfur vacancies in situ bonded on N-doped graphene nanotubes (In─SnS@NG) is ingeniously engineered as a superior anode. Theoretical calculations and in situ/ex situ characterizations illustrate that the introduced Sn(In)─N interfacial bonds immensely strengthen composites integration and boost charge transfer, then In single atom substitution effectively elevates d band center and enhances Na adsorption.

Targeting ATP7A-Dependent Copper Metabolic Homeostasis Induces Cuproptosis and Suppresses the Progression of Mutant KRAS-Driven Lung Cancer.

Despite progress in tumor-targeted therapy, oncogenic KRAS remains a major challenge in treating lung adenocarcinoma (LUAD). In clinical practice, KRASG12C inhibitors have limited response rates and are associated with acquired drug resistance. Cuproptosis is a recently identified form of copper (Cu)-mediated cell death, and previous studies have revealed that Cu metabolism plays an important role in the development of KRAS-driven tumors.

Dihydroartemisinin targets ANXA2 to suppress hepatocellular carcinoma angiogenesis through the PI3K/AKT signaling pathway.

Background: Annexin A2 (ANXA2), implicated in the progression of multiple cancers, is considered a promising biomarker for anti-cancer therapies. Our research explores the molecular mechanisms of ANXA2 in hepatocellular carcinoma (HCC) and discovers the potential of traditional Chinese medicine compounds to target ANXA2, aiming to improve current HCC therapeutic approaches.

Methods: Our study leveraged TCGA data to investigate ANXA2 expression in HCC, complemented by gene set enrichment analysis to elucidate its potential impact.

A unified cell atlas of vascular plants reveals cell-type foundational genes and accelerates gene discovery.

The pace of gene discovery in plants has slowed as forward genetic screens reach saturation. To address this, we built a unified single-cell atlas of shoot apices from six vascular plant species spanning major evolutionary groups. This cross-species resource allowed us to identify a core set of cell-type foundational genes linked to key tissues such as the epidermis, xylem, and phloem, streamlining gene discovery with greater accuracy.

Astrocyte Secretome Profiling via Biorthogonal Labeling Unveils Novel Factors Relevant to Neurodegenerative Diseases.

Secreted proteins are key mediators of intercellular communication in multicellular organisms. However, progress in secretomics has been hindered by the lack of effective methods for capturing secreted proteins. Here, we present a two-step secretome enrichment method (tsSEM) that integrates unnatural amino acid labeling with click chemistry-based biorthogonal reaction, enabling robust in vitro secretome profiling in the presence of serum.

Application value of transparent-cap-assisted colonoscopy: A randomized clinical trial.

Colonoscopy provides limited protection against interval colorectal cancer. This study aims to investigate the application value of transparent-cap-assisted colonoscopy (CAC) regarding cecal intubation time and polyp detection rate. This prospective randomized controlled trial recruited 480 patients in our hospitals.

Enhancing Chemical Prediction in Plasma Protein Binding: A Deep Learning Model Combining Molecular Descriptors and Fingerprint Representation With Attention Mechanisms.

Plasma protein binding (PPB) is an important pharmacokinetic parameter. It is important to measure the PPB properties of drug molecules during drug development. However, in vivo or in vitro measurements are time-consuming.

Trans-Scale Progressive Failure Analysis Methodology for Composite Materials Incorporating Interfacial Phase Effect.

Fiber-reinforced resin matrix composites are generally composed of fibers and matrix with significantly different properties, which are non-uniform and anisotropic in nature. Macro-failure criteria generally view composite plies as a uniform whole and do not accurately reflect fiber- and matrix-scale failures. In this study, the interface phase effect between fiber and matrix has been introduced into the frame of trans-scale analysis to better model the failure process, and the equivalent mechanical property characterization model of the interface phase has also been established.

NSUN2-mediated m5C modification of PGK1 mRNA promotes cell growth, invasion, stemness and glycolysis in gastric cancer.

To explore functions and mechanisms in gastric cancer (GC) progression. The mRNA and protein levels of NSUN2 and phosphoglycerate kinase 1 (PGK1) were determined by qRT-PCR and western blot. Cell proliferation, apoptosis, invasion and stemness were examined using CCK8 assay, EdU assay, flow cytometry, transwell assay and sphere formation assay.

Decline in the Relative Abundance of Antibiotic Resistance Genes in Long-Term Fertilized Soil and Its Driving Factors.

The changes in antibiotic resistance genes (ARGs) in long-term fertilized soil remain controversial. We aimed to analyze the variation characteristics of ARGs in long-term fertilized soil using metagenomic sequencing. The relative abundance of ARGs did not increase significantly after 7 years of fertilization.

Chronic exposure to environmentally-relevant sulfamethoxazole alters ammonia-oxidizing microbial communities in managed aquifer recharge systems.

Managed aquifer recharge (MAR) is a critical technology for water resource management and purification, yet its capacity to remove antibiotics remains limited. Understanding the response of ammonia-oxidizing microorganisms (AOMs) to antibiotics exposure is essential for optimizing MAR-based antibiotic mitigation strategies. This study investigated the long-term effects of sulfamethoxazole (SMX, ∼500 ng/L) on AOM communities through a 20-month controlled MAR column experiment.