Novel surveillance protocol for gastric cancer based on CEA: a high-volume multi-center study.

Tumor markers are commonly used in gastric cancer patients, but their effectiveness in monitoring recurrences is not optimal. This study aims to evaluate the recurrence predictive performance of carcinoembryonic antigen (CEA) across different baseline groups and establish a new surveillance protocol. We analyzed data from 1708 patients at Sun Yat-Sen University Cancer Center with stage I-III gastric adenocarcinoma.

UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice.

Objective: To investigate the therapeutic and ameliorative effects of the Myeloid Cell Leukemia 1 protein (MCL-1) inhibitor UMI-77 on experimental murine periodontitis via mitophagy activation, with a focus on comparing administration routes (local/intraperitoneal) and doses (high/low/combined).

Methods: A ligature-induced periodontitis model was established in 54 male C57BL/6 J mice, randomized into 9 groups (n = 6 per group): normal control (Group Aa), periodontitis model (Group Ab), positive control (Group Ac, local minocycline), local PBS control (Group Ad), intraperitoneal PBS control (Group Ae), local high-dose UMI-77 (Group Ba, 2 mg/kg), local low-dose UMI-77 (Group Bb, 1 mg/kg), intraperitoneal UMI-77 (Group Ca, 2 mg/kg), and combined intraperitoneal UMI-77 + local minocycline (Group Cb, 2 mg/kg + standard minocycline regimen). Outcomes included periodontal bleeding on probing (BOP), alveolar bone resorption via micro-CT, histopathological analysis (HE/methylene blue staining), MCL-1 expression (Western blot), autolysosome detection (transmission electron microscopy, TEM), and systemic organ safety (HE staining).

Dihydroartemisinin targets ANXA2 to suppress hepatocellular carcinoma angiogenesis through the PI3K/AKT signaling pathway.

Background: Annexin A2 (ANXA2), implicated in the progression of multiple cancers, is considered a promising biomarker for anti-cancer therapies. Our research explores the molecular mechanisms of ANXA2 in hepatocellular carcinoma (HCC) and discovers the potential of traditional Chinese medicine compounds to target ANXA2, aiming to improve current HCC therapeutic approaches.

Methods: Our study leveraged TCGA data to investigate ANXA2 expression in HCC, complemented by gene set enrichment analysis to elucidate its potential impact.

The effects of masseter muscle morphology on three-dimensional occlusion and temporomandibular joint in adult patients with skeletal class II malocclusion: a CBCT study.

Introduction: This retrospective study aimed to compare the masseter muscle morphology, static and dynamic occlusion, and temporomandibular joint (TMJ) characteristics among adult patients with skeletal Class II malocclusion exhibiting different vertical patterns. Additionally, the correlations among these three factors were examined.

Methods: A total of 87 adult participants (mean ± standard deviation age = 25.

Multi-Color Switchable Luminescence in Organic-Inorganic Metal Halides via Local Polyhedron Regulation Under Light and Temperature Stimuli.

Organic-inorganic metal halides (OIMHs) with multi-color switchable luminescence have raised pervasive attention in the field of sensing, optoelectronics, anti-counterfeiting, information encryption and storage. However, the complexity of soft lattice structures makes it difficult to establish design rules for realizing the luminescence regulation, which greatly hinders their practical applications. Herein, a series of 0D OIMHs are designed, including PASbCl, PAInCl, PMAInCl, PEAInCl·HO and PPAInCl.

Heterogeneity of the liver cancer tumor microenvironment: mitochondrial metabolism and causal inference through Mendelian randomization.

Background: This study presents a comprehensive investigation into the molecular mechanisms of hepatocellular carcinoma (HCC) through an innovative application of Mendelian randomization (MR) analysis, integrated with immune cell profiling and metabolomic assessment.

Methods: Utilizing two-sample Mendelian randomization (TSMR) with data from large-scale GWAS studies, including immune cell profiles from the UK Biobank (n = 1629) and HCC cases from a multi-ethnic meta-analysis (775 cases, 1332 controls), we identified significant causal associations between specific immune cell populations, serum metabolites, and HCC risk. This study employed a multi-omics approach, including Principal Component Analysis (PCA), Gene Set Enrichment Analysis (GSEA), to conduct a comprehensive analysis of the liver cancer TME.

Aurora kinase-a expression heterogeneity and potential benefit of combination therapy in prostate adenocarcinoma.

Background: Aurora kinase A (AURKA) is aberrantly expressed in a large number of tumors and promotes tumor progression by regulating the cell cycle, chromosomal instability, and drug resistance. However, its heterogeneous expression and combination therapy benefit in prostate adenocarcinoma (PRAD) is unclear.

Methods: In this study, we integrated TCGA pan-cancer multi-omics data and GEO data to analyze the RNA, methylation, protein expression, and genomic alteration characteristics of AURKA.

Starch Digestion Characteristics of Different Starch Sources and Their Effects on Goslings' Apparent Nutrient Utilization.

This study used integrated in vitro and in vivo approaches to investigate how the starch source (glutinous rice, indica rice, maize, or high-amylose rice) influences starch digestion kinetics and, consequently, the apparent nutrient utilization and amino acid metabolism in goslings. Four diets were formulated using glutinous rice, indica rice, maize, and high-amylose rice, and in vitro digestion and animal experiments were carried out. The data showed the particle sizes of the four starches: glutinous rice ≈ indica rice < corn < amylose.

Expose flexible conformations for intrinsically disordered protein.

The folding conformation of native protein has flexibility in different degrees, which may bring difficulty in presenting the structures, and also it causes complexity in understanding the relationship between structure and functions. Although many methods and databases provide information for intrinsically disordered protein (IDP), they are mainly limited to determining the intrinsically disordered regions (IDR) lacking knowledge of possible folding patterns. To overcome the barrier, the protein structure fingerprint technology has been developed, which includes PFSC (Protein Folding Shape Code) (Yang, 2008) and PFVM (Protein Folding Variation Matrix) (Yang et al.

Risk factor and operation influence of intracranial hemorrhage following ventriculoperitoneal shunt.

Intracranial hemorrhage is a rare but significant complication of ventriculoperitoneal (VP) shunt surgery. This study aimed to identify and assess the risk factors associated with intracranial hemorrhage in patients undergoing VP shunt surgery. This retrospective study included patients who underwent a VP shunt surgery between January 2021 and July 2023.

Efficient photoelectrocatalytic performances using a WO/BiVO heterojunction photoanode: applied bias-promoted photoinduced charge transfer and separation.

Combining tungsten trioxide (WO) with bismuth vanadate (BiVO) to form a heterojunction photoanode offers a promising solution to achieving highly efficient photoelectrocatalytic (PEC) performances. In this work, we successfully fabricated the WO/BiVO heterojunction on tungsten (W) foil a hydrothermal route, followed by a successive ionic layer adsorption and reaction (SILAR) process. The PEC performances for synergetic H evolution and organic pollutant degradation were significantly enhanced after the BiVO nanoparticles were loaded on the WO photoanode.

Communication initiated by hepatocytes: The driver of HSC activation and liver fibrosis.

Liver fibrosis (LF) refers to the excessive deposition and abnormal distribution of the extracellular matrix (ECM) caused by acute or chronic liver injury, which affects the prognosis of liver diseases. Activated HSCs play a central role in LF through their ability to differentiate into myofibroblasts (MFBs) and secrete ECM. Intercellular communication within the liver is important for HSC activation and LF, whether in the initial or persistent stage.

Sappanumols A-C, Three Homoisoflavonoids with Antiinflammatory Activities from .

Sappanumols A-C (-, respectively), three unprecedented homoisoflavonoids, were isolated from . Their structures were elucidated by comprehensive spectroscopic analysis and ECD computation methods. Compound demonstrated inhibitory effects on LPS-induced NO production in BV-2 cells with an IC value of 16.

Optimal sites for miniscrew insertion in anterior aesthetic region: a CBCT study for different vertical skeletal patterns.

Introduction: The objective of this retrospective cohort study was to measure the root distance, bone thickness and bone density in maxillary anterior region with different vertical skeletal patterns based on CBCT data, and provide reference for the optimal site for miniscrew insertion in anterior aesthetic region.

Methods: 60 adult patients(18-29years) with skeletal Class I angle (ANB angle = 2° ± 2°) were selected and divided into three groups (n = 20) according to vertical skeletal patterns.The population was divided into 3 groups according to the measured SN-GoGn angle: hypodivergent (SN-GoGn < 27°), average (27°≤ SN-GoGn ≤ 37°) and hyperdivergent (SN-GoGn > 37°) groups.

Wavelength-Tunable of Broad Red to Near-Infrared Emission in (Sr,Ba)ScO :Eu Phosphors: Crystal Field Effects and Thermal Stability.

In this work, a series of Eu-activated phosphors, including SrScO:xEu, BaSrScO:0.015Eu (0 ≤ ≤ 1), and BaScO:xEu, were successfully synthesized via a sol-gel method. The SrScO:xEu phosphors exhibited a broad red emission band centered at 609 nm under 430 nm blue-light excitation, with a measured internal quantum yield of 47.

DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy.

Background: Synovitis is a key factor in temporomandibular joint osteoarthritis (TMJOA) and could be an early sign of the disease. Notably, synovitis and its macrophage component represent a target of interest for developing treatments. Dental pulp stem cells (DPSCs) are derived from the neural crest, coincidentally with maxillofacial tissues, thus attracting significant interest in situ maxillofacial regenerative medicine.

Sub-1 nm CuO-Phosphomolybdic Acid Nanosheets for Ultrasound-Controlled Pyroptosis Activation and Tumor Immunotherapy.

Inducing pyroptosis effectively transforms immunosuppressive "cold tumors" into immunogenic "hot tumors" to enhance tumor immunotherapy. However, uncontrolled pyroptosis activation risks systemic inflammation and tumor metastasis. In this study, we used a solvothermal method to synthesize a sub-1 nm copper oxide-phosphomolybdic acid nanosheet (CuO-PMA) for ultrasound (US)-controlled reactive oxygen species (ROS) generation to induce pyroptosis.

Clinicopathologic and prognosis of 30 patients with FH-deficient renal cell carcinoma: a single-center retrospective study.

Background: FH-Deficient Renal Cell Carcinoma (FH-RCC) is a rare, aggressive cancer with poor prognosis and treatment challenges. Immunohistochemical (IHC), including PD-1, PD-L1, PD-L2, and CTLA-4, play a key role in survival outcomes and therapeutic decisions, highlighting the need to evaluate their significance in FH-RCC.

Methods: The expression of IHC including PD-1, PD-L1, PD-L2 and CTLA-4 in tumor cells was evaluated.

Multi-GWAS analysis illuminates druggable targets for rheumatoid arthritis.

Objective: Despite the treatment choices for rheumatoid arthritis (RA) increasing, there remain unmet preventive and therapeutic needs for RA. This study aimed to identify effective drug target genes to reduce RA risk through the multi-genome-wide association studies analysis.

Methods: A Mendelian randomization (MR) analysis was conducted to investigate the causal effects of druggable expression quantitative trait loci (eQTLs) in the blood on RA.

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression.

Ceramide metabolism dysregulation links to colorectal cancer (CRC) progression, yet the mechanism remains unknown. d18:1/26:0 ceramide (C26) levels were elevated in patients with CRC and mouse models, which activated epidermal growth factor receptor (EGFR) by binding its extracellular region to promote cancer cell proliferation. The rise of C26 levels was mainly driven by heightened ceramide synthase 3 (CERS3) activity.

Multifunctional hydrogel with self-healing and recyclability based on self-catalytic Fe/TA system for sustainable E-skin application.

Hydrogel-based materials for e-skin applications have aroused tremendous attention due to their ability to simulate human skin's sensory capabilities and possess mechanical properties comparable to those of skin. When used as sensors attached to the skin, hydrogels are inevitably subject to damage, highlighting the need for self-healing properties. Furthermore, the lack of recyclability in traditional hydrogel sensors is detrimental to sustainability.

Choroid Plexus Fibroblast-ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury.

Mounting evidence has indicated that immune signals originating from the brain's border tissues will exert a profound influence on brain parenchyma neural cells. However,  the structural component alterations and immune cell infiltration characteristics of choroid plexus (ChP) following traumatic brain injury (TBI) remain incompletely understood. Here, using single-cell RNA sequencing and histological analysis, the accumulation of group 2 innate lymphoid cell (ILC2) in the ChP stroma post-TBI is identified.

Zn Lattice Site-Dependent Emission of Sb-Doped (ETBT)ZnBr Organic-Inorganic Halide Perovskite for Tunable Lighting and Night-Vision Applications.

In the realm of lighting and display technologies, the pursuit of single-matrix multifunctional light sources that are both environmentally friendly and highly tunable is of the utmost necessity. We obtained an organic-inorganic halide perovskite crystal (OIHPCs) (ETBT)ZnBr, which possesses two distinct crystallographic sites for Zn, namely Zn1 and Zn2. By doping with Sb, a broad emission with two prominent emission peaks at 530 and 670 nm has been achieved, which originate from the triplet emission of Sb occupied at different luminescent centers.

Mitochondrial Tumor Suppressor 1A Attenuates Myocardial Infarction Injury by Maintaining the Coupling Between Mitochondria and Endoplasmic Reticulum.

Background: Pathological cardiac remodeling after myocardial infarction (MI) is a leading cause of heart failure and sudden death. The detailed mechanisms underlying the transition to heart failure after MI are not fully understood. Disruptions in the endoplasmic reticulum (ER)-mitochondria connectivity, along with mitochondrial dysfunction, are substantial contributors to this remodeling process.