Associations Between Gestational Polybrominated Diphenyl Ether (PBDE) Serum Concentrations and Child Sleep Outcomes from Ages 2 to 8 Years.

Gestational polybrominated diphenyl ethers (PBDEs) exposures have been associated with thyroid disruption in pregnant women and adverse neurobehavioral outcomes in their children, but it is unknown if they interfere with children's sleep patterns. We assessed gestational PBDE exposure (16 weeks) and child sleep patterns from ages 2 to 8 years using 410 mother-child dyads in the Health Outcomes and Measures of the Environment (HOME) Study. Gestational biomarkers of serum PBDEs include PBDE-153 (GM±GSD: 5.

Elevated salinity decreases soil multifunctionality by driving bacterial community structure and network complexity.

Soil salinization has emerged as a critical environmental challenge threatening the sustainable development of terrestrial ecosystems globally. While the detrimental effects of soil salinization on plant growth, soil nutrient dynamics, and microbial communities are well-documented, how salinity-driven shifts in microbial nutrient limitation and co-occurrence network complexity collectively regulate soil multifunctionality (SMF) remains poorly resolved, particularly in agroecosystems. We conducted a salinity gradient mesocosm experiment (1.

Controlling Magnetic Anisotropy of Endohedral Lanthanide Ions by Carbene Addition: Paramagnetic NMR, Lanthanide Luminescence, and Single-Molecule Magnetism in Adamantylidene Adducts of MScN@C (M = Nd, Dy).

Metallofullerenes with endohedral lanthanides have emerged as a versatile class of single-molecule magnets owing to strong single-ion magnetic anisotropy, which can be realized in the interior of the fullerene cage. Since exohedral chemical modification of fullerenes is often used to adjust their properties and processability for prospective practical applications, it is necessary to understand how it can affect their magnetic properties. In this work, we studied how a popular [2 + 1] cycloaddition reaction, photochemical addition of adamantylidene (Ad), affects single-ion magnetic anisotropy and single-molecule magnetism of MScN@C (M = Nd, Dy).

Discrimination and evaluation of commercial large yellow croaker (Larimichthys crocea): Odor and taste-active compounds.

The absence of reliable identification technologies limits the authentication of geographical origin and growth conditions in large yellow croakers (LYCs). This study addressed this issue by analyzing odor and taste-active compounds to enable effective differentiation and quality evaluation. The findings revealed that inorganic sulfides, alcohols, aldehydes, ketones, nitrogen-containing oxides, and methyl compounds served as potential odor markers for the rapid discrimination of LYC meat from various origins, with 3-methyl-1-butanol and hexanal identified as key distinguishing odor compounds.

Efficacy and safety of tazemetostat, an EZH2 inhibitor, in Chinese patients with relapsed/refractory follicular lymphoma: a multicentre, single-arm, phase 2 study.

Background: Tazemetostat, the first enhancer of zeste homolog 2 (EZH2) inhibitor approved by the U.S. Food and Drug Administration, has shown efficacy in a global population with relapsed or refractory (R/R) follicular lymphoma (FL).

A simple widely applicable hairy root transformation method for gene function studies in medicinal plants.

Genetic transformation is a fundamental tool in molecular biology research of medicinal plants. Tailoring transgenic technologies to each distinct medicinal plant would necessitate a substantial investment of time and effort. Here, we present a simple hairy root transformation method that does not require sterile conditions, utilizing strain K599 and the visible RUBY reporter system.

Umbilical cord-derived exosomes alleviate spinal cord injury by regulating microglial polarization through miR-340-5p-mediated modulation of the JAK/STAT3 signaling pathway.

Spinal cord injury (SCI) is a condition of the central nervous system, results in impairments in both sensory and motor functions. Presently, there exists a deficiency in efficacious therapies. Nonetheless, employing exosomes, a derivative of human umbilical cord mesenchymal stem cells (hucMSCs), is proven to be a successful approach in treating SCI, yet the exact way they function is still not well understood.

Unraveling the metabolic network of volatile flavor dynamics development during the golden pomfret fermentation driven by core bacteria: a combined multi-omics analysis.

Fermented golden pomfret (FGP) flavor formation is a complex process. This study explored the FGP flavor formation pattern through multi-omics techniques. A total of 71 volatile compounds were detected.

Lithium-Ion Dynamic Interface Engineering of Nano-Charged Composite Polymer Electrolytes for Solid-State Lithium-Metal Batteries.

Composite polymer electrolytes (CPEs) offer a promising solution for all-solid-state lithium-metal batteries (ASSLMBs). However, conventional nanofillers with Lewis-acid-base surfaces make limited contribution to improving the overall performance of CPEs due to their difficulty in achieving robust electrochemical and mechanical interfaces simultaneously. Here, by regulating the surface charge characteristics of halloysite nanotube (HNT), we propose a concept of lithium-ion dynamic interface (Li-DI) engineering in nano-charged CPE (NCCPE).

Vancomycin-sensitive gut microbiota mediate Dendrobii β-1,4-mannan degradation and anti-colitis activity in mice.

While Dendrobii β-1,4-mannan (DOP) shows promise in treating colitis, previous research only correlated changes in gut microbiota composition with DOP's effects, without elucidating the specific mechanism by which gut microbiota mediates DOP's bioactivities. This study addresses this crucial gap by demonstrating the essential role of vancomycin-sensitive gut bacteria in mediating the anti-colitis effects of DOP. Using targeted antibiotic perturbation, we found that vancomycin, but not neomycin, abolished both DOP degradation and its therapeutic effects in colitis mice.

Analysis and Correction of the Shrinkage Prediction Model for Manufactured Sand Concrete.

With the continuous depletion of natural river sand resources and the escalating ecological degradation caused by excessive sand mining, manufactured sand has emerged as a sustainable and environmentally favorable alternative aggregate, playing an increasingly important role in the advancement of green construction materials. Nevertheless, the shrinkage behavior of manufactured sand concrete (MSC) exhibits significant deviations from that of conventional natural sand concrete due to differences in the material characteristics. Existing shrinkage prediction models-such as ACI 209, CEB-FIP 2010, B3, and GL 2000-fail to adequately incorporate the specific properties and substitution effects of manufactured sand, thereby limiting their predictive accuracy and applicability.

Effect of PGPRs on the Rhizosphere Microbial Community Structure and Yield of Silage Maize in Saline-Alkaline Fields.

Plant Growth Promoting Rhizobacteria, PGPR, can protect plants against soil-borne diseases and abiotic stress conditions. The primary objective of this study was to evaluate the effects of different PGPRs (TF1, TF2, TF3, and TF4) on the rhizosphere microbial community of silage maize in a saline-alkaline field via Illumina MiSeq high-throughput sequencing technology. Results demonstrated that different PGPRs significantly increased the harvest density (by 21.

Identification of Protein Cryptic Sites via Conformational Dynamics Capturing and Water-Based Pocket Characterization in Molecular Dynamics Simulations.

Employing molecular dynamics (MD) simulation to study the formation of novel protein cryptic sites has attracted increasing interest in the field of drug discovery. One specific challenge in this area is finding a viable method to accurately identify and characterize cryptic site transitions from MD simulation results while minimizing the need for extensive human input. Since the formation of cryptic sites often involves significant conformational changes in the protein structure, a method capable of capturing and describing these dynamic pocket transitions with precision is essential.

A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response.

Recent studies highlight the antioxidant role of lipid droplets (LDs) in shielding unsaturated lipids from peroxidation. While LDs accumulate during oxidative stress, the underlying mechanism remains unclear. Our previous research revealed that intracellular amino acids directly bind to and activate the E3 ubiquitin ligase Ubr1 to degrade Plin2, an LD protein inhibiting lipolysis.

Tongue Image-Based Diagnosis of Acute Respiratory Tract Infection Using Machine Learning: Algorithm Development and Validation.

Background: Human adenoviruses (HAdVs) and COVID-19 are prominent respiratory pathogens with overlapping clinical presentations, including fever, cough, and sore throat, posing significant diagnostic challenges without viral testing. Tongue image diagnosis, a noninvasive method used in traditional Chinese medicine, has shown correlations with specific respiratory infections, but its application remains underexplored in differentiating HAdVs from COVID-19. Advances in artificial intelligence offer opportunities to enhance tongue image analysis for more objective and accurate diagnostics.

Bloodstream infection caused by coinfection of and : a case report and literature review.

This CARE-guided report details a rare case of bloodstream infection caused by coinfection of and in a 69-year-old male with diabetic foot. and are an opportunistic pathogen that rarely causes human infection, while bloodstream infection is more rarely. They are tend to occur in immunocompromised individuals and are highly susceptible to mixed infections with other opportunistic pathogens.

High Latent-Heat, Soft yet Robust Crystalline Salogels via Dual-Network Design and Solvent Engineering.

Solid-liquid phase change materials (PCMs) hold great promise for addressing challenges in thermal energy storage and temperature management. Yet, they suffer from severe issues of melting leakage and crystalline rigidity in practical applications. Here, an approach is proposed to achieve flexible, high-latent heat PCMs with intrinsic softness and toughness in the crystalline state through the combination of dual polymer networks and inorganic salt hydrates.

Robot-assisted surgery for pediatric tumors: A single-center study of 114 cases.

Purpose: Although robot-assisted surgery has been widely adopted for adult malignancies, its application in pediatric oncology remains contentious because of limited evidence. This study aims to assess the safety, feasibility, and surgical indications of robot-assisted surgery in pediatric oncology.

Method: A retrospective analysis was conducted on pediatric patients who underwent robot-assisted surgery at the Department of Surgical Oncology, Beijing Children's Hospital, between June 2021 and January 2024.

Quinoxaline derivatives in identifying novel VEGFR-2 inhibitors: A combined 3D-QSAR, molecular docking and molecular dynamics simulation.

Vascular endothelial growth factor receptor 2 (VEGFR-2) is a key target for cancer treatment. VEGFR-2 inhibitors, which would initiate apoptosis, have been identified. To derive novel and potent VEGFR-2 inhibitors, a series of quinoxaline derivatives were studied using a combination of molecular modeling approaches, including three-dimensional quantitative structure-activity relationship (3D-QSAR), molecular docking, and molecular dynamics (MD) simulations.

Recyclable Engineering of Metal-Organic Frameworks toward Sustainable Water Remediation: From Strategies to Applications.

Metal-organic frameworks (MOFs) are extensively used to purify wastewater because of their high specific surface areas and unique photoresponsive electron transport channels. Unfortunately, extensive powder forms of MOFs are challenging to recycle, resulting in additional costs and secondary contamination. Therefore, researchers have attempted to incorporate magnetic components or self-supporting architectures to achieve solid-liquid separation and continuous operation in easy-to-use devices.

Comparison of Dexmedetomidine and Propofol for Magnetic Resonance Imaging in Children: A Meta-Analysis.

Paediatric magnetic resonance imaging (MRI) allows visualisation of internal structures in children without the use of ionising radiation. It often requires sedation to minimise patient's movement to enhance image quality. Dexmedetomidine and propofol are widely used as sedative agents, however, their comparative efficacy remains debated.