Recyclable Engineering of Metal-Organic Frameworks toward Sustainable Water Remediation: From Strategies to Applications.

Metal-organic frameworks (MOFs) are extensively used to purify wastewater because of their high specific surface areas and unique photoresponsive electron transport channels. Unfortunately, extensive powder forms of MOFs are challenging to recycle, resulting in additional costs and secondary contamination. Therefore, researchers have attempted to incorporate magnetic components or self-supporting architectures to achieve solid-liquid separation and continuous operation in easy-to-use devices.

Ultrasonography of the rectus femoris, a tool to assess the severity of sarcopenia in lung cancer patients: An observational study.

Lung cancer has a higher incidence and mortality rate than other cancers do. Sarcopenia significantly affects therapeutic outcomes and prognostic prospects in patients with lung cancer. Rapid identification and early intervention for sarcopenia are priorities.

MAP3K15 facilitates multiple viral genes expression in crustaceans via Dorsal-CC-CL-STAT axis besides the JNK/P38 pathway.

The mitogen-activated protein kinase (MAPK) pathway is a conserved signaling system that responds to extracellular signals and translates them into appropriate cellular responses. While multiple MAPK kinase kinases (MAP3Ks) play a crucial role in the step wise transmission of MAPK signals in response to the pathogen infection, little is known about the function of MAP3K15 (also known as apoptosis signal-regulated kinase 3, ASK3) in viral infection. Here, we provide evidence that shrimp MAP3K15 undergoes phosphorylation and activation during a DNA virus, white spot syndrome virus (WSSV) infection, the activated MAP3K15 interacted with the NF-кB homolog, Dorsal, to promote its nuclear translocation for expression of the coiled-coil-containing C-type lectin (CC-CL) and the viral immediate early (ie) genes.

Antibiotic resistant bacteria (ARB) and genes (ARGs) in urban wastewater treatment plants: influencing factors, mechanisms, and removal efficiency.

Urban wastewater treatment plants (UWWTPs) are major sources of antibiotic-resistant bacteria (ARB) and genes (ARGs) in the environment. Mitigating their impact requires understanding their sources, proliferation factors, and treatment mechanisms. While several studies have examined ARB and ARG concentrations and persistence post-effluent discharge, there is limited research on how intrinsic, environmental, and operational factors influence their prevalence.

Patient's perceived empathy can predict doctor-patient relationship in medical interaction.

Background: Patient perceived empathy plays a major role in establishing a good doctor-patient relationship. Therefore, this study explores the relationship among patient perceived empathy, quality of doctor-patient communication, and evaluation of the doctor-patient relationship while initially investigating the possible factors influencing patient perceived empathy.

Methods: We used the C-CARE scale, the C-SEGUE framework, and the C-PDRQ-15 scale to measure patient perceived empathy, ratings of doctor-patient communication quality, and ratings of patient-doctor relationships, respectively.

Pull-Down Techniques for Determining Virus-Host Protein Interactions.

Pull-down techniques are essential for identifying direct protein-protein interactions in vitro and play a pivotal role in the study of virus-host protein interactions. These methods rely on a bait protein immobilized on a solid support to capture target prey proteins, which are subsequently eluted and identified. In the context of viral infection research, pull-down techniques offer high specificity and low background interference, which are crucial for elucidating protein interaction networks and investigating cellular signaling pathways.

First Report of the Molecular Prevalence of Trichomonads from Oral Cavities in Household Dogs and Cats in East China.

Background: Recently, several trichomonads species including Trichomonas tenax, Trichomonas brixi and Tetratrichomonas sp. have been found in the oral cavities in dogs and cats. Although the number of dogs and cats is rapidly increasing in China, the prevalence and zoonotic potential of oral trichomonads in dogs and cats remains unclear.

Online desalting of glycans labeled with 8-aminopyrene-1,3,6-trisulfonic acid via capillary electrophoresis.

Glycan analysis plays a critical role in elucidating pathological mechanisms and advancing precision therapeutics. Among the highly sensitive methods for glycan analysis, the 8-aminopyrene-1,3,6-trisulfonic acid (APTS) labeling technique coupled with capillary electrophoresis (CE) stands out. However, the high-salt reaction conditions inherent to APTS labeling necessitate rigorous purification.

Wireless transmission of internal hazard signals in Li-ion batteries.

High-capacity lithium-ion batteries (LIBs) play a critical role as power sources across diverse applications, including portable electronics, electric vehicles (EVs) and renewable-energy-storage systems. However, there is growing concern about the safety of integrated LIB systems, with reports of up to 9,486 incidents between 2020 and 2024 (ref. ).

Activated partial thromboplastin time levels and coronary artery lesions in Kawasaki disease: A retrospective cohort study.

Objective: Kawasaki disease (KD) is an acute systemic inflammation, that affects medium-sized arteries. Coronary artery lesions (CALs) were the most serious complication or sequelae of KD. The intense inflammatory response leads to platelet activation, further exacerbating inflammation, which plays an important role in the pathogenesis of CALs in KD patients.

Visible Light-triggered Smart P(NIPAM-NVK)/PANI Antifouling Coating with Flexible Switching Between Photothermal-Photocatalytic Synergistic Antifouling Mechanisms and Fouling Release.

Biofouling on submerged equipment causes significant economic losses and threatens human safety, necessitating the urgent development of innovative and effective antifouling technologies. Herein, a visible light-triggered thermoresponsive organic semiconducting copolymer, poly(N-isopropylacrylamide-N-vinylcarbazole) (P(NIPAM-NVK)) with a low critical solution temperature (LCST), is successfully synthesized via radical copolymerization of N-isopropylacrylamide (NIPAM) and N-vinylcarbazole (NVK). Compositing P(NIPAM-NVK) with photoactive polyaniline (PANI) created P(NIPAM-NVK)/PANI coatings with excellent multi-synergistic antifouling properties under visible light.

Clinical characteristics of cervical lymphadenopathy in Kawasaki disease and the generation of related cervical complications: a retrospective cohort study.

Objectives: Cervical lymphadenopathy (CL) is a significant but underexplored feature of Kawasaki disease (KD), especially during its early stages. Although CL is a recognized diagnostic criterion for KD, it is frequently misdiagnosed as bacterial cervical lymphadenitis (BCL). This study aimed to investigate the clinical and imaging characteristics of CL in KD, particularly in cases, where KD initially presents with fever and cervical lymphadenopathy (LKD).

Smart photo-driven composite system containing thermosensitive P(NIPAM-NVK) and photoactive PANI for the rapid removal of anionic dyes.

A smart composite system based on thermosensitive polymers and photosensitive polyaniline (PANI) was constructed in this work, enabling efficient photo-driven adsorption and separation of anionic dyes within a short time. Thermosensitive copolymers (P(NIPAM-NVK)) of N-isopropylacrylamide (NIPAM) and N-vinylcarbazole (NVK) with adjustable low critical solution temperatures (LCST) were synthesized via a free radical copolymerization method. PANI was then composited with P(NIPAM-NVK) as a photothermal agent and dye adsorbent.

Data-driven cultural background fusion for environmental art image classification: Technical support of the dual Kernel squeeze and excitation network.

This study aims to explore a data-driven cultural background fusion method to improve the accuracy of environmental art image classification. A novel Dual Kernel Squeeze and Excitation Network (DKSE-Net) model is proposed for the complex cultural background and diverse visual representation in environmental art images. This model combines the advantages of adaptive adjustment of receptive fields using the Selective Kernel Network (SKNet) and the characteristics of enhancing channel features using the Squeeze and Excitation Network (SENet).

Bibliometric analysis: a study of the microenvironment in cervical cancer (2000-2024).

Objective: The incidence of cervical cancer has increased in recent years. The tumor microenvironment (TME) is the local biological environment involved in tumor occurrence and development. This study aimed to conduct a comprehensive analysis of the global research on the TME in cervical cancer (CC), providing a knowledge framework in this field from a holistic and systematic perspective based on a bibliometric analysis.

Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response.

Cancer-associated fibroblasts (CAF) play a crucial role in tumor progression and immune regulation. However, the functional heterogeneity of CAFs remains unclear. Here, we identify antigen-presenting CAFs (apCAF), characterized by high MHC II expression, in gastric cancer (GC) tumors and find that apCAFs are preferentially located near tertiary lymphoid structures.

Predicting 90-day risk of urinary tract infections following urostomy in bladder cancer patients using machine learning and explainability.

This research aims to design and validate a machine learning model to predict the probability of urinary tract infections within 90 days post-urostomy in bladder cancer patients. Clinical and follow-up information from 317 patients who had urostomy procedures at the First Affiliated Hospital of Shanxi Medical University (May 2018-May 2024) were analyzed. The dataset were partitioned into training and testing sets, and feature selection was executed via the Least Absolute Shrinkage and Selection Operator regression technique.

Clinical characteristics of Kawasaki disease with pulmonary radiographic abnormalities and its impact on the incidence of coronary artery lesions: a randomized retrospective cohort study.

Objective: The aim of this study was to investigate the characteristics of Kawasaki disease (KD) in patients demonstrating pneumonia-like changes and pulmonary complications, as well as the subsequent impact on coronary artery lesions, by comparing them with those of KD patients with normal pulmonary imaging.

Method: From January 1, 2013 to October 1, 2022, this study included paediatric patients diagnosed with KD who were registered in the KD database at Yuying Children's Hospital affiliated with Wenzhou Medical University. Patients were divided into three distinct groups based on the presence and severity of abnormalities observed via lung imaging.

Climate change, air pollution and chronic respiratory diseases: understanding risk factors and the need for adaptive strategies.

Under the background of climate change, the escalating air pollution and extreme weather events have been identified as risk factors for chronic respiratory diseases (CRD), causing serious public health burden worldwide. This review aims to summarize the effects of changed atmospheric environment caused by climate change on CRD. Results indicated an increased risk of CRD (mainly COPD, asthma) associated with environmental factors, such as air pollutants, adverse meteorological conditions, extreme temperatures, sandstorms, wildfire, and atmospheric allergens.

Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke.

Background: White matter hyperintensity (WMH) and brain atrophy, as imaging marker of cerebral small-vessel diseases (CSVD), have a high prevalence and strong prognostic value in stroke. We aimed to explore the association between lymphocyte count, a maker of inflammation, and WMH and brain atrophy in patients with acute ischemic stroke (AIS).

Methods: A total of 727 AIS patients with lymphocyte count and brain magnetic resonance imaging data were enrolled.

FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity.

FAP-positive cancer-associated fibroblasts (CAFs), recognized as a critical subset of CAFs, have been implicated in fostering an immunosuppressive tumor microenvironment in various cancers. However, their potential mechanisms of immunosuppression, particularly in modulating T cells, remain elusive. In this study, multiple internal cohorts consisting of 328 patients as well as 5 external cohorts were integrated to delineate the association between unfavorable prognosis or therapeutic resistance and FAP CAFs in gastric cancer patients.

Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction.

Purpose: Cardiomyocyte death is a major cytopathologic response in acute myocardial infarction (AMI) and involves complex inflammatory interactions. Although existing reports indicating that mixed lineage kinase domain-like protein (MLKL) is involved in macrophage necroptosis and inflammasome activation, the downstream mechanism of MLKL in necroptosis remain poorly characterized in AMI.

Methods: MLKL knockout mice (MLKL), RIPK3 knockout mice (RIPK3), and macrophage-specific MLKL conditional knockout mice (MLKL) were established.

Correction: Li et al. Preliminary Evaluation of Protective Efficacy of Inactivated Senecavirus A on Pigs. 2021, , 157.

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Bioaugmentation strategies in co-composting anaerobically digested food waste with agricultural by-products: Enhancing fertilizer quality and microbial communities.

Effective management of urban solid waste is critical for achieving sustainable development goals. One key aspect of this challenge is the recycling of anaerobically digested residues from anaerobic digestion of food waste, which plays a pivotal role in promoting sustainability. However, there is a gap in understanding the feasibility and effectiveness of converting these digested residues into valuable fertilizers through composting.