MAP3K15 facilitates multiple viral genes expression in crustaceans via Dorsal-CC-CL-STAT axis besides the JNK/P38 pathway.

The mitogen-activated protein kinase (MAPK) pathway is a conserved signaling system that responds to extracellular signals and translates them into appropriate cellular responses. While multiple MAPK kinase kinases (MAP3Ks) play a crucial role in the step wise transmission of MAPK signals in response to the pathogen infection, little is known about the function of MAP3K15 (also known as apoptosis signal-regulated kinase 3, ASK3) in viral infection. Here, we provide evidence that shrimp MAP3K15 undergoes phosphorylation and activation during a DNA virus, white spot syndrome virus (WSSV) infection, the activated MAP3K15 interacted with the NF-кB homolog, Dorsal, to promote its nuclear translocation for expression of the coiled-coil-containing C-type lectin (CC-CL) and the viral immediate early (ie) genes.

The correlation between serum 25-hydroxyvitamin D3 and oxidative balance score in patients with tuberculosis infection.

Background: Previous study had reported the imbalance of pro- and anti-oxidants in tuberculosis (TB), which was involved in the TB progression. This study aimed to identify the key oxidative stress indicator associated with oxidative balance in patients with TB infection.

Methods: Overall, 339 participants with TB were included in this study.

Peroxiredoxin 4 Interacts With Domeless and Participates in Antibacterial Immune Response Through the JAK/STAT Pathway.

The JAK/STAT pathway plays an important role in the development and immune responses of animals. In vertebrates, families of cytokines or growth factors act as activators of the JAK/STAT pathway; however, the activators for the JAK/STAT signaling pathway in arthropods are largely unknown. Herein we report a new ligand, peroxiredoxin 4 (Prx4), for the Domeless in the JAK/STAT pathway of shrimp .