Temporal Patterns and Risk Factors for Pulmonary Embolism Associated with Anti-Tumor Therapies in Patients with Lung Cancer.

Objective: This study aimed to characterize the association between pulmonary embolism (PE) onset and various anti-tumor therapeutic approaches in patients with lung cancer, with the goal of identifying potential high-risk populations.

Methods: A retrospective analysis was conducted on clinical records from 2019 to 2025, among the 84,000 inpatients with lung cancer, 106 patients developed PE during hospitalization for anti-tumor treatment, who were confirmed using spiral computed tomography (CT) or pulmonary angiography per CTS (2018) and NEJM (2010) criteria. Data were collected on patient demographics, cancer staging, treatment type, and time to PE onset.

CLDN4 promotes ferroptosis and inflammation involving JAK2/STAT3 pathway in acute pancreatitis.

Acute pancreatitis (AP) is a severe inflammatory disease characterized by pancreatic acinar cell injury and oxidative stress. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, has been implicated in AP pathogenesis. However, the molecular mechanisms linking ferroptosis to AP remain unclear.

The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling.

Pyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa. PYCR1 contributes to the pathogenesis of malignancies and fibrotic diseases via mechanisms involving metabolic reprogramming, Extracellular Matrix (ECM) remodelling, and redox homeostasis maintenance.

Umbilical cord-derived exosomes alleviate spinal cord injury by regulating microglial polarization through miR-340-5p-mediated modulation of the JAK/STAT3 signaling pathway.

Spinal cord injury (SCI) is a condition of the central nervous system, results in impairments in both sensory and motor functions. Presently, there exists a deficiency in efficacious therapies. Nonetheless, employing exosomes, a derivative of human umbilical cord mesenchymal stem cells (hucMSCs), is proven to be a successful approach in treating SCI, yet the exact way they function is still not well understood.

Isocitrate Dehydrogenase Wild-type Glioblastoma Resection Under Fluorescein Sodium and White Light Guidance Based on Response Assessment in Neuro-Oncology Resect Criteria: Fluorescein Significantly Enhances Complete Resection Rate of Enhanced Tumors.

Background And Objectives: Increasing the extent of resection (EOR) of the contrast-enhanced (CE) portion of glioblastoma can lead to survival benefits. There has never been a unified assessment of the specific EOR that sodium fluorescein-guided surgery can achieve. Based on the latest resection classification from the Response Assessment in Neuro-Oncology (RANO) resection group, we conducted a grouped analysis of the tumor resection extent by comparing with surgeries performed under white light (WL).

Mechanistic insights into Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonates (PFOS)-induced nitrification acceleration: Interkingdom collaboration of AOA-comammox in calcareous soils.

Emerging ecological risks of Per - and polyfluoroalkyl substances (PFASs) in terrestrial environments have received extensive attention. Yet, their impact on microbially-mediated nitrification processes in soils remains insufficiently investigated. Through a 42-day microcosm incubation experiment, we examined how two representative PFASs exposure, i.

Reconstruction of Large Oromandibular Defects: A Single Chimeric Thoracodorsal Artery Flap With Scapula Versus Double Free Flaps.

Background: Reconstructing extensive composite defects remains a significant challenge, as it requires a flap incorporating both bone and a substantial amount of soft tissue. This study introduces the chimeric thoracodorsal artery flap with the scapula and latissimus dorsi (cTDAF-SLD) as a viable and comprehensive option for reconstructing large oromandibular defects.

Methods: Twenty-nine patients with mandibular-invading oral cancer underwent radical tumor resection, followed by oromandibular reconstruction using either a chimeric thoracodorsal artery flap with the scapula and latissimus dorsi (cTDAF-SLD, n=18) or a simultaneous combination of a fibular flap and an anterolateral thigh (ALT) flap (SCFAF, n=11).

Investigating the Components Change of Steamed Corydalis yanhusuo via Mass Spectrometry Imaging, HS-GC-IMS, HPLC, and Network Pharmacology to Unveil Mechanism for Antichronic Atrophic Gastritis.

Corydalis yanhusuo (YHS), a traditional Chinese medicine (TCM), was commonly steamed before clinical usage for chronic atrophic gastritis (CAG). However, the reasonable steaming time had not occurred, and bioactive components of potential mechanisms of YHS for CAG were still unclear. Thus, the main purpose of this study is to investigate the necessity of steaming processing of YHS before using it in clinical via mass spectrometry imaging (MSI).

Heat shock proteins related signature characterizes immune status and predicts prognosis of gliomas.

Glioma classification is crucial for effective diagnosis and treatment. Heat Shock Proteins (HSPs) have been associated with tumor development and progression. In this study, we established a prognostic model for glioma based on Heat Shock Proteins-associated genes (HSPGs).

The global, regional and national burden of pancreatitis due to alcohol use: Results from the Global Burden of Disease Study 2021 and projections to 2040.

Background: Alcohol use is a major risk factor for pancreatitis and global mortality. Despite its impact, comprehensive analyses of the burden across regions and sociodemographic strata remain scarce. This study examines global trends (1990-2021) and projects future burdens to 2040.

Coherent Multi-Dimensional Spectroscopy Reveals Homogeneous Lineshape Dynamics in CsPbBr Quantum Dots.

Lead halide perovskite (LHP) quantum dots (QD) are an attractive material for light emissive applications due to their lattice, which is both dynamically disordered and defect tolerant. The development of LHP QD for quantum emitters critically depends on the characterization of their homogeneous lineshapes. Homogeneous lineshapes are measured by single dot photoluminescence spectroscopy only at cryogenic temperatures for which their lattice dynamics are frozen out.

Sublethal laser interstitial thermal therapy leads to confined neurological deficits and glioblastoma regression.

Purpose: Laser interstitial thermal therapy (LITT) is a novel, minimally invasive treatment for intracranial lesions. In addition to a direct ablation effect, it can cause sublethal damage at mild temperatures. The impact of sublethal damage on the eloquent brain cortex, neural function, and growth of glioblastomas has not yet been fully investigated.

Application of systemic immune-inflammation index in survival prediction after radical resection of gallbladder cancer: A multicenter retrospective clinical study.

Background: The Systemic Immune-Inflammation Index (SII) is a novel biomarker reflecting immune and inflammatory status, increasingly used for prognostic evaluation in various cancers. Its prognostic value in gallbladder cancer (GBC) remains unclear. This study investigates SII as a predictor of postoperative survival in GBC patients undergoing radical resection.

A solid-phase enzymatic synthesis platform for the facile production of 2'-fluoroarabinonucleic acid (FANA) and chimeric XNA oligonucleotides using an evolved XNA polymerase.

Xenobiotic nucleic acids (XNAs) significantly expand the range of genetic polymers and serve as promising alternatives to DNA and RNA for numerous biological applications. However, the extensive exploration and application of XNAs are limited by low sustainability and yields in solid-phase oligonucleotide synthesis, as well as by the unavailability of efficient XNA polymerases for polymerase-mediated XNA production. To address the limitations in XNA production, we developed a solid-phase enzymatic XNA oligonucleotide synthesis platform using a laboratory-evolved XNA polymerase, SFM5-7, which exhibits excellent activity for synthesizing DNA, RNA, 2'-fluoroarabinonucleic acid (FANA), and other 2'-modified XNA oligonucleotides.

Facile electrochemical determination of acetaminophen at micromolar levels utilizing conjugated bimetallic Co-Zn porphyrin polymer electrodes as sensing platforms.

The increasing threat of pharmaceutical pollution to public health and the environment is a critical issue. This research endeavors to tackle the challenge by developing an advanced electrochemical sensor for the accurate detection of acetaminophen (APAP). A highly sensitive electrochemical sensor, based on a porphyrin polymer, was designed for this purpose.

Global burden of metabolic-associated fatty liver disease among women of childbearing age: Trends from 1990 to 2021 and projections to 2040.

Background: Metabolic-associated fatty liver disease (MAFLD) is a growing global health concern, particularly among women of childbearing age (WCBA). We aimed to analyze the global burden of MAFLD among WCBA from 1990 to 2021 and project trends to 2040.

Methods: Data on incidence, prevalence, deaths, and disability-adjusted life years (DALYs) were extracted from the Global Burden of Disease Study 2021.

Successful resection of a huge hepatocellular carcinoma during pregnancy: case report and review of the literature.

Background: Hepatocellular carcinoma during pregnancy is rare and poses significant potential risks to both the pregnant individual and the fetus. Here, we report a case of hepatocellular carcinoma during pregnancy. The 28-week gestational is a critical point of fetal maturation.

Room-temperature cavity exciton-polariton condensation in perovskite quantum dots.

The exploitation of the strong light-matter coupling regime and exciton-polariton condensates has emerged as a compelling approach to introduce strong interactions and nonlinearities into numerous photonic applications. The use of colloidal semiconductor quantum dots with strong three-dimensional confinement as the active material in optical microcavities would be highly advantageous due to their versatile structural and compositional tunability and wet-chemical processability, as well as potentially enhanced, confinement-induced polaritonic interactions. Yet, to date, exciton-polariton condensation in a microcavity has neither been achieved with epitaxial nor with colloidal quantum dots.

A rapid and efficient microenvironment improving hyaluronic acid microneedle dressing for burn wound synergistic treatment.

Burn wounds are often accompanied by severe oxidative stress, sustained high expression of inflammation and solid bacterial biofilms formation. Therefore, it is urgent and important to develop strategies for effectively penetrate biofilms and rapidly regulate the burn pathological microenvironment. Herein, a multi-functional microneedle system was constructed for burn wounds synergistic treatment.

Rapid diagnosis of TERT promoter mutation using Terahertz absorption spectroscopy in glioblastoma.

Glioblastoma (GBM) is a highly aggressive brain tumor with poor outcomes and limited treatment options. The telomerase reverse transcriptase (TERT) promoter mutation, one of the key biomarkers in GBM, is linked to tumor progression and prognosis. This study employed terahertz time-domain spectroscopy (THz-TDS) to analyze frozen GBM tissue sections, extracting six spectral features: absorption coefficient, dielectric loss factor, dielectric constant, extinction coefficient, refractive index, and dielectric loss tangent.

Multi-omics approaches for identifying the PANoptosis signature and prognostic model via a multimachine-learning computational framework for intrahepatic cholangiocarcinoma.

Background And Aims: The aims of the present study were to characterize the PANoptosis signature in intrahepatic cholangiocarcinoma (ICC) patients, construct a novel model to guide clinical diagnosis and treatment, and further explore the associated molecular mechanisms of drug resistance.

Approach And Results: In total, 85 PANoptosis-related genes that possess both PANoptosis and multi-omics features were, respectively, screened from transcriptomic data from the OEP001105 public cohort and from transcriptomic and proteomic sequencing data from The First Affiliated Hospital of Chongqing Medical University. A novel framework integrating Cox regression analysis and 5 machine learning algorithms was developed to identify the 5 hub genes (POSTN, SFN, MYOF, HOGA1, and PECR).

Connecting the Dots: Stress Granule and Cardiovascular Diseases.

Stress granules (SGs) are membrane-less cytoplasmic assemblies composed of mRNAs and RNA-binding proteins (RBPs) that transiently form to cope with various cellular stressors by halting mRNA translation and, consequently, protein synthesis. SG formation plays a crucial role in regulating multiple cellular processes, including cellular senescence, inflammatory responses, and adaptation to oxidative stress under both physiological and pathological conditions. Dysregulation of SG assembly and disassembly has been implicated in the pathogenesis of various diseases, including cardiovascular diseases (CVDs), cancer, viral and bacterial infections, and degenerative diseases.

Mendelian Randomization Combined with Single-Cell Transcriptome Analysis Reveals the Role of the Key Gene PCLAF in the Pathogenesis of Atopic Dermatitis.

Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by itching and rashes, influenced by genetic, environmental, and immune factors. Despite significant research, the molecular mechanisms underlying AD are not fully understood. This study aims to integrate single-cell RNA sequencing (scRNA-seq) with Mendelian Randomization (MR) to uncover genetic and metabolic pathways contributing to AD.