Temporal Patterns and Risk Factors for Pulmonary Embolism Associated with Anti-Tumor Therapies in Patients with Lung Cancer.

Objective: This study aimed to characterize the association between pulmonary embolism (PE) onset and various anti-tumor therapeutic approaches in patients with lung cancer, with the goal of identifying potential high-risk populations.

Methods: A retrospective analysis was conducted on clinical records from 2019 to 2025, among the 84,000 inpatients with lung cancer, 106 patients developed PE during hospitalization for anti-tumor treatment, who were confirmed using spiral computed tomography (CT) or pulmonary angiography per CTS (2018) and NEJM (2010) criteria. Data were collected on patient demographics, cancer staging, treatment type, and time to PE onset.

Dexmedetomidine and the glymphatic system: a new perspective in managing postoperative cognitive dysfunction.

Postoperative cognitive dysfunction (POCD) is a common and significant neurological complication, occurring more frequently in elderly individuals and those with frailty or underlying neurodegenerative conditions, though it is not limited to these populations. The glymphatic system-a brain-wide clearance network dependent on aquaporin-4 (AQP4) polarity, arterial pulsation, and sleep-driven cerebrospinal fluid (CSF)-interstitial fluid exchange-has recently emerged as a promising target for cognitive protection. Dexmedetomidine (Dex), a selective α2-adrenergic receptor agonist, facilitates glymphatic function by mimicking non-REM sleep patterns and reducing central norepinephrine tone.

Chlorholones A-H, bioactive sesquiterpenoids with diverse skeletons from Chloranthus holostegius.

Eight previously undescribed sesquiterpenoids with different skeletons, designated as chlorholones A-H (1-8), including three noreudesmane-type sesquiterpenoids (1-3, the first discovery of this type in the genus), one germacrane-type sesquiterpenoid (4), one acorane-type sesquiterpenoid (5), two cadinene-type sesquiterpenoids (6-7) and one guaiane-type sesquiterpenoid (8), together with eight known sesquiterpenoids (9-16), were identified from the whole plant of Chloranthus holostegius. A combination of spectral analysis, electron circular dichroism calculations, and X-ray crystallography were employed in the structural characterization. Among the isolated compounds, 10 exhibited notable anti-inflammatory activity, showing significant inhibition of nitric oxide (NO) release in LPS-induced RAW 264.

Naringin mitigates paraquat-induced pulmonary epithelial-mesenchymal transition and fibrosis by modulating the NDRG1/JNK/PPARγ signaling pathway.

Paraquat (PQ) is a widely used herbicide known to induce lung injury and fibrosis in humans. Naringin (Nar), a naturally occurring flavonoid, possesses anti-inflammatory and anti-fibrotic properties. This study explores the protective mechanisms of Nar against PQ-induced epithelial-mesenchymal transition (EMT) and pulmonary fibrosis, focusing on the N-Myc downstream-regulated gene 1 (NDRG1) and peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathways.

Room-Temperature phosphorescent materials constructed based on Cucurbit[8]uril for encryption and anti-counterfeiting.

In this study, a supramolecular assembly composed of cucurbit[8]uril (Q[8]) and 6-bromoisoquinoline derivative (BI-BOH) was constructed. The 6-bromoisoquinoline moiety of BI-BOH entered the hydrophobic cavity of Q[8], forming a 1:2 assembly Q[8]-BI-BOH, with a relatively low level (ΔE = 0.03 eV), strengthening the intersystem crossing (ISC) process between the singlet state and the triplet state.

Novel benzamide derivatives with indole moiety as dual-target antiviral agents: Rational design, efficient synthesis, and potent anti-influenza activity through concurrent binding to PA terminal domain and viral nucleoprotein.

In this study, a series of benzamide derivatives with an indole moiety as dual-target inhibitors were designed, synthesized and evaluated against the RNA-dependent RNA polymerase (RdRp) complex of influenza viruses. The target compounds can simultaneously disrupt two key molecular interactions: the PA terminal domain and the nucleoprotein (NP) oligomerization. Through efficient synthesis and structure-activity relationship (SAR) analysis, compounds 8e and 8f as highly potent inhibitors were identified.

Direct C-H fluorination/heteroarylation of oxindoles with quinoxalin-2(1)-ones using Selectfluor.

Herein, we present an efficient and feasible strategy for direct C-H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp)-H bond with quinoxalin-2(1)-ones based on a radical coupling reaction Selectfluor, a bifunctional reagent, as both the oxidant and fluorine source. This methodology provides a potential protocol to obtain 3-heteroaryl 3-fluorooxindoles in medium to excellent yields.

Uncovering the naturally occurring covalent inhibitors of SARS-CoV-2 M from the Chinese medicine sappanwood and deciphering their synergistic anti-M effects.

Ethnopharmacological Relevance: The Chinese medicine sappanwood is primarily sourced from the dried heartwood of the medicinal plant Caesalpinia sappan Linn., which has been found with a variety of valuable properties including anti-inflammatory, anti-oxidant, and anti-viral effects. Preliminary investigations have demonstrated that sappanwood showed strong anti-SARS-CoV-2 M effects, but the key constituents responsible for SARS-CoV-2 M inhibition and their anti-M mechanisms have not been uncovered.

Research progress on the association between lung cancer and pulmonary embolism.

Pulmonary embolism (PE), a form of venous thromboembolism, is a frequently observed complication in malignancies, with a notably high incidence in individuals with lung cancer. The presence of PE markedly reduces the quality of life and has a significant impact on the prognosis of those diagnosed with both lung cancer and PE. As a result, timely diagnosis and intervention are of paramount importance.

Identification of prognostic factors of chronic pulmonary aspergillosis: a retrospective cohort of 106 patients.

Background: The morbidity and mortality of chronic pulmonary aspergillosis (CPA) are very high. We aimed to investigate the prognostic factors of patients with CPA, especially focusing on the underlying pulmonary disease and the probable co-infection of bacterial.

Methods: We retrospectively analyzed 106 CPA patients from November 2019 to August 2023.

: current insights and complementary review from Chinese cases.

is an emerging zoonotic pathogen associated with bacteremia, myiasis, and soft tissue infections. It is insufficiently identified and underestimated due to reasons, such as shortcomings of the traditional identification techniques and language barriers in local case reports from different regions. In this review, we summarize the currently available literature.

Engineering a xylose fermenting yeast for lignocellulosic ethanol production.

Lignocellulosic ethanol is produced by yeast fermentation of lignocellulosic hydrolysates generated by chemical pretreatment and enzymatic hydrolysis of plant cell walls. The conversion of xylose into ethanol in hydrolysates containing microbial inhibitors is a major bottleneck in biofuel production. We identified sodium salts as the primary yeast inhibitors, and evolved a Saccharomyces cerevisiae strain overexpressing xylose catabolism genes in xylose or glucose-mixed medium containing sodium salts.

Identification of candidate genes related to hybrid sterility by genomic structural variation and transcriptome analyses in cattle-yak.

Hybrids between closely related but genetically incompatible species are often inviable or sterile. Cattle-yak, an interspecific hybrid of yak and cattle, exhibits male-specific sterility, which limits the fixation of its desired traits and prevents genetic improvement in yak through crossbreeding. Transcriptome profiles of testicular tissues have been generated in cattle, yak, and cattle-yak; however, the genetic variations underlying differential gene expression associated with hybrid sterility have yet to be elucidated.

Dihydroartemisinin enhances the radiosensitivity of breast cancer by targeting ferroptosis signaling pathway through hsa_circ_0001610.

Objective: This study aimed to elucidate how DHA enhances the radiosensitivity of BC and to explain its potential mechanisms of action.

Methods: The circular structure of hsa_circ_0001610 was confirmed by Sanger sequencing, RNase R treatment, RT-PCR analysis using gDNA or cDNA. Cellular localization of hsa_circ_0001610 and microRNA-139-5p (miR-139-5p) was detected by fluorescence in situ hybridization.

Prion protein E219K polymorphism: from the discovery of the KANNO blood group to interventions for human prion disease.

KANNO is a new human blood group that was recently discovered. The KANNO antigen shares the gene with the prion protein and the prion protein E219K polymorphism determines the presence or absence of the KANNO antigen and the development of anti-KANNO alloantibodies. These alloantibodies specifically react with prion proteins, which serve as substrates for conversion into pathological isoforms in some prion diseases and may serve as effective targets for resisting prion infection.

Progress on the role of LIN28A/B in tumor development and progression.

LIN28A and its homolog LIN28B are highly conserved RNA-binding proteins that play important roles in early embryonic development, somatic cell reprogramming, metabolism and tumorigenesis. LIN28A/B are highly expressed in a variety of malignant tumors such as breast cancer. They play important roles in the initiation, maintenance, and metastasis of tumors and are associated with poor prognosis.

Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension.

Background: Portal hypertension (PHT), primarily induced by cirrhosis, manifests severe symptoms impacting patient survival. Although transjugular intrahepatic portosystemic shunt (TIPS) is a critical intervention for managing PHT, it carries risks like hepatic encephalopathy, thus affecting patient survival prognosis. To our knowledge, existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on outcomes.

[Analysis of mechanism of core points in acupuncture and moxibustion treatment for epilepsy based on data mining].

Objectives: To explore the mechanism of core points in acupuncture and moxibustion treatment for epilepsy by using data mining technique, so as to provide a reference for clinical practice and experimental research.

Methods: The data comes from relevant documents collected from CNKI, Wanfang, SinoMed, VIP, PubMed, Embase, Cochrane Library, EBSCO, Web of Science databases. The selected acupoints were analyzed in descriptive statistics, high-frequency acupoints group and core acupoint prescription.

Selectfluor Mediated Direct C-H Fluorination of 3-Heteroaryl-Oxindoles.

An efficient transition-metal-free fluorination synthesis of -H-free 3-heteroaryl-oxindoles with Selectfluor was depicted. Under mild reaction conditions, a series of 3-heteroaryl-fluorooxindoles were produced in yield of 62-88% using Selectfluor as a fluorine source.

Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis.

Background: The pathogenesis of rheumatoid arthritis (RA) is an immune imbalance, in which various inflammatory immune cells and pro-inflammatory factors are involved. Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, has been found to have increased expression in the joints of patients with RA compared to healthy individuals. However, the causal relationship between the expression level of IL-17 or IL-17 receptor (IL-17R) and RA remained unknown.

Promotion Effect of Coexposure to a High-Fat Diet and Nano-Diethylnitrosamine on the Progression of Fatty Liver Malignant Transformation into Liver Cancer.

Overconsumption of high-fat foods increases the risk of fatty liver disease (FLD) and liver cancer with long pathogenic cycles. It is also known that the intake of the chemical poison nitrosamine and its nanopreparations can promote the development of liver injuries, such as FLD, and hepatic fibrosis, and significantly shorten the formation time of the liver cancer cycle. The present work confirmed that the coexposure of a high-fat diet (HFD) and nano-diethylnitrosamine (nano-DEN) altered the tumor microenvironment and studied the effect of this coexposure on the progression of fatty liver malignant transformation into liver cancer.

The effect of music intervention on sedation in elderly patients undergoing transurethral resection of prostate under spinal anesthesia: a prospective randomized controlled clinical trial.

Purpose: Music intervention is commonly used as a non-pharmacologic therapeutic modality to alleviate anxiety in perioperative patients. This study aimed to assess the sedative and anxiolytic effects of music on elderly patients receiving transurethral resection of prostate (TURP) under spinal anesthesia.

Methods: This was a prospective randomized controlled trial on patients who aged over 60 and received TURP under spinal anesthesia.