Selectfluor Mediated Direct C-H Fluorination of 3-Heteroaryl-Oxindoles.

J Org Chem

Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.

Published: January 2024


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Article Abstract

An efficient transition-metal-free fluorination synthesis of -H-free 3-heteroaryl-oxindoles with Selectfluor was depicted. Under mild reaction conditions, a series of 3-heteroaryl-fluorooxindoles were produced in yield of 62-88% using Selectfluor as a fluorine source.

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http://dx.doi.org/10.1021/acs.joc.3c02063DOI Listing

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