Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia-Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling-Mediated Neutrophil Extracellular Traps Formation.

Mitigating myocardial ischemia-reperfusion (IR) injury is essential for enhancing the success of heart transplantation (HT) and improving patient outcomes. During HT, infiltrating neutrophils are influenced and regulated by various other cell types, contributing to myocardial IR injury through the excessive release of neutrophil extracellular traps (NETs). Nonetheless, the precise mechanisms underlying the interactions between neutrophils and other non-cardiomyocytes remain largely unexplored.

A single fluorescent probe for simultaneous detection of polarity, viscosity, and esterase.

Background: The dynamic interplay between esterase activity and physicochemical microenvironments-such as polarity and viscosity-is critical for decoding early cellular dysfunction in processes like apoptosis, ferroptosis, and drug-induced toxicity. However, conventional probes typically report only a single parameter, obscuring interdependent changes in enzyme activity and membrane properties. This technological gap limits our ability to capture real-time, spatially resolved fluctuations within subcellular compartments.

Mechanistic Study on Orpiment Pigment Discoloration Induced by Reactive Oxygen Species.

Orpiment (AsS), a yellow mineral pigment widely used in historical artworks, undergoes degradation that seriously threatens the integrity of Dunhuang murals. Reactive oxygen species (ROS) exist widely in air, which may be one reason for the color change of pigments. This study aims to investigate the degradation effects and mechanisms of four ROS-hydroxyl radical (·OH), singlet oxygen (O), peroxynitrite anion (ONOO), and hydrogen peroxide (HO)-on orpiment.

Population Pharmacokinetics of Nifedipine in High-Altitude and Plain Patients With Hypertension.

The pharmacokinetic characteristics of drugs are altered under high-altitude hypoxia. We aim to describe the population pharmacokinetics of nifedipine to investigate the effects of high-altitude hypoxia on the pharmacokinetics of nifedipine in hypertensive patients. A total of 206 plasma concentrations were collected from 50 patients with hypertension in plateau areas and 53 in plain areas.

Latent profile analysis of kinesiophobia in patients after lumbar spine surgery.

Purpose: This study aimed to assess the current status of kinesiophobia in patients following lumbar spine surgery, categorize patients based on the latent characteristics of their kinesiophobia, and explore the influencing factors across different subgroups.

Methods: A cross-sectional study was conducted between August 2024 and March 2025 in two general hospitals in Jingzhou, China. Participants completed a demographic questionnaire, the Tampa Scale for Kinesiophobia (TSK), Hospital Anxiety and Depression Scale (HADS), General Self-Efficacy Scale (GSES), Perceived Social Support Scale (PSSS), and Pain Catastrophizing Scale (PCS).

Establishing a clinical prediction model of neurosyphilis via a lumbar-puncture-free nomogram.

Objectives: Neurosyphilis (NS) can cause a range of central nervous system (CNS) damage, from asymptomatic states to severe mental disorders. While lumbar puncture is a reliable diagnostic method for NS, it is often poorly accepted due to its invasive nature, particularly by patients with mild symptoms. This study aims to develop a prediction model for the early diagnosis of NS that without requiring lumbar puncture.

High efficiency classification of thyroid cytopathological images based on knowledge distillation and vision transformer.

Thyroid cancer is one of the most common types of cancer, pathological diagnosis based on Fine Needle Aspiration Cytology is clinically used as the standard for assessing thyroid cancer. However, the complex structure and large-scale data volume of thyroid pathology images pose challenges in terms of accuracy and efficiency for automatic diagnosis. To address this practical problem, this paper proposes a knowledge distillation method called Multi-Dimensional Knowledge Distillation, which involves feature-based distillation and response-based distillation.

The effect of postoperative chemotherapy on blood glucose and prognosis in patients with advanced ovarian cancer.

Objective: Recent studies have shown that chemotherapy can cause abnormal glucose metabolism in cancer patients; however, little is known about the association of blood glucose (BG) with chemotherapy in ovarian cancer. In this study, we investigated the effect of chemotherapy on glucose metabolism in patients with advanced ovarian cancer and its effect on patient prognosis.

Methods: We retrospectively analyzed blood glucose and other clinical data from 100 patients with advanced ovarian cancer (International Federation of Gynecology and Obstetrics, FIGO III/IV) before and after chemotherapy.

A rapid and efficient red-light-activated Cre recombinase system for genome engineering in mammalian cells and transgenic mice.

The Cre-loxP recombination system enables precise genome engineering; however, existing photoactivatable Cre tools suffer from several limitations, including low DNA recombination efficiency, background activation, slow activation kinetics, and poor tissue penetration. Here, we present REDMAPCre, a red-light-controlled split-Cre system based on the ΔPhyA/FHY1 interaction. REDMAPCre enables rapid activation (1-s illumination) and achieves an 85-fold increase in reporter expression over background levels.

Duration of diabetes, glycemic control and intracranial atherosclerotic plaque vulnerability.

Background: Intracranial vulnerable plaque, characterized by intraplaque hemorrhage (IPH), surface irregularity, positive remodeling, and plaque enhancement, is associated with cerebrovascular events. History of diabetes mellitus (DM) was reported to be a potential predictor of plaque vulnerability, but the predictive value of DM-related variables for it is still uncertain. The purpose of this study was to investigate the association of diabetes duration and glycemic control with symptomatic plaque vulnerability, in comparison to non-diabetic patients.

Association of admission blood glucose and postoperation fast blood glucose with futile recanalization in patients with endovascular therapy.

Background: Futile recanalization (FR), defined as patients with long-term functional dependence despite successful recanalization, is common in patients with large-vessel stroke undergoing endovascular treatment (EVT). The present study aimed to identify the relationship between blood glucose and FR.

Methods: Patients admitted to our stroke center in China between November 2019 and September 2022 were recruited according to the inclusion criteria and exclusion criteria.

A retrospective observational study on the prognostic role of inflammatory markers in futile recanalization after endovascular treatment for large-vessel stroke.

ObjectiveEndovascular treatment has proven to be effective in improving the outcome of patients with large-vessel stroke. However, more than half of the patients experience poor outcomes despite successful recanalization, which was defined as futile recanalization. The present study aimed to identify the relationship between multiple inflammatory markers (before and after endovascular treatment) and futile recanalization.

Evaluation of the disease burden of nosocomial infection among inpatients in a cancer hospital based on propensity score matching.

Background: Oncology patients, as an immunocompromised population, are particularly susceptible to hospital-acquired infections (HAIs). This study aims to establish a scientifically sound model to estimate the disease burden associated with HAIs in oncology patients, providing valuable decision-making support for healthcare systems and public health management.

Methods: Propensity score matching (PSM) was employed.

Impact of Previous Glycemic Control on High-Resolution MRI Plaque Characteristics and Stroke Mechanisms in Patients with Middle Cerebral Artery Atherosclerosis.

Background And Purpose: Although diabetes mellitus (DM) is a consistently documented risk factor for the plaque vulnerability, the effect of diabetes mellitus and glycemic control on the characteristics of intracranial plaques and stroke mechanism has yet to be explored. This study aimed to explore whether prestroke glycemic control is linked to plaque instability and could result in varying types and mechanisms of stroke.

Materials And Methods: We retrospectively included 107 patients with infarction attributed to atherosclerotic stenosis of the M1 segment of the MCA within 4 weeks of symptom onset, all of whom underwent high-resolution MR imaging.

Photoinduced Formal Intermolecular Ene-Yne Metathesis: Regioselective Synthesis of Chromene Derivatives via an Electron Donor-Acceptor Complex.

By leveraging synergistic photochemical and phosphate ester catalysis, we developed a photoinduced formal ene-yne metathesis protocol enabling regioselective chromene construction via concurrent alkene C═C and imine C═N bond reorganization. A series of unexplored chromenes were synthesized in the -configuration via simultaneous formation of four new bonds. Gram-scale synthesis and mechanistic studies were conducted.

Impact of rain-shelter cultivation on rhizosphere microecology and kiwifruit quality.

The effects of kiwifruit rain shelter cultivation on the microecological characteristics of the rhizosphere soil and fruit yield and quality remain uncertain. Therefore, we compared the differences in rhizosphere soil physicochemical properties, microbial populations, enzyme activities, microbial biomass, and fruit yield and quality between kiwifruit rain shelter and open-field cultivation. Additionally, correlations among these parameters were determined.

A Digital Approach to Extracting Horizontally Impacted Mandibular Third Molars: The Cross-Sectioning Method.

Introduction: Surgical extraction of horizontally impacted mandibular third molars, particularly those requiring osteotomy, is highly sensitive to the surgeons' experience and poses challenges for residents to master. This study introduces the Cross-sectioning method developed through digital measurement and resistance analysis to minimise bone removal during extraction.

Materials And Methods: A comparative study of 400 patients (200 per group) undergoing either Cross-sectioning or Traditional method was conducted.

Amino-substituted triazatriangulenium photosensitizers for CO capture and aminocarbonylation to amides.

Efficient photoreduction of CO to CO using noble-metal-free systems remains a significant challenge in artificial photosynthesis. Developing low-cost photosensitizers capable of capturing CO and facilitating electron transfer is therefore essential. Here, we report an amino-substituted triazatriangulenium photosensitizer (A-TATA) that enables light harvesting and CO capture in a photocatalytic system.

Infliximab for patients with moderate to severely active ulcerative colitis: an updated meta-analysis of randomized controlled trials.

Background And Aims: Ulcerative colitis (UC) is a serious inflammatory bowel disease with significant morbidity and mortality. Infliximab (IFX), a TNF-alpha antagonist, is recommended by the American Gastroenterological Association, but its clinical effectiveness and safety are based on limited studies. This meta-analysis of randomized controlled trials (RCTs) evaluates the efficacy and safety of IFX in moderate-to-severe active UC, providing evidence for its clinical application.

FAP as a prognostic biomarker and radiomics-based predictor of angiogenesis-associated recurrence in Adamantinomatous craniopharyngioma.

Background: Adamantinomatous craniopharyngioma (ACP) is a histologically benign yet clinically aggressive intracranial tumor characterized by high recurrence rates. Fibroblast activation protein (FAP), a marker of cancer-associated fibroblasts (CAFs), is implicated in tumor progression and microenvironment remodeling. This study evaluates the prognostic significance of FAP and develops a radiomics-based model for non-invasive preoperative risk stratification.

A population-based study on safety and health of drinking tea (hawk tea).

Background: A herbal tea of leaves and stems of , named Hawk tea locally, has been traditionally consumed in some places in southwestern China. However, there is no human based evidence about the safety and health effects of drinking hawk tea. This study aims to illustrate possible healthy effects of consuming hawk tea in a population with a habit of drinking hawk tea in Chongqing city.

Copper(II)-Catalyzed Regioselective Cascade Reaction of β,γ-Alkynyl-α-Imino Esters with α-Amino Acid-Derived Esters.

A cascade reaction between β,γ-alkynyl-α-imino esters and α-amino acid-derived esters has been developed, enabling the efficient synthesis of a series of novel α-amino acid derivatives featuring oxazolone moieties under mild reaction conditions. Control experiments and mechanistic studies were conducted to elucidate the reaction pathway and gain insights into the underlying process.

Global, regional, and national burden of endometriosis among women of childbearing age from 1990 to 2021: a cross-sectional analysis from the 2021 global burden of disease study.

Background: Endometriosis is a major contributor to infertility and pelvic pain, which brings a significant burden on family and society. Although the data of endometriosis in Global Burden of Disease (GBD) 2019 was reviewed, no updated analysis has been conducted using GBD 2021, and the disease burden across different age groups has not been analyzed. The aim of this cross-sectional analysis was to provide an up-to-date assessment of the prevalence, incidence, and disability-adjusted life-years (DALYs) of endometriosis from 1990 to 2021 at the global, national, and regional levels.

Lipoprotein(a) associates with high-resolution MRI-assessed intracranial plaque vulnerability and long-term stroke recurrence.

Objectives: Lipoprotein(a) [Lp(a)] was related to increased risk of major adverse cardiovascular events. We aimed to explore the association between Lp(a) levels and intracranial plaque vulnerable features identified through high-resolution magnetic resonance imaging (HRMRI), along with their prognostic significance.

Materials And Methods: A total of 210 consecutive patients with symptomatic intracranial atherosclerosis stenosis (sICAS) who underwent Lp(a) measurement and HRMRI were retrospectively collected.