Causal relationship between plasma liposomes and autoimmune thyroid disease: a Mendelian randomization study.

Background: Autoimmune thyroid disease is an autoimmune disease. Observational studies have shown that individuals with thyroid dysfunction have dyslipidemia. However, it is uncertain whether there is a causal relationship between the two.

Ionic Liquid Top Surface Engineering: In Situ GIWAXS Insights Into 1D/3D Heterojunction Perovskite Formation.

Low-dimensional perovskites have been demonstrated repeatedly to improve the performance of perovskite photovoltaic devices in both light-to-electricity conversion efficiency and device durability. In this work, the ionic liquid (IL) 1-ethyl-3-methylimidazolium hydrogen sulfate (EMIMHSO) is innovatively introduced as a capping layer, which interacts with the residual PbI on the 3D perovskite top surface to generate the 1D perovskite, EMIMPbI. By adjusting the concentration of the IL, 1D perovskite formations with distinct morphologies is achieved.

Three-Dimensional Non-Stationary MIMO Channel Modeling for UAV-Based Terahertz Wireless Communication Systems.

Terahertz (THz) wireless communications can support ultra-high data rates and secure wireless links with miniaturized devices for unmanned aerial vehicle (UAV) communications. In this paper, a three-dimensional (3D) non-stationary geometry-based stochastic channel model (GSCM) is proposed for multiple-input multiple-output (MIMO) communication links between the UAVs in the THz band. The proposed channel model considers not only the 3D scattering and reflection scenarios (i.

The Effect of Frailty on Prognosis of Patients Undergoing Abdominal Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis.

Background: This study aimed to systematically review the impact of frailty on outcomes following abdominal aortic aneurysm (AAA) surgery.

Methods: MEDLINE, Embase, and Scopus were searched for studies of frailty on AAA surgery. A modified Newcastle-Ottawa scale was used to assess the quality of the included studies.

Dynamic and interpretable deep learning model for predicting respiratory failure following cardiac surgery.

Background: Postoperative respiratory failure following cardiac surgery (CS-PRF) remains a critical complication with substantial morbidity and mortality. Current risk prediction models are limited by static assessments and suboptimal accuracy. This study aimed to develop and validate a dynamic, machine learning–based model to enhance perioperative risk stratification for CS-PRF.

Tetramethylpyrazine protects against myocardial ischemia/reperfusion injury via regulating Myl2-mediated NLRP3 signaling pathway inhibition.

The protective mechanism of tetramethylpyrazine (TMP), an alkaloid derived from the Chinese herbal remedy Ligusticum chuanxiong, in relation to myocardial ischemia/reperfusion injury (MIRI) is not yet fully understood. To investigate the therapeutic effects of TMP, we established an in vivo rat model of MIRI and an in vitro hypoxia and reoxygenation (H/R) model using H9c2 cells. First, TMP significantly reduced the infiltration of inflammatory cells in the myocardium, decreased serum levels of myocardial injury markers (CK-MB, cTnT and LDH), and alleviated myocardial infarct size in I/R rats.

METTL3 Modulates Autophagy by Targeting TFEB in Myocardial Hypertrophy.

The aim of this study was to investigate the mechanism of m6A methylation in pathological myocardial hypertrophy (PMH), focusing on whether the methyltransferase METTL3 regulates the expression and nuclear translocation of the transcription factor EB (TFEB), thereby affecting autophagic activity and exacerbating the development of myocardial hypertrophy.An in vivo PMH model was established in mice via transverse aortic constriction (TAC), and an in vitro hypertrophy model was established using H9C2 cells stimulated with angiotensin II (AngII). HE staining, Western blotting, qRT-PCR, immunofluorescence, and dual-color autophagy flux analyses were employed to detect the expression of autophagy-related proteins (LC3, Beclin-1, P62, ATG5) and apoptosis levels.

Power-Independent Microwave Photonic Instantaneous Frequency Measurement System.

The ability to perform instantaneous frequency measurement (IFM) of unknown microwave signals holds significant importance across various application domains. This paper presents a power-independent microwave photonic IFM system. The proposed system implements frequency measurement through the construction of an amplitude comparison function (ACF) curve, achieved by introducing a frequency-dependent time delay via an optical tunable delay line (OTDL) for the signal under test (SUT).

Sleep drive, not total sleep amount, increases seizure risk.

Sleep loss has been associated with increased seizure risk since antiquity. Using automated video detection of spontaneous seizures in Drosophila epilepsy models, we show that seizures worsen only when sleep restriction raises homeostatic "sleep drive," not simply when total sleep amount falls. This is supported by the paradoxical finding that acute activation of sleep-promoting circuits worsens seizures, because it increases sleep drive without changing sleep amount.

Electrochemical coupling of carbon monoxide and amine on iodide coordination stabilized Cu site.

The use of renewable electricity to drive the electrocatalytic coupling of CO with nitrogen-containing organics offers a promising strategy for producing high-value chemicals. In this work, we conduct a systematic investigation of the coordination effect between iodide and copper oxide to generate Cu active sites. These Cu sites enable the electrosynthesis of dimethylacetamide from CO and dimethylamine.

Diversity scheme based hybrid FSO/RF systems in satellite-aerial-ground integrated network with outdated CSI.

Satellite-aerial-ground integrated network (SAGIN) confronts significant challenges from weather-induced impairments and transmission attenuation. To address this issue, this paper proposes a weather-dependent hybrid FSO/RF switching scheme for SAGIN, accounting for both weather effects and outdated channel state information (CSI). Specifically, three different working modes and two diversity schemes are designed to further mitigate the impact of adverse weather.

PFAS in animal by-products in Lanzhou, China, and health risk assessment.

Per- and polyfluoroalkyl substances (PFAS) are an emerging class of organic compounds that are widely used in industrial production and therefore can be found in the environment. Dietary intake is the main route of human exposure to PFAS, especially in animal-derived foods. In this study, 25 PFAS compounds were determined in 234 animal by-products sold in Lanzhou City, China, by LC-MS/MS.

The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the gut.

The gut microbiome plays a key role in the maintenance of host metabolic homeostasis and health. Most metabolic processes cycle with a 24-hour rhythm, but the extent to which the microbiome influences metabolite cycling under different conditions, such as variations in dietary composition, remains largely unknown. In this study, we utilized high temporal resolution metabolite profiling of the gut to investigate the role of the microbiome in metabolite cycling.

Exposure assessment and risk calculations for mycotoxins contaminating coix seed sold in Gansu Province, China.

In order to understand the current situation of mycotoxin contamination and risk assessment of dietary exposure of coix seed ( sold in Gansu Province, China, a total of 67 coix seed samples were collected from the local markets and supermarkets in 14 prefectures and cities in Gansu Province. Sixteen mycotoxins were determined by isotope dilution liquid chromatography-tandem mass spectrometry. The results showed that 37.

Zoonotic diseases in China: epidemiological trends, incidence forecasting, and comparative analysis between real-world surveillance data and Global Burden of Disease 2021 estimates.

Background: Zoonotic diseases remain a significant public health challenge in China. This study examines the temporal trends, disease burden, and demographic patterns of major zoonoses from 2010 to 2023.

Methods: This study analyzed data from China's National Notifiable Infectious Disease Reporting System (NNIDRS, 2010-2023) on nine major zoonoses, including echinococcosis, brucellosis, leptospirosis, anthrax, leishmaniasis, encephalitis (Japanese encephalitis), hemorrhagic fever, rabies, and schistosomiasis.

Interactive effects between soil properties and bacterial communities in tomato rhizosphere under the application of microbial agents.

Background: The purpose of this study was to determine the impact of microbial agents on physicochemical properties, enzyme activities, and bacterial communities in tomato ( L.) rhizosphere soil in order to provide a theoretical foundation for the stability of tomato rhizosphere soil microecology and the ecological preservation of farmland soil.

Methods: Tomato rhizosphere soils treated with various microbial agents, as well as an untreated control (FQ_CK), were analyzed.

Radiomics and machine learning for osteoporosis detection using abdominal computed tomography: a retrospective multicenter study.

Objective: This study aimed to develop and validate a predictive model to detect osteoporosis using radiomic features and machine learning (ML) approaches from lumbar spine computed tomography (CT) images during an abdominal CT examination.

Methods: A total of 509 patients who underwent both quantitative CT (QCT) and abdominal CT examinations (training group, n = 279; internal validation group, n = 120; external validation group, n = 110) were analyzed in this retrospective study from two centers. Radiomic features were extracted from the lumbar spine CT images.

Phenolic compounds, antioxidant and α-glucosidase inhibitory activities from moringa oleifera seed by-products.

Moringa oleifera seed husks, the traditional non-medicinal parts of M. oleifera seed, are usually discarded or burned, which pollute the environment and waste resources. In an unprecedented study, the antioxidant and α-glucosidase inhibitory activities of crude extracts from the medicinal and by-product parts of M.

The Integrative Taxonomy and Mitochondrial Genome Evolution of Freshwater Planarians (Platyhelminthes: Tricladida): The Discovery of a New Clade in Southern China.

Background: The genus (Platyhelminthes: Tricladida) includes a large diversity of free-living freshwater flatworms and is important for studies on regeneration and evolution. This study aims to describe a newly discovered asexual planarian species from southern China and explore its genetic characteristics and regenerative abilities.

Methods: An integrative taxonomic analysis was conducted using morphology, karyology, histology, molecular phylogeny (18S, 28S, COI, mitogenome), and genome size estimation via flow cytometry.

Fully Realizing the Bipolar Energy Storage Capability of Radical Polymer-Grafted Graphene Sheets for Zinc-Organic Battery Cathodes.

Radical polymers, containing stable nitroxyl radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), within their repeating units, are considered as bipolar cathode materials capable of undergoing both oxidation and reduction in the redox process. However, in most cases, TEMPOcontaining radical polymers are exclusively employed as p-type cathode materials, initially oxidized to a positively charged state, with only one electron being stored or released in the redox process of TEMPO units. Here, a kind of composite material, poly(2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl methacrylate) (PTMA) grafted to reduced graphene oxide, rGO-g-PTMA, is applied as cathode material for zinc-organic battery.

Nickel in cereal foods in Gansu Province and health risk assessment.

The nickel contamination in 243 samples of cereals and their products in Gansu Province was analysed by ICP-MS. The overall nickel detection rate was 89.3% and the average nickel content was 0.

[Integrated multiomics reveal mechanism of Aidi Injection in attenuating doxorubicin-induced cardiotoxicity].

The combination of Aidi Injection(ADI) and doxorubicin(DOX) is a common strategy in the treatment of cancer, which can achieve synergistic anti-tumor effects while attenuating the cardiotoxicity caused by DOX. This study aims to investigate the mechanism of ADI in attenuating DOX-induced cardiotoxicity by multi-omics. DOX was used to induce cardiotoxicity in mice, and the cardioprotective effects of ADI were evaluated based on biochemical indicators and pathological changes.