Sensitization to inhaled and food allergen sources in patients with allergic diseases in Eastern China.

Background: Allergen exposure plays a critical role in the onset of allergic disease, and the distribution of allergens varies by geographic location, climate, and lifestyle.

Methods: A retrospective analysis was conducted on the data of 4,149 patients with clinically suspected allergic diseases who sought medical care at Changzhou Third People's Hospital. The total IgE and specific IgE (sIgE) levels for 19 inhaled and food allergen sources were assessed using the Mediwiss AllergyScreen system.

Associations Between Lymphopenia and the Development/Recovery of Acute Kidney Injury Among Patients Hospitalized With Respiratory Virus Infections.

Rationale & Objective: Lymphopenia may have a potential mechanism on the development of acute kidney injury (AKI) after respiratory virus infection but has never been revealed. We aimed to investigate the relationship between lymphopenia and AKI in patients hospitalized with respiratory virus infections.

Study & Design: A single-center and retrospective cohort study.

Multi-loci phylogeny reveals unexpected novelty of the complex (Thelephoraceae, Thelephorales) from China.

is a well-known species morphologically characterized by coralloid and leathery basidiomata with numerous fuscous purple to blackish-brown branches. It was once considered to exhibit a wide ecological range and distribution area. However, comprehensive phylogenetic analysis based on four loci (ITS, nrLSU, , and nrSSU) revealed that represents a species complex consisting of at least 12 cryptic taxa, with a biogeographic distribution pattern bounded by geographic regions: Asia, Eurasia, Europe, and North America.

Drug Metabolism and Pharmacokinetic Evaluation of a Novel RNase H2 Inhibitor for the Treatment of Triple-Negative Breast Cancer.

A thorough understanding of pharmacokinetics and metabolism is critical during early drug development. This study investigates the absorption, distribution, metabolism, and excretion (ADME) profile of R14, a novel compound, using a combination of in vitro and in vivo approaches. In vitro studies included Caco-2 permeability assays, metabolic stability evaluations in liver microsomes and hepatocytes, and identification of CYP isoforms responsible for R14 metabolism.

Low serum 25 hydroxyvitamin D Is associated with severe metabolic dysfunction-associated steatotic liver disease in individuals with overweight/obesity: A cross-sectional study.

The role of vitamin D status in metabolic dysfunction-associated steatotic liver disease (MASLD) remains controversial. Furthermore, research evaluating the relationship between vitamin D status and abdominal fat distribution is limited. Therefore, we hypothesized that serum vitamin D is inversely associated with the severity of liver fat content (LFC) in populations with overweight/obesity.

Fabrication of ZnO quantum dots and InO nanofiber composite photocatalysts for selective Cr(Ⅵ) detection and reduction.

Hexavalent chromium (Cr(VI)) as one of the most highly toxic heavy metal ion in the water environment, thus its detection and treatment play a cardinal role in environmental assessment and treatment. In this study, ZnO quantum dots (ZnO-QDs) were successfully synthesized via the sol-gel method, with a narrow size distribution between 2 and 9 nm (average size of approximately 4.96 nm).

Synthesis, Characterization, and Properties of Polyvinyl Alcohol/Jackfruit Peel Carboxymethylcellulose/Graphene Oxide/Kaolin Composite Hydrogels.

This study presents an environmentally benign composite hydrogel system by combining polyvinyl alcohol (PVA) with carboxymethyl cellulose derived from jackfruit peel waste (JCMC), subsequently reinforced with graphene oxide (GO) and Kaolin nanoparticles for enhanced Congo red (CR) adsorption. The structural properties of the synthesized hydrogels were comprehensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). FTIR analysis confirmed hydrogel formation through hydrogen bonding interactions, while XRD and SEM revealed the uniform dispersion of GO and Kaolin within the polymer matrix, resulting in an improved adsorption performance.

Combined Genetic and Transcriptional Study Unveils the Role of Gene Mutations in Congenital Diarrhea.

: Congenital diarrhea is persistent diarrhea that manifests during the neonatal period. Mutations in , which is crucial for triglyceride synthesis and lipid absorption in the small intestine, are causal factors for congenital diarrhea. In this study, we aimed to determine the value of tissue RNA sequencing (RNA-seq) for assisting with the clinical diagnosis of some genetic variants of uncertain significance.

Electrochemically Driven Nickel-Catalyzed Synthesis of Aryl Alkyl Ketones by the Cross-Coupling of Carboxylic Esters with Alkylpyridinium Salts.

An electrochemical Ni-catalyzed reductive cross-coupling of arylcarboxylic esters with alkylpyridinium salts has been developed. Various aryl alkyl ketones are obtained in good to excellent yields (up to 86% yield). The reaction tolerated a variety of primary alkylpyridinium salts, including substrates with protic functional groups and derivatives of bioactive molecules.

Synthesis and biological evaluation of novel nitrogen-containing heterocyclic derivatives as potential anticancer agents.

Based on screening results, a series of nitrogen-containing five-membered heterocyclic compounds were designed and synthesized for anticancer evaluation. Among them, 7 s, featuring a 1,2,3-triazole scaffold, exhibited the most potent antiproliferative activity against four human cancer cell lines (IC₅₀ < 10 μM). Mechanistic studies revealed that 7 s downregulated phosphorylated AKT (p-AKT) protein at 5 μM.

Ionic Liquid Top Surface Engineering: In Situ GIWAXS Insights Into 1D/3D Heterojunction Perovskite Formation.

Low-dimensional perovskites have been demonstrated repeatedly to improve the performance of perovskite photovoltaic devices in both light-to-electricity conversion efficiency and device durability. In this work, the ionic liquid (IL) 1-ethyl-3-methylimidazolium hydrogen sulfate (EMIMHSO) is innovatively introduced as a capping layer, which interacts with the residual PbI on the 3D perovskite top surface to generate the 1D perovskite, EMIMPbI. By adjusting the concentration of the IL, 1D perovskite formations with distinct morphologies is achieved.

Aligning Logits Generatively for Principled Black-Box Knowledge Distillation in the Wild.

Black-Box Knowledge Distillation (B2KD) is a conservative task in cloud-to-edge model compression, emphasizing the protection of data privacy and model copyrights on both the cloud and edge. With invisible data and models hosted on the server, B2KD aims to utilize only the API queries of the teacher model's inference results in the cloud to effectively distill a lightweight student model deployed on edge devices. B2KD faces challenges such as limited Internet exchange and edge-cloud disparity in data distribution.

Treatment of idiopathic sudden sensorineural hearing loss with press needle.

Objectives: To compare the effects of conventional therapy and press needle combined therapy on idiopathic sudden sensorineural hearing loss.

Methods: The retrospective case-control study was conducted from December 2023 to January 2024 at Department of Otorhinolaryngology, Changzhou Third People's Hospital, China, and comprised patients with idiopathic sudden sensorineural hearing loss ISSNHL admitted from September 2021 to November 2023. The patients were divided into control group CON in which conventional therapy was used, and the PN group in which the press needle therapy was given additionally.

Luminescence modulation via solvent-triggered single-crystal-to-single-crystal transformation in a non-porous molecular crystal.

Stimuli-responsive crystalline materials have demonstrated significant potential for developing multifunctional systems. Achieving precise structural modulation in non-porous crystalline phases remains a critical challenge, particularly in correlating molecular-level conformational changes with macroscopic properties. Here, we report a solvatomorphic crystalline system, (1-azabicyclo[2.

Public Attention to Mpox in China During the Pandemic: Qualitative Analysis of TikTok Data Using Latent Dirichlet Allocation Topic Modeling.

Background: Mpox has reemerged as a global public health concern. With the growing reliance on social media for health information dissemination, understanding public perception through these platforms is essential for designing effective health promotion strategies.

Objective: This study analyzes TikTok data related to mpox using Latent Dirichlet Allocation (LDA) topic modeling.

Advancing electrocardiogram synthesis: Analyzing key metrics for enhanced evaluation.

The development of large, high-quality ECG datasets is essential for advancing automated cardiac disease diagnosis. However, challenges such as limited access to data, small dataset sizes, and class imbalances persist. Deep generative models offer an effective solution by generating synthetic ECG data, which not only addresses data scarcity but also enhances data privacy.

Challenges in the diagnosis of esophageal cancer with intramural gastric metastasis: Two case reports.

Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent gastrointestinal malignancy associated with significant morbidity and mortality rates. Tumor metastasis leads to a poor prognosis for patients. Intramural gastric metastasis (IGM), is an uncommon pathway of ESCC metastasis, and is more likely to occur when tumor cells show deep infiltration.

Pulmonary protective and antiinflammatory effects of dexmedetomidine in cardiac surgery with cardiopulmonary bypass: a systematic review and metaanalysis.

Objective: This study aims to investigate pulmonary protective and antiinflammatory effects of dexmedetomidine (DEX) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) by meta-analysis.

Methods: Six databases were searched to collect trials on the pulmonary protective and anti-inflammatory effects of DEX in cardiac surgery with CPB. The search period was from the establishment of each database to August 1, 2024.

Amphoteric coplanar conjugated molecules enabling efficient and stable perovskite/silicon tandem solar cells.

The perovskite/silicon tandem solar cells (TSCs) offers a state-of-the-art solution for achieving unparalleled efficiency and cost-effectiveness in solar energy conversion. However, the fabrication of high-quality wide-bandgap perovskite films with a thickness of 1 μm on nano-textured silicon substrates remains a formidable challenge. Herein, we designed an amphoteric coplanar conjugated molecule (ACCM) guided by the principles of density functional theory and Brønsted acid-base chemistry.

Construction and application of emergency critical care patient care plan based on Delphi method.

This study evaluates the efficacy of a Delphi-method-based nursing plan for critically ill emergency patients. A total of 80 critically ill patients admitted to the emergency department between January 2021 and January 2023 were included in the study, divided into 2 groups: the control group (n = 40) receiving routine emergency care, and the observation group (n = 40) receiving a nursing plan based on the Delphi method. The Delphi process involved the formation of an expert panel, followed by multiple rounds of anonymous feedback.

Analysis of the effectiveness of combined CT angiography, MMP-9, and PAF testing in the assessment of vascular restenosis in acute coronary syndromes after atorvastatin combined with tirofiban therapy.

Background: Acute Coronary Syndrome (ACS) is a very common cardiovascular disease in clinical practice with a very high risk of death. In this study, we observed the effectiveness of CT angiography (CTA), matrix metalloproteinase-9 (MMP-9) and platelet-activating factor (PAF) in the assessment of ACS.

Methods: A total of 124 patients with ACS admitted to our hospital from June 2022 to March 2024 were enrolled as study subjects.

prevents NRF2 nuclear translocation to drive hypoperfusion-related cognitive deficits by targeting .

-based therapeutics represent a promising approach for treating multiple diseases, yet the key regulatory in chronic cerebral hypoperfusion (CCH)-related cognitive impairment remains unclear. Here, we identify as consistently upregulated in both male and female mild cognitive impairment (MCI) and late-stage of Alzheimer's disease (AD) patients, as well as in the basal forebrain of both male and female postmortem AD specimens and male CCH rats. Knockdown of in the basal forebrain alleviated CCH-induced cognitive deficits.