Publications by authors named "Ya Qian Zhou"
Luminescence modulation via solvent-triggered single-crystal-to-single-crystal transformation in a non-porous molecular crystal.
Acta Crystallogr C Struct Chem
September 2025
Stimuli-responsive crystalline materials have demonstrated significant potential for developing multifunctional systems. Achieving precise structural modulation in non-porous crystalline phases remains a critical challenge, particularly in correlating molecular-level conformational changes with macroscopic properties. Here, we report a solvatomorphic crystalline system, (1-azabicyclo[2.
View Article and Find Full Text PDFArticle Synopsis
- - The quality control of herbal medicines is crucial for ensuring their effectiveness in clinical use, but current quality evaluation methods often overlook the link between chemical properties and clinical efficacy.
- - This study introduces a new quality standard system, the efficacy-oriented Q-marker of the effect-constituent index (ECI), focusing on Scutellariae Radix (SR), a popular herbal medicine known for its various therapeutic properties.
- - By analyzing key markers associated with anti-inflammatory effects, the study demonstrates that the ECI can effectively correlate with and predict the therapeutic quality of SR, offering insights that could improve quality evaluation for other herbal medicines.
Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats.
Acta Pharmacol Sin
August 2019
Cinnamic acid and its analogues (pyragrel and ozagrel) undergo chain-shortened (β-oxidative) and reductive metabolism on acyl side chain. In this study, we characterized the β-oxidative and reductive metabolism on acyl side chain of cinnamic acid and its analogues using primary rat hepatocytes, hepatic mitochondrial, and microsomal systems. A compartmental model including parent compounds and metabolites was developed to characterize in vivo β-oxidative and reductive metabolism following an intravenous dose of parent compounds to rats.
View Article and Find Full Text PDF