Case Report: A rare presentation of vascular Ehlers-Danlos syndrome with a massive hemothorax and a chest wall hematoma.

Background: Vascular Ehlers-Danlos syndrome (vEDS) is a rare but life-threatening subtype of the Ehlers-Danlos syndromes (EDS), a group of inherited connective tissue disorders with significant clinical and genetic heterogeneity. vEDS is mainly caused by mutations in the gene, leading to type III collagen abnormalities. vEDS is characterized by increased vascular fragility and predisposition to serious complications such as arterial rupture and gastrointestinal perforation.

Treatment of idiopathic sudden sensorineural hearing loss with press needle.

Objectives: To compare the effects of conventional therapy and press needle combined therapy on idiopathic sudden sensorineural hearing loss.

Methods: The retrospective case-control study was conducted from December 2023 to January 2024 at Department of Otorhinolaryngology, Changzhou Third People's Hospital, China, and comprised patients with idiopathic sudden sensorineural hearing loss ISSNHL admitted from September 2021 to November 2023. The patients were divided into control group CON in which conventional therapy was used, and the PN group in which the press needle therapy was given additionally.

Fabric-Based Flexible Pressure Sensor Arrays with Ultra-Wide Pressure Range for Lower Limb Motion Capture System.

The lower limb motion capture technology has garnered significant attention as a pivotal enabler in extended reality, sports science, film production, and medical rehabilitation. However, existing mature systems face critical challenges, including restricted operational environments, interference with natural activities, and cumbersome wearability. Here, a flexible insole pressure sensor array with an ultra-wide sensing range is developed using dip coating, laser cutting, and hot pressing, enabling lower limb motion capture.

Laser double-layer slicing of SiC wafers by using axial dual-focus.

Silicon carbide (SiC) is a critical semiconductor material extensively used in high-performance electronic power devices. However, achieving high-efficiency, low-loss SiC substrates remains a significant challenge. This study introduces an innovative dual-focus, double-layer laser slicing technique for SiC, incorporating spherical aberration correction into the traditional weighted Gerchberg-Saxton (GSW) approach.

Effects of Different Digital Interventions on Breastfeeding Outcomes: A Systematic Review and Network Meta-analysis.

Context: Breastfeeding has significant benefits for maternal and infant health; however, the global exclusive breastfeeding rate remains low.

Objective: Digital interventions have shown potential in improving breastfeeding rates. This study aims to evaluate and identify the most effective digital interventions through a network meta-analysis.

Mixed infections and heteroresistance of among multidrug-resistant tuberculosis in China: a genomic epidemiology study.

Mixed infection refers to the presence of multiple strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes. Mixed infections and heteroresistance with can complicate drug resistance diagnosis, treatment options, and transmission inference. We conducted a population-based genomic epidemiological study of multidrug-resistant tuberculosis (MDR-TB) in Shanghai, China, between January 1, 2005, and December 31, 2018, to evaluate the prevalence and impact of mixed infection and heteroresistance on MDR-TB diagnosis and treatment outcomes.

Frailty in Alzheimer's disease: A bibliometric analysis of research hotspots, emerging trends, and knowledge structure.

BackgroundFrailty has emerged as a major public health concern in aging populations, particularly among individuals with Alzheimer's disease (AD), where it exacerbates adverse outcomes and signals dementia progression. While research on frailty in AD has grown rapidly, a thorough analysis of key research hotspots and trends remains insufficient.ObjectiveThis study employs bibliometric methods to systematically explore core themes, identify potential frontiers and emerging directions in this field.

Thick polyethylene films lessen pollution footprint while highlighting environmental merit and maize yielding in drylands.

It is crucial to lessen secondary pollution of plastic film mulching (PFM) in drylands, where high and stable yielding of crops are highly dependent on PFM. To explore the solution, field investigations were conducted in dryland maize using the plastic films with four different thicknesses (0.015, 0.

Epidemiologic and Bacterial Factors Facilitating Long-Term Transmission of Multidrug-Resistant Tuberculosis in Shanghai, China.

Background: Long-term transmission of multidrug-resistant tuberculosis (MDR-TB) challenges TB control by generating new cases and enabling the emergence of extensively resistant strains. We investigated its epidemiologic and bacterial drivers in Shanghai, China.

Methods: We conducted a retrospective study of M.

First Report of Leaf Spot Caused by on in China.

Polygonatum sibiricum Redouté, a perennial herb in the genus of Polygonatum, is extensively used as a medicinal plant in China. In May 2023, serious leaf spot disease of P. sibiricum with incidence of thirty percent in a 0.

Genomic epidemiology analysis of extremely drug-resistant tuberculosis in Shanghai, China.

Tuberculosis (TB), particularly extremely drug-resistant TB (EDR-TB), remains a significant public health concern worldwide. Understanding the transmission patterns and epidemiological characteristics of EDR-TB is vital for effective disease control. Between 1 January 2006 and 31 December 2018, we collected clinical strains in Shanghai, with whole-genome sequencing performed on 58 identified clinical EDR-TB strains.

Emergence of carbapenem resistant Escherichia coli, Morganella morganii, Providencia rettgeri harboring bla genes in minks from China.

Although carbapenems have not been approved for animal use, carbapenem-resistant Enterobacteriaceae (CRE) strains are increasingly being detected in animals, posing a significant public health risk. However, the epidemiological characteristics of CRE isolates in animals remain elusive. We comprehensively investigated the genetic features of carbapenem-resistant Enterobacteriaceae isolates recovered from minks in Shandong province, China.

Effects of two typical organophosphate flame retardants on DNA damage of GT1-7 cells and relevant molecular mechanism.

The tris (2-chloroethyl) phosphate (TCEP) and tri-n-butyl phosphate (TNBP) are two typical organophosphate esters (OPEs), which have estrogenic activity. However, fewer studies have been conducted on their genotoxicity and mechanisms. In this study, we evaluated the effects of TCEP and TNBP on cellular DNA damage in GT1-7 cells and examined the role of estrogen signaling in regulating DNA damage.

Enterohepatic circulation-inspired nano-platform for less-hepatotoxicity hepatocellular carcinoma therapy.

Hepatocellular carcinoma (HCC) has a poor prognosis because it is often diagnosed after clinical deterioration and lacks effective therapies. The advent of tumor-targeting therapeutics provided a promise in the landscape of advanced HCC but it is still ongoing due to the indistinguishable receptor expression and receptor abundance between hepatocytes and HCC cells. Herein, a GSH-responsive prodrug, CA-PEG-ss-PTX, was synthesized with cholic acid (CA), paclitaxel (PTX) and polyethylene glycol (PEG) and further applied to physically encapsulate PTX, forming PTX/CA-PEG-ss-PTX (PTX/CPSP).

Sterile seed germination and seedling cultivation of .

Background: Maxim. is a high-quality, high-yield, edible oil tree species native to eastern Asia, where it plays important roles in ensuring national food and oil security, promoting ecological development, and facilitating rural revitalization. However, the commercial development of .

Well-being and biological cost of family members affected by substance use disorder of others.

This cross-sectional study assessed the well-being of family members affected (AFMs) by substance use disorder (SUD) of other family members. Mental symptoms, social avoidance, and quality of life (QoL) were measured for 775 Chinese AFMs and 206 controls. Saliva from 65 AFMs and 31 controls was analyzed for cortisol, BDNF, proBDNF, and mRNA levels of BDNF and its receptors (TrkB, P75, Sortilin).

Safety of Baricitinib in Adults with Severe Alopecia Areata from Two Phase III Trials Over a Median of 2.3 Years and Up to 4 Years of Treatment.

Background: We report pooled safety data for baricitinib treatment of severe alopecia areata in patients in BRAVE-AA1 (phase II/III) and BRAVE-AA2 (phase III), including data from the long-term extension and bridging extension periods.

Methods: Data are reported from the extended dataset (patients receiving continuous baricitinib 2 mg or 4 mg) and the all-baricitinib dataset (all patients receiving any dose of baricitinib at any time during the trials). Safety outcomes include treatment-emergent adverse events, adverse events of special interest, and abnormal changes in laboratory test results.

Association between blood inflammatory status and the survival of tuberculosis: a five-year cohort study.

Background: Blood inflammatory status is closely associated with tuberculosis (TB) progression. Emerging inflammatory indices from different leukocyte subtypes have become a prognostic hotspot for various diseases, yet their application in TB prognosis remains limited. This study aims to assess the impact of inflammatory status on TB patients' prognosis and its potential as a prognostic indicator to optimize prognostic assessment and therapeutic strategies.

Emergence of plasmid-mediated fosfomycin resistance among harboring , (X4), and genes in wild birds.

Unlabelled: Fosfomycin represents a last-line reserve antibiotic for the treatment of infections caused by multidrug-resistant (MDR) bacteria. Nevertheless, the advent of plasmid-mediated fosfomycin resistance among bacteria from humans and food animals incurs great concern. This study reports the detection and genomic portrait of the plasmid-mediated fosfomycin resistance gene, , amid from wild birds co-harboring plasmid-mediated tigecycline resistance gene(X4), and colistin resistance gene, .

The σNS protein of NDRV antagonizes TRIM59-mediated antiviral innate immune response of Cherry Valley duck.

In recent years, outbreak of the novel duck reovirus (NDRV) disease has occurred frequently in duck populations. Due to its rapid spreading, absence of effective control methods, and high treatment costs, the NDRV disease has caused huge losses to waterfowl breeding in China. As reported, four non-structural (NS) proteins are encoded by the NDRV genome, among which the σNS protein is an RNA-binding protein that can improve the stability of bound RNA by forming oligomers (Adams and Cory, 1998).

Safety, efficacy, and immunogenicity of a novel IgG degrading enzyme (KJ103): results from two randomised, blinded, phase 1 clinical trials.

The approved intravenous adeno-associated virus (AAV) therapies are limited by the widespread prevalence of pre-existing anti-AAV antibodies in the general population, which are known to restrict patients' ability to receive gene therapy and limit transfection efficacy in vivo. To address this challenge, we have developed a novel recombinant human immunoglobulin G degrading enzyme KJ103, characterized by low immunogenicity and clinical value for the elimination of anti-AAV antibodies in gene transfer. Herein, we conducted two randomized, blinded, placebo-controlled, single ascending dose Phase I studies in China and New Zealand, to evaluate the pharmacokinetics, pharmacodynamics, safety and immunogenicity of KJ103 in healthy volunteers.

Association between body mass index at birth and neonatal health outcomes in preterm infants: A retrospective analysis.

Background: Studies on how birth body mass index (BMI) affects health outcomes in preterm infants are relatively limited.

Aim: To analyze the association between BMI at birth and neonatal health outcomes in extremely low and very low birth weight preterm infants in China.

Methods: Used data from the Chinese Premature Infant Informatization Platform (2022-2023).

Self-template manufacturing of on-skin electrodes with 3D multi-channel structure for standard 3-limb-lead ECG suit.

Wearable electrocardiogram (ECG) devices are the mainstream technology in the diagnosis of various cardiovascular diseases, in which soft, flexible, permeable electrodes are the key link in human-machine interface to capture bioelectrical signals. Herein, we propose a self-template strategy to fabricate silver-coated fiber/silicone (AgCF-S) electrodes. With a simple dissolving-curing-redissolving process, the polyvinyl acetate shell around the AgCF core is in-situ removed to form a three-dimensional (3D) multi-channel structure.

Biomimic Nanodrugs Overcome Tumor Immunosuppressive Microenvironment to Enhance Cuproptosis/Chemodynamic-Induced Cancer Immunotherapy.

Elesclomol (ES) as an efficient Cu ionophore can specifically transport Cu into mitochondria and disrupt intracellular Cu homeostasis. Extra intracellular Cu induces cuproptosis and chemodynamic therapy (CDT), which further cascades immunogenic cell death (ICD) and activates antitumor immune responses. However, the tumor immunosuppressive microenvironment (TIM) attenuates the efficiency of the immune response.