CLIP-based Multi-modal Feature Learning for Cloth-changing Person Re-Identification.

Contrastive Language-Image Pre-training (CLIP) has achieved remarkable results in the field of person re-identification (ReID) due to its excellent cross-modal understanding ability and high scalability. Since the text encoder of CLIP mainly focuses on easy-to-describe attributes such as clothing, and clothing is the main interference factor that reduces the recognition accuracy in cloth-changing person ReID (CC ReID). Consequently, directly applying CLIP to cloth-changing scenario may be difficult to adapt to such dynamic feature changes, thereby affecting the precision of identification.

Decoding the Feeding Mystery of Adoretus sinicus: A Comparative Study of Mouthpart Morphology Among Four Species of Rutelinae (Coleoptera: Scarabaeidae).

Mouthparts exhibit diverse morphological features in scarab beetles, resulting from the adaptation to the various living and feeding habits. Adoretini is a small tribe of Rutelinae, remarkable for bearing a beak-like projection on the labrum. However, the correlation between peculiar structures and feeding habits remain unsatisfactory.

User Satisfaction With Pregnancy Management Apps in Mainland China: User-Generated Content Analysis and Text Mining Study.

Background: China's 3-child policy has increased the demand for scientific and personalized pregnancy health management. The convenience of mobile health has promoted the use of pregnancy management apps among pregnant women. User satisfaction has a significant impact on continued use intention.

Pediatric metabolic dysfunction-associated steatotic liver disease and the gut microbiome: from research landscape to targeted modulation.

Metabolic dysfunction-associated steatotic liver disease (MASLD), formally known as non-alcoholic fatty liver disease, has become the most common form of chronic liver disease in children. The spectrum of pediatric MASLD ranges from simple steatosis to steatohepatitis, fibrosis, cirrhosis, and in rare cases, hepatocellular carcinoma. Its pathogenesis involves a complex interplay among genetic, epigenetic, and environmental factors, along with alterations in the gut microbiota and its associated metabolites.

Environmental fate of POPs under climate change: Regulation of POPs distribution by soil organic matter and microbial communities during glacial retreat.

Glacial retreat zones are highly sensitive to climate change. This makes them unique models of vegetation succession that reflect interactions among soil development, microbes, and the behavior of chemicals. In this study, the fate of persistent organic pollutants (POPs) during soil succession in glacial retreat areas was investigated, with a focus on the roles of soil organic matter (SOM) and microbial communities.

Co-analysis of network pharmacology and metabolomics: revealing the mechanism of using mixed strains to produce multi-stage fermentation products of fresh blue honeysuckle ( L.) to against hyperlipidemia.

This study systematically investigated the molecular mechanism of the physicochemical properties, bioactive compound spectrum, and lipid-lowering activity of fermented L. juice (FLJ) by sequential fermentation of compound lactic acid bacteria and yeast. The results indicated that compared to other methods, the sequential fermentation strategy (SFL-Y) could significantly enhance the levels of bioactive substances (flavonoids, SOD enzyme) and lipid-lowering activity.

Laser double-layer slicing of SiC wafers by using axial dual-focus.

Silicon carbide (SiC) is a critical semiconductor material extensively used in high-performance electronic power devices. However, achieving high-efficiency, low-loss SiC substrates remains a significant challenge. This study introduces an innovative dual-focus, double-layer laser slicing technique for SiC, incorporating spherical aberration correction into the traditional weighted Gerchberg-Saxton (GSW) approach.

Photoexcited CRY1 physically interacts with ATG8 to regulate selective autophagy of HY5 and photomorphogenesis in Arabidopsis.

Cryptochromes (CRYs) are blue light photoreceptors that regulate various light responses in plants, including photomorphogenesis. Autophagy is a tightly controlled intracellular degradation pathway that plays a critical role in plant growth and development. CRY signaling inhibits the 26S proteasome-dependent degradation of LONG HYPOCOTYL 5 (HY5) through interactions with the CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1)-SUPPRESSOR OF PHYA-105 1 (SPA1) complex.

Consumer or Decomposer? Behavioral and Morphological Diagnosis of White Grubs.

Determining the ecological role of insect larvae is crucial for pest control and resource utilization, which usually relies on accurate species identification. White grubs, the larvae of Scarabaeoidea, exhibit highly diverse behaviors but share a similar morphology, making identification challenging. In this study, an improved six-armed olfactometer was used to test the feeding preferences of two sympatric white grubs, and .

The effectiveness and safety of ofatumumab for the treatment of pemphigus vulgaris: a cohort study based on a registry database.

Background: Ofatumumab, a fully human anti-CD20 monoclonal antibody administered subcutaneously and indicated for multiple sclerosis, might theoretically be effective for patients with pemphigus vulgaris (PV).

Objective: To evaluate the effectiveness and safety of ofatumumab in patients with PV.

Methods: This cohort study was based on a registry database of autoimmune bullous diseases at West China Hospital (AIBD-WCH), including two groups.

The role and mechanism of ARID1A in immunotherapy of gastric cancer.

Objective: This study aimed to clarify the clinical significance of ARID1A expression in gastric cancer (GC) and explore its mechanistic role in regulating PD-L1 expression during immunotherapy response.

Methods: A comprehensive analysis of ARID1A expression was conducted in 205 gastric adenocarcinoma specimens and 30 matched paracancerous tissues. ARID1A and PD-L1 expression profiles were assessed through immunohistochemical analysis.

Multi-omics analysis reveals the specific role of biocontrol reagents against tomato bacterial wilt.

Bacterial wilt caused by is considered one of the most important diseases that cause economic losses to tomato. Currently, eco-friendly biocontrol agents have been increasingly considered as effective approaches to control tomato bacterial wilt. However, the specific mechanisms by which biocontrol bacteria with distinct functions exert their effects remain unclear.

Decoupling of atomic interactions for accurate thermodynamic prediction in FCC alloys.

Accurate prediction of thermodynamic properties and phase equilibria in multicomponent Ni-based superalloys and high/medium-entropy alloys (HEAs/MEAs) poses persistent challenges due to complex atomic interactions and data scarcity. Here we present a simple yet powerful solution: a CALPHAD framework that bypasses computational and experimental bottlenecks by strategically decoupling nearest-neighbor (NN) and long-range (LR) interactions in face-centered cubic (FCC) alloys. The core innovation lies in a four-sublattice compound energy formalism (4SL-CEF) that embeds strong NN interactions into a physics-based "reference surface" derived from computationally efficient quasi-harmonic approximation (QHA) calculations, while confining excess terms to weak LR interactions-constrained to narrow, physically reasonable ranges, serving solely to refine phase equilibria.

Effects of omega-3 fatty acids supplementation on lipids and pregnancy outcomes in pregnant women.

Objectives: To assess the impact of Omega-3 fatty acid supplementation on maternal blood lipid profiles and pregnancy outcomes.

Methods: This study retrospectively analyzed data from pregnant women with previous pregnancy loss and infertility, divided participants into an intervention group ( = 60) and a control group ( = 218) based on the use of Omega-3 fatty acid supplements during pregnancy, compared blood lipids between the two groups, and analyzed the effect of Omega-3 fatty acids on pregnancy outcomes.

Results: After a 5-week intervention with Omega-3 fatty acids, significant reductions in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) levels were observed.

GPCRs identified on mitochondrial membranes: New therapeutic targets for diseases.

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in eukaryotes, with nearly 800 genes coding for these proteins. They are involved in many physiological processes, such as light perception, taste and smell, neurotransmitter, metabolism, endocrine and exocrine, cell growth and migration. Importantly, GPCRs and their ligands are the targets of approximately one third of all marketed drugs.

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML.

Background: Comprehensive analysis of single-cell transcriptome and chromatin accessibility will contribute to interpret the heterogeneity of acute myeloid leukemia (AML). We hypothesize that integrating single-cell transcriptomic and chromatin accessibility landscapes underlying t(8;21) AML will provide valuable insights into its heterogeneous cellular properties and gene regulatory programs.

Methods: Here, we conducted paired single-cell RNA-sequencing (scRNA-seq) and single-cell ATAC sequencing on bone marrow samples from newly diagnosed t(8;21) AML patients and healthy controls.

An ultra-high performance parallel (UHPP) framework for complex 4radiotherapy planning.

. In radiotherapy, dose distribution conformity and compactness are critical to patient outcomes. Advanced techniques like4πradiotherapy leverage non-coplanar beams for superior dosimetry by exploring additional degrees of freedom.

Diagnostic performance of dual-layer spectral detector CT in differentiating middle ear cholesteatoma from chronic suppurative otitis media.

Objective: To investigate the diagnostic performance of dual-layer spectral detector CT (DLCT) in differentiating middle ear cholesteatoma and chronic suppurative otitis media (CSOM).

Materials And Methods: This prospective, institutional review board-approved study consecutively enrolled patients with suspected middle ear cholesteatoma or CSOM from January to July 2024. All participants underwent DLCT scanning before surgery.

[ Formula attenuates osteoclast differentiation in rheumatoid arthritis by inhibiting the HIF-1α/BNIP3 autophagy signaling pathway].

Objectives: To investigate the effect of Formula (QGKSF) for alleviating osteoclast differentiation in rheumatoid arthritis and the underlying mechanism.

Methods: RAW264.7 cells cultured under hypoxic conditions were treated with RANKL to induce osteoclast differentiation and incubated with normal rat serum or sera from rats medicated with methotrexate (MTX) or QGKSF at low and high doses.

Functional and expression profiling of DREB genes in Ma Bamboo (Dendrocalamus latiflorus Munro) reveals their role in abiotic stress adaptation.

Ma bamboo (Dendrocalamus latiflorus Munro) is a key giant bamboo in South Asia, highly sensitive to abiotic stresses. Dehydration-Responsive Element-Binding (DREB) transcription factors (TFs) are an important gene family involved in plant growth, metabolic regulation, and environmental responses. Although the roles of DREB TFs in plant growth, metabolic regulation, and environmental responses are well studied, little is known in Ma bamboo.

Triazine Calixarene as a Dual-Channel Chemosensor for the Reversible Detection of Cu and I Ions via Water Content Modulation.

Rationally designing and synthesizing chemosensors capable of simultaneously detecting both anions and cations via water content modulation is challenging. In this study, we synthesized and characterized a novel triazine calixarene derivative-based iodide and copper ion-selective fluorescent "turn-off" sensor. This dual-channeled fluorescent probe is able to recognize Cu and I ions simultaneously in aqueous systems.

Sanguinarine-induced proteomic changes in methicillin-resistant .

The escalating threat of methicillin-resistant (MRSA) infections, coupled with the dwindling efficacy of current antibiotics, highlights the urgent need for novel antimicrobial agents.In this study, we demonstrate that sanguinarine - a plant-derived benzophenanthridine alkaloid - exerts potent antibacterial activity against MRSA, with a minimum inhibitory concentration (MIC) of 20 mg/L. To elucidate the molecular mechanisms underlying its antibacterial effects, we conducted a comprehensive, time-resolved proteomic analysis of MRSA upon sanguinarine exposure, quantifying a total of 1,037 proteins, among which significant alterations were observed at each time point over a 120-min treatment period.

Temporal trends in the incidence of adverse effects of medical treatment in BRICS countries from 1990 to 2021: an age-period cohort analysis.

Background: Significant disability-adjusted life year (DALY) losses are caused annually by adverse effects of medical treatment (AEMT), a serious public health concern worldwide that continuously strains nations' socioeconomic progress. As they account for more than half of the world's population and exhibit notable variation in healthcare resource distribution, the BRICS nations-Brazil, Russia, India, China, and South Africa-have emerged as a crucial observational cohort for researching healthcare safety issues. This study evaluated trends in the incidence of AEMT across BRICS nations from 1990 to 2021.

Global, Regional, and National Burden of Traumatic Brain Injury, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021.

Traumatic brain injury (TBI) is a major global health concern, contributing substantially to mortality and disability. While previous studies have reported the global and regional burden of TBI, few have explored its long-term trends, cause-specific burden, sociodemographic disparities, and future projections in a comprehensive framework. To address this gap, we conducted a retrospective analysis using the Global Burden of Disease 2021 data to estimate TBI incidence, prevalence, and years lived with disability across sex, age, and Sociodemographic Index (SDI) quintiles.

Correction: Fingolimod inhibits inflammation but exacerbates brain edema in the acute phases of cerebral ischemia in diabetic mice.

[This corrects the article DOI: 10.3389/fnins.2020.