Event-triggered dynamic landing control of cooperative USV-UAV plant with the compensation mechanism for rolling kinematics.

In this paper, an event-triggered fuzzy control algorithm is proposed for the unmanned surface vessel (USV) and unmanned aerial vehicle (UAV) cooperative plant to achieve the high-precision landing mission. In the guidance module, an L virtual ship-L virtual aerial vehicle (LVS-LVA) guidance principle is developed to generate the reasonable reference signals for the USV-UAV plant under the landing mission. The proposed guidance principle incorporates a rolling kinematic compensation mechanism based on the 4-degree-of-freedom model of USV, specifically designed to counteract wave-induced rolling disturbances during UAV landing operations on unstable marine platforms.

The integrated treatment of photodynamic therapy and oncolytic Virotherapy: A dual-modal paradigm for breast Cancer.

Triple-negative breast cancer (TNBC) is a serious threat to lives and health. We developed a dual approach of Photodynamic therapy (PDT) and Newcastle Disease Oncolytic Virus (NDV) to mediate killing effects and anti-tumor immune effects against TNBC. In this study, we firstly verified that PDT combined with NDV effectively eliminated tumor cells.

The Synthesis and Photoluminescence Properties of Novel Sr(AlO)(WO): Eu Green-Emitting Phosphors for White LEDs.

Phosphors, as the crucial material of phosphor-converted white light-emitting diodes (pc-WLEDs), have played an essential role in improving luminescent efficiency and regulating color rendering index (CRI). Hence, we have successfully synthesized a novel Eu doped Sr(AlO)(WO) (SAWO) green phosphor for the first time using the solid-state reaction, as well as systematically investigated its phase and crystal structure, luminescent properties, and thermal stability. The SAWO:x mol%Eu (0.

CLIP-based Multi-modal Feature Learning for Cloth-changing Person Re-Identification.

Contrastive Language-Image Pre-training (CLIP) has achieved remarkable results in the field of person re-identification (ReID) due to its excellent cross-modal understanding ability and high scalability. Since the text encoder of CLIP mainly focuses on easy-to-describe attributes such as clothing, and clothing is the main interference factor that reduces the recognition accuracy in cloth-changing person ReID (CC ReID). Consequently, directly applying CLIP to cloth-changing scenario may be difficult to adapt to such dynamic feature changes, thereby affecting the precision of identification.

Whole-exome sequencing in a patient with a history of esophageal squamous cell carcinoma to discriminate recurrent disease from a second primary tumor.

A 52-year-old man who previously underwent McKeown esophagectomy to treat lower thoracic esophageal squamous cell carcinoma (ESCC) and subsequently received radical radiotherapy to treat cervical lymph node malignancy (squamous cell carcinoma on pathology; presumed to be metastasis of the primary tumor) presented with recurrent cervical lymphadenopathy during periodic reexamination. On admission, gastroscopy revealed a 0.5 × 0.

CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription.

Despite advancements in EGFR- and KRAS-targeted therapies for lung adenocarcinoma (LUAD), novel targets are needed for patients unresponsive or resistant to current treatments. This study demonstrates the critical role of CREPT in modulating ERK-downstream gene transcription in LUAD progression. CREPT expression and function were investigated using human LUAD tissues, EGFR/KRAS mutant LUAD cell lines, and mouse models.

The predictive value of preoperative inflammatory status for anastomotic leakage after esophagectomy for esophageal cancer.

Background: Anastomotic leakage is one of the most severe complications after esophageal cancer surgery. The purpose of this study was to evaluate the impact of preoperative inflammatory status on anastomotic leakage after esophageal cancer surgery and to construct a model for predicting anastomotic leakage after esophageal cancer surgery.

Methods: A retrospective analysis was conducted on 1106 patients with esophageal cancer who underwent surgical treatment between September 2018 and December 2022.

Rare complications after esophagectomy: incidence, clinical features, risk factors, management, and prevention.

In recent years, common postoperative complications after esophagectomy have received increasing attention. However, the attention paid to rare complications, which often lead to serious consequences if they are not diagnosed in a timely manner, has not been sufficient. In this article, we present both the clinical and imaging features of rare complications following esophagectomy and strategies for their prevention and management.

Research on the influence factors of radial velocity based on a coherent-dispersion spectrometer.

High precision extrasolar planet detection based on the radial velocity (RV) method has important scientific significance for studying planet formation, galaxy evolution, and exploring the origin of life and extraterrestrial civilizations. The asymmetric common-path coherent-dispersion spectrometer (CODES) has great potential in the field of exoplanet detection due to its high stability and high throughput. However, the non-ideal characteristics of the telescope and limitation of the detector resolution will cause the problem of uneven distribution of received starlight intensity and the sub-pixel Doppler shift.

A holistic genome dataset of bacteria and archaea of mangrove sediments.

Background: Mangroves are one of the most productive marine ecosystems with high ecosystem service value. The sediment microbial communities contribute to pivotal ecological functions in mangrove ecosystems. However, the study of mangrove sediment microbiomes is limited.

PreDigs: A Database of Context-specific Cell-type Markers and Precise Cell Subtypes for Digestive Cell Annotation.

Research on cell type markers helps investigators explore the diverse cellular compositions of gastrointestinal tumors. This enhances our understanding of tumor heterogeneity and its impact on disease progression and treatment response. However, integrating large-scale datasets and the lack of standardized cell type identification remain challenges.

Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy.

Melanoma results in the formation of malignant tumors and is the deadliest form of skin cancer with high mortality rate. Immunotherapy for melanoma has made great breakthroughs in recent decades. However, low patient response rates and side effects due to the immunosuppressive tumor microenvironment (iTME) and tumor heterogeneity limit the clinical application of melanoma immunotherapy.

An effective multistage mouse model of esophageal carcinogenesis for preclinical and computational pathology applications.

The use of carcinogen-induced multistage carcinogenesis animal models of esophageal squamous cell carcinoma (CIMCM of ESCC) is limited by prolonged timelines, high toxicity, and excessive mutational burden. In this study, we report the establishment of an effective mouse CIMCM of ESCC by using 4-nitroquinoline-1-oxide (4NQO) as a carcinogen and sorafenib (SOR) as a tumor promoter. We show that SOR specifically activates the Raf-MEK-ERK signaling pathway in normal esophageal stratified squamous epithelium cells, thereby promoting tumor progression.

Mechanistic insights into the anti-depressant effect of quercetin: an integrated bibliometrics, bioinformatics, and animal experimentation.

Objectives: Accumulating clinical evidence demonstrates the therapeutic potential of Traditional Chinese Medicine (TCM) in mitigating depressive disorders. This research focuses on quercetin, a principal bioactive constituent shared among five classical TCM antidepressant formulations, to systematically decode its multi-target mechanisms via an integrative framework combining neuroinflammatory modulation and synaptic plasticity regulation.

Methods: A tripartite experimental design was implemented.

Isolation and Structural Characterization of Melanins from Red and Yellow Varieties of .

Melanin is a complex natural pigment that imparts a variety of colors to the fruiting bodies of edible fungi, influencing both their nutritional quality and commercial value. is an emerging type of edible fungus that has been widely cultivated in recent years. It can be categorized into red and yellow varieties based on cap color, while its pigment characteristics remain unclear.

[Effect of electroacupuncture on cGAS/STING/NLRP3 pathway of the cerebral cortex in rats with cerebral ischemia reperfusion injury].

Objectives: To observe the effect of electroacupuncture (EA) on cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING)/NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway of the cerebral cortex in rats with cerebral ischemia reperfusion injury and investigate the underlying mechanisms of EA in improving cerebral ischemia reperfusion injury.

Methods: A total of 45 SD rats were randomly assigned into sham-operation group, model group and EA group, with 15 rats in each group. The modified thread embolism method was used to establish the model of cerebral ischemia reperfusion injury.

Alleviation of dry eye disease with lyophilized extracellular vesicles.

Dry eye disease (DED), a prevalent ocular condition affecting millions globally, necessitates the development of innovative therapeutic strategies for long-term management. Although extracellular vesicles (EVs) have shown therapeutic potential for DED, their clinical translation has been substantially limited by stability issues during storage. In this study, a novel lyophilization strategy incorporating ectoine - a natural osmolyte with superior bio-stabilization capabilities - was developed to address these challenges.

Nimotuzumab plus chemotherapy and immunotherapy as first-line/neoadjuvant therapy for advanced esophageal squamous cell carcinoma.

Background: Nimotuzumab has shown promising efficacy in esophageal squamous cell carcinoma (ESCC). However, the efficacy and safety of nimotuzumab plus chemotherapy and immunotherapy as first-line/neoadjuvant therapy for patients with advanced ESCC remain unclear.

Methods: We performed a real world study of patients with advanced ESCC from December 2019 to April 2024.

Intrauterine inflammation exposure may increase the risk of late-onset sepsis in premature infants: a retrospective cohort study.

Background: Preterm birth associated with intrauterine inflammation (IUI) has been linked to alterations in postnatal immunity and severe inflammatory complications during infancy. However, the impact of IUI on late-onset sepsis (LOS), a leading cause of mortality and morbidity in preterm infants, remains unclear. This study aims to elucidate the effect of IUI on the incidence of LOS in preterm infants by analyzing cytokine levels and white blood cell differential counts in cord blood within 24 h after birth.

TonguExpert: A Deep Learning-Based Algorithm Platform for Fine-Grained Extraction and Classification of Tongue Phenotypes.

Unlabelled: Tongue analysis holds promise for disease detection and health monitoring, especially in traditional Chinese medicine. However, its subjectivity hinders clinical applications. Deep learning offers a path for automated tongue diagnosis, yet existing methods struggle to capture subtle details, and the lack of large datasets hampers the development of robust and generalizable models.

Comparison of single-port inflatable mediastinoscopic esophagectomy and thoracoscopic esophagectomy in patients with esophageal squamous cell carcinoma after neoadjuvant chemoimmunotherapy.

Objective: Currently, the application of single-port inflatable mediastinoscopic esophagectomy in patients with locally advanced esophageal squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy is relatively rare. This study aims to compare the clinical efficacy of single-port inflatable mediastinoscopic esophagectomy with that of thoracoscopic esophagectomy for locally advanced esophageal squamous cell carcinoma following neoadjuvant chemoimmunotherapy.

Methods: We retrospectively analyzed the perioperative data of 118 patients who underwent minimally invasive esophagectomy.

Photo-induced hydrous organic aggregates for photoactivatable luminescence.

Harnessing light to regulate molecular aggregation behavior has become an essential approach to confer useful properties for functional materials at the aggregate level. Current examples of photo-induced aggregation predominantly occur in solution, but the solvent-ubiquitous as it is-is often overlooked as a potential participant in the aggregation process. In this study, photo-induced hydrous organic aggregates (HOA) are reported based on a hydrophobic nitroaromatic compound (NPAC).

Quantitative Mapping of Oxygen Affinity to Local Chemical Environments in Ti-Zr-Nb-Ta Alloys via Machine Learning.

Simultaneously enhancing strength and ductility is a longstanding challenge in materials science. Recent studies show that incorporating oxygen into Ti-Zr-family refractory high-entropy alloys (HEAs) can overcome this trade-off, with improved properties stemming from interstitial oxygen occupancy. However, oxygen occupancy is inherently site-specific and strongly influenced by local chemical environments, complicating quantitative predictions of oxygen solution energies at individual sites.

PPARα activation attenuated heat-induced myocardial injury in mice.

With climate change and global warming, extreme heatwaves occurred with more intense and higher frequency, significantly increasing the mortality rate associated with cardiovascular diseases. Using a mouse model of heat stress, the study aimed to clarify the adverse effects on heart, elucidate the underlying mechanism and explore the potential preventative strategies. Firstly, heat stress induced significant myocardial injury, which was further exacerbated even after termination of heat exposure.