Glia maturation factor-β deficiency improves insulin resistance by promoting CARM1-mediated lipid turnover.

Insulin resistance (IR) is a major factor for obesity-associated type 2 diabetes. The molecular mechanisms of IR and its systemic control remain poorly understood, and pharmacological drugs to ameliorate IR are an unmet need. So finding new therapeutic targets and drugs is important.

Long-term nitrogen addition facilitates phosphorus uptake by the roots of .

We conducted a field nitrogen addition experiment in a subtropical natural forest taking ammonium nitrate as nitrogen source. There were three nitrogen addition levels: 0, 20, and 80 kg N·hm·a, corresponding to the control, low nitrogen, and high nitrogen treatments, respectively. In the ninth year of treatments, we collected samples of surface soil from 0 to 15 cm to determine soil basic chemical properties, microbial community composition, acid phosphatase activity, and analyzed leaf nitrogen and phosphorus contents, leaf phosphorus fractions, and fine root biomass and phosphorus content in .

Mapping cellular cytosolic pH in vivo under physiological and pathophysiological conditions.

Cytosolic pH (pHc) is one of the most essential intracellular microenvironments profoundly affecting charges, conformations and therefore functions of macromolecules. It remains challenging to quantitatively measure pHc at single cell resolution in vivo and how pHc of a specific cell type dynamically responds to physiological or pathophysiological fluctuations remains elusive. Smad5 is a pHc sensor with accelerated nuclear export upon pHc alkalization and ideally the nucleocytoplasmic ratio of Smad5 would be a potential indicator of pHc.

Global Burden of Alcohol-Associated Liver Disease Across 204 Countries, 1990-2021: GBD 2021 Findings.

Background And Aims: Alcohol-associated liver disease (ALD) is a general term for liver diseases caused by long-term and excessive alcohol consumption, which poses a serious threat to human health.

Methods: The data were collected from the estimates of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) in 2021. We focused on the impacts of age, gender, risk factors and the socio-demographic index (SDI).

RETRACTED: Yuan et al. Green Remanufacturer's Mixed Collection Channel Strategy Considering Enterprise's Environmental Responsibility and the Fairness Concern in Reverse Green Supply Chain. , , 3405.

The journal retracts the article "Green Remanufacturer's Mixed Collection Channel Strategy Considering Enterprise's Environmental Responsibility and the Fairness Concern in Reverse Green Supply Chain" [...

Stimuli-Responsive Drug Delivery Systems for Enhanced Melanoma Immunotherapy.

Melanoma results in the formation of malignant tumors and is the deadliest form of skin cancer with high mortality rate. Immunotherapy for melanoma has made great breakthroughs in recent decades. However, low patient response rates and side effects due to the immunosuppressive tumor microenvironment (iTME) and tumor heterogeneity limit the clinical application of melanoma immunotherapy.

An annotated chromosome-level genome of a troglophilic spider (Pimoa clavata).

Climatic upheavals throughout Earth's history have driven species to subterranean refugia, where stable microclimates buffer environmental extremes. The spider family Pimoidae, relict lineages sensitive to thermal fluctuations, exemplifies this climate-driven habitat transition. Here, we present the first chromosome-level genome of Pimoa clavata, a troglophilic spider endemic to Beijing's mountainous caves.

Clinical significance and gene prediction of a novel classification system based on tacrolimus concentration-to-dose ratio in the early post-liver transplant period.

Background And Aims: Classification system of tacrolimus elimination and its clinical significance has not been well described in liver transplantation. This study aimed to present a novel tacrolimus clearance clinical-FIS (Fast-Intermediate-Slow) classification and its gene prediction system.

Methods: Patients from 3 transplant centers were enrolled in this study.

Environmental impact of brine and cooling water mixing ratios on marine water quality and biota: a comparative field study.

The co-discharge of brine and cooling water is widely regarded as a preferred method for desalination brine disposal. However, existing research on the effectiveness of this approach primarily relies on software simulations, with limited studies addressing its impact in real marine environments. This study conducted a field investigation to evaluate the effects of co-discharge of brine and cooling water on water quality, plankton, and macrobenthic organisms in the receiving marine ecosystem.

RNA Interference-Aided Functional Characterization of Juvenile Hormone Signaling During Vitellogenesis in Two Coleoptera Species.

In Tribolium castaneum, juvenile hormone (JH) signal, through Methoprene-tolerant (Met)/Taiman (Tai) heterodimer, regulates vitellogenesis. Considering that Coleoptera is by far the largest animal taxon, whether JH pathway controls vitellogenesis remains to be clarified in other Coleopteran species. In the current paper, temporal expression determination revealed that JH signal is triggered in the young female adults in two Henosepilachna species, consistent with active oogenesis and vitellogenesis in these beetles.

A global perspective on autoinducer-2-mediated cell communication in prokaryotes.

Animal communication within a community is essential for their survival and reproduction. This phenomenon is not restricted to animals but is also prevalent in prokaryotes, which employ quorum sensing (QS) mechanisms for communication and behavior. Despite their importance, cell-cell communication in prokaryotes has not been cataloged in detail.

Interplay between MAPK signaling pathway and autophagy in skin aging: mechanistic insights and therapeutic implications.

Skin aging manifests as structural degradation, functional decline, and heightened disease susceptibility. Central to this process is the overactivation of the mitogen-activated protein kinase (MAPK) signaling pathway triggered by reactive oxygen species (ROS). Autophagy, a lysosomal degradation mechanism essential for maintaining cellular homeostasis, demonstrates context-dependent duality in skin aging by mediating cytoprotective effects and stress-induced dysfunction.

The effect of continuous positive airway pressure on nocturnal blood pressure among obstructive sleep apnea-hypopnea syndrome patients.

Purpose: Few articles focus on the effect of CPAP on the nocturnal blood pressure in OSA patients. This study aims to evaluate the effects of continuous positive airway pressure (CPAP) therapy on nocturnal blood pressure in individuals with obstructive sleep apnea-hypopnea syndrome (OSAHS), which fills the research gap. Additionally, differences in nocturnal blood pressure measurements before and after CPAP therapy were analyzed across varying disease severities.

Isolation and characterization of the virulent porcine epidemic diarrhea virus strain CHGS20 in China.

Porcine epidemic diarrhea virus (PEDV) is the etiological agent of porcine epidemic diarrhea (PED), which threatens the swine industry worldwide. Although commercial PEDV vaccines are available, the disease continues to plague the swine industry in China. Therefore, isolating PEDV from clinical samples is beneficial for conducting molecular epidemiological investigations, developing effective vaccines and diagnostic methods, and investigating pathogenic mechanisms.

Altering the bacterial community: sour soup decreased CO production and improved the fermentation quality of and mixed silages.

Introduction: Carbon dioxide (CO) generated during the ensiling process is a source of greenhouse gas emissions and a reason for the loss of nutrients during ensiling.

Methods: (B), (T) and their mixtures (B7T3, B5T5 and B3T7) were ensiled with sour soup (S) and (LAB) to investigate the effects of additives on silage quality, CO2 production and bacterial communities.

Results: After 45 days of fermentation, the B3T7 treatment resulted in the lowest CO production, a relatively high lactic acid content (pH < 4.

[Effect of Obstructive Sleep Apnea Syndrome on Nocturnal Ambulatory Blood Pressure Monitoring Results in Older Adults Without Cardiovascular or Cerebrovascular Diseases].

Objective: To investigate the effect of obstructive sleep apnea syndrome (OSAS) on nocturnal ambulatory blood pressure monitoring results in older adults without cardiovascular or cerebrovascular diseases, and to identify factors causing fluctuations in nocturnal blood pressure in older adults with OSAS.

Methods: A total of 169 older adult OSAS patients with no history of cardiovascular or cerebrovascular diseases were enrolled. According to their severity of OSAS, the participants were divided into 4 groups, including a normal OSAS group, a mild OSAS group, a moderate OSAS group, and a severe OSAS group.

Effects of WeChat-based telehealth on patients reported outcomes of hypertension: a randomized controlled trial.

Patient-reported outcomes (PROs) are assessments based on patients' self-perception. This study aimed to explore whether WeChat-based health education is more effective than traditional health education in terms of improving PROs for hypertensive patients during a 3-month period. This prospective, single-center, single-blind randomized controlled trial was conducted from April to August 2022 at the hypertension ward of Yunnan Province Fuwai Cardiovascular Hospital.

Uncovering common disease mechanisms and critical biomarkers in Crohn's disease with concurrent psoriasis and exploring potential therapeutic agents.

Introduction: Research findings show a substantial correlation between Crohn's disease and psoriasis. However, the exact cause or pathogenesis of the concurrent manifestations of these two conditions in the same individuals remains uncertain. This research aimed to scrutinize the important molecules and mechanisms responsible for the concomitance of Crohn's disease and Psoriasis by using quantitative bioinformatics utilizing a publicly available RNA sequencing repository.

Effect of comprehensive nursing interventions on psychological well-being and treatment adherence in dementia patients.

Objective: To investigate the effects of comprehensive nursing interventions on psychological well-being and rehabilitation treatment adherence in patients with dementia.

Methods: A retrospective analysis was conducted on 90 dementia patients treated at the First Hospital of Fuyang Hangzhou. Patients were divided into an observation group (n=45) and a control group (n=45).

Study on a Traditional Chinese Medicine constitution recognition model using tongue image characteristics and deep learning: a prospective dual-center investigation.

Purpose: The objective of this study was to develop a quantitatively analyzed Traditional Chinese Medicine (TCM) constitution recognition model utilizing tongue fusion features and deep learning techniques.

Methods: A prospective investigation was conducted on participants undergoing TCM constitution assessment at two medical centers. Tongue images and corresponding TCM constitution data were collected from 1374 participants using specialized equipment.

Diversity survey of spiders (Araneae, Pholcidae) from eastern Sichuan and neighboring areas, with descriptions of six new species.

Thirteen spider species of the genus Walckenaer, 1805 are reported from a diversity survey in eastern Sichuan and neighboring areas (northeastern Yunnan and western Guizhou). They belong to three species groups and include six newly described species: Li, Li & Yao, (♂♀, Yunnan) in the group; Li, Li & Yao, (♂♀, Sichuan) and Li, Li & Yao, (♂♀, Sichuan) in the group; Li, Li & Yao, (♂♀, Sichuan), Li, Li & Yao, (♂♀, Sichuan) and Li, Li & Yao, (♂♀, Sichuan) in the group. Zhu, Zhang, Zhang & Chen, 2005 is recorded from Yunnan for the first time and Zhang & Zhu, 2009 is recorded from Guizhou and Sichuan for the first time.

Nettle supplementation improves antioxidant status and modulates inflammatory response by altering lysophosphatidylcholines and enterolactone metabolism in dairy cows.

Nettle is not only a nutrient-rich forage but also possesses the potential to act as a nutritional and physiological regulator. This study investigated the effects of supplementing nettle hay into the total mixed rations (TMR) on milk yield, milk composition, antioxidant capacity, immune function, and plasma metabolome in dairy cows. Twenty multiparous Holstein cows with similar days in milk (102 ± 8 d), milk production (39 ± 3 kg/d), milk fat (3.

Intravoxel incoherent motion diffusion-weighted imaging for ruling out high-risk esophageal varices in cirrhosis.

Purpose: To explore the role of liver- and spleen-based Intravoxel Incoherent Motion Diffusion-weighted Imaging (IVIM) imaging in ruling out high-risk esophageal varices (HREVs) in patients with cirrhosis and compare it with other noninvasive tests (NITs).

Methods: Patients with liver cirrhosis who underwent paired Esophagogastroduod-enoscopy (EGD) and upper abdominal IVIM imaging between January 2015 and December 2021 were retrospectively enrolled. Logistic regression analyses were performed to determine the potential predictors of HREVs.

Tailoring Defect-Rich Porous Carbon Nanosheets Via Phase-Transition Salt Templating for Ultrahigh Lithium-Ion Storage and Robust Oxygen Electrocatalysis.

Precise control over defects and porous structures in carbon materials is crucial for enhancing their performance in energy storage and conversion. In this study, an innovative salt template method is introduced to synthesize nitrogen-doped, defect-rich porous carbon nanosheets (ST/MS-NC-1000) using leafy zeolitic imidazolate frameworks and NaCl salt. Results reveal that crystalline NaCl acts as a structural template to guide the formation of nanosheet, while molten NaCl etches the carbon framework, significantly increasing defect density and specific surface area.