Remnant Preservation in Anterior Cruciate Ligament Reconstruction Versus Non-Preservation Methods: A Systematic Review and Meta-Analysis.

To manage anterior cruciate ligament (ACL) injury, both remnant-preserving anterior cruciate ligament reconstruction (ACLR) and standard ACLR without remnant preservation are applied. This study aims to systematically evaluate clinical outcomes of remnant-preserving versus standard ACLR techniques by analyzing randomized controlled trials (RCTs). The PubMed, Embase, and Cochrane Library databases were used to identify studies published from January 2000 to November 2024.

Study on the nonlinear characteristic of a longitudinal piezoelectric ultrasound transducer with stepped horn.

Longitudinal vibration sandwich piezoelectric transducers with a stepped horn are widely used in high-intensity ultrasonic applications such as ultrasonic welding, ultrasonic machining, and ultrasonic cleaning. In these applications, due to the increased losses, transducers exhibit nonlinear phenomena such as heating, resonance frequency drift, and amplitude saturation. Consequently, existing linear theoretical models are no longer suitable for analyzing the nonlinear characteristics of such transducers.

Differential expression of microRNA-3127-5p and its molecular mechanisms in polycystic ovary syndrome.

Introduction: The present study was undertaken to elucidate the expression status and molecular mechanism underlying microRNA-3127-5p (miR-3127-5p) in polycystic ovary syndrome (PCOS).

Material And Methods: A total of 50 PCOS and 50 non-PCOS patients were recruited as research subjects. Quantitative real-time polymerase chain reaction was employed to assess the relative abundances of miR-3127-5p in serum, cumulus cells (CCs), and granulosa cells (GCs) from PCOS patients.

Causal Effect of Plasma Fatty Acid Profiles on Psoriasis Risk: Genetic Evidence from a Mendelian Randomization Study.

Introduction: Emerging evidence indicates that omega-3 fatty acids from fish oil may serve as beneficial dietary supplements for psoriasis management. Clinical observations demonstrate a significant association between psoriasis improvement and increased docosahexaenoic acid (DHA) levels. However, the causal relationship between fatty acids and psoriasis risk requires further investigation.

Which Graft Is Associated With Better Outcomes in ACL Reconstruction? A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.

Background: In clinical practice, different surgical methods, including autografts, allografts, and artificial ligaments, have been used in reconstruction after ACL injuries. However, the available evidence is conflicting in terms of which approach has yielded better patient-reported outcomes, joint stability, and risk of graft reinjury. A network meta-analysis allows the comparison of approaches that have not been compared head-to-head in individual RCTs.

Building the future of exercise oncology: current status of international workforce development and integration into standard cancer care.

The complex requirements of people with cancer can impact the provision of safe, effective, evidence-based exercise prescription. Consequently, a range of essential competencies are required from the exercise oncology workforce. There is a global need for a standardized approach to the development of this workforce.

Tuning the Fermi Level of Silver Nanoparticles by Thiocyanate Ions for Plasmonic Catalysis.

The Fermi level of plasmonic metals governs the generation and energetics of hot electrons, thereby determining their catalytic behavior. Herein, we introduce thiocyanate ions (SCN) as surface ligands to modulate the Fermi level of silver. Their strong and stable chemisorption enables efficient tuning of the electronic structure over a broad range.

[BnaNRT1.5s mediates nitrate transporter to regulate nitrogen use efficiency in ].

Improving the nitrogen use efficiency (NUE) of is of significant importance for achieving the national goal of zero growth in chemical fertilizer application and ensuring the green development of the rapeseed industry. This study aims to explore the effects of the nitrate transporter gene BnaNRT1.5s on the nitrogen transport and NUE of .

Single-cell transcriptional landscape of peripheral myeloid cells in autoimmune diseases.

Myeloid cells are pivotal in autoimmune disorder development due to their varied immune response functions yet understanding them at the single-cell level in such conditions is limited. To address this gap, we analyzed 351,905 myeloid cells from 375 single-cell RNA sequencing samples covering 14 autoimmune diseases, which allowed us to classify myeloid cells into 13 distinct subsets with unique immunological profiles. Through pseudotime analysis, we identified a branching process leading to two intermediary inflammatory subtypes and observed dysregulation in eight co-expression modules crucial for monocyte function across autoimmune conditions.

Association Between Dietary Inflammatory Index and Obesity-Related Hypertension: A Cross-sectional Study.

Background: Inflammation plays a significant role in the development of hypertension and obesity, and specific dietary patterns can influence systemic inflammation. However, the link between dietary inflammatory potential and obesity-related hypertension (ORH) remains unclear.

Objective: In this study, our aim was to evaluate the association between the Dietary Inflammatory Index (DII) and ORH using data from the National Health and Nutrition Examination Survey 1999 to 2020.

Efficacy Analysis of Arthroscopic Treatment of Synovial Chondromatosis of the Knee: A Retrospective Study of More Than Five Years.

Objective: The synovial chondromatosis is an exceptionally rare benign condition, predominantly found in the knee joint, and can result in pain, restricted mobility, and potential irreversible damage to the joint and cartilage. Despite the utilization of arthroscopic techniques in the surgical management of synovial chondromatosis, there remains a paucity of long-term assessment regarding its efficacy. The main objectives of this study include: (i) investigating the long-term efficacy of arthroscopic surgery in patients with knee synovial chondromatosis;(ii) identifying factors influencing functional improvement in patients post-surgery function.

Effects of flow rate on pressure and nephrons during flexible ureteroscopy with intelligent control of renal pelvic pressure: an in-vivo pig model.

Purpose: To investigate the effects of flow rate on pressure and nephron injury during flexible ureteroscopy with intelligent renal pelvic pressure (RPP) control in an in vivo pig model.

Methods: Twelve kidneys from six female pigs were randomly divided into six groups. Pressure-controlled (PC) and non-pressure-controlled (NPC) groups were continuously perfused at a flow rate of 50 mL/min (group A), 100 mL/min (group B), and 150 mL/min (group C) for 30 min.

BC-1 improves collagen-induced arthritis in mice by modulating IgD and BCR-NF-κB signalling pathway of B cells.

Rheumatoid arthritis (RA) is an autoimmune disease lacking effective treatment drugs. Beesia calthaefolia Ulbr. widely distributes in the southwest and northwest of China.

Bacterial Foreignization Nanosystem Elicits Multi-Phenotypic T Cells for Antitumor Immunity.

T lymphocytes are pivotal targets in clinical cancer immunotherapy; however, tumor cells frequently evade the T-cell attacks by altering the intrinsic immunogenicity manifested as adjuvanticity, antigenicity, and reactogenicity. Here, a bacterial outer membrane vesicle (OMVs)-based nanosystem is presented to elicit robust T-cell responses by reshaping tumor immunogenicity. OMVs are engineered with vesicular stomatitis virus G-protein that facilitates the fusion of OMVs with tumor cells, leading to tumor "foreignization" and adjuvanticity augment.

Altering the bacterial community: sour soup decreased CO production and improved the fermentation quality of and mixed silages.

Introduction: Carbon dioxide (CO) generated during the ensiling process is a source of greenhouse gas emissions and a reason for the loss of nutrients during ensiling.

Methods: (B), (T) and their mixtures (B7T3, B5T5 and B3T7) were ensiled with sour soup (S) and (LAB) to investigate the effects of additives on silage quality, CO2 production and bacterial communities.

Results: After 45 days of fermentation, the B3T7 treatment resulted in the lowest CO production, a relatively high lactic acid content (pH < 4.

Nrf2-activated mitophagy and ferroptosis suppression synergistically mediate tangeretin's protection against hepatic ischemia-reperfusion injury.

Background: Liver ischemia-reperfusion (I/R) injury frequently arises during liver surgery and significantly contributes to postoperative liver failure and graft dysfunction. Tangeretin (TAN), a polymethoxy flavone present in citrus peel, has demonstrated notable antioxidant and anti-inflammatory effects. Despite this, its effects and mechanisms underlying liver I/R injury remain unclear.

Selective Functionalization of Benzene Ring via Carbene-Initiated [4,5]-Rearrangement.

The extreme similarity in electronic and steric reactivity among the C─H bonds present on alkyl-substituted aromatic rings presents a formidable challenge when it comes to achieving high selectivity during the para-selective functionalization of these bonds. This article presents a unique study that delves into the para-selective functionalization or dearomatization functionalization of benzene rings, achieved through the reaction of carbenes with allyl sulfoxides. Mechanistic investigations suggest that the transformation likely proceeds via an uncommon carbene-mediated [4,5]-rearrangement process.

Size- and Composition-Dependent Hygroscopic Growth of Sub-20 nm Atmospherically Relevant Particles: Implications for New Particle Survival.

New particle formation (NPF) is a significant source of atmospheric particle number concentration and cloud condensation nuclei. The fate of nascent particles is dependent on their ability to take up water, a process influenced by particle size, composition, and morphology. However, there is a lack of comprehensive characterization of the hygroscopic properties of sub-20 nm particles that are compositionally similar to those of atmospheric new particles, leading to uncertainties in predicting their growth and survival.

A Review of the Mechanisms of Astragaloside IV and Berberine in Vascular Dysfunction Associated with Obesity and Diabetes.

The global epidemic of obesity and diabetes imposes a significant strain on healthcare systems, substantially elevating the risk of vascular dysfunction and its associated complications. Astragaloside IV (AS-IV) and berberine (BBR) have demonstrated considerable promise in addressing vascular issues linked to these conditions. This review examines the mechanisms driving their vascular protective effects, drawing on evidence from preclinical studies to compare and contrast their modes of action.

Oxygenated Organic Molecules over the Boundary Layer Aloft in Beijing.

Oxygenated organic molecules (OOMs) originate from both direct emissions and secondary formation via the oxidation of volatile organic compounds (VOCs) emitted from biogenic and anthropogenic sources. OOMs are suggested to play a crucial role in the nucleation and growth of newly formed particles, which in turn influence climate, health and air quality. However, OOMs and the associated nucleation and growth of aerosols in the boundary layer aloft are not considered in atmospheric chemistry models owing to limited observation data.

NAD biosynthesis and mitochondrial repair in acute kidney injury via ultrasound-responsive thylakoid-integrating liposomes.

Acute kidney injury (AKI) impairs the energy metabolism and antioxidant capacity of renal proximal tubular cells. Here we show that ultrasound-responsive liposomes integrating thylakoid fragments and encapsulating L-ascorbic acid can restore the energy supply and antioxidant capacity of the tubular cells as well as renal function in animal models of AKI. After intravenous injection, the liposomes preferentially accumulated in the injured kidneys and were internalized by proximal tubular cells.

METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension.

Background: FUNDC1-mediated mitochondria-associated endoplasmic reticulum membrane (MAM) Ca conduction is crucial in cardiac hypertrophy. N6-methyladenosine (m6A) methylation, a crucial mRNA modification, is implicated in this process. We hypothesise that m6A regulation of FUNDC1-mediated MAM-associated Ca overload contributes to obesity hypertension (OBH) cardiac hypertrophy.

Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model.

Ethnopharmacological Relevance: Kai-Xin-San (KXS) has been used for centuries in the treatment of depression. However, its antidepressant efficacy and the mechanisms involved in treatment-resistant depression (TRD) are not well understood.

Aim Of The Study: This study aimed to examine whether KXS can improve TRD by restoring tryptophan (TRP) metabolism balance.

Enhancing alfalfa and sorghum silage quality using agricultural wastes: fermentation dynamics, microbial communities, and functional insights.

At present, there are many researches on the nutritional quality and fermentation quality of forage silage by adding distillers' grain and fruit residue, but few researches on the succession and function prediction of microbiotic community. In this study, the potential of Moutai distillers' grain (MDG), Rosa roxburghii pomace (RP) and Lactobacillus acidophilus (LAB) to improve silage quality during anaerobic storage of alfalfa and sorghum was investigated. Harvested alfalfa and sorghum were ensiled without (CK) or with MDG, RP, LAB, LAB + MDG or LAB + RP for 45 days at 21-25 °C.