Diagnosis methods for pancreatic cancer with the technique of deep learning: a review and a meta-analysis.

Background: Early diagnosis can significantly improve survival rate of Pancreatic ductal adenocarcinoma (PDAC), but due to the insidious and non-specific early symptoms, most patients are not suitable for surgery when diagnosed. Traditional imaging techniques and an increasing number of non-imaging diagnostic methods have been used for the early diagnosis of pancreatic cancer (PC) through deep learning (DL).

Objective: This review summarizes diagnosis methods for pancreatic cancer with the technique of deep learning and looks forward to the future development directions of deep learning for early diagnosis of pancreatic cancer.

SCAP Interacts with Trim27 to Promote Vascular Neointimal Hyperplasia by Regulating the Stability and Ubiquitination of IκBα.

Pathological vascular remodeling and intimal hyperplasia after vascular injury are representative pathological processes in age-associated vascular diseases. Previous data from our laboratory have indicated that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) contributes to physiological angiogenesis during embryonic development. However, the role of SCAP in neointima formation is not fully understood.

Association between CDSS score and 30-day mortality in nonAPL acute leukemia patients with intracranial hemorrhage: a cohort study.

Objectives: The aim of this study was to investigate the correlation between CDSS (Chinese DIC Scoring System) score and 30-day mortality in patients with intracranial hemorrhage (ICH) with nonacute promyelocytic leukemia (APL) acute leukemia.

Methods: This cohort study enrolled patients with non-APL acute leukemia complicated by ICH. The CDSS score was assessed in this patient population.

Exploration and analysis of methylglyoxal-driven chronic inflammation in polycystic ovary syndrome.

Introduction: Chronic low-grade inflammation drives polycystic ovary syndrome (PCOS)-related metabolic disorders, but the underlying mechanisms remain unclear. Methylglyoxal, a key ovarian metabolite, promotes inflammation when elevated, its role in PCOS-related inflammation remains uncharacterized.

Objectives: This study aimed to identify the role of methylglyoxal in PCOS-related inflammation and its mechanisms of action.

Surgical management and adverse factors for recurrence and long-term survival in adenoid cystic carcinoma patients with intracranial extension: A retrospective cohort study.

Limited data regarding intracranial adenoid cystic carcinomas (ACCs) were available. The authors aimed to elaborate on the clinical characteristics, treatment strategy, and poor outcomes of the disease. Clinical data from all cases of intracranial ACCs treated at our institute were reviewed retrospectively to evaluate their clinical characteristics, management, and outcomes.

Terahertz channel power and BER performance in rain.

Terahertz (THz) communications have emerged as a promising technology for 6G networks due to their potential for achieving terabit-per-second data rates. However, the impact of rainfall on THz channel characteristics remains incompletely understood, particularly regarding power attenuation mechanisms and bit error rate (BER) performance. This paper presents a systematic measurement-based and theoretical investigation of line-of-sight (LoS) THz channel behavior under rainfall conditions, methodically examining both power attenuation mechanisms and bit error rate (BER) performance.

Syntactic denoising and multi-strategy auxiliary enhancement for aspect-based sentiment analysis.

Aspect-based sentiment analysis (ABSA) aims to identify the sentiment polarity associated with specific aspect terms within sentences. Existing studies have primarily focused on constructing graphs from dependency trees of sentences to extract syntactic features. However, given that public datasets are often derived from online reviews, the syntactic structures of these sentences frequently exhibit irregularities.

TET3 is a common epigenetic immunomodulator of pathogenic macrophages.

Through a combination of single-cell/single-nucleus RNA-sequencing (sc/snRNA-seq) data analysis, immunohistochemistry, and primary macrophage studies, we have identified pathogenic macrophages characterized by TET3 overexpression (Toe-Macs) in three major human diseases associated with chronic inflammation: metabolic dysfunction-associated steatohepatitis (MASH), non-small cell lung cancer (NSCLC), and endometriosis. These macrophages are induced by common factors present in the disease microenvironment (DME). Crucially, the universal reliance on TET3 overexpression among these macrophages enables their selective elimination as a single population, irrespective of heterogeneity in other molecular markers.

Low-temperature plasma mutagenesis breeding of Chlorella sorokiniana mutant strains for efficient carbon sequestration.

In this study, low-temperature plasma was used to achieve mutagenesis of Chlorella sorokiniana and two mutants with good traits were successfully obtained after several rounds of screening. The results showed that the biomass of the mutants was increased by 15.31% and 19.

Studies on Deprotonation from OH Groups of Alditols by Heavy Rare Earth Ions.

This study investigates single-crystal structures of Lu/erythritol and nine rare earth-glycerol complexes, revealing deprotonation of normally inert OH groups via μ-bridging (so-called DIOμ phenomenon). The pH drops upon alditol addition correlate with the deprotonation extent, showing increased deprotonation with decreasing lanthanide ionic radius (lanthanide contraction) and exceptionally high deprotonation for Sc. In all the rare earth/alditol complexes with the DIOμ phenomenon, two μ-bridges merge into an MO cluster (M is a rare earth ion) that is not very stable due to the Coulombic repulsion between two M and between two O.

Clinical Efficacy of the Indigo Thrombectomy Catheter in Acute Superior Mesenteric Artery Embolism: A Single-center Retrospective Analysis.

Introduction: This study aims to evaluate the clinical efficacy and safety of the Indigo thrombectomy catheter in the treatment of acute superior mesenteric artery embolism (SMAE).

Methods: We conducted a single-center retrospective analysis of 15 patients who underwent endovascular thrombectomy using the Indigo Catheter between May 2023 and October 2024. The procedure was performed within 4 h of presentation.

Effect of decellularization protocols on the biomechanical properties of porcine ovarian extracellular matrix.

Decellularized extracellular matrix (d-ECM) serves as an ideal scaffold for constructing artificial ovaries, a promising approach to fertility preservation for patients experiencing premature ovarian failure. The biomechanical properties of d-ECM are crucial for the development and maturation of follicles. However, there is no standardized or comprehensive framework for evaluating the various decellularization methods proposed in the literature.

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues.

Objective: Colorectal cancer (CRC) is the third most common tumor worldwide and the second leading cause of cancer-related deaths. Colorectal cancer progresses slowly, and patients have to endure pain for a long time, both before and after surgery. The incidence rate has been increasing year by year in recent years, and the survival rate of patients is low.

Advanced stability and energy storage capacity in hierarchically engineered BiNaTiO-based multilayer capacitors.

Multilayer ceramic capacitors are cornerstone components of modern electronic systems. Yet ensuring reliability under demanding operational conditions, such as elevated temperatures and prolonged cycling, while achieving holistic optimization of recoverable energy density and efficiency remains a significant challenge. Herein, we implement a polar glass state strategy that catalyzes a profound enhancement in energy storage performance by modulating dynamic and thermodynamic processes.

Tunable Ni-Based Alloys as Electrons Donor in Dielectric Isolated Islands to Achieve Broad Frequency Electromagnetic Wave Absorption.

Nitrogen-doped carbon (NC) nanosheets with tunable electronic features have been considered as effective dielectric materials to tackle the severe electromagnetic pollution. However, it is still a critical issue to reconcile the contradiction between the skin effect originates from the intrinsic high conductivity of NC and the optimal dielectric loss capability. Herein, we prepared NC nanosheets consisting of numerous microdomain to simultaneously achieve good impedance matching and dielectric dissipation performance.

Protective Effects of Ginseng Soluble Dietary Fiber and Its Fecal Microbiota Extract on Antibiotic-Induced Gut Dysbiosis Obese Mice.

Prolonged or improper antibiotic use may increase the risk of obesity. Ginseng soluble dietary fiber (G-SDF) has been shown to inhibit obesity and promote the growth of intestinal probiotics. However, its role in antibiotic-induced gut dysbiosis obese mice (ADIO) remains unclear, and this study aimed to elucidate this role.

Feasibility study of fully automatic measurement of adenoid size on lateral neck and head radiographs using deep learning.

Background: The objective and reliable quantification of adenoid size is pivotal for precise clinical diagnosis and the formulation of effective treatment strategies. Conventional manual measurement techniques, however, are often labor-intensive and time-consuming.

Objective: To develop and validate a fully automated system for measuring adenoid size using deep learning (DL) on lateral head and neck radiographs.

Lifetime Risk of First Symptomatic ICH or Seizure in Familial Cerebral Cavernous Malformations: A Multicenter Patient Data Analysis.

Background And Objectives: Familial cavernous malformations (FCMs) are vascular lesions that pose a lifelong risk of symptomatic hemorrhage (SH) and seizures, yet their natural history remains unclear. This study aims to determine the cumulative lifetime risk of a first SH and/or seizure and assess whether genetic variations influence these risks.

Methods: This international, multicenter retrospective cohort study included data from 16 tertiary referral centers and 1 patient advocacy group.

Ten-Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy.

Ten-eleven translocation (TET) family proteins are Fe(II)- and α-ketoglutarate-dependent dioxygenases, comprising three family members: TET1, TET2, and TET3. These enzymes drive DNA demethylation by sequentially oxidizing 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine. Through these reactions, TET proteins remodel the epigenetic landscape and interact with transcription factors and RNA polymerase II to regulate gene expression, cell lineage specification, and embryonic development.

Comprehensive multi-omics pan-cancer analysis revealed EGFLAM as a potential prognostic and immune infiltration-associated biomarker.

EGFLAM is a versatile protein widely expressed in multiple human tissues, yet its function in pan-cancer is not fully understood. To investigate the molecular function of EGFLAM, a comprehensive pan-cancer analysis was carried out using several public databases and bioinformatics tools. Ultimately, confirmatory experiments were conducted in vitro with gastric cancer cell lines.

Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial.

Biliary tract cancer (BTC) has a poor prognosis with limited treatment options. This phase 2 trial randomized 80 patients with unresectable/metastatic BTC 1:1 to sintilimab, anlotinib, and gemcitabine/cisplatin (SAGC) or chemotherapy alone (GC). At 13.

Enhancing reproducibility in stable isotope analysis (SIA) of fish eye lenses: A comparison between lamina number and diameter.

Analyzing stable isotopes in archival tissues, such as fish eye lenses, is used to document shifts in feeding ecology, diet, habitat use, and to reconstruct life history. Fish eye lenses grow throughout their ontogeny, forming multiple sequential layers, or laminae. These laminae represent the chronology of the fish's life, much like tree rings, which record environmental conditions over time.

Comparative study of Chinese herbal enema combined with Mesalazine versus Mesalazine alone in the treatment of ulcerative colitis: A randomized controlled trial.

Background: Mesalazine is a standard treatment for ulcerative colitis (UC). However, it is unclear whether the efficacy of mesalazine combined with traditional Chinese medicine (TCM) enemas is superior to that of mesalazine alone. Therefore, this study aimed to evaluate the clinical effectiveness of TCM enema hydrotherapy combined with mesalazine for active UC.

QSM predicts haemorrhage risk in brainstem cavernous malformations: a multicentre prospective study.

Background: This study investigates the predictive value of baseline quantitative susceptibility mapping (QSM) metrics for assessing the risk of future symptomatic haemorrhages in patients with brainstem cavernous malformations (CMs).

Methods: From July 2020 to September 2023, a prospective multicentre cohort of 155 patients with brainstem CMs was enrolled from 12 institutions. We analysed baseline QSM metrics, including lesional mean, median, IQR and maximum susceptibility.

Ovarian aging at single-cell resolution: Current paradigms and perspectives.

Ovarian failure is a key event in female reproductive aging, resulting in the depletion of follicular reserve and a decline in fertility. In addition, it triggers systemic pathological changes, including osteoporosis and cardiovascular disease, due to decreased estrogen levels. Despite extensive study, mapping senescent ovarian cells is challenging due to the multicellular composition and heterogeneity of the ovary.