Chinese Healthy Eating Index (CHEI) and risk of hypertension: A prospective cohort study in China.

The Chinese Healthy Eating Index (CHEI) is a valuable tool for assessing dietary quality. However, the relationship between CHEI and the risk of hypertension remains unclear. Therefore, a total of 1342 adults without hypertension at baseline and provided at least two survey data from 1997 to 2018 were included.

High-fat diets influence breast cancer progression by modulating CAF-immune cell interactions through PLAT signaling.

Breast cancer progression is profoundly influenced by interactions within the tumor microenvironment, particularly between cancer-associated fibroblasts and immune cells. This study investigated how cancer-associated fibroblasts impact immune cells in the context of high-fat diets, focusing on key genes involved in these interactions. By analyzing breast cancer-related single-cell and bulk RNA sequencing data, we identified candidate genes in cancer-associated fibroblasts that influence immune cell behavior.

Twenty-five-year changes in alcohol environment in US metropolitan areas: Examining patterns by area level sociodemographic characteristics.

Limiting the availability of alcohol is one of the most effective approaches for reducing alcohol misuse and its health consequences. However, few studies have examined the changing trajectories of alcohol environment characterized jointly by on- and off-premises outlets and their sociodemographic disparities. We aimed to (1) explore 25-year profiles of changes in the alcohol environment in urban areas in the U.

Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts.

Locusts are characterized by a large genome size, polyphenism and an X0 sex determination system. Here we generated chromosome-level genomes for both desert and migratory locusts, as well as a comprehensive chromatin map for the latter. We found that genome enlargement is associated with an increased number of enhancers in expanded intronic regions.

Network analysis of proactive health behaviors, parent-adolescent communication, and depressive symptoms among adolescents in China.

Background: Prior research has suggested that depressive symptoms are associated with proactive health behaviors and parent-adolescent communication in adolescents. However, few studies have examined the dynamic interplay among these constructs. This study aimed to explore the complex network relationships among adolescents' proactive health behaviors, parent-adolescent communication, and depressive symptoms.

Latent variable sequence identification for cognitive models with neural network estimators.

Extracting time-varying latent variables from computational cognitive models plays a key role in uncovering the dynamic cognitive processes that drive behaviors. However, existing methods are limited to inferring latent variable sequences in a relatively narrow class of cognitive models. For example, a broad class of relevant cognitive models with intractable likelihood is currently out of reach of standard techniques, based on maximum a posteriori parameter estimation.

Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury.

Dysregulation of cell death plays a critical role in the onset and progression of numerous human diseases. Distinct forms of regulated cell death, such as necroptosis and ferroptosis, have been implicated in the pathogenesis of various conditions, including neurodegenerative disorders and acute kidney injury. Strategies that concurrently target both necroptosis and ferroptosis present significant potential for improving therapeutic outcomes.

Global, regional, and national burden and trends of headache disorders among children and adolescent (5-24 years old) from 1990 to 2021.

Background: Headache disorders are a significant public health concern among children and adolescents, contributing to substantial morbidity. This study assesses the global, regional, and national burden of headache disorders, including migraine and tension-type headache (TTH), from 1990 to 2021 using data from the Global Burden of Disease (GBD) 2021.

Methods: We analyzed the incidence, prevalence, and years lived with disability (YLDs) of headache disorders in individuals aged 5–24 years across 204 countries and territories.

Knowledge, Attitudes and Practices Regarding Venous Thromboembolism Prevention Among Orthopaedic Nurses in Comprehensive Hospitals: A Cross-Sectional Survey.

Aims: This study aimed to investigate the current status of knowledge, attitudes and practices regarding venous thromboembolism (VTE) prevention among orthopaedic nurses in comprehensive hospitals in Yichang, Hubei Province, China, and to analyse influencing factors to provide a reference for implementing VTE prevention strategies.

Methods: From February to March 2024, a total of 257 orthopaedic nurses from nine comprehensive hospitals in Yichang were surveyed using a convenience sampling method and investigated with a knowledge, attitudes and practices questionnaire for VTE prevention. Multiple linear regression analysis was conducted to identify factors influencing knowledge, attitudes and practices regarding VTE prevention among orthopaedic nurses.

Nomogram based on pan-immune-inflammation value to predict short-term prognosis in spontaneous intracerebral hemorrhage.

Introduction: The aim of this study was to investigate the impact of the Pan-Immune-Inflammation Value (PIV) on the prognosis of spontaneous intracerebral hemorrhage (ICH) and to develop and validate a nomogram for identifying patients with a poor prognosis following ICH.

Methods: We retrospectively collected the clinical data of 742 patients with ICH admitted to the Affiliated Hospital of Xuzhou Medical University from September 2018 to March 2024. A modified Rankin Scale score > 3 at 90 days after discharge was defined as a poor short-term prognosis.

Effect of Skin Temperature Management in Winter on the Complications of Expander and Skin Expansion Efficiency in Ear Reconstruction.

Objective: To explore the effect of home skin temperature management in winter on the complications of expander and skin expansion efficiency in ear reconstruction patients.

Methods: A total of 58 patients were involved and divided into control group and experimental group according to the different postoperative nursing methods. The control group was given routine nursing, and the experimental group received additional home hot compress guidance.

Nanoshield Architecture Harnessing Neoantigen-Targeting Peptides Enables Durable Post-surgical Glioma Immunotherapy.

Despite advances in immunotherapy, its efficacy against postoperative glioma recurrence remains limited. Here, we present a neoantigen-targeting peptide nanoshield that synergizes with glioma resection to eliminate residual tumor cells and prevent relapse. The nanoshield architecture is constructed using a multicationic protein (MCP) as the structural scaffold, which is assembled with the mutated isocitrate dehydrogenase 1 (muIDH1) neoantigen.

Network toxicology and molecular docking elucidate the hepatotoxic and carcinogenic mechanisms of potassium sorbate validated by in vitro assays.

Potassium sorbate is a preservative widely used in various industrial products, and its potential toxicity and environmental risks are worthy of further exploration. This study provides a novel elucidation of the ecological toxicity mechanism of potassium sorbate, supported by in vitro cell model validation, thereby offering system-level to molecular-level analysis for the risk assessment and management of food additives. A total of 124 and 106 potential targets for hepatotoxicity and carcinogenicity were identified, respectively, and protein-protein interaction networks and Cytoscape were used to determine the hub genes associated with the toxicity of potassium sorbate.

Central glutathione mitigates obesity-induced social phobia: evidence from human and animal studies.

Objective: To explore the impact of obesity on social phobia and the therapeutic effect of the antioxidant glutathione on this disorder.

Methods: A total of 600 subjects were divided into an Obese Group and a Control Group. Four scales were utilized to determine social phobia, and magnetic resonance spectroscopy was applied to evaluate the central glutathione levels.

LINC00313 functions as an oncogenic propellant and immunosuppressive marker in lung adenocarcinoma.

Background: Despite advances in treatments, the prognosis for lung adenocarcinoma (LUAD) remains poor, underscoring the urgent need to identify novel therapeutic strategies. This study was conducted to investigate the potential role of LINC00313 as a biomarker and therapeutic target for LUAD.

Methods: Databases GEPIA2 and GEO were used to analyze LINC00313 expression and prognosis.

Synthesis and Enantioselective Recognition of Chiral Macrocycles with Abundant Binding Sites.

Chiral macrocycles /-C with abundant recognition sites were synthesized via a simple four-step reaction procedure. These homochiral macrocycles can be easily purified by silica gel column chromatography without the demand for chiral separation. Their structures have been carefully characterized using X-ray crystallography and NMR spectroscopy.

Safety Profiles of Trofinetide in Pediatric Rett Syndrome Population: A Real-World Postmarketing Pharmacovigilance Analysis.

Purpose: Trofinetide, a synthetic analog of glycine-proline-glutamate, is the only approved therapy for Rett syndrome. This study evaluated the safety profile of trofinetide in pediatric patients with Rett syndrome using real-world pharmacovigilance data.

Methods: Adverse event (AE) reports were extracted from the U.

Dominant-negative effects of Weaver syndrome-associated EZH2 variants.

Heterozygous missense mutations in cause Weaver syndrome (WS), a developmental disorder characterized by intellectual disability and overgrowth. encodes the enzymatic subunit of Polycomb repressive complex 2 (PRC2), which mediates monomethylation, dimethylation, and trimethylation of histone H3 lysine 27 (H3K27me1/2/3). Most WS-associated EZH2 variants lack functional characterization but are presumed loss-of-function.

Individualized transcranial direct current stimulation combined with foot core exercise improves foot and ankle sensorimotor function and static postural control in individuals with chronic ankle instability.

Objective: This study aimed to investigate the effects of four-week individualized transcranial direct current stimulation (tDCS) combined with foot core exercise (FCE) on foot and ankle sensorimotor function and postural control in individuals with chronic ankle instability (CAI).

Methods: Thirty-four CAI individuals were randomly assigned to a tDCS combined with FCE group (tDCS group, n = 17) and a sham stimulation combined with FCE group (control group, n = 17). All participants received individualized stimulation combined with FCE and sham stimulation combined with FCE, respectively, three times a week for 20 min per session over four weeks.

Unified Modality Separation: A Vision-Language Framework for Unsupervised Domain Adaptation.

Unsupervised domain adaptation (UDA) enables models trained on a labeled source domain to handle new unlabeled domains. Recently, pre-trained vision-language models (VLMs) have demonstrated promising zero-shot performance by leveraging semantic information to facilitate target tasks. By aligning vision and text embeddings, VLMs have shown notable success in bridging domain gaps.

Design and synthesis of lactam analogs of andrographolide and discovery of their anticancer activity as dual EGFR and VEGFR2 inhibitors.

The diterpene andrographolide, a nature-derived product, exerts a wide range of pharmacological effects, including anti-inflammatory, antiviral, immunostimulatory, and anticancer activities, due to its ability to target multiple pathways. In this study, some andrographolide derivatives of an enlarged decalin structure with a seven-membered ring or an isoxazole-fused decalin structure were designed, synthesized, and evaluated for their activity against cancer cell growth and angiogenesis. Among them, compound AGW-11 (designated as compound 8) showed potent and broad-spectrum anticancer activity and anti-angiogenic activity in vitro.

Anticlustering for sample allocation to minimize batch effects.

High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign samples to balanced batches, minimizing covariate imbalance and supporting user-defined constraints such as batch size, number of batches, and "must-link" assignments. In simulations, anticlustering outperforms existing methods in assigning balanced batches.

HPVPool-Seq: a genotype-guided pooling strategy for cost-effective next-generation sequencing detection of HPV integration in cervical samples.

Unlabelled: Integration of high-risk human papillomavirus (hrHPV) DNA is a critical event in carcinogenesis and a promising biomarker for risk stratification. However, the high cost of next-generation sequencing (NGS) limits its widespread clinical adoption. We developed HPVPool-Seq, an innovative pooling strategy that leverages the inherent diversity of HPV genotypes as natural barcodes, enabling cost-effective, scalable integration detection.

Synthetic biology-driven design and bioproduction of mechanical proteins.

Structural proteins, with exceptional structural versatility and tailored properties, have inspired the design of mechanically robust biomaterials with diverse applications. Nevertheless, the heterologous biosynthesis of high-performance structural proteins faces inherent challenges due to their characteristic high molecular weight, highly repetitive sequences, and intricate folding patterns, frequently leading to reduced production yields, structural defects, and compromised mechanical properties. To overcome these limitations, researchers have adopted various strategies to refine sequence architectures and optimize heterologous expression systems of recombinant structural proteins.

Activation of the stress-activated protein kinase JNK in response to herpes simplex virus-1 infection coordinates transition of BRD4 from chromosome association to transcription elongation.

The c-Jun N-terminal kinase (JNK) signaling pathway is required for herpes simplex virus 1 lytic infection and reactivation from latency. JNK signaling regulates cellular processes in response to stress through transcriptional regulation. However, the mechanisms by which JNK regulates HSV-1 infection are less defined.