Impact of the absence of opioid anesthesia on postoperative outcome indicators: a systematic review and meta-analysis.

Objective: This study aimed to examine the effect of opioid-free anesthesia (OFA) on postoperative outcome indicators and explore its application in thoracoscopic or laparoscopic as well as non-thoracoscopic or laparoscopic surgeries, providing a scientific basis for clinical decision-making.

Method: A systematic search was conducted for clinical studies comparing OFA and opioid-based anesthesia (OBA) published from the establishment of the databases to May 2025 using databases such as PubMed, Web of Science, Embase, and Cochrane Library. The primary outcome was the incidence of postoperative nausea and vomiting (PONV).

Global, regional, and national burden and trends of headache disorders among children and adolescent (5-24 years old) from 1990 to 2021.

Background: Headache disorders are a significant public health concern among children and adolescents, contributing to substantial morbidity. This study assesses the global, regional, and national burden of headache disorders, including migraine and tension-type headache (TTH), from 1990 to 2021 using data from the Global Burden of Disease (GBD) 2021.

Methods: We analyzed the incidence, prevalence, and years lived with disability (YLDs) of headache disorders in individuals aged 5–24 years across 204 countries and territories.

Prognostic value of LncRNA DLGAP1-AS2 in bladder cancer and its regulatory effect on tumor progression.

Background: Bladder cancer (BLCA) represents one of the most prevalent malignant neoplasms within the urinary system, and its incidence is progressively rising annually in China.

Objectives: This research investigated the clinical significance of DLGAP1-AS2, and examined its potential mechanisms in modulating the behavior of BLCA cells.

Methods: This study collected cancerous and normal tissue samples from 86 BLCA patients.

Near-diffraction-limited picosecond laser based on aberration-compensated end-pumped Nd:YAG rod amplifiers with more than 100 MW peak power and 300 W average power.

A high-energy picosecond laser based on high-power diodes end-pumped Nd:YAG rod amplifiers with efficient birefringence compensation was demonstrated. The maximum linearly polarized output power from the amplifiers was up to 302 W at 250 kHz with a pulse energy of 1.2 mJ, achieving a peak power of more than 100 MW.

Global, regional, and national prevalence and trends of gynecological diseases among women of childbearing age from 1990 to 2021: An analysis of the global burden of disease study 2021.

Purpose: The global prevalence and trends of gynecological diseases (GDs) among women of childbearing age (WCBA) remain unclear and may be underestimated. This study aims to evaluate the prevalence of GDs at global, regional, and national levels and assess changes from 1990 to 2021.

Methods: Data on the annual prevalence of major GDs, including uterine fibroids, polycystic ovarian syndrome (PCOS), female infertility, endometriosis, genital prolapse, premenstrual syndrome (PMS), and other GDs, were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.

Clinical Efficacy of a Salicylic Acid-Containing Gel on Acne Management and Skin Barrier Function: A 21-Day Prospective Study.

Background: Acne vulgaris is a common skin condition characterized by excessive sebum production, inflammation, and compromised skin barrier function. Effective treatments should target both lesion reduction and skin hydration while maintaining tolerability.

Objective: This study aimed to evaluate the efficacy and tolerability of a salicylic acid-containing gel in reducing sebum levels, improving skin hydration, strengthening the skin barrier, and alleviating acne severity over 21 days.

BCMA-targeted CAR T cell therapy can effectively induce disease remission in refractory lupus nephritis.

Objectives: This study aims to evaluate the safety and efficacy of anti-B cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells in treating refractory lupus nephritis (LN).

Methods: This is an open-label, single-arm clinical trial assessing anti-BCMA CAR T cells in treating refractory LN patients. CAR T cells were infused following lymphodepletion therapy with cyclophosphamide and fludarabine.

Effects of a Ceramide-Containing Glycinate-Based Cleanser on the Condition of Oily Skin and Skin Post-IPL Treatments.

Background: Currently, many studies are exploring the effects of cleansers containing petrolatum and fatty acids on skin condition, but no research has yet investigated the impact of cleansers containing ceramides on skin condition.

Aims: Therefore, this study aims to explore whether a ceramide-containing glycinate-based cleanser can improve the skin conditions of oily skin and skin post-intense pulsed light (IPL) treatments, with a particular focus on the skin barrier.

Methods: In this study, 88 volunteers were recruited and divided into two groups.

Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis.

Colorectal cancer pathogenesis is a multifactorial process, with genetic factors playing a significant role in cancer development. A review of published meta-analyses on MTHFR gene polymorphisms and colorectal cancer susceptibility showed inconsistent findings and failed to assess the reliability of statistically significant results. Case-control studies were manually searched in databases to investigate the association between MTHFR gene polymorphisms and colorectal cancer.

Global burden and trend of tuberculosis in children and adolescents (under 15 years old) from 1990 to 2021, with projections to 2040.

Background: Tuberculosis (TB) remains a significant global health issue, but its burden among children and adolescents under 15 years old is not well quantified. This study evaluates TB trends in this age group from 1990 to 2021 and projects future trends through 2040.

Methods: We used data from the Global Burden of Disease Study (GBD) 2021 to assess the incidence and mortality of TB in children and adolescents (under 15) from 1990 to 2021.

Global burden and trend of stroke attributable to metabolic risks among young adults (20-39 years old) from 1990 to 2021.

Objectives: Stroke is increasingly affecting young adults, with metabolic-risk factors playing a critical role in this trend. This study aims to assess the global burden and trends of stroke and its subtypes attributable to metabolic-risks in young adults from 1990 to 2021.

Methods: Data from the Global Burden of Disease Study (GBD) 2021 were analyzed to assess the disability-adjusted life years (DALYs) attributed to metabolic-risks for stroke and its subtypes in young adults across 204 countries and territories.

Controlling Crystallization of Aqueous-Processed Planar Perovskite Films via Sodium Dodecyl Sulfonate Surfactant Modulation.

Solution processing represents a widely adopted methodology for perovskite solar cell (PSC) fabrication. Nevertheless, the prevalent use of toxic solvents and anti-solvents in conventional approaches presents significant challenges for PSC commercialization. Water, as an environmentally benign solvent with exceptional Pb(NO) solubility, offers a promising alternative for perovskite film preparation.

Knowledge, Attitude and Practice Concerning Central Line-Associated Bloodstream Infection Prevention Among ICU Nurses in China: A Multicenter, Cross-Sectional Study.

Background: Globally, there has been a general decline in the occurrence of central line-associated bloodstream infection (CLABSI). Still, CLABSI remains a common healthcare-associated infection in the ICUs of hospitals in developing countries.

Aim: The aim of the study was to assess knowledge, attitude and practice among ICU nurses in China concerning CLABSI prevention.

Nanomotor-driven precision therapy for peritoneal metastasis.

Peritoneal metastasis (PM) is a terminal stage of gastrointestinal cancers, often resulting in poor survival outcomes. Traditional treatments like cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown some effectiveness but are associated with significant risks. This study presents a novel nanomotor-based drug delivery system (M@MnO-Au-mSiO@CDDP) designed to enhance the efficacy of PM treatment.

Development and validation of a disulfidptosis-related genes signature for predicting outcomes and immunotherapy in acute myeloid leukemia.

Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor outcomes and high recurrence. Disulfidptosis, a novel form of programmed cell death driven by aberrant disulfide bonds and F-actin collapse, provides insights into cancer progression and treatment.

Methods: We investigated the correlation network and prognostic values of disulfidptosis-related genes (DRGs) in AML.

A Droplet-Based Electricity Nanogenerator with Press-Release Structure for Revealing the Coupling of Displacement and Conducting Currents.

Contact electrification (CE) and electrostatic induction (EI) are believed to be the core processes in classic liquid-solid triboelectric nanogenerators (L-S TENGs), including the classical transistor-like droplet-based electricity generator (DEG) and other forms of DEGs. Recently reported total current DEGs made full use of CE, EI, and charge transfer (CT) effects and realized the coupling of displacement and conducting currents. However, this method has only been revealed in special structures, which have limitations depending on the falling location of droplets.

Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review.

High-grade myofibroblastic sarcoma (HGMS) is exceedingly rare and highly aggressive, with a poor prognosis. Currently, there is no consensus on its definition. Wide resection is the standard of care for most patients, but clinical data on treatment outcomes remain limited.

The Association between PTPN22 SNPs and susceptibility to type 1 diabetes: An updated meta-analysis.

Type 1 diabetes (T1D) is a significant global health concern, characterized by the autoimmune destruction of insulin-producing pancreatic β-cells, resulting in lifelong dependence on insulin therapy. Although genetic predisposition plays a crucial role in the pathogenesis of T1D, environmental factors also contribute to its onset and progression. Recent research has identified a number of genetic polymorphisms, particularly in the protein tyrosine phosphatase non-receptor 22 gene (PTPN22), that are strongly associated with an increased risk of T1D and may serve as potential biomarkers for early diagnosis and prevention.

Four new phenolic compounds from stems and leaves of (Daylily).

Four new phenolic compounds, hemerodiphenylethanes A-D (), along with eight known compounds methyl 2,4-dihydroxy-6-[2-(4-hydroxyphenyl) ethyl] benzoate (), methyl 2,4-dihydroxy-6-(4-hydroxyphenethyl)-3-methylbenzoate (), neochlorogenic acid (), isoquercetin (), isorhamnetin-3-O-β-D-galactoside (), velutin (), rutin (), and (+)-syringaresinol (), were isolated from the stems and leaves of Baroni (Daylily). Their structures were elucidated based on HR-ESI-MS, 1D- and 2D-NMR spectra, and ECD calculations. Among them, both compounds and were isolated from the genus , and compounds and were isolated from this plant species for the first time.

Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases.

The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated with a risk of acute myeloid leukemia (AML) transformation. However, the chronic nature of disease transformation complicates longitudinal high-throughput sequencing studies of patients with PV before and after AML transformation.

Modified carboxylate cellulose nanofibers/graphene composite as triboelectric and conducting electrode in single electrode triboelectric nanogenerator with superior acid/alkali resistance.

Single-electrode triboelectric nanogenerator (SE-TENG) is essentially useful when only one triboelectric electrode can connect to external load. Conventional metal electrodes are susceptible to corrosion in open environments characterized by high humidity and acidic or alkaline conditions. Thus, the material used for the triboelectric layer must exhibit robust resistance to environmental acids and alkalis.

Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer.

Background: Prostate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response. Histone modifications play key roles in tumor progression and treatment resistance, but their regulatory effects in PCa remain poorly understood.

Methods: We utilized integrative multi-omics analysis and machine learning to explore histone modification-driven heterogeneity in PCa.

Evidence-Based Practice in Maintenance of Central Venous Catheters Among Intensive Care Unit Nurses: A Cross-Sectional Multi-Center Study.

Aims And Objectives: To investigate evidence-based practices and examine rates of adherence to bundles on maintenance of central venous catheters among intensive care unit nurses in 22 selected hospitals.

Background: Although there has been an overwhelming increase in the use of evidence-based practices to reduce Central Line-Associated Bloodstream Infections, also known as bundles, there continues to be a considerable gap between clinical practice and evidence.

Design: This study employs a multi-center cross-sectional design.