Variation characteristics and driving factors of vegetation coverage in Longquan Urban Forest Park, Chengdu, China.

Urban forest parks play a pivotal role in maintaining urban ecological security. The dynamics in fractional vegetation coverage (FVC) are key indicators for evaluating their ecological restoration effectiveness and sustainable management. Based on normalized difference vegetation index data of Chengdu Longquan Mountain Urban Forest Park from Landsat satellites spanning from 1993 to 2023, we used a comprehensive suite of analytical methods including Theil-Sen median slope estimation, Median-Kendall trend tests, additive seasonal and trend breakpoint detection, and the optimal partial geo-detector model (OPGD) to analyze both linear and nonlinear spatiotemporal variations of FVC within the park as well as driving factors.

Unraveling the co-catalytic mechanism in Fenton-like reaction with diatomic Fe/Mo catalysts: Accelerating the Fe(Ⅱ)/Fe(Ⅲ) conversion and PAA efficient activation.

This study attempts to address the technical challenge of poor valence cycling and low activation efficiency of Fe-based catalysts in peracetic acid (PAA)-based advanced oxidation processes (AOPs) for organic micropollutant treatment. The successful synthesis of the Mo doped Fe-based catalyst (FeMo@CN) achieved efficient PAA activation and rapid degradation of organic micropollutants. Mechanistic studies showed that both radical pathway (•OH and CHCOOO•) and non-radical pathway (O) synergistically contributed to bisphenol A (BPA) degradation.

O-GlcNAcylation-dependent liquid-liquid phase separation regulates the nuclear translocation of YAP to exacerbate vascular neointimal hyperplasia.

Suppressing the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs), key pathological features of vascular neointimal hyperplasia (NIH), is an effective strategy for treating vascular insufficiency disorders caused by intimal remodeling. Increasing evidence suggests that Yes-associated protein (YAP) contributes to the abnormal proliferation and migration of VSMCs. However, the mechanisms by which YAP leads to NIH are poorly understood.

Discoidin, CUB and LCCL domain containing 2 modulates angiogenesis by inhibiting VEGF receptor 2 endocytosis in endothelial cells.

The internalization of vascular endothelial growth factor receptor-2 (VEGFR-2) occurs in response to VEGF treatment, and it is eventually transported to the plasma membrane by several endosomes such as Rab5 and Rab11, which are responsible for transporting vesicles from the cytoplasm to plasma membrane. Therefore, the homeostasis of VEGFR-2 internalization and recycling is critical for maintaining the normality of the VEGF signaling pathway and regulates angiogenesis. Previous studies have shown that discoidin, CUB and LCCL domain containing 2 (DCBLD2) can promote the proliferation and migration of vascular endothelial cells (ECs) by promoting the VEGF signaling pathway, but the potential role of DCBLD2 on VEGFR-2 endocytosis remains unclear.

Healthy sleep patterns and risk of incident cardiovascular disease, liver-related events, and all-cause mortality among individuals with metabolic dysfunction--associated steatotic liver disease: A large prospective cohort study.

Objectives: This study aimed to investigate the association between overall healthy sleep patterns and cardiovascular disease, liver-related events, and all-cause mortality among individuals with metabolic dysfunction--associated steatotic liver disease.

Methods: This cohort study included 123,228 participants with metabolic dysfunction--associated steatotic liver disease from the UK Biobank, who had detailed sleep assessment at baseline. The healthy sleep pattern was constructed by a composite healthy sleep score that incorporated different sleep behaviors.

Breaking the Efficiency-Stability-Sustainability Trilemma in all-perovskite Tandem Solar Modules via Oxidative Blockchain Molecular Engineering.

Narrow-bandgap (NBG) tin-lead (Sn-Pb) perovskites are vital for all-perovskite tandem solar modules (TSMs), yet their commercialization remains limited by challenges in balancing efficiency, stability, and sustainability. Here, we presented an oxidation-triggered blockchain molecular (BCM) interface engineering strategy, which modified the poly (3,4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) surface and constructed a dynamic functional layer at the buried PEDOT:PSS/Sn-Pb perovskite interface through synergistic effects of biocompatible rutin molecules and their oxidation derivatives. This approach enabled full-cycle optimization from film formation to operational longevity via sequential regulation of crystallization and carrier dynamics, along with persistent defect passivation through synergistic coordination and hydrogen bonding.

Prognostic value of LncRNA DLGAP1-AS2 in bladder cancer and its regulatory effect on tumor progression.

Background: Bladder cancer (BLCA) represents one of the most prevalent malignant neoplasms within the urinary system, and its incidence is progressively rising annually in China.

Objectives: This research investigated the clinical significance of DLGAP1-AS2, and examined its potential mechanisms in modulating the behavior of BLCA cells.

Methods: This study collected cancerous and normal tissue samples from 86 BLCA patients.

Unveiling the UHR threshold in American adult: a new biomarker for early diabetes detection from NHANES study.

Background And Aims: This study examines the association between the serum uric acid high-density lipoprotein cholesterol ratio (UHR) biomarker and the risk of prediabetes and diabetes, a relationship that remains under-researched, to provide insights for diabetes prevention.

Methods And Results: This study utilized data from 13,975 American participants in the National Health and Nutrition Examination Survey (2011-2018). Logistic regression models, restricted cubic splines (RCS) analysis and subgroup analyses were employed to examine the association between UHR and prediabetes/diabetes.

Auditory object representation in the bat hippocampus.

Cognitive maps enable the flexible selection of navigation paths. Acoustic cognitive maps, constructed from the spatial layout of sonar auditory objects, support bat navigation in natural settings; however, the neural building blocks of acoustic maps remain unknown. Here, we demonstrate auditory object representation in the hippocampus of echolocating bats and test the hypothesis that active tracking drives hippocampal auditory object representation.

A Spatiotemporal Causal Model for Revealing Developmental Changes in Infants' Brain Effective Connectivity Networks During the First Year of Life.

Objective: The infant's brain undergoes significant structural and physiological transformations during the first year of life. Although extensive research has explored brain development during this critical period, most studies relied on traditional functional connectivity rather than effective connectivity (EC).

Methods: We proposed a novel spatiotemporal Granger causality model for discovering causal relationships from time series.

Licochalcone A inhibits glioma migration, invasion, and growth by triggering mitochondrial dysfunction and ROS-mediated oxidative damage.

Glioma is a common malignant tumor in nervous system, but the treatment efficacy is still unsatisfactory. Licochalcone A (Lic-A) is a kind of flavonoid isolated from glycyrrhiza and shows anti-tumor effect. This study aimed to investigate anti-tumor efficacy of Lic-A on glioma using both in vivo and in vitro models.

Cardiomyoprotective effect of Tanshinone IIA in diabetic cardiomyopathy achieved through enhancing PINK1-Parkin dependent mitophagy.

This study aimed to explore the beneficial effects and underlying protection mechanism of Tanshinone IIA (TSIIA) in diabetic cardiomyopathy (DCM) from the perspectives of mitophagy and mitochondrial integrity. Here, we found that TSIIA significantly increased STZ-induced body weight (L-TSIIA, 299.5 vs.

Research Progress in Bleeding Risk Assessment of Non-Vitamin K Antagonist Oral Anticoagulant in Atrial Fibrillation.

The introduction of non-vitamin K antagonist oral anticoagulant (NOAC) into clinical use heralds a new age for anticoagulation therapy in patients with atrial fibrillation (AF).However,anticoagulation-related bleeding is currently a major challenge in the anticoagulation process.Assessing the risk of anticoagulation-related bleeding is an important part for the management of patients with AF.

Methacrylated Carrageenan/Gelatin Interpenetrating Network Microspheres Loaded with Targeted Drugs and combined with PD-L1 Inhibitors for Hepatocellular Carcinoma Treatment.

Hepatocellular carcinoma (HCC) is a highly fatal malignant tumor. The clinical outcomes of vascular interventional therapy for HCC based on existing drug-eluting microspheres remain unsatisfactory. This study adopted a unique fabrication method to synthesize methacrylated carrageenan/gelatin hydrogel embolic microspheres (MCGs).

Evaluation of precursor MicroRNA (pre-miRNA) as a powerful tool for robust CHO production cell line platform development.

Chinese hamster ovary (CHO) cells are the most widely used host for the commercial production of recombinant therapeutic proteins. The rapidly growing demand for large quantities of biologics at controllable cost-of-goods requires continuous cell engineering and process optimization of the CHO host cells. MicroRNAs (miRNAs) have been shown to enhance recombinant protein production in CHO cells.

Hsa_circ_0007991 Promotes Immune Evasion in Hepatocellular Carcinoma via Regulation of the miR-505-3p/CANX Axis.

Objective: This study aimed to investigate the expression and functional role of hsa_circ_0007991 in hepatocellular carcinoma (HCC).

Methods: RNA expression data of HCC and corresponding non-tumor liver tissues were obtained from the GEO database, and differential expression analysis was conducted to identify significantly dysregulated circRNAs. A total of 68 clinical samples from HCC patients were collected, and hsa_circ_0007991 level was quantified using RT-qPCR.

LNP-enclosed NamiRNA inhibits pancreatic cancer proliferation and migration via dual pathways.

Background: Pancreatic cancer is a highly aggressive malignancy characterized by limited treatment options, poor prognosis, and high mortality rates. nuclear activating miRNA (NamiRNA) enhances gene expression by interacting with nuclear enhancers, offering a novel avenue for understanding gene regulation in cancer. This study explores the dual role of mir-200c in regulating tumor proliferation and migration in pancreatic cancer, with the aim of identifying potential therapeutic strategies.

A carbon-nanotube-based electron source with a 0.3-eV energy spread and an unconventional time delay.

Conventional metal-tip-based laser-driven electron sources are normally constrained by a trade-off between energy spread and pulse width due to optical-field-induced free electron acceleration. This makes it challenging to surpass the current state-of-the-art, which exhibits energy spreads exceeding 1 eV and pulse durations of hundreds of femtoseconds. Here we report an unconventional delayed emission from a one-dimensional carbon-nanotube-based electron source.

Engineered NIR-Responsive Exosomes for Synergistic Photoimmunotherapy of Hepatocellular Carcinoma.

T-cell immunotherapy holds tremendous promise for treating various types of cancer by boosting the infiltration and activity of T cells within tumor tissues. However, efficient recruitment of peripheral T cells to the tumor microenvironment (TME) remains a major clinical challenge. To address this limitation, here, we report an exosomal (EXO) immunotherapy for remodeling the immunosuppressive TME of hepatocellular carcinoma (HCC) into an immunosupportive state in a remotely controllable manner, for which the HCC-secreted exosomes are engineered with CXCL9 chemokine and cypate photothermal transducers (cypate@EXO-CXCL9).

Engineering Separated Dual O Reduction Cores into One Polymer Framework for Boosting Hydrogen Peroxide Production.

Photocatalytic hydrogen peroxide (HO) production through the oxygen reduction reaction (ORR) pathway has emerged as a promising sustainable alternative. However, a significant challenge in this field lies in the development of highly efficient photocatalysts capable of achieving high-concentration HO production. Here the rational design of two O reduction cores into one polymer framework is showcased for synergistically facilitating HO production via the "self-marketing & cooperation" strategy.

PubMed knowledge graph 2.0: Connecting papers, patents, and clinical trials in biomedical science.

Papers, patents, and clinical trials are essential scientific resources in biomedicine, crucial for knowledge sharing and dissemination. However, these documents are often stored in disparate databases with varying management standards and data formats, making it challenging to form systematic and fine-grained connections among them. To address this issue, we construct PKG 2.

Recombinant Chitinase 3-like 1 Alleviates Liver Transplantation-induced Cold Ischemia/Reperfusion Injury by Promoting M2 Polarization of Kupffer Cells.

Background: Hepatic cold ischemia/reperfusion injury (IRI) significantly restricts graft utilization and adversely affects the prognosis of liver transplantation recipients. The overactivation of Kupffer cells (KCs) is recognized as a significant cellular response in hepatic IRI. This study aimed to investigate the potential of recombinant chitinase 3-like 1 (rCHI3L1) to regulate M2 polarization of KCs and alleviate hepatic cold IRI.