Clinical Evidence of Acupoint Stimulation for Primary Dysmenorrhea: A Systematic Review and Updated Meta-Analysis.

Purpose: Meridian-based acupoint stimulation is increasingly used for primary dysmenorrhea (PD), yet its evidence remains inconsistent. This systematic review aims to evaluate efficacy and safety of both invasive and noninvasive acupoint stimulation for PD through analysis of randomized controlled trials (RCTs).

Methods: The PROSPERO registration number is CRD42024586857.

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy.

Despite the success of autologous chimeric antigen receptor (CAR)-T cell therapy, achieving persistence and avoiding rejection in allogeneic settings remains challenging. We showed that signal peptide peptidase-like 3 (SPPL3) deletion enabled glycan-mediated immune evasion in primary T cells. SPPL3 deletion modified glycan profiles on T cells, restricted ligand accessibility, and reduced allogeneic immunity without compromising the functionality of anti-CD19 CAR molecules.

Histone H3 lysine 18 lactylation attenuates neuroinflammation and neurological damage by regulating microglial plxnb2 after ischemic stroke.

Microglia are major resident immune cells in the central nervous system and are actively involved in the pathogenesis of ischemic stroke. Histone lactylation confers macrophage homeostatic gene expressions and regulates physiological and immune-related pathological conditions. However, the spatiotemporal expression and functional role of histone lactylation in microglial reprogramming and neurological injuries after ischemic stroke remain elusive.

Pulse pressure after thrombectomy predicts functional outcomes and mortality in acute ischemic stroke with large artery occlusion.

Post-procedure blood pressure (BP) strongly influences the prognosis of ischemic stroke patients with large vessel occlusion. However, no consensus or guidelines currently exist regarding BP targets and management after endovascular thrombectomy (EVT). Although several recent clinical trials have investigated BP management after EVT, their conclusions were inconsistent and contradictory.

Nomogram Model for Predicting Risk of Postoperative Delirium in Adult Liver Transplant Patients: A Retrospective Study.

Background: Postoperative delirium is a common and serious complication following liver transplantation, early identification of high-risk patients is crucial for implementing preventive strategies and improving clinical outcomes.

Objective: To develop and validate a prediction model for postoperative delirium (POD) in adult liver transplant patients using preoperative baseline characteristics, intraoperative factors and postoperative parameters available within 24 hours after surgery. The model aims to assess the risk of POD and provide early identification of high-risk patients.

The Role of the Subnucleus Reticularis Dorsalis (SRD) in Pain Modulation: A Literature Review.

The subnucleus reticularis dorsalis (SRD), also known as the dorsal reticular nucleus (DRt) or dorsal medullary reticular nucleus (MdD), which resides at the caudal end of the medulla, plays a pivotal role in regulating pain perception. Despite extensive research efforts to unravel its mechanisms, the operational intricacies of SRD remain poorly understood. Advances in experimental methodologies such as brain imaging and chemogenetics have facilitated deeper investigations into the involvement of SRD in various pain disorders.

Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants.

Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain are used to treat and prevent COVID-19. However, the rapid evolution of SARS-CoV-2 drives continuous escape from therapeutic mAbs. Therefore, the ability to identify broadly neutralizing antibodies (bnAbs) to future variants is needed.

Subnational trend and driving factors for pancreatic cancer burden in China, 1990-2021: an analysis based on the Global Burden of Disease Study 2021.

Background: The mortality of pancreatic cancer in China showed an increasing trend between 2005 and 2020, with significant discrepancies in the burden of pancreatic cancer in provinces.

Methods: We analyzed numbers of death, incidence, disability-adjusted life years (DALY) and corresponding age-standardized rates for pancreatic cancer in China using data from the Global Burden of Disease Study 2021. We conducted trend analysis in pancreatic cancer burden over time by age group and gender.

[Mechanisms by Which Paraventricular Hypothalamic Nucleus Participates in the Acupuncture Treatment of Diseases].

In recent years, a growing body of research has demonstrated that acupuncture can be used to effectively treat a diverse range of diseases, including functional gastrointestinal disorders, cardiovascular diseases, as well as anxiety and depression, through the modulation of the paraventricular hypothalamic nucleus (PVN). Acupuncture may exert its therapeutic effect either by modulating specific neurons within the PVN, such as corticotropin releasing hormone (CRH) neurons, or by regulating the release of hormones, such as oxytocin (OXT) and vasopressin (VP), and the activity of neural circuits associated with the PVN. This review summarizes the mechanisms by which PVN is involved in acupuncture treatment, including its regulatory mechanisms in gastrointestinal diseases, cardiovascular diseases, and negative emotions and pain.

AaHR78 mediates the effects of 20E on growth and reproduction in Aedes aegypti.

Nuclear receptors are critical components of various physiological pathways, significantly influencing insect signal transduction. Although the role of HR78 in tracheal and nervous system development has been well-studied, its function during transformation and reproduction remains underexplored. This study characterizes the nuclear receptor gene AaHR78 in Aedes aegypti, which possesses distinct sequence features, including a DNA-binding domain and a ligand-binding domain.

Risk Factors Involved in the Blood (Leukocyte-Depleted Suspended Red Blood Cells and Plasma) Transfusion During Glioma Operations.

Background: The use of blood transfusion in surgery is increasing, and the blood supply is getting tighter. The number of glioma surgeries is increasing year by year, and reports of studies on blood transfusion in glioma surgery are relatively rare.

Purpose: To investigate the risk factors for intraoperative blood (leukocyte-depleted suspended red blood cells and plasma) transfusion in glioma patients.

Analysis of Midgut Bacterial Communities in Larvae and Adult Mosquitoes of Invaded by Three Different Microorganisms.

The midgut microbiota of is crucial for the mosquito's development, nutrition, and immunity. However, its communities are also distinctively influenced by the colonization of different microorganisms, influencing its susceptibility to pathogens and transmission capacity. In this study, we investigated the effects of infections with , , and on the midgut microbial composition of .

The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction.

Background: Heart failure poses a huge burden on the global population, and approximately 50% cases have reduced ejection fraction, namely, heart failure with reduced ejection fraction (HFrEF). The research was supposed to explore the relationship between serum hsa-miR-21-5p expression and the severity/prognosis of HFrEF.

Methods: A retrospective analysis was conducted on 105 HFrEF patients and 86 healthy volunteers.

miR-11903a modulates CLIPB9-mediated pathogen defense and longevity in Aedes aegypti.

Arthropod melanization is a crucial defense mechanism mediated by a complex cascade of CLIP domain serine proteases (CLIPs). In this study, it was confirmed that microRNA-11903a (miR-11903a) targets Aedes-CLIPB9 (AeCLIPB9) by bioinformatics prediction and dual-luciferase reporter assays. Following intrathoracic injection of miR-11903a agomir and antagomir, Real-time quantitative polymerase chain reaction confirmed that AeCLIPB9 is negatively regulated by miR-11903a.

Loss of chemerin prevents ovariectomy-induced osteoporosis in mice through intraosseous vascular remodeling.

Chemerin, an adipocyte-secreted adipokine, can regulate bone resorption and bone formation and is a promising therapy for postmenopausal osteoporosis. However, the effect of endogenous chemerin on intraosseous vascular remodeling in postmenopausal osteoporosis remains unclear. In this study, we investigated the effect of chemerin on osteogenesis formation and intraosseous vascular remodeling in ovariectomized Rarres2 knockout (Rarres2) mice.

Burden of melanoma in China and its provinces from 1990 to 2021: an analysis for the Global Burden of Disease Study 2021.

Background: The incidence of melanoma in China has been increasing over the past few decades. This study aimed to investigate the burden of melanoma at both national and subnational level in China, where the population is rapidly aging.

Methods: The annual melanoma data from 1990 to 2021 was collected from the Global Burden of Disease (GBD) 2021 China subnational study.

Acupuncture Treats Sepsis through Immune Modulation and Organ Protection.

Sepsis is a secondary condition resulting from severe systemic infections. It is a significant contributor to mortality in critically ill patients with rapid onset and severe symptoms. Acupuncture is a traditional Chinese medical treatment.

Anti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.

Ethnopharmacological Relevance: The seeds of Hovenia acerba water extract (HAW) are used as an edible traditional Chinese medicine to treat diseases related to hyperuricemia (HUA).

Aim Of The Study: To evaluate HAW for its anti-HUA effect and to figure out their underlying mechanisms.

Materials And Methods: The anti-HUA effects were evaluated on a mouse model by testing HAW's effects on the levels of serum uric acid (SUA), the biochemical indicators of liver and kidney function, and the histology of liver and kidney.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1.

The continuous evolution of SARS-CoV-2, particularly the emergence of the BA.2.86/JN.