[Role of minocycline-loaded silica nanospheres in the regulation of periodontitis inflammation in rats].

Purpose: To investigate the effect of minocycline hydrochloride(MH) loaded nano-silica microspheres(MSNion) on the inflammatory regulation of periodontitis in rats.

Methods: Mesoporous silica(MSN) was prepared by classical St?ber method and MSNion was obtained by doping hydroxyapatite. MH was loaded into MSNion by magnetic stirring, and chitosan (COS), which had anti-inflammatory and antibacterial effect, was adsorbed on its surface by using charge interactions, forming MH@MSNion@COS microspheres.

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy.

Despite the success of autologous chimeric antigen receptor (CAR)-T cell therapy, achieving persistence and avoiding rejection in allogeneic settings remains challenging. We showed that signal peptide peptidase-like 3 (SPPL3) deletion enabled glycan-mediated immune evasion in primary T cells. SPPL3 deletion modified glycan profiles on T cells, restricted ligand accessibility, and reduced allogeneic immunity without compromising the functionality of anti-CD19 CAR molecules.

Research and application of an evaluation mechanism for enterprise information systems.

This research focuses on the challenges in implementing and operating enterprise information systems, mainly the construction barriers and unclear value demonstration. From an intelligent data-driven perspective, a comprehensive evaluation mechanism was designed based on a multi-dimensional index system covering planning, construction, operation, and effectiveness, using an improved normal cloud model to evaluate the application quality and practical effects of information systems. By selecting 150 representative information systems across multiple industries such as tobacco, healthcare, and finance, collecting 31,500 pieces of evaluation data, and conducting comparative analysis experiments, the results show that the evaluation results of this mechanism are accurate and highly consistent with objective reality.

The Decision-Making Experience of Self-Management Behaviors in Home Peritoneal Dialysis for Patients with Diabetic Nephropathy: A Qualitative Study Using the Theory of Planned Behavior.

Purpose: Self-management among diabetic kidney disease(DKD) patients receiving home peritoneal dialysis(PD) remains a significant challenge, warranting further exploration. In this study, the Theory of Planned Behavior (TPB) was used to clarify patients' decision-making processes and understand the reasons for adhering to and changing behaviors.

Methods: Semi-structured interviews were conducted with 16 DKD patients who were undergoing follow-up and receiving home PD.

Exploring the influence of urban green space and urban morphology on urban heat Islands using street view and satellite imagery.

Urban green spaces are essential for regulating land surface temperature (LST), but current research frequently neglects their structural complexity and perceived accessibility by humans. To bridge this gap, our study utilizes two complimentary metrics: the satellite-derived Normalized Difference Vegetation Index (NDVI) and the street-level Green View Index (GVI), both employed to assess Guangzhou's urban thermal environment. Distinct statistical and spatial distribution patterns of NDVI and GVI were identified among districts in Guangzhou, China.

Electrification of wind-blown microplastics and its implication for transport of floating microplastics in air.

An ongoing debate exists on the magnitude of microplastics (MPs) emissions from the soil-air interface. Electrification of airborne microplastics MPs complicated the issue of modelling the transport of MPs by wind. Here, we first report new observations of wind-blown MP particles pronounced charged through wind tunnel experiments.

Cationic Cyclodextrin Loaded Photosensitizer Ce6 for the Treatment of Periodontitis.

Periodontitis is a bacterial infectious disease. Photodynamic therapy (PDT) offers high selectivity, drug-resistance-free treatment, and immune regulation. The second-generation porphyrin photosensitizer Ce6 excels in reactive oxygen species (ROS) production.

Innovations in modern low-LET radiotherapy regimens for locally advanced non-small cell lung cancer: a meta-analysis and systematic review of high-dose-rate brachytherapy, stereotactic body radiotherapy, and hypofractionated proton therapy.

Background: This study assesses recent treatments for locally advanced non-small cell lung cancer (LA-NSCLC) ineligible for surgery, comparing high-dose-rate (HDR) brachytherapy with conventional low linear energy transfer (LET) hypofractionated radiotherapy methods.

Methods: From 9435 papers, 8 meeting criteria were selected, covering 484 LA-NSCLC patients (2005-2019). Analysis focused on comparing outcomes, exploring biologically effective doses (BED), and examining toxicities.

Precise Control of Lead Halide and Ammonium Salt Stoichiometric Ratios for Efficient Perovskite Solar Cells.

The precise stoichiometric ratio of lead halide and organic ammonium salts is a fundamental yet unresolved scientific challenge in perovskite solar cells (PSCs). Conventional deposition techniques fail to establish a definitive structure-performance relationship due to limitations in quantitative control, leading to inconsistent film quality and ambiguous reaction pathways. In this work, a precise quantitative deposition approach using drop-on-demand inkjet printing to systematically investigate the impact of organic salt deposition surface density on PSC performance is developed.

Ammonia volatilization and nitrous oxide emission and their responses to environmental indicators under different irrigation levels and nitrogen fertilizer synergists.

Nitrous oxide (NO) and ammonia (NH) emission are the main pathways for gaseous nitrogen loss, which decrease fertilizer utilization while increasing environmental risks. The present research aimed to examine (1) the effect of irrigation amounts and nitrogen fertilizer synergist types on the emissions of NH and NO from winter wheat field in Guanzhong Plain of China; and (2) the responses of them to soil environmental indicators. The study included two irrigation levels: low irrigation (W1) and high irrigation (W2), and four types of nitrogen fertilizer synergist: urease inhibitor (UI), nitrification inhibitor (NI), dual-acting inhibitor (DI), no N synergist (only urea, U), and no nitrogen application (N0).

Ultrathin polymer membrane for improved hole extraction and ion blocking in perovskite solar cells.

Highly efficient perovskite solar cells (PSCs) in the n-i-p structure have demonstrated limited operational lifetimes, primarily due to the layer-to-layer ion diffusion in the perovskite/doped hole-transport layer (HTL) heterojunction, leading to conductivity drop in HTL and component loss in perovskite. Herein, we introduce an ultrathin (~7 nm) p-type polymeric interlayer (D18) with excellent ion-blocking ability between perovskite and HTL to address these issues. The ultrathin D18 interlayer effectively inhibits the layer-to-layer diffusion of lithium, methylammonium, formamidium, and iodide ions.

Ameliorating Oxidative Stress-Aggravated Adipose Tissue Senescence by Sesamol in Aged Obese Mice via Nrf2/p38MAPK Signaling.

Adipocyte senescence is one of the major common features correlated with aging, which can also lead to obesity, and aggravated oxidative stress contributes to cell senescence. Sesamol, a lignan from plants found in sesame, has been proven to alleviate obesity. However, the effects and mechanisms of sesamol on adipose tissue senescence remain unclear.

Surface reconstruction of wide-bandgap perovskites enables efficient perovskite/silicon tandem solar cells.

Wide-bandgap perovskite solar cells (WBG-PSCs) are critical for developing perovskite/silicon tandem solar cells. The defect-rich surface of WBG-PSCs will lead to severe interfacial carrier loss and phase segregation, deteriorating the device's performance. Herein, we develop a surface reconstruction method by removing the defect-rich crystal surface by nano-polishing and then passivating the newly exposed high-crystallinity surface.

Navigating the Adoption Maze: Evolutionary Dynamics of Stakeholder Behavior in AI-Driven Elderly Care Solutions.

In the face of a rapidly aging population and the increasing demand for elderly care, the adoption of artificial intelligence (AI) in healthcare products has emerged as a promising solution to enhance service delivery. This paper investigates the behavioral evolution of multiple stakeholders-namely, government entities, AI healthcare enterprises, and medical professionals-in the adoption process of AI-enabled elderly care products. By employing an evolutionary game theory model, we analyze the stability strategies of these stakeholders under varying initial conditions.

Sesamol Alleviated Lipotoxicity-Induced Dysfunction in MIN6 Cells via Facilitating Cellular Senescence Caused by Endoplasmic Reticulum Stress.

Obesity is found to be a significant risk factor for type 2 diabetes mellitus (T2DM), attributed to lipotoxicity-induced β-cell dysfunction. However, the specific mechanism involved in the process remains incompletely unclarified. The current study demonstrated lipotoxicity resulted in the activation of ER stress, which increased the protein level of TXNIP, thereby inducing senescence-assiciated dysfunction in MIN6 cells under high fat environment.

Cross-Linkable Fullerene Electron Transport Layer with Internal Encapsulation Capability for Efficient and Stable Inverted Perovskite Solar Cells.

A stable and compact fullerene electron transport layer (ETL) is crucial for high-performance inverted perovskite solar cells (PSCs). However, traditional fullerene-based ETLs like C and PCBM are prone to aggregate under operational conditions, a challenge recently recognized by academic and industrial researchers. Here, we designed and synthesized a novel cross-linkable fullerene molecule, bis((3-methyloxetan-3-yl)methyl) malonate-C monoadduct (BCM), for use as an ETL in PSCs.

The application effect of the segmented teaching method in training medical students on clinical practice skills.

Background: The surgical clinical practice skill training is an important part of medical undergraduate education. Surgical skills are complex and difficult to master. However, the traditional teaching method has some disadvantages, for example, low student participation, weak learning atmosphere, inadequate mastery of the subject matter.

Efficient and Stable Monolithic Perovskite/Silicon Tandem Solar Cells Enabled by Contact-Resistance-Tunable Indium Tin Oxide Interlayer.

The imperfect charge behavior at the interfaces of perovskite/electron-transport layer (ETL)/transparent conducting oxide (TCO) limits the further performance improvement of perovskite/silicon tandem solar cells. Herein, an indium tin oxide interlayer is deposited between ETL and TCO to address this issue. Specifically, the interlayer is prepared using an all-physical and HO-free method, electron-beam evaporation, which can avoid any potential damage to the underlying perovskite and ETL layers.

Sesamol Alleviates Sarcopenia via Activating AKT/mTOR/FoxO1 Signal Pathway in Aged Obese Mice.

Sesamol is a major bioactive component extracted from sesame seeds and has various medicinal properties. However, the effects of sesamol on sarcopenia associated with aging and obesity remains unclear. Therefore, the protective effects and underlying mechanisms of sesamol on sarcopenia was evaluated in aged and obese C57BL/6 J male mouse models fed a high fat diet and C2C12 myotubes co-treated with D-gal and PA in this study.

A Biodegradable Nano-Drug Delivery Platform for Co-Delivery of Minocycline and Chitosan to Achieve Efficient and Safe Non-Surgical Periodontitis Therapy.

Introduction: Mesoporous silica nanoparticles (MSN) are widely used as ideal nanovehicles for the delivery of chemotherapeutic drugs. However, the balance between high anti-periodontitis activity and low biotoxicity has been challenging to maintain in most relevant studies owing to the slow degradation of silica in living organisms.

Method: In this study, -responsive hydroxyapatite (HAP) was doped into the MSN skeleton, and the chemotherapeutic drug minocycline hydrochloride (MH) was loaded into the pores of MSN, forming a negatively charged drug delivery system.

Primary intraorbital inflammatory lumpy lesion: A rare case report.

Rationale: Eosinophilic angiocentric fibrosis (EAF) is considered to be a kind of benign IgG4-related disease, and it is more often found in the nasal cavity. We present a pretty rare case of orbital EAF that is unlike any other reported case for this case is an IgG4 negative orbital EAF and successfully treated by the fronto orbitozygomatic approach surgery.

Patient Concerns: This is a 68-year-old man from a rural area of Inner Mongolia Autonomous Region, went to our hospital for a 2-month history of vision loss with a local hospital orbital computer tomography which showed that there was a lesion in his left orbit.

Suppressing Halide Segregation via Pyridine-Derivative Isomers Enables Efficient 1.68 eV Bandgap Perovskite Solar Cells.

Light-induced phase segregation is one of the main issues restricting the efficiency and stability of wide-bandgap perovskite solar cells (WBG PSCs). Small organic molecules with abundant functional groups can passivate various defects, and therefore suppress the ionic migration channels for phase segregation. Herein, a series of pyridine-derivative isomers containing amino and carboxyl are applied to modify the perovskite surface.