The complex inflammatory indexes predict the prognostic risk for patients with acute coronary syndrome undergoing percutaneous coronary intervention.

Introduction: An accurate assessment of prognostic risk is widely recognized to be important in improving the survival of patients with acute coronary syndrome (ACS). This study aimed to investigate the roles of neutrophil-to-lymphocyte * platelet (NLPR) and neutrophil-lymphocyte (NLR) ratios with high- and (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels in predicting the risk of major adverse cardiovascular events (MACEs) in patients with ACS undergoing percutaneous coronary intervention (PCI).

Results: Overall, 1,263 patients with ACS undergoing PCI between January 2016 and December 2018 were consecutively enrolled.

NeuroD1 drives a KAT2A-FDFT1 signaling axis to promote cholesterol biosynthesis and hepatocellular carcinoma progression via histone H3K27 acetylation.

Abnormal lipid metabolism is one of the hallmarks of cancer. Lipid metabolic reprogramming, which has been observed in various tumors, could participate in tumor occurrence, invasion, and metastasis of tumors by regulating various carcinogenic signaling pathways. However, the molecular mechanism that regulates tumor cell lipid metabolic reprogramming has not been fully elucidated.

Engineered Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Mitigate Liver Fibrosis by Delivering USP10 to Reprogram Macrophage Phenotype.

The utilization of mesenchymal stem cells (MSCs) serves as an encouraging strategy for treating liver fibrosis. However, precise mechanisms are not completely understood. Recently, small extracellular vesicles (sEVs) have emerged as major paracrine effectors mediating the anti-fibrotic effects of MSCs.

Demographic and Clinicopathologic Characteristics of 3723 Patients with Primary Oral Squamous Cell Carcinoma: A Consecutive, Single-Center Study Over 11 Years (2012-2023).

Objective: This study aimed to investigate the demographic and clinicopathologic characteristics of oral squamous cell carcinoma (OSCC) and explore the risk factors associated with OSCC pathological TNM (pTNM) stage.

Methods: This retrospective study included patients with OSCC from 2012 to 2023. Data analyzed included demographics, clinicopathological characteristics, and treatment.

DNA Methylation-Activated LaCOMT1 Expression Promotes Cluster Root Formation of White Lupin via a Mechanism Involving the Melatonin Synthesis.

White lupin exhibits remarkable adaptability to phosphorus (P)-deficient soil through the development of cluster roots (CR), thereby enhancing P use sufficiency. Despite its crucial role, the underlying mechanism governing CR formation remains elusive. Here, we reveal an elevated DNA methylation level through whole-genome bisulfite sequencing in CR in response to P deficiency, particularly in gene and flanking regions, suggesting a responsive epigenetic mechanism.

ST6GAL1-Mediated Sialylation Stabilizes PD-L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer.

Abnormal glycogene expression is a recognized cancer hallmark, but its impact on the colorectal cancer (CRC) tumor microenvironment (TME) remains unclear. Utilizing bioinformatics analysis on TCGA and GEO datasets, a seven-glycogene signature is identified for precise glycogene-based classification in CRC. ST6GAL1, a key focus, emerges as a significant predictor of poor prognosis, with its upregulation linked to unfavorable outcomes in CRC.

E2-based mRNA vaccine encapsulated in lipid nanoparticles protects pigs against classical swine fever virus.

Unlabelled: Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), remains a significant threat to the global pig industry. Recent advances in mRNA vaccines offered a promising platform for combating CSFV. In this study, we designed and evaluated three lipid nanoparticle (LNP)-encapsulated mRNA vaccine candidates encoding the ectodomain of E2 glycoprotein (E2_EX), E2_EX fused with the transmembrane (TM) region of the PEDV S protein (E2tm), and E2_EX fused with the TM region of the influenza virus HA protein (E2tm-HA).

Genomic landscape and immunological profile of glioblastoma in East Asian patients.

Glioblastoma multiforme (GBM) shows profound inter- and intratumoral heterogeneity, but differences across ancestries remain understudied. We assemble the largest cohort of GBMs from East Asian patients (EAS-GBM) and perform genomic and transcriptomic analyses. Transcriptomic clustering reveals distinct EAS-GBM molecular subtypes-proliferative (PL), neurosynaptic (NS), metabolic (MB), and immunomodulatory (IM)-based on activated biological pathways.

Biocompatible Multifunctional Polymeric Material for Mineralized Tissue Adhesion.

This study develops a biocompatible multifunctional thiol-ene resin system for adhesion to dentin mineralized tissue. Adhesive resins maintain the strength and longevity of dental composite restorations through chemophysical bonding to exposed dentin surfaces after cavity preparations. Monomers of conventional adhesive systems may result in inhomogeneous polymer networks and the release of residual monomers that cause cytotoxicity.

Exploring the Complexities of Liver Transplantation for Secondary Hemophagocytic Lymphohistiocytosis-Associated Acute Liver Failure.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by the aberrant activation of macrophages. Liver dysfunction is often observed in patients with HLH and has the potential to advance to acute liver failure (ALF). However, limited data exist regarding the application of liver transplantation (LTx) for the management of HLH-associated acute liver failure (HLH-ALF).

Large language model driven transferable key information extraction mechanism for nonstandardized tables.

Extracting key information from unstructured tables poses significant challenges due to layout variability, dependence on large annotated datasets, and inability of existing methods to directly output structured formats like JSON. These limitations hinder scalability and generalization to unseen document formats. We propose the Large Language Model Driven Transferable Key Information Extraction Mechanism (LLM-TKIE), which employs text detection to identify relevant regions in document images, followed by text recognition to extract content.

Addition of hydrothermal biochar significantly alters growth of forage oats and rhizosphere microbiota.

There are few reports on the application of biochar in forage oat cultivation. Therefore, we compared the effects of adding different amounts of hydrothermal biochar on the growth of forage oats and the properties of rhizosphere soil. Results indicated that biochar significantly enhanced forage oats biomass, crude protein (CP) content, and chlorophyll content, with optimal effects at a 10 t/ha application rate.

A portable smartphone-assisted Tb/Eu-MOF agar slice probes for the visual detection of fluoroquinolones.

The extensive use of fluoroquinolones (FQs) leads to food residues, which present a significant risk to human health. A portable smartphone-assisted detection platform based on Tb/Eu-MOF nanomaterial was established for the detection of FQs, with the enrofloxacin (ENR) serving as a representative sample. Five Tb/Eu-MOFs with different bimetallic proportions were synthesized, and the Tb/Eu-MOFs (3:1) served as the optimal sensing element.

Assessing the impact of day and night urban outdoor environments on women's physiological and psychological states using pedestrian-centric street view images.

The urban environment significantly influences women's health and overall quality of life. However, less attention has been given to how the diurnal differences in these environments affect women's physiological and psychological responses during their experiences within them. This study employed field experiments, questionnaires, pedestrian-centric street view images, and deep learning methods to assess how residential, commercial, and leisure environments impact women's physiological and psychological states during both daytime and nighttime.

High-moisture alfalfa silage fermentation: a comparative study on the impact of additives including formic acid, , cinnamon essential oil, and wood vinegar.

Applying additives to high-moisture alfalfa silage is crucial for ensuring fermentation quality. The study selected two conventional silage additives (formic acid [FA] and [LP]) and two additives with the potential to improve silage fermentation quality (cinnamon essential oil [CEO] and wood vinegar [WV]) as the subjects of the research, with the control group sprayed with an equal amount of distilled water (CK). We compared the fermentation products of high-moisture alfalfa silage at 3 d, 7 d, 15 d, 30 d, and 60 d with different additives and evaluated the dry matter (DM) digestibility, crude protein (CP) digestibility, and the bacterial community composition, co-occurrence network, function, and phenotype prediction of the alfalfa silage at 60 d of fermentation.

A general form of covariate adjustment in clinical trials under covariate-adaptive randomization.

In randomized clinical trials, adjusting for baseline covariates can improve credibility and efficiency for demonstrating and quantifying treatment effects. This article studies the augmented inverse propensity weighted estimator, which is a general form of covariate adjustment that uses linear, generalized linear and nonparametric or machine learning models for the conditional mean of the response given covariates. Under covariate-adaptive randomization, we establish general theorems that show a complete picture of the asymptotic normality, efficiency gain and applicability of augmented inverse propensity weighted estimators.

[Current status of acupuncture education and reflections on future reforms].

Education is a crucial element in the development of acupuncture as a discipline, providing essential talent support for its future advancement. A structured interview was conducted with renowned acupuncture expert Professor , focusing on key topics such as the core of acupuncture education, the connotation and development of acupuncture textbooks, and acupuncture teaching models. Through in-depth discussion, the current problems in acupuncture education were analyzed, and possible solutions were explored, aiming to offer ideas for the innovative development of acupuncture education.

Experimental and analytical investigation of Frost heave characteristics in red-bed coarse-grained materials incorporating particle breakage effect.

The eastern part of the Qinghai-Tibet Plateau is located in the high-altitude freeze-thaw region, where terrestrial clastic red beds formed by sedimentation since the Mesozoic are widely distributed. Recently, red-bed coarse-grained materials (CGMs) have been increasingly utilised in construction in projects across western China. However, owing to the high degree of weathering and low strength, red-bed CGMs are susceptible to particle breakage under impact loads during compaction.

Anomalous Phonon Evolution via Out-of-Plane Strain Engineering in van der Waals Epitaxial VO Film.

Vanadium oxide (VO) exhibits a unique phase transition, making it promising for ultrafast switches, neuromorphic computing, and memory devices. Interfacial strain engineering is a universal strategy for manipulating the phase transition behavior of VO films, but most studies have focused only on in-plane strain (epitaxial) due to the challenges of applying out-of-plane strain. Here, we address this gap by employing a diamond anvil cell-based high-pressure method to investigate the phase transition properties of VO films under strong out-of-plane strain.

Formulation optimization, in vitro and in vivo correlation, and long-acting analgesic efficacy of dezocine-loaded microspheres overcoming the "quick sand" phenomenon.

Polymeric acids and their copolymer-based microspheres constitute a critical platform for extended and controlled-release drug delivery systems. However, the precipitated drug crystals (commonly termed "quick sand" phenomenon) during microsphere fabrication significantly limits their application for specific drug molecules, leading to suboptimal drug loading (DL) and encapsulation efficiency (EE) in final products. In this study, dezocine-loaded microspheres (Dez-Ms) were fabricated using microfluidic reactor technology.

Barriers in bone tumor treatment: the emerging role of drug delivery systems.

Bone tumors are rare and diverse neoplasms with local and systemic impacts. Current therapies like surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy have had mixed success; significant hurdles persist. Surgery may cause a series of complications and has limited applicability.

Non-Destructive Detection of Fruit Quality: Technologies, Applications and Prospects.

Fruit quality testing plays a crucial role in the advancement of fruit industry, which is related to market competitiveness, consumer satisfaction and production process optimization. In recent years, nondestructive testing technology has become a research hotspot due to its outstanding advantages. In this paper, the principle, application, advantages and disadvantages of optical, acoustic, electromagnetics, dielectric properties research and electronic nose non-destructive testing technology in fruit quality testing are systematically reviewed.

[Effect evaluation of comprehensive environmental health intervention on health knowledge, attitude and practice of community residents on air pollution].

Objective: To understand the current status of residents' knowledge-attitudes-practice(KAP)towards air pollution and environmental health in four cities, and to evaluate the effectiveness of interventions.

Methods: Using cluster sampling, a comprehensive intervention targeting KAP regarding air pollution and environmental health was conducted among 2431 adult residents in Beijing City, Yichang City, Dandong City and Lhasa City in 2023. Baseline surveys and effectiveness evaluation surveys were conducted before and after the intervention.

Medical care-seeking attitude and behaviour for urinary incontinence and associated factors among Chinese adult women.

Background: It is estimated that many women globally suffer from urinary incontinence (UI); however, widespread reluctance remains to seek medical care for this condition. This delay contributes to the increasing prevalence of UI as a significant public health concern. The aim of this study is to assess medical care-seeking attitudes towards UI in the general female population, as well as the medical care-seeking behaviors of patients, and identify potential barriers.

Application of artificial intelligence lesion labeling system-assisted endoscopic submucosal dissection for the treatment of esophageal lesions in a low-volume center: a prospective cohort study.

Background And Aims: Multiple artificial intelligence (AI) systems have been developed to assist with endoscopic diagnosis. We established the first real-time AI lesion-labeling system to assist in delineating lesion margin during endoscopic submucosal dissection (ESD). We aimed to further validate the efficacy of this system in improving histological complete resection rate especially for beginners in low-volume centers.