Shape Memory Collagen Scaffolds Sustain Large-Scale Cyclic Loading.

Natural biopolymer hydrogels often suffer from relatively low moduli and an inability to maintain structure and mechanics under cyclic loading, limiting their utility in dynamic mechanical environments. Here, a cross-linked collagen cryogel scaffold was fabricated by precompression to densify the network. Following lyophilization, the porous scaffolds sustained >90% axial compressive strain with 200 cycles.

Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.

The accumulation of senescent cells (SNCs) contributes to tissue dysfunction and age-related diseases, creating an urgent need for effective senolytic strategies. We identified a metabolic vulnerability in SNCs characterized by marked downregulation of asparagine synthetase (ASNS), rendering them uniquely dependent on exogenous asparagine (Asn). This vulnerability was exploited through combined treatment with L-asparaginase (ASNase) and autophagy inhibitors, which synergistically deplete Asn via complementary mechanisms: ASNase degrades extracellular Asn pools, while autophagy inhibition blocks intracellular protein recycling as an alternative Asn source.

The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites.

Purpose: Tinnitus is a complex disease whose pathophysiological mechanisms are still not fully elucidated. Dysregulation of circulating inflammatory proteins and metabolites is thought to play a crucial role in tinnitus pathophysiology, but the causal relationships and specific biological pathways linking these factors to tinnitus persistence remain unestablished.

Methods: We performed a two-sample Mendelian randomization (MR) analysis using tinnitus genome-wide association study (GWAS) data from FinnGen biobanking and GWAS data from metabolites and circulating inflammatory factors in GWAS directories.

Genomic Investigation of a Bacillus subtilis Strain Sourced from Commercially Available Milk Powder in China Reveals Potential Risk Factors.

Background: Milk powder is a key food source, especially for infants and vulnerable groups. However, Bacillus contamination during production, storage, or handling can cause spoilage, quality issues, or health risks. This study identified and isolated from commercially available Chinese milk powder.

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron-Mediated Lung-to-Brain Axis.

Mesenchymal stromal cells (MSC) have emerged as a promising therapeutic option for neuropathic pain (NP), but the mechanisms remain elusive. Using murine pain models, it is demonstrated that MSC effectively alleviates pain, with efficacy comparable to dexmedetomidine, a moderate analgesic. Mechanistically, peripheral delivery of MSC-activated pulmonary Npy2r-expressing vagal sensory neurons, which project to the nucleus tractus solitarius and ventral lateral periaqueductal gray area, drives analgesia via the vagal lung-to-brain pathway.

Correction: Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis and .

[This corrects the article DOI: 10.3389/fmicb.2025.

Synthesis of ordered mesoporous metal oxides by solvent evaporation-induced cooperative assembly.

Ordered mesoporous metal oxides (OMMOs) with periodically interconnected mesopores and crystalline framework have attracted ever-growing attention due to their high specific surface area, well-defined mesoscopic structures and adjustable pore-wall chemical microenvironment. It has been difficult to rationally design OMMO syntheses because the hydrolysis of metal salts is difficult to control; it is also difficult to find precursors that have a strong enough interaction with the structure-directing agents and oxides to overcome the formation of disordered metal oxide crystals rather than frameworks at the temperatures required for calcination. Here we describe an evaporation-induced cooperative assembly (EICA) approach for the controllable synthesis of high-quality OMMOs (for example, WO).

Biocompatible Multifunctional Polymeric Material for Mineralized Tissue Adhesion.

This study develops a biocompatible multifunctional thiol-ene resin system for adhesion to dentin mineralized tissue. Adhesive resins maintain the strength and longevity of dental composite restorations through chemophysical bonding to exposed dentin surfaces after cavity preparations. Monomers of conventional adhesive systems may result in inhomogeneous polymer networks and the release of residual monomers that cause cytotoxicity.

GLUT3 enhances chemosensitivity in glioblastoma by transporting temozolomide and capecitabine.

Glioblastoma multiforme (GBM), the most aggressive brain cancer, is highly resistant to chemotherapy, which profoundly affects patient survival and prognosis. Temozolomide (TMZ), the sole first-line chemotherapeutic agent for GBM, faces substantial challenges in overcoming this resistance. Despite the belief that TMZ is well-absorbed in the small intestine and can effectively cross the blood-brain barrier due to its small molecular size, emerging evidence suggests that its uptake is not merely through passive diffusion across the lipid bilayer but is regulated by Wnt signaling.

High-efficiency co-registration of OPM-MEG and MRI using point cloud processing.

Optically pumped magnetometers (OPMs) offer high temporal and spatial resolution for magnetoencephalography (MEG) applications, particularly in noninvasive brain mapping and epilepsy diagnosis. However, effective MEG-MRI co-registration remains challenging. This study presents a novel co-registration technique utilizing OPMs to achieve rapid registration speeds and submillimeter precision, addressing the limitations of traditional methods.

Excessive mitochondrial stress response triggers neuronal injury through the persistent eIF2α phosphorylation in mice exposed to manganese.

Manganese (Mn) overexposure-induced neurocognitive abnormalities are intensively linked to hippocampal neuronal injury, but the neurotoxic mechanisms involved are ambiguous. Under various mitochondrial stress, mitochondrial stress response (MSR) is activated and plays a dual role in cells, promoting adaptive survival while also contributing to detrimental damage, depending on the severity of mitochondrial dysfunction. Excessive MSR can lead to inevitable cell death and organ damage, ultimately driving the onset and progression of numerous disorders.

Imaging a light-induced molecular elimination reaction with an X-ray free-electron laser.

Tracking the motion of individual atoms during chemical reactions represents a severe experimental challenge, especially if several competing reaction pathways exist or if the reaction is governed by the correlated motion of more than two molecular constituents. Here we demonstrate how ultrashort X-ray pulses combined with coincident ion imaging can be used to trace molecular iodine elimination from laser-irradiated diiodomethane (CHI), a reaction channel of fundamental importance but small relative yield that involves the breaking of two molecular bonds and the formation of a new one. We map bending vibrations of the bound molecule, disentangle different dissociation pathways, image the correlated motion of the iodine atoms and the methylene group leading to molecular iodine ejection, and trace the vibrational motion of the formed product.

Association of nutritional intake with myopia and astigmatism.

This study investigates the association between dietary lutein and zeaxanthin intake and the prevalence of myopia and astigmatism using data from the NHANES 2007-2008 survey. A total of 3,759 participants aged 12-59 years were analyzed. Myopia was classified into emmetropia, low myopia, and high myopia based on spherical equivalent refraction (SER), while astigmatism was categorized into high, low, and moderate based on right eye cylinder degree.

Whether an optimal strategy exists for VTE prevention in critically ill patients: Insights from guidelines and randomized controlled trials.

Background: Critically ill patients face challenges in venous thromboembolism (VTE) prevention, with limited consensus on the efficacy of different anticoagulants and prevention methods. This study aims to systematically evaluate the quality of existing clinical practice guidelines (CPGs) and the efficacy and safety of various anticoagulation regimens for VTE prevention in such patients.

Methods: CPGs quality was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II and Reporting Items for Practice Guidelines in Healthcare (RIGHT) tools.

In Situ Synthesis of Ordered Macroporous Metal Oxides Monolayer on MEMS Chips: Toward Gas Sensor Arrays for Artificial Olfactory.

Metal oxide semiconductor gas sensors have attracted particular attention due to their merits of high sensitivity and easy integration. However, their insufficient selectivity severely limited their applications, especially in identifying low-concentration gases in a complex environment. Herein, inspired by the human olfaction, an in situ colloidal assembly strategy is developed to directly synthesize ordered macroporous metal oxide monolayers on micro-electromechanical system (MEMS) chips.

Exploring Immunogenetic Mechanisms in Parkinson's Disease Using Single-Cell Transcriptomics and Mendelian Randomization.

Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neuron. Although the role of immunity in PD has been increasingly recognized, the immunogenetic mechanisms underpinning its progression remain largely unresolved.

Methods: We employed an integrative approach combining Mendelian randomization (MR), expression quantitative trait loci analysis, and single-cell RNA sequencing to investigate immune cell infiltration and transcriptional regulation in PD.

HSP104 and HSP20-L Are Required by Aspergillus nidulans in Response to Attack by Fungivorous Springtail Sinella curviseta.

Heat shock proteins (HSPs) are conserved biomolecules that are consistently expressed and upregulated in response to stress. However, whether fungi activate HSPs in response to fungivorous arthropods' attack remains unclear. In this study, we investigated the function of HSP104 and HSP20-L in Aspergillus nidulans upon Sinella curviseta stress.

AEBP1 as a promising therapeutic target for skeletal muscle insulin resistance in type 2 diabetes mellitus: Convergent evidence from Mendelian randomization and functional validation.

Background: The pathogenesis of type 2 diabetes mellitus (T2DM) is closely related to skeletal muscle insulin resistance (IR). Currently, there is still a lack of relevant treatments. Summary-data-based Mendelian randomization (SMR) is a vital tool for identifying druggable targets in skeletal muscle to develop T2DM treatments.

Effectiveness and safety of different electromagnetic stimulation therapies in treating post-stroke insomnia: A network meta-analysis of randomized controlled trials.

Objectives: To evaluate the efficacy and safety of different electromagnetic therapies for the treatment of post-stroke insomnia (PSI). Thus, we conducted a network meta-analysis to provide evidence-based insights for clinical practice.

Methods: Databases such as PubMed, Excerpt Medica Database (Embase), Cochrane Library Central Register of Controlled Trials, APA PsycInfo, China National Knowledge Infrastructure Database, Wanfang, and SinoMed were used to retrieve randomized controlled trials (RCTs) on electromagnetic therapy for PSI, with a search deadline of Sep 2024 for each database.

Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis and .

Background: The prevalence of nonalcoholic steatohepatitis (NASH) is increasing every year, and there are very few approved therapeutic agents globally, making the search for potentially targeted therapeutic agents important.

Aims: To investigate the anti-NASH effect of tetrahydrocurcumin (THC) and to further study the biological mechanism of THC anti-NASH from the perspective of intestinal flora.

Methods: Seven-week-old female male C57BL/6J mice were randomly divided into two batches of six groups: (1) control group, (2) model group, (3) positive control group, (4) THC low-dose group, (5) THC medium-dose group, and (6) THC high-dose group.

Analysis of spatiotemporal evolution and driving factors of ecological environment quality in the Ili-Balkhash Lake Basin in Central Asia.

The Central Asian area is faced with unprecedented challenges due to the fragility of its ecological environment and under the double pressure of global warming and intensified human activities. As a typical transboundary watershed in Central Asia, the ecological system quality of the Ili-Balkhash Lake Basin (IBLB) is of vital importance to the sustainable development of the whole region. In this study, we constructed the Remote Sensing Ecological Index (RSEI) for the IBLB (2000-2020) using the MODIS dataset on the Google Earth Engine platform and applied Sen's slope and Mann-Kendall (Sen-MK) trend analysis methods to assess RSEI trends.

Common mechanisms of Gut microbe-based strategies for the treatment of intestine-related diseases: based on multi-target interactions with the intestinal barrier.

The concurrent occurrence and exacerbation of multiple diseases, including geriatric diseases and chronic diseases, impose a heavy burden on human health and medical expenses. Clarifying the common mechanisms of related multifarious diseases and developing preventive and therapeutic strategies with synergistic effects for multiple diseases are of great significance in alleviating the burden on the medical system and reducing patients' burden of drug metabolism. Recent studies have revealed that gut microbiota disorders and intestinal barrier damage, which consequently cause metabolic and immunological disorders, may be a common pathological basis underlying various intestinal-related diseases.

Evaluating strategies for preventing splanchnic vein thrombosis after splenectomy in cirrhosis: Evidence from published trials and retrospective cohort data.

Background: Splanchnic vein thrombosis (SVT) is a common complication following splenectomy in cirrhotic patients, yet the optimal prophylactic antithrombotic regimen remains unclear. This study combines data from published trials with our institutions to assess the efficacy of various strategies.

Methods: We systematically searched five English and Chinese databases from inception to October 2024 for randomized controlled trials (RCTs) and cohort studies focused on SVT prevention after splenectomy, then conducting a network comparison to evaluate SVT incidence across different prophylactic regimens.

Biocompatible Multi-functional Polymeric Material for Mineralized Tissue Adhesion.

This study developed a biocompatible multifunctional thiol-ene resin system for adhesion to dentin mineralized tissue. Adhesive resins maintain the strength and longevity of dental composite restorations through chemophysical bonding to exposed dentin surfaces after cavity preparations. Dental pulp cells are exposed to residual monomers transported through dentinal tubules.

Interface Engineering p-n Heterostructured Core-Shell Mesoporous Particles for Cascade Catalysis Promoted Gas Sensing.

Cells have greatly inspired advancements in chemical processes, including leveraging the idea of cascade catalysis to drive thermodynamically unfavorable reactions and mimicking the compartmentalized architecture to design novel nanostructures. Here, a single-particle cascade catalysis promoted gas sensing platform is inspired to be designed (denoted as CoSnO@mCeO) by positionally assembling n-type mesoporous CeO catalytic shell on p-type CoSnO gas sensitive core. Uniform CoSn(OH)@mCe(OH) core-shell particles with tailored mesostructures, tunable large mesopores, and adjustable shell thicknesses are first constructed.