Hepatitis Virus Infection Predicts Heterogeneous Enhancement Patterns in Intrahepatic Cholangiocarcinoma on Contrast-Enhanced Ultrasound: A Retrospective Radiological Cohort Study.

Background: Chronic hepatitis is a significant risk factor for intrahepatic cholangiocarcinoma (ICC). Accurate identification of hepatitis-associated ICC is critical for optimizing clinical management. This study aimed to differentiate hepatitis-associated ICC from non-hepatitis cases by integrating clinical and contrast-enhanced ultrasound (CEUS) features.

Pollen-inspired magnetic nanoparticles with dual-recognition sensing interfaces for intelligent-response modulation of circulating tumor cells capture and release.

A critical prerequisite for translating circulating tumor cells (CTCs) detection technologies into clinical practice is achieving high-efficiency capture and non-destructive release of low-abundance CTCs in blood. In recent years, innovative designs and surface modification of bioinspired topological micro/nanostructured materials have provided efficient solutions to capture and release CTCs. Motivated by pollen morphology and multimodal regulation, this study designed pollen-inspired spiky topological magnetic nanoparticles (IP-GSMNs) based on dual-recognition interface and intelligent-response modulation for high-efficiency capture and non-destructive release of CTCs from peripheral whole blood.

IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells.

Introduction: , a zoonotic parasitic disease, induces complex immune regulation during infection. The inflammatory responses and immunosuppressive mechanisms co-exist to maintain immune homeostasis in schistosomiasis. B7-H4 is a critical immune checkpoint molecule that modulates T cell activation and exerts immunosuppressive effects.

Metal/non-metal doped graphene quantum dots as dual fluorescent probes for detection of pesticide residues and heavy metal ions.

Heavy metals (Fe) and pesticides (diquat) pose serious threats to the environment and human health, necessitating the development of efficient detection technologies. In this study, metal/non-metal doped graphene quantum dots (GQDs) were developed. Given excellent sensitivity, stability and selectivity, it was used as a fluorescent probe with multiple functions for simultaneous detection of two pollutants.

Effects of new-type fertilizers and irrigation regimes on carbon footprint of double-season rice system.

To elucidate the responses of yield and carbon footprint of double-season rice production systems to new-type fertilizers and irrigation regimes, we investigated the effects of three new-type fertilizers, viz, controlled-release urea (CRU), nitrapyrin-treated urea (CP), and effective microorganisms (EM) (conventional fertilizer as control), and two irrigation regimes, conventional flooding (W) and shallow water irrigation (W), on yield, greenhouse gas emissions and carbon footprint of early- and late-season rice by the FAO-CROPWAT 8.0 modeling in combination with field experiments (2020-2021). The results showed that compared to the conventional fertilizer (CK), three new-type fertilizers increased rice yield.

A 20-year research trend analysis of the artificial intelligence on scoliosis using bibliometric methods.

Background: This bibliometric analysis aimed to map the knowledge network of artificial intelligence in scoliosis.

Methods: Studies on artificial intelligence published from January 2003 to December 2024 are retrieved from Web of Science Core Collection (WoSCC). The contributions of countries, institutions, authors, and journals are identified using VOSviewer, Online Analysis Platform of Literature Metrology (http://biblimetric.

Revolution or trap? Long-term diffusion of bioplastics in China: Economic losses, health benefits, and policy pathways based on a multi-module CGE-LCA model.

Bioplastics, which are made from crops and are biodegradable, are considered a sustainable alternative to petroleum-based plastics for reducing emissions and pollution. However, there is currently insufficient systematic assessment of the long-term economic, health, and environmental impacts, as well as the long-term policy effects and consumer diffusion patterns, of large-scale promotion of bioplastics in different regions of China. To address this gap, this study developed a multi-regional dynamic simulation framework integrating a recursive dynamic computable general equilibrium model (CGE), life cycle assessment (LCA), and consumer social network analysis.

CXCR6 recruits Th2 cells and promotes liver fibrosis in schistosomiasis japonica.

Background: Schistosomiasis is a parasitic disease that significantly endangers human health and hampers social development. The accumulation of eggs in the liver can lead to granuloma formation and liver fibrosis. Investigating the immune mechanisms involved may reveal new therapeutic targets for schistosomiasis.

Response of phytoplankton productivity to in-situ measures against eutrophication in reservoirs of Japan in recent decades.

Eutrophication countermeasures have been implemented in various reservoirs across Japan to mitigate phytoplankton blooms. However, the responses of phytoplankton to these countermeasures are not yet fully understood. This study aimed to investigate the impact of in-reservoir eutrophication measures on phytoplankton productivity using relevant datasets covering 55 reservoirs in Japan from 1993 to 2017.

Respiratory-related safety profiles of ciprofol (cipepofol) for anesthesia/sedation in Chinese elderly patients undergoing gastroscopy: a multicenter, parallel controlled clinical trial (REST trial).

Background: A post-marketing, parallel-controlled clinical trial (REST trial) was conducted to evaluate the safety and efficacy of cipepofol versus propofol for the induction of anesthesia/sedation in Chinese elderly patients undergoing gastroscopy.

Methods: All enrolled patients aged ≥65 years were assigned randomly in a 1:1 ratio to be administered intravenous cipepofol-0.3 mg/kg or propofol-1.

Exploring the role of surface micro-topography in governing dissolved nitrogen dynamics in agricultural runoff during rainfall.

Understanding the migration characteristics of dissolved nitrogen from farmlands to runoff during rainfall is essential for managing agricultural non-point source pollution. The effects of tillage-induced surface micro-topography on the migration dynamics of dissolved nitrogen from soils to runoff have not been sufficiently explored. In this study, simulated rainfall experiments were conducted to investigate the export pathways, loads, and composition characteristics of dissolved nitrogen, including NO-N, NH-N, and dissolved organic nitrogen (DON).

Total ginsenosides and ginsenoside Rb2 delay hepatocyte senescence by regulating NAD metabolism and promoting IDO2/QPRT expression.

Background: Imbalances in nicotinamide adenine dinucleotide (NAD) homeostasis accelerate aging, and targeting NAD metabolism is a potential strategy for delaying aging. Ginsenoside, as the main active ingredient of Panax ginseng Meyer, exert age-delaying effects. However, the potential molecular mechanism by which total ginsenosides (GS) affect NAD metabolism remains unclear.

Teachers' emotional labor in parent-teacher interactions: key elements and theoretical logic from a grounded theory approach.

In the context of home-school cooperation becoming an important part of global education reform, the burdens of teachers' emotional labor in parent-teacher interactions has increased. Their emotional labor in parent-teacher interactions not only affects home-school cooperation but also influences teachers' well-being both professionally and personally. In response to the challenge of growing emotional labor burdens on teachers, the research on the key elements and theoretical logic of teachers' emotional labor in parent-teacher interactions is of great significance.

Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm.

Thoracoabdominal aortic aneurysm (TAAA) involves both the thoracic and abdominal aorta and surgical treatment requires reconstructing several important visceral branch arteries. Open surgery is considered the standard treatment for TAAA, but it carries high risks and many complications. With the advancement of endovascular techniques, endovascular repair of TAAA has gradually become a new trend in treatment.

Transcriptomic-proteomic analysis reveals the regulatory mechanisms of Alfalfa () in response to .

Alfalfa () is the most widely cultivated and important forage crop worldwide, owing to its high protein content. However, alfalfa root rot seriously affects and restricts the yield and quality. This study explores the response mechanism of alfalfa to root rot.

Cadmium exposure and advanced cardiovascular-kidney-metabolic syndrome: An integrated multi-organ perspective based on epidemiology and adverse outcome pathways.

While metal exposures are linked to cardiovascular and renal diseases, their role in cardiorenal comorbidity remains poorly understood. Using the American Heart Association's Cardiovascular-Kidney-Metabolic Syndrome (CKM syndrome) framework, we combined population epidemiology and Adverse Outcome Pathway (AOP) analysis to explore how cadmium exposure influences CKM progression and advanced-stage outcomes. Data from 5865 adults aged 30-79 years in the National Health and Nutrition Examination Surveys (NHANES) were analyzed to investigate serum metal exposure patterns and CKM syndrome progression.

HMC ameliorates myocardial ischaemia-reperfusion injury through suppressing cuproptosis via the de-ubiquitination and stabilization of ATP7A.

Background And Purpose: Myocardial ischaemia-reperfusion injury (MI/RI) is a major contributor to poor prognosis following revascularization in myocardial infarction patients, yet targeted therapies remain elusive. While hesperidin methyl chalcone (HMC) demonstrates antioxidant and vasoprotective properties, its role in modulating regulated cell death pathways during MI/RI is undefined. This study investigates the cardioprotective effects of HMC against MI/RI and its underlying mechanisms.

Compact and power-efficient 3 × 3 silicon photonic interferometer thermo-optic switch.

A thermo-optic 3 × 3 interferometer switch is proposed and demonstrated experimentally on silicon photonic platform. The switch is composed of two 3 × 3 multi-mode interferometer (MMI) and three interferometer arms equipped with spiral thermo-optic phase shifters (STOPS). The switching operation of the device is successfully demonstrated by heating the STOPS.

Modulating the nonlinear refractive index through F/O ratio to reduce the self-focusing effect of fluorophosphate glasses.

In this study, we systematically investigated the relationship between the F/O ratio and the nonlinear refractive index of fluorophosphate glass, revealing that the nonlinear refractive index decreased exponentially as the F/O ratio increased. A formula for calculating the nonlinear refractive index based on the composition of fluorophosphate glasses was proposed. Since the nonlinear refractive index is directly related to self-focusing damage, we demonstrated through femtosecond laser-induced damage experiments that the F/O ratio can effectively modulate the self-focusing damage properties of fluorophosphate glass.

Acupuncture for benign prostatic hyperplasia in the elderly: A systematic review of acupoints.

Background: Benign prostatic hyperplasia (BPH) affects >50% of males aged ≥50 years, causing lower urinary tract symptoms that significantly impair quality of life. While acupuncture is increasingly used for BPH management, its acupoint selection patterns remain unstandardized.

Methods: Clinical studies on acupuncture/moxibustion for BPH published before September 30, 2024, were retrieved from CNKI, WANFANG, VIP, PubMed, and ScienceDirect.

KCTD10 promoting PD-L1 expression in colorectal cancer enhanced the anti-tumor effect of PD-1 antibody.

Colorectal cancer is a highly prevalent malignant tumor of the digestive tract worldwide. Immunotherapy has emerged as a critical therapeutic approach for CRC patients. We observed that KCTD10 expression is significantly downregulated in colorectal cancer tissues compared to normal tissues, and patients with higher KCTD10 expression exhibited prolonged survival.

Oncogenic NFE2L2 mutations in plasma ctDNA and tumors are predictors and prognosticators of chemoradiation therapy in resectable esophageal squamous cell carcinoma.

Background: The poor prognosis of resectable esophageal squamous cell carcinoma (ESCC) poses an unmet need to identify early predictive and prognostic genomic biomarkers to improve treatment outcome and risk stratification.

Methods: Mutational profiling was performed for 171 ESCC patients receiving curative neoadjuvant chemoradiation treatment (nCRT). The discovery cohort included 100 ESCC formalin-fixed paraffin-embedded (FFPE) tumor specimens; the validation FFPE cohort consisted of serial ctDNA samples from 71 patients.

A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. Chemotherapy is one of the first-line clinical therapeutic strategies for HCC. Still, the effectiveness of chemotherapy is hampered by the tumor immunosuppressive microenvironment and drug resistance caused by insufficient delivery.

Spinal Cord Stimulation for Chronic Neuropathic Pain: Research Progress in Molecular and Circuit Mechanisms.

Background: Spinal cord stimulation (SCS) is an effective surgical intervention for treating chronic neuropathic pain conditions that are refractory to other management options, such as opioids, physical therapy, nerve blocks, or radiofrequency ablation. It is currently clinically approved as the main therapeutic procedure for persistent low back pain. As we understand these mechanisms better, SCS could have novel clinical applications.