All-trans retinoic acid exacerbates Stevens-Johnson syndrome and toxic epidermal necrolysis via TNF signaling pathways: A network toxicology, molecular docking, and experimental study.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe hypersensitivity reactions characterized by extensive epidermal necrosis, often induced by medications. This research aims to investigate the involvement of all-trans retinoic acid (ATRA), a derivative of vitamin A known to induce dermatological toxicity resembling SJS/TEN, in the development of these conditions. Utilizing network toxicology methodologies, molecular docking technology, and experimental validation, we identified 159 common targets between ATRA and SJS, 38 with TEN, and 27 shared among all three conditions through databases such as SwissTargetPrediction and GeneCards.

Hydrogen sulfide (HS) Alleviates Diabetic Myocardial Fibrosis by Suppressing Pyroptosis via Inhibiting DNMT3a-mediated Sestrin2 CpG Promoter Hypermethylation.

Background: Diabetic cardiomyopathy (DCM) represents an important concern associated with diabetes, inhibiting pyroptosis has shown promising results in alleviating DCM symptoms. The objective of this work is to investigate the role and underlying mechanism of hydrogen sulfide (HS) in the suppression of pyroptosis in the context of diabetic myocardial fibrosis (MF).

Methods: The effect of HS on pyroptosis was detected using CCK-8, ELISA, and flow cytometry.

China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024).

Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders.

The value of intellectual structural imbalance in the differentiation of autism spectrum disorder and attention deficit hyperactivity disorder.

Background: The study delves into the intricate task of differentiating intellectual structures among children diagnosed with the high-functioning Autism Spectrum Disorder (HF-ASD), Attention Deficit Hyperactivity Disorder (ADHD), or comorbidity (ASD+ADHD), aiming to assist in their clinical differentiation, with the goal of refining clinical diagnoses and developing targeted therapeutic interventions.

Methods: The study included 200 outpatients aged 6.5-13.

Glutathione S-transferase in the differentiation of adventitious buds from callus.

Introduction: holds cultural and horticultural significance in traditional Chinese gardens, as a regional endemic species in Yunnan Province. However, during the regeneration process of , there is often a phenomenon of low efficiency of adventitious bud differentiation or no adventitious bud differentiation at all.

Methods: In previous study, we observed significant morphological differences between the callus tissues of 'Zipao' and wild species.

Development and validation of models based on clinical and CT features: multivariate analysis for predicting vascular invasion in non-small cell lung cancer.

Background: Lymphovascular invasion (LVI) is a high-risk pathological marker for the evaluation of metastasis and prognosis of non-small cell lung cancer (NSCLC). Preoperative computed tomography (CT) prediction of vascular invasion in NSCLC is essential for clinical identification of high-risk patients and development of treatment strategies. This study aimed to develop and validate a model for predicting LVI in NSCLC based on clinical and CT features.

Valley-Layer-Polarized Anomalous Hall Effect in a Two-Dimensional Multiferroic van der Waals Material.

Emerging phenomena such as the valley Hall effect and layer Hall effect, showing promise for next-generation electronics and valleytronic devices, have attracted considerable attention. However, most studies of the layer Hall effect have been restricted to antiferromagnetic or topological systems. Based on first-principles calculations, we establish a valley-layertronics framework and predict that two-dimensional ScI is a multiferroic material exhibiting substantial spontaneous valley polarization in both its monolayer (93.

Linking short-term ozone exposure to mental health in Chinese adults: Lung function as a mediator beyond respiratory impairment.

Introduction: This study aimed to evaluate the association between short-term ozone exposure and anxiety and depressive symptoms in a nationally representative Chinese population and to explore the mediating role of lung function.

Methods: This study included 42,234 Chinese adults from the China Pulmonary Health Study, conducted from 2012 to 2015. Ozone and other meteorological exposures were matched to participants' residential addresses based on latitude and longitude coordinates.

An artificial intelligence cloud platform for OCT-based retinal anomalies screening system in real clinical environments.

Millions of individuals worldwide suffer from retinal anomalies, which can lead to irreversible vision loss. However, the number of ophthalmologists is highly mismatched with the population base in China, especially in many rural and underdeveloped towns. To tackle these challenges, this paper developed an Artificial Intelligence Cloud Platform for OCT-based Retinal Anomalies Screening (AI-PORAS), which is capable of detecting 15 retinal anomalies in OCT images to enhance remote diagnostic efficiency.

Comparative study on the distribution of Pacinian corpuscles in the pancreas.

Background: Pacinian corpuscles (PCs) are pressure- and vibration-sensitive mechanoreceptors found in hairless skin, external genitalia, joints, ligaments, lymph nodes, prostate, bladder, etc. While they are documented in the pancreas of cats, their presence in the normal pancreas remains speculative.

Purpose: The present study therefore investigated the distribution of PCs in the normal human pancreas and compared the findings with those in several other animal species.

Lnc-THAP7-AS1 suppresses the ovarian cancer progression by targeting miR-92b-5p/fatty acid 2-hydroxylase signal axis.

Background: Ovarian cancer (OC) ranks among the most lethal gynecological malignancies. Research has highlighted long noncoding RNAs (lncRNAs) as promising novel molecular targets for cancer therapy. This study endeavors to identify novel lncRNAs, elucidate their specific roles, and unravel their regulatory mechanism in OC development.

Early 24-Hour Changes in Systemic Immune-Inflammation Index Predict Acute Kidney Injury and Mortality in ICU Patients.

To determine whether early dynamic changes in the systemic immune-inflammation index (SII) improve prediction of acute kidney injury (AKI) and 1-year mortality in critically ill patients. In this retrospective cohort study of 17,491 ICU admissions from the MIMIC-IV database, we calculated three SII metrics within the first 24 h of ICU stay: the 24-h SII_slope and the extreme values (SII_min, SII_max). LASSO-selected multivariable logistic regression was used to predict AKI, and Cox proportional hazards models assessed associations with 1-year mortality.

Facile Engineering of CoS@NiS Heterostructures for Efficient Oxygen Evolution Reaction.

Hydrogen production by the electrolysis of water has become an important way to prepare green hydrogen because of its simple process and high product purity. However, the oxygen evolution reaction (OER) in the electrolysis process has a high overpotential, which leads to the increase of energy consumption. Developing efficient, stable and low-cost electrolytic water catalyst is the core challenge to reduce the reaction energy barrier and improve the energy conversion efficiency.

Carbohydrate Quantity vs. Quality in Polycystic Ovary Syndrome: Population-Based Meta-Analysis Combined with GBD Data-Driven Assessment.

Introduction: Polycystic ovary syndrome (PCOS), a common metabolic-endocrine disorder, is linked to low-quality carbohydrate intake, though evidence remains controversial. This research aimed to evaluate carbohydrate quantity/quality impacts on PCOS by combining global trends from the Global Burden of Disease (GBD) 2021 database with pooled study from individual-level data.

Methods: We analyzed GBD 2021 data to assess annual trends in PCOS incidence and low-grain/high-sugar-sweetened beverage consumption.

A "Space-for-Time" Strategy Based on Single-Cell Dual-Isotope ICP-MS Analysis Enabling High-Throughput and Sensitive Quantification of miRNAs in Breast Cancer Cells for Therapeutic Assessment.

miRNAs regulate cancer progression and serve as both biomarkers and therapeutic targets in chemotherapy and gene therapy. Current analytical platforms lack the capacity to concurrently satisfy single-cell resolution and target specificity while maintaining high-throughput performance and cost-effectiveness. This limitation underscores the critical demand for innovative precision detection technologies.

Ambient ozone exposure and acute blood oxygen desaturation: Role of airflow limitation.

Background: Ambient ozone exposure has been linked to increased cardiovascular risk, but the underlying mechanisms, particularly in relation to hypoxia, remain unclear. This study aimed to evaluate the association between short-term ozone exposure and oxygen saturation in a nationally representative population in China and to assess the mediating role of airflow limitation.

Methods: The study included 48,789 participants from the China Pulmonary Health study.

Temperature-activated in situ hydrogel augments tumor treatment.

In situ gels with tumor-targeted therapy often struggle with precise spatiotemporal drug release, compromising their efficacy in complex and heterogenous tumors. Here, we present a temperature-activated in situ hydrogel (PTT-Br@mPEG-PLGA and Gem@TCM-TK-PEG in chitosan and PF127 gel, denoted as PP + GC gel. Therein, the photothermal compound PTT-Br is fully named 6-bromo-1-ethyl-2-(2-(6-hydroxy-2,3-dihydro-1H-xanthen-4-yl)vinyl)quinolin-1-ium, while the reactive oxygen species (ROS)-responsive polymer TCM-TK-PEG is fully named tricyano methylene pyridine-thioketal-polyethylene glycol.

Incidence of pneumonitis with CTLA-4 inhibitors in non-small cell lung cancer: a systematic review and meta-analysis.

Background: CTLA-4 inhibitors, such as tremelimumab and ipilimumab, are increasingly used in the treatment of non-small cell lung cancer (NSCLC). This meta-analysis aims to evaluate the incidence of pneumonitis associated with these inhibitors and explore potential differences between individual agents.

Methods: A systematic search across three online databases identified 911 records.

P300 event-related potentials as diagnostic biomarkers for attention deficit hyperactivity disorder in children.

Objectives: This study aimed to evaluate the utility of P300 event-related potentials (ERPs) as neurophysiological biomarkers for diagnosing attention deficit hyperactivity disorder (ADHD) and to establish preliminary diagnostic thresholds for their use.

Methods: A total of 106 children diagnosed with ADHD and 66 healthy controls were enrolled. Using a visual Oddball paradigm, P300 parameters were recorded at Fz, Cz, and Pz zones.

Cold stress enhances cryotolerance in B6 via membrane lipid remodeling and differential protein expression.

Understanding the molecular mechanisms underlying the cryotolerance of lactic acid bacteria is critical for preserving their viability in food processing. In this study, B6 and KF7 with different phenotypic properties were pretreated at 4 °C for 2 h before liquid nitrogen freezing. Cold-stressed B6 exhibited significantly higher survival (53 %) than KF7 (30 %) and untreated controls (44 % vs.

A Novel Approach to Differentiate Prostate Cancer from Prostatitis in the Peripheral Zone.

Objectives: To analyze the different imaging manifestations of prostatitis and prostate cancer (PCa), and propose systematic differentiation and validate its diagnostic performance.

Methods: Men with histologically proven prostatitis or PCa who had pretreatment multiparametric MRI (mpMRI) and lesions in the PZ were retrospectively identified from January 2018 to May 2022. The images were evaluated by two experienced radiologists, and key imaging features for differential diagnosis were summarized and analyzed via univariable and multivariable logistic regression.

Metabolomics-Based Characterization of Fungal Ball Sinusitis.

This study used nontargeted metabolomics to characterize metabolic alterations in fungal ball sinusitis (FBS), identify differential metabolites, and explore their roles in fungal infection, immune dysregulation, and histopathological mechanisms. This study prospectively enrolled 30 patients with FBS and 29 controls with isolated nasal septum deviation who underwent surgery at Beijing Tongren Hospital between February 2023 and April 2024. Specimens of collected fungal balls and secretions of the middle meatus were analyzed for metabolites.

Transcriptomic analysis identifies key genes associated with nutrient deprivation responses in infectious bursal disease virus infection.

Unlabelled: Infectious bursal disease virus (IBDV) causes a highly contagious and immunosuppressive disease that severely impacts the poultry industry. However, the molecular basis of IBDV-induced immunosuppression remains poorly understood. In this study, we investigate key genes implicated in this process, focusing on the interplay between metabolism and immune regulation.

Nanotentacle-Armed Flexible Affinity Interface Enables Streamlined Capture, Labeling, and Release of Circulating Tumor Cells.

Liquid biopsy based on circulating tumor cells (CTCs) is regarded as a promising approach for cancer diagnosis, therapeutic evaluation, and metastasis monitoring. However, conventional CTC identification processes after CTC isolation are labor-intensive and can lead to CTC inactivation. Here, we present a nanotentacle-armed flexible affinity interface (NataFace) designed for the capture, release, and labeling of CTCs.