Dynamic Fe─F Coordination Triggered Structure-Adaptive Fe-N-C for Efficient Oxygen Reduction Electrocatalysis.

The sustainable and widespread developments of fuel cells require material innovation toward the sluggish oxygen reduction reaction (ORR). Although iron and nitrogen co-doped carbon material (Fe-N-C) is a promising alternative to scarce and expensive platinum-based electrocatalysts, the linear scaling relationships among the intermediates' adsorption energy limit maximum performance. Herein, we propose a coordination-adaptive catalyst design to bypass the intrinsic scaling relations through incorporating quasi-covalent Fe─F bond.

Integrating Peritumoral and Intratumoral Radiomics with Deep Learning for Preoperative Prediction of Lymphovascular Invasion in Invasive Breast Cancer Using DCE-MRI.

BackgroundLymphovascular invasion (LVI) is a critical factor in breast cancer (BC) prognosis and treatment planning, yet preoperative non-invasive assessment remains challenging. This research proposes the design and validation of a comprehensive artificial intelligence (AI) system that combines intratumoral and peritumoral radiomic analysis, deep learning (DL)-derived features, and clinical risk indicators extracted from dynamic contrast-enhanced MRI (DCE-MRI), with the goal of predicting LVI status in patients with BC.MethodsThis multi-institutional retrospective study included 496 IBC patients (training cohort: n = 344; validation cohort: n = 152).

Feasibility and Prognostic Analysis of Neoadjuvant Therapy Followed by Breast-Conserving Surgery for Invasive Ductal Carcinoma Combined with Ductal Carcinoma in Situ.

Objective: This study aim to investigate the oncological safety of neoadjuvant therapy (NAT) followed by breast-conserving surgery (BCS) for invasive ductal carcinoma (IDC) patients with the presence of ductal carcinoma (DCIS) on pre-NAT biopsy.

Methods: The data of women with IDC who underwent radical surgery between January 2013 and December 2021 were retrospectively reviewed from two institutions. The study endpoints were 5-year disease-free survival (DFS) and local recurrence-fee survival (LRFS).

Aligned d-orbital energy level of dual-atom sites catalysts for oxygen reduction reaction in anion exchange membrane fuel cells.

The inherent scaling relationships between adsorption energies of oxygen-containing intermediates impose an intrinsic limitation on the maximum oxygen reduction reaction (ORR) activity, which represents one of the bottlenecks for the practical application of anion exchange membrane fuel cells (AEMFCs). To address this challenge, we align the 3dz orbital energy levels of Fe and Co to selectively customize the dissociative ORR pathway without the formation of OOH* intermediates, circumventing the conventional OH*-OOH* scaling relations. This rational design is achieved by atomic phosphorus(P) substitution, which not only optimizes orbital matching towards O-O cis-bridge adsorption, but also stabilizes the spontaneously adsorbed OH ligand as an electronic modifier.

Urban Wetland Sediments in Yangzhou: Physicochemical Properties, Microbial Communities, and Functional Associations.

Urban wetlands play a crucial role in maintaining ecological balance, carbon sequestration, and water purification. Sediments are key carriers for wetlands to store elements such as carbon, nitrogen, and phosphorus in the aquatic environment. This study analyzed different sediment layers of seven wetlands in Yangzhou, aiming to explore the relationship between physicochemical factors and microbial communities in wetland sediments, as well as to predict the functions of microbial communities.

Chromosome-level genome assembly of Ulmus parvifolia identifies genomic signatures and transcriptional profiling underlying Dutch elm disease resistance.

The lack of a high-quality Ulmus parvifolia genome assembly has impeded research on disease resistance and hindered breeding programs for resilient elm cultivars. In this study, we presented a chromosome-level genome assembly of U. parvifolia using integrated sequencing technologies.

A "Space-for-Time" Strategy Based on Single-Cell Dual-Isotope ICP-MS Analysis Enabling High-Throughput and Sensitive Quantification of miRNAs in Breast Cancer Cells for Therapeutic Assessment.

miRNAs regulate cancer progression and serve as both biomarkers and therapeutic targets in chemotherapy and gene therapy. Current analytical platforms lack the capacity to concurrently satisfy single-cell resolution and target specificity while maintaining high-throughput performance and cost-effectiveness. This limitation underscores the critical demand for innovative precision detection technologies.

Origin centric and part based pose decomposition for 3D human pose estimation.

Transformer-based approaches have recently made significant advancements in 3D human pose estimation from 2D inputs. Existing methods typically either consider the entire 2D skeleton for global features extraction or break it into independent parts for local features learning. However, capturing the spatial dependencies of the entire 2D skeleton does not effectively facilitate learning local spatial features, while partitioning the skeleton into independent segments disrupts the relevance of individual joints to the whole.

Early Post-discharge Pain Trajectories After Thoracoscopic Sublobar Resection for Stage IA Non-small Cell Lung Cancer.

Background: Thoracoscopic sublobar resection is emerging as a main treatment option for early-stage non-small cell lung cancer (NSCLC). This study aimed to determine whether distinct early post-discharge pain trajectories could be identified in patients with stage IA NSCLC undergoing thoracoscopic sublobar resection.

Methods: The data were collected from a longitudinal prospective observational cohort (CN-PRO-Lung 3).

Natural killer cell granule protein 7 contributes to CD8 T cell-mediated platelet apoptosis in immune thrombocytopenia.

Background: CD8 T cells participate in the pathogenesis of primary immune thrombocytopenia (ITP). Natural killer cell granule protein 7 (NKG7) is essential for natural killer cell and CD8 T cell cytotoxicity. The function of NKG7 in CD8 T cells in ITP remains unclear.

Bidirectional Electron Relay at TiN-TiO Interfaces Enables Oxidation-Resistant Ru for High-Potential Hydrogen Oxidation Catalysis.

Ruthenium-based catalysts are pivotal as cost-effective alternatives to Pt for alkaline hydrogen oxidation reaction (HOR). However, they typically face irreversible deactivation above 0.2 V vs.

Fibulin2 is a good diagnostic and prognostic indicator for sepsis.

Background: Sepsis is a life-threatening syndrome characterized by multiple organ dysfunction resulting from a maladjusted host response to infection. It remains a leading cause of morbidity and mortality worldwide. Early intervention for sepsis improves clinical outcomes.

The association of neutrophil-lymphocyte ratio and prognostic nutritional index with the development to chronic critical illness and their prognosis.

Background: The association between neutrophil-lymphocyte ratio (NLR) prognostic nutritional index (PNI) and chronic critical illness (CCI) is unclear. We aimed to explore the association between NLR and PNI with CCI and whether it could be used as a tool for risk stratification in such patients.

Methods: A retrospective cohort study was conducted using the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database.

Global Diabatic Potential Energy Surfaces of the PH System and Dynamics Studies of the P(P) + D Reaction.

Global diabatic potential energy surfaces (PESs) of the PH associated with 1A″ and 2A″ states were constructed by using a neural network method combined with a symmetry-adapted function. In the construction of PESs, high-level points were calculated by the multireference configuration interaction method in conjunction with the aug-cc-pVQZ basis set for H and the aug-cc-pwCVQZ basis set for P. The topographical features of the diabatic PESs were discussed and compared with the results, confirming that the diabatic PESs were successfully constructed.

Dihydroartemisinin Suppresses LOXL2-Mediated Glycerophospholipid Metabolic Reprogramming to Induce Cuproptosis in Colorectal Cancer Cells.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, second only to lung cancer. Dihydroartemisinin (DHA), a derivative of traditional Chinese medicine, has demonstrated anticancer properties; however, its role in modulating cuproptosis remains unclear. Lysyl oxidase-like 2 (LOXL2), a copper-dependent amine oxidase, has been implicated in cuproptosis regulation, though its mechanistic involvement requires further elucidation.

Complications Associated With Circumcision in a Community-Based Hospital.

Introduction: Infant male circumcision is a common elective procedure in the United States. Complications include bleeding, glans injury, insufficient or excessive skin removal, and adhesions. We assessed percentages and factors associated with complications of circumcisions at our community-based hospital from 2010 to 2020.

Neuroinflammatory mechanism of Volatile oil from Acori graminei Rhizoma in tourette syndrome: GC-MS, network pharmacology and experimental validation.

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics that significantly impair childhood development. Volatile oil from Acori graminei Rhizoma (VOA), known for its anti-inflammatory and neuroprotective properties, holds therapeutic potential for TS, though its molecular mechanisms remain undefined. In this study, VOA was extracted via hydrodistillation (yield: 1.

Heterointerface Anchored Ir with Localized Strong Orbital Coupling for Durable Proton Exchange Membrane Water Electrolysis.

The imperative to minimize iridium usage in proton exchange membrane water electrolysis (PEMWE) process presents a pivotal challenge for hydrogen economy deployment, while inherent destabilization of iridium (Ir) active sites under corrosive operational conditions, originating from insufficient Ir bonding strength, remains a fundamental barrier. Here, we resolve this dilemma through heterointerface-engineered stabilization, where the strategically constructed Nb-TiO rutile/anatase heterophase homojunction stabilizes Ir sites with enhanced orbital overlap and intensified charge transfer. This atomic-scale anchoring mechanism, validated by operando characterization and theoretical calculations, strengthens Ir─O bonding and optimizes *OOH adsorption energetics, thereby enabling concurrent activity-stability improvements.

Preparation of Non-Covalent BPTCD/g-CN Heterojunction Photocatalysts and Photodegradation of Organic Dyes Under Solar Irradiation.

In this study, the BPTCD/g-CN heterojunction photocatalyst was successfully prepared by the hydrothermal method. BPTCD (3,3',4,4'-benzophenone tetracarboxylic dianhydride) is immobilised on the surface of g-CN by non-covalent π-π stacking. The BPTCD/g-CN heterojunction photocatalyst is an all-organic photocatalyst with significantly improved photocatalytic performance compared with g-CN.

Global research trends and hotspots in prognostic prediction models for pancreatic cancer: a bibliometric analysis.

Background: Pancreatic cancer is a highly aggressive malignancy of the digestive system, characterized by insidious onset and rapid progression. Most cases are diagnosed at advanced stages, complicating surgical resection and presenting significant challenges for clinical treatment. Recent advancements have emphasized individualized treatment strategies tailored to patients' specific conditions.

Transition metal single-atoms anchored on MoC MXenes for enhanced hydrogen oxidation reaction: a density functional theory study.

Alkaline anion-exchange membrane fuel cells (AEMFCs) have garnered significant attention as promising energy conversion devices, yet their development remains hindered by the scarcity of efficient platinum-free electrocatalysts for the hydrogen oxidation reaction (HOR). Here, we systematically investigated the HOR catalytic performance of transition metal single-atoms supported by MoC (TM-MoC, TM = Fe, Co, Ni, Cu, Zn, Ru, Rh, Pd, Ag, Ir, Pt) using first-principles density functional theory (DFT) calculations. Theoretical calculations indicate that the integration of TM atoms with MoC substrates modulates the electronic structure, and establishes dual active sites comprising TM and adjacent Mo atoms.

Pneumococcal serotype distribution and coverage of existing and pipeline pneumococcal vaccines.

Background: Next-generation pneumococcal conjugate vaccines (PCVs) target an expanding array of serotype antigens. We assessed the proportions of invasive pneumococcal disease (IPD) and pneumococcal acute respiratory infections (ARIs) caused by serotypes targeted by existing and pipeline PCVs, and annual U.S.

Genetic diagnosis and prenatal diagnosis of patients with cystic kidney disease in Southwest China.

Background: Cystic kidney disease is a heterogeneous chronic kidney disease. It is often difficult to make a definitive diagnosis based on clinical and ultrasound features alone.

Methods: A total of 40 families with cystic kidney disease from Southwest China to meet their genetic counseling and prenatal diagnosis needs.

White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage.

Objective: To investigate the value of admission blood routine and coagulation function parameters in predicting acute symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods: This retrospective study included 423 patients with aSAH admitted to the Department of Neurosurgery of the Third Affiliated Hospital of Soochow University from November 2013 to September 2020. Demographic, clinical and laboratory data were collected.