LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment.

Background: Endometrial cancer (EC), a leading gynecologic malignancy, demonstrates a rising global incidence that imposes significant clinical and socioeconomic burdens. While the RNA-binding protein LIN28B has been reported to promote the progression of EC, its mechanistic role in driving tumor progression and immune modulation remains poorly characterized. This study specifically investigates whether LIN28B promotes EC progression through MYC upregulation and its influence on tumor immune microenvironment remodeling.

White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage.

Objective: To investigate the value of admission blood routine and coagulation function parameters in predicting acute symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods: This retrospective study included 423 patients with aSAH admitted to the Department of Neurosurgery of the Third Affiliated Hospital of Soochow University from November 2013 to September 2020. Demographic, clinical and laboratory data were collected.

An efficient method for coupled rotation and torsion of oriented AXn1-BYn2 molecules with application to BF2BCl2.

A new and concise method to obtain the eigenvalues and eigenfunctions of a two-dimensional rotational-torsional Hamiltonian with correct boundary conditions is proposed for oriented AXn1-BYn2 type molecules. The corresponding eigenfunctions are not only eigenfunctions of the Hamiltonian but also common eigenfunctions of several symmetry operators. Numerical calculations for the lowest 1000 rotational-torsional eigenstates of BF2BCl2 demonstrate the advantages and applicability of our method.

5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway.

Background: Renal ischemia/reperfusion (I/R) injury is a prevalent clinical complication characterized by high incidence and mortality rates. The endogenous metabolite, 5-Methoxytryptophan (5-MTP), derived from tryptophan, possesses anti-inflammatory and antioxidant properties. However, its role in renal I/R injury remains unclear.

Construction and validation of a histone-related gene signature for the diagnosis of endometriosis.

Objectives: Endometriosis is a common chronic disease in childbearing women and a major cause of infertility. Our study aimed to identify and validate a novel gene signature for diagnosing endometriosis based on histone-related genes (HRGs), and to investigate their biological functions in endometriosis.

Material And Methods: RNA sequence data were downloaded from the Gene Expression Omnibus database, and HRGs were retrieved from the GeneCards database.

Constructing a Hospital Department Development-Level Assessment Model: Machine Learning and Expert Consultation Approach in Complex Hospital Data Environments.

Background: Every hospital manager aims to build harmonious, mutually beneficial, and steady-state departments. Therefore, it is important to explore a hospital department development assessment model based on objective hospital data.

Objective: This study aims to use a novel machine learning algorithm to identify key evaluation indexes for hospital departments, offering insights for strategic planning and resource allocation in hospital management.

Genome-Wide Analysis and Expression Profiling of Lectin Receptor-like Kinase Genes in Watermelon ().

Watermelon is one of the most important edible plants worldwide. Owing to its special cultivation conditions, watermelon is exposed to many biological and abiotic stresses during its development. Lectin receptor-like kinases (LecRLKs) are plant-specific membrane proteins that play important roles in sensing and responding to environmental stimuli.

Prognostic value of neutrophil-to-lymphocyte ratio change in patients with locally advanced non-small cell lung cancer treated with thoracic radiotherapy.

In prior investigations, a correlation was established between patient outcomes in locally advanced non-small cell lung cancer (LA-NSCLC) following thoracic irradiation and parameters, such as pre/post-treatment neutrophil-to-lymphocyte ratio (NLR) and NLR change (ΔNLR). However, these parameters could potentially be influenced by radiation-related variables, such as gross tumor volume (GTV). The primary aim of this study was to elucidate the factors impacting post-treatment NLR and ΔNLR and to further assess their prognostic relevance.

Restriction on molecular fluxionality by substitution: A case study for the 1,10-dicyanobullvalene.

We show herein that 1,10-dicyano substitution restricts the paragon fluxionality of bullvalene to just 14 isomers which isomerize along a single cycle. The restricted fluxionality of 1,10-dicyanobullvalene (DCB) is investigated by means of: (i) Bonding analyses of the isomer structures using the adaptive natural density partitioning (AdNDP). (ii) Quantum dynamical simulations of the isomerizations along the cyclic intrinsic reaction coordinate of the potential energy surface (PES).

Transcriptome and single-cell analysis reveal disulfidptosis-related modification patterns of tumor microenvironment and prognosis in osteosarcoma.

Osteosarcoma (OS) is the most common malignant bone tumor with high pathological heterogeneity. Our study aimed to investigate disulfidptosis-related modification patterns in OS and their relationship with survival outcomes in patients with OS. We analyzed the single-cell-level expression profiles of disulfidptosis-related genes (DSRGs) in both OS microenvironment and OS subclusters, and HMGB1 was found to be crucial for intercellular regulation of OS disulfidptosis.

SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.

Background: Ovarian cancer (OC) is the most lethal gynecologic malignant tumour. The mechanism promoting OC initiation and progression remains unclear. SET domain bifurcated histone lysine methyltransferase 1(SETDB1) acts as an oncogene in a variety of tumours.

Ultrasonic imaging of delamination in thick CFRP laminates using an energy-compensation reverse time migration method.

In ultrasonic reflection method, the precision of defect detection in thick carbon fiber reinforced plastics (CFRP) is compromised by acoustic energy attenuation. An energy-compensation reverse time migration (ECRTM) method is proposed to identify multiple defects accurately. Forward and backward wavefields are formed using the finite element method within an anisotropic acoustic model based on the Christoffel equation and Bond transformation.

Radiomics nomogram for preoperative differentiation of early-stage serous borderline ovarian tumors and serous malignant ovarian tumors.

Objectives: This study aimed to construct a radiomics nomogram and validate its performance in the preoperative differentiation between early-stage (I and II) serous borderline ovarian tumors (SBOTs) and serous malignant ovarian tumors (SMOTs).

Methods: Data were collected from 80 patients with early-stage SBOTs and 102 with early-stage SMOTs (training set: = 127; validation set: = 55). Univariate and multivariate analyses were performed to identify the independent clinicoradiological factors.

4-Octyl itaconate alleviates renal ischemia reperfusion injury by ameliorating endoplasmic reticulum stress via Nrf2 pathway.

Renal ischemia-reperfusion injury (IRI) is a common clinical complication of multiple severe diseases. Owing to its high mortality and the lack of effective treatment, renal IRI is still an intractable problem for clinicians. Itaconate, which is a metabolite of cis-aconitate, can exert anti-inflammatory and antioxidant roles in many diseases.

Multiscale levels CO decouple reinforcement in China.

Decoupling economic growth from CO emissions is imperative for China. Meanwhile, establishing a consistent and comprehensive decoupling inventory that includes national (N), regional and provincial (RP), and city and county (CC) levels is essential for further policy formulation. This research aims to investigate the decoupling status using the "N-RP-CC" approach while considering changes in decoupling trends at the different levels.

Effect of different metastasis patterns on the prognosis of patients with stage III high-grade serous ovarian cancer.

To investigate the effect of different metastatic patterns of stage III high-grade serous ovarian cancer on the patient prognosis. The clinical data of 134 patients with Stage III, high-grade serous ovarian cancer diagnosed in The Affiliated Hospital of Qingdao University from January 2018 to April 2020 were retrospectively collected, and the patients were grouped according to metastasis mode. Patients with simple lymph node metastasis (SLNM) were included in the SLNM group, and patients with simple abdominal implantation alone and patients with abdominal metastasis combined with lymph node metastasis were all in the abdominal metastasis (AM) group.

A review on guided-ultrasonic-wave-based structural health monitoring: From fundamental theory to machine learning techniques.

The development of structural health monitoring (SHM) techniques is of great importance to improve the structural efficiency and safety. With advantages of long propagation distances, high damage sensitivity, and economic feasibility, guided-ultrasonic-wave-based SHM is recognized as one of the most promising technologies for large-scale engineering structures. However, the propagation characteristics of guided ultrasonic waves in in-service engineering structures are highly complex, which results in difficulties in developing precise and efficient signal feature mining methods.

Changes in Fruit Quality Phytochemicals of Late-Mature Peach 'Yonglian No.1' during Storage.

In this study, the changes in quality parameters and sensory-influencing parameters from the peel, red flesh, and white flesh of 'Yonglian No.1' peach fruits were analyzed during cold storage. The results indicated that the contents of total soluble solids (TSS), soluble sugar, organic acid, vitamin C, total anthocyanin, phenol, and flavonoids, as well as the good fruit rate varied depending on the storage stages and storage treatments.

Impact of intergenerational support and medical expenditures on depression: Evidence from rural older adults in China.

Objective: Globally, depression has become a major health issue among older adults, who experience poor physical health and high medical expenditures. In Asian countries, older adults are greatly dependent on their children. This study assessed the impact of different types of intergenerational support and medical expenditures on depression among older adults in rural China.

Contact Characteristics and Tribological Properties of the Weaving Surface of Mn-Cu and Fe-Zn Damping Alloys.

In this paper, laser texturing is performed on the surface of Mn-Cu and Fe-Zn damping alloys and the tribological properties of the samples with various surface weaves under dry-sliding conditions are investigated. The results show that the surface weave parameters affect the size of the contact surface and change the number of micro-convex bodies at the contact interface. This leads to changes in the tangential damping of the contact and further affects the magnitude of the friction coefficient.

Imaging a defect in layered media with different shaped interfaces using reverse time migration without velocity model known a priori.

In this work, the highly accurate image of a defect in the layered media using a reverse time migration (RTM) is obtained without priori information of the interface geometry and acoustic velocity of the lower medium. The interface of layered media is reconstructed by RTM, and its profile is determined using the reconstructed image within the range of -6 to 0 dB. At the assumed acoustic velocity of the lower medium, the minimum variance of the possible position distribution of a defect is evaluated to be an acoustic velocity of the lower medium by processing the travel times of the defect scattered echoes.

Biological Control and Plant Growth Promotion by Volatile Organic Compounds of T-51.

spp. are widely used in plant disease control and growth promotion due to their high efficacy and multiple biocontrol mechanisms. T-51 is an effective biocontrol agent against gray mold disease by direct contact.

Cloning and Expression Analysis of Flavonoid 3', 5'-Hydroxylase Gene from .

The full-length cDNA sequence of gene from the was obtained by RT-PCR and RACE, whose GenBank accession number is JQ678765. The sequence contains a 1521 bp open reading frame, 120 bp 5'UTR and 61 bp 3'UTR, encoding a total of 506 amino acids. The molecular mass of the predicted protein is 56.