and Endosymbiont in Ticks from Western China.

spp. are widespread in ticks. , the agents of Q fever, is vectored by ticks and is well known for its veterinary and medical importance.

Olfactory training improves cognition and modifies brain networks in type 2 diabetes patients with mild cognitive impairment: A 16-week randomised controlled trial.

Aims: Type 2 diabetes (T2D) related cognitive impairment links to comorbid and modifiable olfactory dysfunction; however, the efficacy of olfactory training (OT) to mitigate cognitive decline specifically in these patients with mild cognitive impairment (MCI) remains unestablished. This study aimed to determine whether OT alleviates cognitive decline in this population.

Materials And Methods: In this 16-week, open-label trial, 60 T2D participants with MCI were randomly assigned (1:1) to OT or routine care (control).

Arriving at ultralow wear using cellulose/two-material composites.

The development of environmentally friendly solid lubricants with exceptional wear resistance is imperative to address the escalating environmental concerns and performance limitations of conventional lubricants in demanding tribological applications. This study systematically investigated the wear resistance of hydroxypropyl methylcellulose (HPMC)/tungsten disulfide (WS)/graphene composites under normal applied loads (2 and 4 N) and varying solid lubricant contents (stoichiometric ratios of 0.2 referred to as CWG-0.

3D Spatial Learning for Adsorption Energy Prediction in Multi-Temporal Solution Systems: The MTSS Data Set and a GCN-Based Network.

Existing methods for adsorption energy prediction primarily focus on individual molecules or static molecular pairs, lacking the capabilities to model the diverse spatial configurations found in complex solution systems. While traditional data sets are static, dynamic systems explore a vast conformational space over time. This paper introduces the Multi-Temporal Solution System (MTSS) data set containing 500,000 temporally resolved configurations (3D atomic coordinates + adsorption energy labels) across five solvents.

Functional connectivity signatures of olfactory networks linked to cognitive risk: A functional MRI study in subjective cognitive decline at risk for Alzheimer's disease.

BackgroundIndividuals with subjective cognitive decline (SCD) are at high risk of preclinical Alzheimer's disease (AD). While olfactory dysfunction is evident in AD and mild cognitive impairment (MCI), its presence and neural mechanism in SCD remain unclear.ObjectiveThis study examined functional connectivity (FC) alterations across olfactory networks and their mediating role between olfactory and cognitive functions in SCD and MCI.

Physiological and Performance Adaptations to Running-Based Interval Interventions in Soccer Players: Comparative Analysis of Sprint Interval Training, Small-Sided Games, and Repeated-Sprint Training.

Purpose: The objective of this study was to investigate the impact of a 6-week program involving various forms of running-based interval interventions on the physiological and performance adaptations of male soccer players during preseason.

Methods: A total of 40 young trained collegiate soccer players (21 [1.3] y) were randomly assigned to 4 groups: traditional sprint interval training (SIT, 20-s trials), small-sided games, repeated-sprint training (RST, 5-s trials), and an active control group, each of 10 members.

Dual surface modification strategies for enhanced osteogenesis of titanium through the biomimetic Haversian osteon with deposited CaP to assemble salidroside.

Titanium (Ti) and Ti alloy are the most widely used implant metals, but the limited bioactivity hinders the further clinical application. Aiming to enhance their osteogenesis, dual biomimetic strategies were utilized to decorate the surface of Ti by topological and biochemical cues. Firstly, a series of concentric circles with TiO nanotubes on Ti were fabricated by photolithography and anodic oxidation.

The predictive value of TyG index in patients with vertebrobasilar system thrombectomy.

Introduction: The triglyceride-glucose (TyG) index, a robust surrogate marker of metabolic dysregulation reflecting both insulin resistance and lipid-glucose homeostasis, has emerged as a significant predictor of cerebrovascular outcomes. Given the critical role of metabolic-nutritional status in post-stroke recovery, we supposed that the TyG index may predict the prognosis of ischemic stroke patients who underwent thrombectomy in the posterior circulation.

Methods: We studied 60 patients with cerebral infarction who underwent emergency posterior circulation interventional thrombectomy at a comprehensive stroke center from January 2018 to July 2024.

FGFC1 overcomes Ara-C resistance in acute myeloid leukemia by inducing apoptosis and pyroptosis.

Acute myeloid leukemia (AML) is a hematologic malignancy with a high mortality rate and poor prognosis, largely attributed to the emergence of chemotherapy resistance. Cytarabine (Ara-C), the cornerstone chemotherapeutic agent for AML, faces significant challenges due to the development of resistance, creating an urgent need for novel therapeutic strategies. Pyroptosis as a new form of programmed cell death has emerged as a potential therapeutic target in tumor treatment.

Distribution for platelet antibody in patients with immune-mediated platelet transfusion refractoriness.

Objectives: HLA Class I, HPA (Human platelet antigen), CD36 allo/isoantibodies, and platelet glycoprotein autoantibodies are the primary causes of immune-mediated platelet transfusion refractoriness (iPTR). Detecting these antibodies and selecting antigen-negative platelets for transfusion effectively manages iPTR, but large-scale data on platelet antibody distribution in the Chinese population are scarce.

Methods: From Jan 2021 to Dec 2023, 2073 patients with suspected iPTR underwent platelet cross-matching via solid-phase red blood cell adherence.

Genetically predicted maternal prepregnancy BMI increased risk of childhood intestinal malformation: evidence from a Mendelian randomization study.

The study aimed to explore the causal effect of maternal prepregnancy body mass index (BMI) on congenital malformations of intestine (CMI). The genome-wide association data of BMI and CMI were obtained via the Mendelian randomization (MR) base platform. Single nucleotide polymorphisms (SNPs) significantly associated with BMI in females were identified and used as instrumental variables, and the causal relationship between BMI in females and CMI was examined using the bidirectional two-sample MR analyses research method.

Breakfast consumption behavior was positively associated with cognitive function in Chinese adults aged 55 years and above.

Objectives: This study aims to investigate the relationship between breakfast consumption behavior and cognitive function in Chinese adults aged 55 years and above, and the mediating effect of diet quality.

Methods: Data were drawn from the China Health and Nutrition Survey (CHNS) 1997, 2000, 2004, 2006, 2015, and 2018. Participants aged 55 years and above who had at least two waves of completed data on dietary measures and cognitive assessments were eligible.

Transforming Crowded Coacervates into Multi-Compartmental Hybrid Microreactors for Practical Enzymatic Catalysis.

Advancing the design and construction of artificial protocells with organized complexity, diverse functionality and practical applicability is urgently demanded in vitro synthetic biology and bioengineering but remains a grand challenge. Here, we present a versatile Pickering emulsion-based encapsulation approach to transform membraneless coacervate compartments into robust multicompartmental hybrid microreactors, which concurrently assimilate the expected attributes of hierarchically compartmentalized structure, molecularly crowded environment, selectively permeable ability and mechanically reinforced stability. Single or multiple biological and non-biological catalytic species can be spatially sequestered in specific domains of the hybrid microreactor, enabling spatiotemporal regulation of individual biocatalysis or divergent cascades with high reaction efficiency.

Investigation of Pharmacological Mechanisms and Active Ingredients of L. in Alleviating Renal Urate Deposition via lncRNA H19/miR-21-3p Regulation to Enhance ABCG2 Expression.

Renal urate deposition is a pathological inflammatory condition characterized by the accumulation of urate crystals in the kidneys, resulting from uric acid supersaturation. L. (chicory) is a traditional medicinal herb recognized for its efficacy in treating hyperuricemia and gout; however, its effectiveness and underlying mechanisms in mitigating renal urate deposition remain inadequately understood.

NF1-depleted ER breast cancers are differentially sensitive to CDK4/6 inhibitors.

Neurofibromin/NF1 is a RAS (rat sarcoma virus) GTPase-activating protein and estrogen receptor (ER) transcriptional corepressor. NF1 status, identified by copy number loss or low mRNA/protein expression, is associated with endocrine therapy resistance in ~20% of ER/HER2 (human epidermal growth factor receptor 2) early-stage breast cancers. The identification of targeted treatments for NF1 ER/HER2 breast cancer is therefore a priority.

DeepMVP: deep learning models trained on high-quality data accurately predict PTM sites and variant-induced alterations.

Post-translational modifications (PTMs) are critical regulators of protein function, and their disruption is a key mechanism by which missense variants contribute to disease. Accurate PTM site prediction using deep learning can help identify PTM-altering variants, but progress has been limited by the lack of large, high-quality training datasets. Here, we introduce PTMAtlas, a curated compendium of 397,524 PTM sites generated through systematic reprocessing of 241 public mass-spectrometry datasets, and DeepMVP, a deep learning framework trained on PTMAtlas to predict PTM sites for phosphorylation, acetylation, methylation, sumoylation, ubiquitination and N-glycosylation.

Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase.

Introduction: Diabetes is a significant modifiable risk factor for cognitive dysfunction. There are currently no effective treatments that delay or reverse the progression of cognitive dysfunction. Accumulating evidence demonstrates that specific antidiabetes medications hold promise in improving cognitive function.

Recent advances in tumor immunotherapy based on NK cells.

Immunotherapy has emerged as the established fourth pillar of cancer treatment following surgery, radiotherapy, and chemotherapy, representing a cutting-edge research domain in translational medicine and clinical oncology. Natural killer (NK) cells, a type of innate cytotoxic lymphocyte, possess unique antitumor properties that are independent of major histocompatibility complex (MHC) restrictions, making them promising candidates for "off-the-shelf" therapeutic products. NK cells can eliminate tumor cells through various mechanisms.

Exercise training ameliorates high-fat diet-induced skeletal muscle atrophy and ferroptosis via downregulation of STING.

Background: High-fat diet (HFD)-induced sarcopenic obesity can lead to reductions in muscle fiber diameter, enhanced protein degradation, and various forms of cell death. Exercise training has been shown to alleviate HFD-induced muscle atrophy. However, the underlying mechanism remains unclear.

Nitrogen-doped NiCo-layered double hydroxide nanocage-based solid phase microextraction for highly selective recognition and sensitive detection of nitrogen-containing pesticides.

Pesticides are indispensable products in agricultural production, poses risks to human health, ecological and environmental pollution due to its bioaccumulation and excessive use. Despite existing detection methods, the need for rapid, sensitive, and specific recognition pesticides quantification remains urgent, particularly for widely used nitrogen-containing pesticides. Here, a nitrogen-doped layered double hydroxide nanocage (N-NiCo-LDH) with hollow-structured composite was conjugated via a simple solvothermal method, it was used as the extraction medium for solid-phase microextraction (SPME), which provided abundant hydrogen bonding interactions for nitrogen-containing pesticides.

Microplastic accumulation in endometrial cancer tissues and its metabolic impact.

With increasing global awareness of plastic pollution, microplastics (MPs) have emerged as a potential environmental health hazard. While MPs have been detected in various human tissues, their relevance to gynecological malignancies, particularly endometrial cancer (EC), remains largely unexplored. This study aims to evaluate MP accumulation in EC tissues and investigate its potential impact on tissue metabolic reprogramming.

Loss of cardiolipin and porins bypasses the essentiality of the sigma E cell envelope stress response in .

The Gram-negative cell envelope is composed of an inner and outer membrane, each with different lipid compositions. The inner membrane is predominantly made up of phosphatidylglycerol, phosphatidylethanolamine, and cardiolipin, while the outer membrane contains the same lipids but has a predominantly lipopolysaccharide composition in the outer leaflet. The outer membrane forms a permeability barrier that blocks the entry of toxins and antibiotics; however, it is decorated with outer membrane proteins that allow nutrient uptake and the efflux of intracellular toxins.

An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.

Background: Endogenous retroviruses (ERVs) occupy >8% of the human genome. Aberrant resurgence of ERVs has been implicated recently in several critical pathologies. However, the possible incidence and role of ERV resurgence in heart failure (HF), a leading cause of global morbidity and mortality, remain unexplored.

The Effects of Limonin, Myo-Inositol, and L-Proline on the Cryopreservation of Debao Boar Semen.

Semen cryopreservation is associated with sperm vulnerability to oxidative stress and ice crystal-induced damage, adversely affecting in vitro fertilization (IVF) success. This study aimed to investigate the effects of freezing diluent supplemented with antioxidant limonin (Lim), myo-inositol (MYO), and the ice crystal formation inhibitor L-proline (LP) through sperm motility, morphological integrity, and antioxidant capacity. The Lim (150 mM), MYO (90 mM), and LP (100 mM) significantly ameliorated the quality of post-thaw sperm in Debao boar, and combined treatment of these agents significantly enhanced sperm motility, structural integrity, and antioxidant capacity compared with individual agents ( < 0.

Development of a novel and highly efficient catalyst-free mediated "oxidant-oxidant" process for enhanced decontamination of water contaminants.

Synergistic actions of periodate (PI, IO) and other common oxidants have garnered increasing attention in water treatment. However, previous studies have predominantly focused on single reactive species or been limited by susceptibility to aqueous matrices, thereby posing challenges for broad-spectrum pollutant removal and complex water decontamination. To address this, we proposed an "oxidant-oxidant" strategy that synergistically combined peracetic acid (PAA) with PI for the degradation of micropollutants.