Research on Material Basis and Quality Control of Folium, a Traditional Medicinal and Edible Material.

Folium (AAF) is a traditional medicinal and edible material. However, the pharmacologically active compounds and quality control of AAF have not been fully investigated. To solve these problems, we developed a novel method based on HPLC-Q-Exactive Orbitrap-HRMS for rapid identification of chemical compounds in AAF.

Dual surface modification strategies for enhanced osteogenesis of titanium through the biomimetic Haversian osteon with deposited CaP to assemble salidroside.

Titanium (Ti) and Ti alloy are the most widely used implant metals, but the limited bioactivity hinders the further clinical application. Aiming to enhance their osteogenesis, dual biomimetic strategies were utilized to decorate the surface of Ti by topological and biochemical cues. Firstly, a series of concentric circles with TiO nanotubes on Ti were fabricated by photolithography and anodic oxidation.

Dual-active site engineering of Co/Cu single atoms and nanoclusters on M-N-CNTs (M = Co, Cu, CoCu): Synergistic catalysis for ultrafast hydrogen production from Ammonia borane.

Progress towards a hydrogen economy depends on green and efficient ways to produce hydrogen. A promising route is the catalytic hydrolysis of ammonia borane (AB). To address challenges in catalyst performance and cost for AB hydrolysis, we developed a structurally tuned heterogeneous non-precious metal catalyst based on cobalt (Co) and copper (Cu).

Investigation of molecular mechanisms in silver nanoparticle-induced cytotoxicity from gene to metabolite level.

The aim of this study was to explore the mechanisms in silver nanoparticle (AgNP)-induced cytotoxicity from gene to metabolite levels through an integrative analysis of transcriptomics and metabolomics results. First, transcriptome sequencing technology revealed 1365, 1241, and 2790 genes differentially expressed within human dermal fibroblasts (HDFs) after 4, 8, and 24 h of exposure to silver nanoparticles, which were involved in 250, 248, and 280 biological pathways. Then, by comparing with the metabolomics results, 7 metabolic pathways (purine metabolism pathway, glycerophospholipid metabolism pathway, etc.

Medication Adherence Status and Influencing Factors in Adolescent Kidney Transplant Recipients.

Background: This study investigated medication adherence and related factors in adolescent kidney transplant recipients receiving immunosuppressive drugs.

Methods: Between February and October 2023, 115 adolescent kidney transplant recipients were selected through convenience sampling from follow-up centers in four Chinese tertiary hospitals. The study assessed medication adherence and influencing factors via a general information questionnaire, an adherence assessment scale, a medication belief scale, and an overall happiness scale.

Multiple Secondary Bond-Mediated C-N Coupling over N-Doped Carbon Electrocatalysts.

Electrocatalytic C-N reductive coupling offers a sustainable and eco-friendly approach to producing value-added oximes. The challenge lies in the overstrong chemisorption of N-containing intermediates and carbonyl compounds on metal-based catalysts, which causes low Faradaic efficiency and yield rates, as well as undesired byproducts. Here, we propose a multiple secondary bond-mediated strategy for C-N coupling toward benzaldoxime on a nitrogen-doped graphene-like carbon catalyst (NC).

Investigation of the Neurotoxicity Mechanisms of Ni in Rat Neocortical Neurons Through Transcriptome Analysis.

The cytotoxic effects of Ni released from nickel-based alloy implants on tissues have been a longstanding research focus in biocompatibility studies. However, investigations into the neurotoxicity of Ni remain relatively limited. Building on our previous findings that Ni can rapidly affect the excitability of neuronal networks, this study further investigated the neurotoxic effects of prolonged Ni exposure.

Search for Solar Boosted Dark Matter Particles at the PandaX-4T Experiment.

We present a novel constraint on light dark matter utilizing 1.54 metric ton/year of data acquired from the PandaX-4T dual-phase xenon time projection chamber. This constraint is derived through detecting electronic recoil signals resulting from the interaction with solar-enhanced dark matter flux.

Searching for neutrinoless double-beta decay of Xe with PandaX-4T.

We report the search for neutrinoless double-beta decay of Xe from the PandaX-4T experiment with a 3.7-tonne natural xenon target. The data reconstruction and the background modeling are optimized in the MeV energy region.

Preparation and Application of Hydrophobic and Breathable Carbon Nanocoils/Thermoplastic Polyurethane Flexible Strain Sensors.

The emphasis on physical activity and health monitoring has increased the demand for developing multifunctional, flexible sensors through straightforward methods. A hydrophobic, breathable, and flexible strain sensor was prepared using a filtration method, employing thermoplastic polyurethane (TPU) as a substrate, carbon nanocoils (CNCs) as conductive fillers, and polydimethylsiloxane (PDMS) as a binder. The sensing layer, prepared using the unique three-dimensional helical structure of carbon nanocoils, achieved a hydrophobic angle of 143° and rapidly changed the color of the pH test paper in 5 s.

Association of salt added to food with risk of cardiovascular diseases: A 2-sample Mendelian randomization study.

Salt added to food is believed to potentially influence the risk of cardiovascular diseases (CVD), however, more evidence needs further verification. Here, we conducted a 2-sample Mendelian randomization (MR) study to systematically investigate the associations of salt added to food with 11 types of cardiovascular diseases in the general population. The primary MR analysis adopts the inverse-variance weighting (IVW) method, complemented by ancillary analyses utilizing IVW (fixed effects), weighted medium, maximum likelihood, and penalized weighted median methodologies.

Injectable sodium alginate/4-arm polyethylene glycol-lipoic acid double-network hydrogel loading Ca-tannic acid nanocomposite treats periodontitis via anti-bacteria, ROS scavenging and osteogenesis.

The inflammatory environment of periodontitis with bacteria, excessive reactive oxygen species (ROS) and limited regenerative capacity of alveolar bone makes reconstruction of periodontium become a huge challenge. The present strategies, such as local debridement and antibiotic injection, are difficult to solve above problems completely. Thus, to reverse the progression of the disease, Ca-tannic acid nanocomposites loaded into injectable sodium alginate/4-arm polyethylene glycol-lipoic acid hydrogel (CaTA@Gel) were fabricated, including Ca‑sodium alginate (SA) ionic crosslinking and radical polymerization of lipoic acid-modified 4-arm polyethylene glycol (PEG-SS) under UV illumination.

Search for MeV-Scale Axionlike Particles and Dark Photons with PandaX-4T.

Axionlike particles (ALPs) and dark photons (DPs) are viable dark matter particle candidates. We have searched for possible ALP/DP signals in the PandaX-4T liquid xenon detector using 440  kg·yr of data. A binned likelihood fit is constructed to search for possible mono-energetic peaks induced by the absorption processes between ALPs/DPs and atomic electrons of xenon.

Development of AlN-loaded PET separators from waste water bottle plastics with superior thermal characteristics for next-generation lithium-ion batteries.

Preventing short circuit hazard due to lithium (Li) dendrite formation across a separator from the anode of a lithium-ion battery (LIB) throughout operation is important; however, conventional separator materials cannot fulfil the increasing safety standards of next-generation LIBs. Thus, developing separator materials with high Li dendrite suppression ability in order to prevent short circuit is of paramount importance for realising next-generation LIBs. In this study, aluminum nitride-loaded polyethylene terephthalate (PET/AlN) composites with micro-/nanoarchitecture were synthesized using PET that was recycled from commercial waste bottles an electrospinning strategy.

Predictors of stress among nucleic acid sampling support nurses (NASSNs) during the COVID-19 pandemic.

Background: The COVID-19 pandemic has forced nucleic acid detection to be essential for prevention and control. The psychological and physical health of healthcare staff who conducted nucleic acid sampling (NAS) should be paid attention to. This study aims to investigate the status and explore the predictors of stress among nucleic acid sampling support nurses (NASSNs) by an online survey.

Exploring New Physics with PandaX-4T Low Energy Electronic Recoil Data.

New particles beyond the standard model of particle physics, such as axions, can be effectively searched through their interactions with electrons. We use the large liquid xenon detector PandaX-4T to search for novel electronic recoil signals induced by solar axions, neutrinos with anomalous magnetic moment, axionlike particles, dark photons, and light fermionic dark matter. A detailed background model is established using the latest datasets with 1.

Dark Matter Search Results from 1.54 Tonne·Year Exposure of PandaX-4T.

In this Letter, we report the dark matter search results from the commissioning run (Run0) and the first science run (Run1) of the PandaX-4T experiment. The two datasets were processed with a unified procedure, with the Run1 data treated blindly. The data processing is improved compared to previous work, unifying the low-level signal reconstruction in a wide energy range up to 120 keV.

Accuracy of Freestyle Libre continuous glucose monitoring system in critically ill patients after cardiac surgery.

Background: Hyperglycemia is an independent risk factor for perioperative complications and mortality after cardiac surgery. Freestyle Libre Continuous glucose monitor (CGM) is an interstitial glucose monitoring system, which has been proven to be stable and accurate in various disease.

Materials And Methods: 86 patients with hyperglycemia after cardiac surgery between October 2021 and October 2022 in the cardiovascular ICU, were enrolled in this study.

The Effect of Flexible Flatfoot on the Running Function in School-Age Children.

Flexible flatfoot is common among school-age children and significantly affects walking efficiency, balance stability, and joint-movement coordination in children. The demands on the skeletal structure and muscle function are increased during running; however, the impact of a flexible flatfoot on children's running capabilities is unclear. In this study, we aimed to investigate the effects of flexible flatfoot on the running function of school-age children.

Electrical excitability of neuronal networks based on the voltage threshold of electrical stimulation.

Microelectrode arrays (MEAs) have been widely used in studies on the electrophysiological features of neuronal networks. In classic MEA experiments, spike or burst rates and spike waveforms are the primary characteristics used to evaluate the neuronal network excitability. Here, we introduced a new method to assess the excitability using the voltage threshold of electrical stimulation.

Three-dimensional kinematic analysis can improve the efficacy of acupoint selection for post-stroke patients with upper limb spastic paresis: A randomized controlled trial.

Background: China is seeing a growing demand for rehabilitation treatments for post-stroke upper limb spastic paresis (PSSP-UL). Although acupuncture is known to be effective for PSSP-UL, there is room to enhance its efficacy.

Objective: This study explored a semi-personalized acupuncture approach for PSSP-UL that used three-dimensional kinematic analysis (3DKA) results to select additional acupoints, and investigated the feasibility, efficacy and safety of this approach.

Synergetic pyrolysis of lithium-ion battery cathodes with polyethylene terephthalate for efficient metal recovery and battery regeneration.

Spent LiNiCoMnO (x + y + z = 1) and polyethylene terephthalate are major solid wastes due to the growing Li-ion battery market and widespread plastic usage. Here we propose a synergistic pyrolysis strategy to recover valuable metals by thermally treating LiNiCoMnO and polyethylene terephthalate. With polyethylene terephthalate assistance, LiNiCoMnO decomposes at 400 °C, and fully converts to LiCO, MnO, and Ni-Co alloy at 550 °C within 30 min, using a 1.