Research on Material Basis and Quality Control of Folium, a Traditional Medicinal and Edible Material.

Folium (AAF) is a traditional medicinal and edible material. However, the pharmacologically active compounds and quality control of AAF have not been fully investigated. To solve these problems, we developed a novel method based on HPLC-Q-Exactive Orbitrap-HRMS for rapid identification of chemical compounds in AAF.

Plasticized electrohydraulic robot autopilots in the deep sea.

Soft robots, with their compliant bodies, minimal environmental disturbance, and ability to withstand ambient pressures, offer promising solutions for deep-sea exploration. However, a common challenge of stiffening in soft materials impairs their effective actuation in harsh conditions. In this work, we integrated a liquid dielectric plasticizer within an electrohydraulic soft robot, serving dual critical functions as a softening agent to maintain the softness of the polymer shell and an electrohydraulic fluid for efficient actuation.

Injectable exosome-reinforced konjac glucomannan composite hydrogel for repairing cartilage defect: activation of endogenous antioxidant pathways.

Enhancing the regeneration of cartilage defects remains a formidable challenge, as the dysregulated microenvironment and its crosstalk with chondrocytes play pivotal roles in impairing regeneration. In this study, we proposed a natural plant polysaccharides-derived injectable hydrogel (Exos@EKM) for adapting to irregular cartilage defects. By encapsulating stem cell-derived exosomes (Exos) into polyphenol modified methacryloylated konjac glucomannan (EKM), this hydrogel exerting a potent biological synergistic effect.

Comparative Analysis of Melbourne Rapid Fields Web-Browser Perimeter and Humphrey Field Analyzer in Chinese Glaucoma Patients.

Purpose: This study aims to evaluate the efficacy and practicality of the Melbourne Rapid Fields (MRF) web-browser based perimeter software, compared to the conventional Humphrey Field Analyzer (HFA) 24-2 Swedish Interactive Threshold Algorithm (SITA) Standard Protocol in a hospital environment in China.

Methods: The study was conducted in a clinical practice setting from December 2023 to August 2024. A total of 113 Chinese speaking participants were enrolled, with 91 eyes from 91 patients included in the analysis.

BCMA-targeted CAR T cell therapy can effectively induce disease remission in refractory lupus nephritis.

Objectives: This study aims to evaluate the safety and efficacy of anti-B cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells in treating refractory lupus nephritis (LN).

Methods: This is an open-label, single-arm clinical trial assessing anti-BCMA CAR T cells in treating refractory LN patients. CAR T cells were infused following lymphodepletion therapy with cyclophosphamide and fludarabine.

Injectable natural Tremella-derived hydrogel for reversing ferroptosis-mediated osteoporotic microenvironment imbalance and promoting osteoregeneration.

Osteoporotic bone defects constitute a global health predicament due to their restricted self-repairing capacity. Ferroptosis arising from iron overload represents a crucial pathological characteristic of osteoporosis, depleting osteoblasts and disturbing bone metabolism. Inspired by natural tremella polysaccharide (TP), we developed an injectable composite hydrogel (OGP@DTrep) capable of inhibiting cell ferroptosis via dual mechanisms.

Study of payload calculation and motion prediction for unpowered diving and floating of deep-sea manned submersible.

The preferred method of diving and floating for deep-sea manned submersibles is unpowered. This method has the potential to significantly reduce the energy expenditure of the submersible, extend the operational time of the submersible underwater, and is a fundamental aspect of the submersible's overall underwater operational capability. Environmental parameters, including seawater density and pressure, as well as the displacement volume of the submersible, fluctuate with depth.

Natural fish swim bladder-derived MPN-nanofibrous biomimetic system exhibit ECM-responsive signal regulation and promote robust tendon-bone healing.

Enhanced tendon‒bone healing is of critically importance for achieving optimal postoperative recovery following a rotator cuff tendon tear (rotator cuff tears, RCTs). Although RCTs patch-augmented scaffolds demonstrate clinical potential, there is a paucity of reports on biodegradable scaffolds that effectively integrate high strength and bioactivity. Inspired by the composition and aligned nanofibrous structure of the natural fish bladder matrix (fish swim bladder, FSB), we employed a gallium (Ga)‒tannic acid (TA) metal‒polyphenol network (MPN)-modified decellularized fish bladder matrix (GaPP@FSB) as a novel biomaterial to address this problem.

IKZF1: An important target for the treatment of autoimmune diseases.

IKZF1 is a member of the Ikaros transcription factor family. It is involved in the regulation of the development and function of a variety of immune cells. Mutations or aberrant expression of IKZF1 are closely associated with the development of various immune-related diseases, including hematologic malignancies, solid tumors, and autoimmune diseases.

The Prognostic Significance of SMARCA4 Deficiency in Early-Stage Pulmonary Large Cell Carcinoma.

Background: Large cell carcinoma (LCC) is a rare subtype of non-small cell lung cancer (NSCLC) characterized by high prevalence of SMARCA4 deficiency and aggressive clinical behavior. However, despite these clinical parameters, the benefits of adjuvant therapy in early-stage LCC remain controversial.

Methods: This study included all LCC patients who underwent surgical resection at Shanghai Pulmonary Hospital between June 2017 and April 2023.

Loading tea polyphenols enhances the repair of human umbilical cord mesenchymal stem cell sheet after spinal cord injury.

Background: Spinal cord injury (SCI) is a devastating central nervous system disorder that remains a global health challenge. SCI-induced oxidative stress in the postinjury microenvironment limits tissue repair by provoking the excessive production of reactive oxygen species (ROS). Tea polyphenols (TP), as a natural plant polyphenol, could effectively reduce ROS.

Effects of telitacicept in SLE patients with antiphospholipid antibody positivity: a retrospective self-controlled case series.

Objectives: Antiphospholipid antibody (aPL) is closely related to the manifestation of antiphospholipid syndrome (APS) and an increased risk of thrombosis in systemic lupus erythematosus (SLE) patients. Telitacicept is a new dual B cell inhibitor which has been approved in China to treat SLE, but its application in APS or aPL-positive patients is still lacking. This study aimed to observe the effects of telitacicept in SLE patients with aPL positivity.

NiFe phosphides coupled on TiCT MXene nanosheets for high-efficiency oxygen evolution reaction in alkaline medium.

The development of stable, efficient and cost-effective electrocatalysts is crucial for overcoming the sluggish kinetics of the oxygen evolution reaction (OER) in electrochemical splitting water. Ni-Fe layered bimetallic phosphides (NiFe-P) exhibit considerable promise as electrocatalysts for OER. However, their limited conductivity and low inherent activity present significant challenges.

Knockdown of TGFB2 Attenuates Ischemic Heart Failure by Inhibiting Apoptosis.

Heart failure (HF) is a clinical syndrome resulting from cardiac overload and injury. The molecular mechanisms underlying ischemic HF remain unclear. Using the GSE116250 and GSE203160 datasets, we screened for differentially expressed genes (DEGs) in ischemic HF, identifying 132 overlapping genes.

Thalidomide can effectively prevent relapse in IgG4-related disease outweighing its side effects: a multicentre, randomised, double-blinded, placebo-controlled study.

Objectives: To investigate the effects of thalidomide in preventing disease relapse with 'zero' glucocorticoids (GCs) usage in IgG4-related disease (IgG4-RD).

Methods: This was a multicentre, randomised, double-blinded, placebo-controlled study, in which eligible patients in disease active status were randomised into 2 groups (group 1: GCs+Thalidomide; group 2: GCs+Placebo) at a 1:1 ratio. The primary outcome of this trial was the disease relapse rate at month 12, whereas the secondary outcomes were the disease remission rate at month 12 and the incidence of adverse events (AEs).

Relationship between plasma polymyxin B concentrations and acute kidney injury in critically ill elderly patients: Findings from a prospective study.

Objective: The objective of this study was to determine the relationship between the plasma polymyxin B concentration and renal function in elderly patients.

Methods: This prospective, case-control, observational study included elderly patients who received polymyxin B therapy and were divided into an acute kidney injury (AKI) group and a non-AKI group based on their renal function. We monitored the pharmacokinetics and pharmacodynamics of polymyxin B, including the minimum plasma concentration (C), mean blood drug concentration at steady state (C), and area under the concentration-time curve across 24 h at steady state (AUC) in both study groups.

Strontium-based quaternary ammonium salt chitosan particles for ultrafast hemostasis of open fracture.

The management of open bone defects poses a formidable challenge in clinical practice, primarily due to issues such as profuse bleeding, inflammation, bacterial infections, and compromised bone fracture healing. To tackle these complexities, we have devised a novel hemostatic powder, namely the compound strontium-based chitosan quaternary ammonium salt hemostatic powder (QCS@SrT-TA). This innovative powder leverages the self-assembly of tripolyphosphate and strontium ions, facilitated by a positively charged core cross-linker.

Gut microbial metabolite indole-3-propionic acid alleviates polycystic ovary syndrome in mice by regulating the AhR-NLRP3 axis.

Polycystic ovary syndrome (PCOS) is a complex disorder that significantly impacts female reproductive health and increases the risk of metabolic and reproductive diseases. Emerging evidence suggests that alterations in gut microbiota and their metabolic activities contribute to PCOS pathogenesis, although the underlying mechanisms remain elusive. In the current study, we found that patients with PCOS had altered metabolic profiles, particularly characterized by reduced levels of indole-3-propionic acid (IPA).

Maternal Gut Inflammation Aggravates Acute Liver Failure Through Facilitating Ferroptosis via Altering Gut Microbial Metabolism in Offspring.

Microbial transmission from mother to infant is important for offspring microbiome formation and health. However, it is unclear whether maternal gut inflammation (MGI) during lactation influences mother-to-infant microbial transmission and offspring microbiota and disease susceptibility. In this study, it is found that MGI during lactation altered the gut microbiota of suckling pups by shaping the maternal microbiota in the gut and mammary glands.

Daily activities change is linked to acute angle closure occurrence in COVID-19 co-infected patients.

Objectives: To analyze the influence of daily activity-related factors associated with COVID-19 infection on the occurrence of acute angle closure (AAC).

Methods: A multicenter hospital-based study was conducted at 23 ophthalmic centers in 17 provincial-level regions across China to recruit patients with confirmed AAC during the post-lockdown time of COVID-19 (P-TOC) from Dec 7, 2022, to Jan 17, 2023, and three lockdown time of COVID-19 (TOC) periods, which included the TOC-2022 (Sep 7, 2022 - Dec 6, 2022), TOC-2021(Sep 7, 2021 - Jan 6, 2022) and TOC-2020 (Sep 7, 2020 - Jan 6, 2021). Patient information, including demographic, a questionnaire on daily activity changes during the AAC period, COVID-19 history, and eye examination results, was collected.

Macrophage-derived exosomal miR-2137 regulates pyroptosis in LPS-induced acute lung injury.

Background: Alveolar macrophages (AMs) play a predominant role in acute lung injury (ALI). However, the role of macrophage-derived exosomal miRNAs in lipopolysaccharide (LPS)-induced ALI has not been determined.

Methods: We previously reported that exosomes in the bronchoalveolar lavage fluid (BALF) of mice with ALI were derived predominantly from macrophages.

Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing.

The management of full-thickness skin injuries continues to pose significant challenges. Currently, there is a dearth of comprehensive dressings capable of integrating all stages of wound healing to spatiotemporally regulate biological processes following full-thickness skin injuries. In this study, we report the synthesis of a dandelion-shaped mesoporous strontium-gallium microparticle (GE@SrTPP) achieved through dopamine-mediated strontium ion biomineralization and self-assembly, followed by functionalization with gallium metal polyphenol networks.