Effect of collagen scaffold versus intrauterine device on preventing recurrence of intrauterine adhesions: a multicenter randomized controlled trial.

Objective: To evaluate the efficacy of collagen scaffold versus intrauterine device (IUD) in prevention of adhesion recurrence in moderate intrauterine adhesions (IUA) following hysteroscopic adhesiolysis.

Design: A multicenter, open-label, randomized controlled, two-arm superiority clinical trial.

Setting: Six tertiary university hospitals from February 2023 to September 2024.

Stage-Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis.

Spermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing. Post-translational modifications (PTMs), including phosphorylation, provide a level of protein function flexibility and play important roles in spermiogenesis. Dynamic protein phosphorylation profiles of spermatids are characterized across four different developing steps, and identified phosphorylation regulation of key proteins in spermiogenesis.

The optimal childbearing age and birth spacing in china: a multicenter retrospective cohort study.

Background: We aimed to comprehensively analyze the impact of both maternal age and birth spacing on adverse maternal and neonatal outcomes.

Methods: A total of 151,301 pregnancies in China from January 1, 2010, to December 31, 2021 were included, and 8,222 subjects matched their primary and second pregnancy information. Join point regression was used to analyze the temporal trends of adverse outcomes with maternal age and birth spacing.

The N-terminal region of HASPIN regulates phosphorylation of AURKA and meiotic progression in spermatocytes.

Protein phosphorylation is an important post-translational modification that plays a critical regulatory role in meiosis. HASPIN, a kinase highly conserved from yeast to mammals, is required for male fertility. In this study, we found that the intrinsically disordered N-terminal domain of HASPIN is also required for this function.

Prioritizing robots in intelligent manufacturing using q-rung orthopair fuzzy decision-making method and unknown weight information.

The rapid evolution of intelligent manufacturing systems necessitates the integration of advanced robotics to meet increasing demands for productivity, precision, and adaptability. Robots play an indispensable role across a spectrum of operations, from assembly to inspection, directly influencing the efficiency and effectiveness of modern manufacturing environments. Addressing the critical need for enhanced decision-making in technological investments, this study evaluates and ranks various types of robots using an integrated decision-making framework.

Neuropsychiatric symptom trajectories across cognitive spectrums of Alzheimer's disease: Joint probabilities with cognitive and functional decline.

Objectives: Neuropsychiatric symptoms (NPSs), cognitive and functional decline developed heterogeneously in Alzheimer's disease (AD). We aimed to compare distinct NPS burden trajectories across cognitive spectrums, and their joint probabilities with cognition and function.

Methods: Data were from the Alzheimer's Disease Neuroimaging Initiative cohort.

Factors influencing the birth weight of ART-conceived offspring.

Since the birth of the first infant conceived through assisted reproductive technology (ART) in 1978, over 10 million individuals worldwide have been born using these methods. ART has offered hope to many facing infertility. However, concerns remain regarding potential health risks in ART-conceived offspring.

Laser-emitting aqueous bioreactors for ultrasensitive bioactivity analysis.

Water droplets, acting as natural bioreactors and optical whispering-gallery-mode (WGM) resonators, hold the potential for laser-assisted analysis. However, water/aqueous droplet lasers can only survive in air with a limited lifespan (<100 s) due to rapid evaporation, restricting their applications in bioreactions. To address this challenge, we introduce laser-emitting aqueous bioreactors (LEABs) in fluorocarbon oils.

CUX1 variant and 9p deletion: expanding the spectrum and resolving variable GDD/ID in a family.

Background: Intellectual disability (ID) significantly impacts individual development and imposes a societal burden. Although mild ID accounts for approximately 85% of total cases, research into its genetic etiology remains relatively limited. We investigated a two-generation pedigree exhibiting varying degrees of global developmental delay (GDD) and ID.

AI-Designed Molecules in Drug Discovery, Structural Novelty Evaluation, and Implications.

Achieving structural novelty in drug discovery remains a critical challenge. Artificial intelligence (AI) has demonstrated remarkable potential in deciphering the complex relationships between molecular structures and activities from vast amounts of chemical and biological information. However, its ability to explore novel chemical spaces is underexplored.

Associations between unintentional injuries and bullying victimization in adolescents: evidence from a large-scale cross-sectional study in China.

Background: Little is known about the associations between unintentional injuries from the perspective of parents and their children's bullying victimization. This study aimed to examine the links between parent-reported unintentional injury subtypes and student-reported experiences of bullying victimization from a school-based large-scale survey.

Methods: A total of 30,386 students from 35 primary schools, 27 middle schools, and 6 high schools with available data on unintentional injuries, school bullying victimization, and covariates were included in this study.

Involvement of mediodorsal thalamus and its related neural circuit in pain regulation in mice.

The mediodorsal thalamus (MD) constitutes an integral component of the medial nociceptive transmission system, although its precise role and related neural pathway in pain processing remains incompletely elucidated. While anatomical studies have confirm reciprocal projections between the MD and anterior cingulate cortex (ACC), the functional contribution of ACC-MD neural circuitry to nociceptive regulation has not yet been systematically investigated. In this study, we used immunohistochemistry, pharmacogenetic manipulations, and multidimensional behavioral assessments to investigate the role of the MD and ACC-MD pathway in pain modulation.

Correction: From copper homeostasis to cuproptosis: a new perspective on CNS immune regulation and neurodegenerative diseases.

[This corrects the article DOI: 10.3389/fneur.2025.

Incomplete penetrance and variable phenotypes of a novel NPRL2 frameshift variant: from familial focal epilepsy with variable foci 2 to neurodevelopmental disorders.

Background: Familial focal epilepsy with variable foci 2 (FFEVF2), an autosomal dominant disorder caused by pathogenic heterozygous variants in the gene, is characterized by focal epilepsy originating in different cortical regions of the temporal, frontal, parietal, and occipital lobes of the brain.

Methods: The study included a Chinese family in which proband had epilepsy, and her brother had autism, attention deficit hyperactivity disorder (ADHD), and mild intellectual disability (ID). Blood samples of the two children and their parents were collected for whole exome sequencing (WES).

Catheter Ablation for Refractory Ventricular Tachycardia Early After Acute Myocardial Infarction: Management, electrophysiological characteristics and outcomes.

Background And Aims: Refractory ventricular tachycardia (VT) is a rare but lethal condition in the early phase of acute myocardial infarction (AMI). Its intracardiac mechanism and role of catheter ablation is under-determined. The current study is to evaluate the feasibility and safety of catheter ablation for refractory ventricular tachycardia in early AMI.

Switchable Deep Beamformer for High-quality and Real-time Passive Acoustic Mapping.

Passive acoustic mapping (PAM) is a promising tool for monitoring acoustic cavitation activities in the applications of ultrasound therapy. Data-adaptive beamformers for PAM have better image quality compared with time exposure acoustics (TEA) algorithms. However, the computational cost of data-adaptive beamformers is considerably expensive.

Nomogram-based risk stratification to analyze the value of receiving postoperative adjuvant therapy after neoadjuvant immunochemotherapy for patients with locally advanced esophageal squamous carcinoma.

Purpose: To develop a prognosis nomogram for locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients after neoadjuvant immunochemotherapy (NICT) and assess postoperative adjuvant therapy (PAT) value through survival risk stratification.

Methods: We retrospectively analyzed 297 LA-ESCC patients (2019-2023) receiving NICT with or without PAT, randomly divided into the training and validation cohorts. Independent prognostic factors were determined by Least Absolute Shrinkage and Selection Operator (Lasso) regression and multivariate Cox analysis.

Multifaceted determinants of depressive symptoms in children migrating back from urban to rural areas: An ecological systems theory approach.

Background: While many studies have examined mental health and influencing factors of rural Chinese children who migrated back from urban areas, holistic exploration of multifaceted determinants of their depressive symptoms is lacking; this study, drawing on Bronfenbrenner's ecological systems theory and the process-person-context-time (PPCT) model, investigated multilevel factors' impact on such symptoms and gender differences.

Methods: A cross-sectional survey was conducted in 2022 in Nanling County (Anhui Province) in China. A sample of 859 school students in grades 5-9 completed assessments measuring their depressive symptoms (using the Children's Depression Inventory, CDI) and different blocks of variables (CONTEXT, PERSON, and PROCESS).

Global, regional, and national burden and trends of of stroke in adolescents and young adults from 1992 to 2021.

Background And Purpose: This study aims to examine the global, regional, and national burden of stroke in young adults from 1992 to 2021.

Method: We conducted a comprehensive assessment of stroke metrics among individuals aged 15-49 using data from the 2021 Global Burden of Disease (GBD) database, covering 204 countries at global, regional, and national levels. The metrics evaluated included age-standardized incidence rates (ASIR), death rates (ASDR), disability-adjusted life years (DALYs), average annual percentage changes (AAPCs), and joinpoint regression analysis.

Greenhouse gas emissions in a microbial fuel cell-assisted composting system: Microbial insights into bacterial structures and genetic functions.

Greenhouse gas emissions, including methane (CH), carbon dioxide (CO), and nitrous oxide (NO), have significant environmental impacts during the composting process. Herein, a microbial fuel cell (MFC)-assisted composting system was employed to investigate the emission profiles of these gases. CH and CO emissions were peaked during the temperature-heating phase, while NO emission showed maximum levels during the temperature-heating and maturation phases.

Echinacoside targets the HIF-1α/LDHA axis to modulate A1/A2 astrocyte differentiation and promote glial scar repair following ischemic stroke.

Ethnopharmacological Relevance: Glial scar repair is an emerging approach to ischemic stroke (IS) management, and this process can be both positively and negatively influenced by astrocytes. As a phenylethanoid glycoside derived from Cistanche tubulosa (Schenk) Wight, echinacoside (ECH) exhibits an array of pharmacological effects. However, there has been little research specifically focused on the impact of ECH on glial scar repair following IS.

Catheter Ablation for Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy: Electrophysiological Characteristics and Long-Term Outcomes.

Background: Studies on catheter ablation of hypertrophic cardiomyopathy (HCM)- ventricular tachycardia (VT) are relatively limited and mainly focused on feasibility and safety, whereas the VT distribution and electrophysiological properties remain insufficiently characterized.

Objectives: The aim of this study was to detail the site-specific electrophysiological properties and ablation outcomes in HCM-VT.

Methods: A total of 32 patients with HCM-VT who underwent catheter ablation were included.

Dynamic molecular landscape in dorsal root ganglion for peripheral nerve regeneration promoted by tissue engineered nerve graft.

Introduction: The limited regenerative capacity of the nervous system represents a significant clinical challenge in the context of peripheral nerve injuries. An innovative strategy for sciatic nerve repair has been developed using tissue-engineered nerve grafts (TENGs) composed of skin-derived precursor Schwann-like cells (SKP-SCs) and a silk fibroin-chitosan scaffold. However, the reason why SKP-SCs-TENG demonstrated superior enhanced nerve regeneration compared to the autograft and scaffold groups remains unclear.

White matter changes in recovered COVID-19 patients: insights from DTI, DKI, and NODDI metrics.

Background: COVID-19 affects not only the respiratory system but also the central nervous system, resulting in symptoms such as anosmia and confusion. Understanding the long-term neurological effects of COVID-19 is critical for comprehensive patient care and management.

Purpose: To study the long-term neurological effects of COVID-19, focusing on changes in white matter structural complexity using advanced neuroimaging techniques.