Effect of collagen scaffold versus intrauterine device on preventing recurrence of intrauterine adhesions: a multicenter randomized controlled trial.

Objective: To evaluate the efficacy of collagen scaffold versus intrauterine device (IUD) in prevention of adhesion recurrence in moderate intrauterine adhesions (IUA) following hysteroscopic adhesiolysis.

Design: A multicenter, open-label, randomized controlled, two-arm superiority clinical trial.

Setting: Six tertiary university hospitals from February 2023 to September 2024.

An Integrated Analysis of Transcriptomics and Metabolomics Elucidates the Role and Mechanism of TRPV4 in Blunt Cardiac Injury.

Background/objectives: Blunt cardiac injury (BCI) is a severe medical condition that may arise as a result of various traumas, including motor vehicle accidents and falls. The main objective of this study was to explore the role and underlying mechanisms of the TRPV4 gene in BCI. Elucidating the function of TRPV4 in BCI may reveal potential novel therapeutic targets for the treatment of this condition.

Research on supply chain resilience mechanism of AI-Enabled manufacturing enterprises -based on organizational change perspective.

Artificial intelligence (AI) is fundamentally reshaping supply chain operation modes and innovation paths, which has a significant impact on the development of supply chain resilience. This study utilizes panel data of Chinese A-share listed manufacturing companies from 2013 to 2022 to measure the application of AI through textual analysis and construct firm-level supply chain resilience indicators using factor analysis. The main findings suggest that AI greatly enhances supply chain resilience in the Chinese manufacturing industry, and this result holds in a series of robustness tests.

PZR: Advances in research from cellular signaling Hub to emerging therapeutic targets.

Protein Zero Related (PZR) is a type I transmembrane glycoprotein encoded by the MPZL1 gene and a member of the immunoglobulin superfamily (IgSF). Despite sharing 46 % sequence homology in its extracellular domain with myelin P0 protein (MPZ), PZR exhibits distinct functional specialization. It undergoes alternative splicing to generate three isoforms (PZR, PZRa, PZRb) with tissue-specific expression patterns, predominantly enriched in cardiovascular, renal, and pancreatic tissues, and localized to cell-cell contact sites and migration-associated domains, consistent with its roles in adhesion and motility.

CHAF1A Promotes Preadipocyte Differentiation and Contributes to Macrosomia in Gestational Diabetes Mellitus.

Gestational diabetes mellitus (GDM) leads to macrosomia primarily due to fat accumulation caused by adipocyte differentiation. This study aims to investigate the role and underlying mechanisms of Chromatin assembly factor 1 subunit A (CHAF1A) in GDM-induced macrosomia. CHAF1A expression was compared between the GDM with macrosomia group (n = 25) and the normal glucose with normal weight group (n = 15), and the correlation between CHAF1A and neonatal body composition was examined.

Triage accuracy of a six-gene methylation detection for high-risk HPV-positive Chinese women.

This study aimed to evaluate the triage accuracy of a six-gene methylation detection test in high-risk human papillomavirus-positive women in China. A total of 369 cervical exfoliated cell samples were collected from high-risk human papillomavirus-positive women undergoing cervical cancer screening at Nanjing Drum Tower Hospital from October 2018 to August 2019. The methylation status of six gene was assessed using real-time methylation-specific polymerase chain reaction.

Exploration of potential therapeutic target genes for preeclampsia through genetic analysis.

Preeclampsia (PE) is a prevalent and severe pregnancy-related complication, for which effective intervention targets remain limited, posing significant risks to maternal and fetal health. This study aimed to identify potential therapeutic target genes through genetic analyses. Specifically, we utilized cis-expression quantitative trait loci (cis-eQTL) of druggable genes derived from blood samples obtained from the eQTLGen consortium as exposure data.

enhances salt stress tolerance in flax: genome-wide profiling and functional validation of the SOD gene family.

Superoxide dismutase (SOD) serves as a critical regulator of plant stress adaptation to salinity, drought, and heavy metal toxicity. Flax ( L.), a globally cultivated oilseed and fiber crop, lacks comprehensive genomic characterization of its gene family.

The relationship between group attachment and career adaptability of college students: a moderated mediation model.

Introduction: This study explored the connection between group attachment and career adaptability among college students, considering attachment theory and career construction theory. It also looked into the mediating role of perceived social support and the moderating role of academic achievement level.

Methods: The Career Adapt-Abilities Scale - China Form, The Group Attachment Scale, The Perceived Social Support Scale, and The Academic Achievement Level Questionnaire were used to survey 533 Chinese college students.

Knowledge, Attitude and Practice Regarding Thyroid Disorders in Pregnant Women: A Cross-Sectional Study in Guangdong, China.

Background: Thyroid disorders are diseases that can harm both the fetus and the pregnant woman. This study aimed to investigate the knowledge, attitudes, and practices (KAP) of pregnant women regarding thyroid disorders during pregnancy.

Methods: A cross-sectional study was conducted from May 20, 2024, to June 30, 2024, in the Obstetrics and Gynecology Department of Zhujiang Hospital, Southern Medical University to pregnant women.

Association between daily sitting time and accelerated aging in women: double mediation effects of systemic immune-inflammation index and creatinine.

Objective: To clarify the association between daily sitting time and accelerated aging in women, and explored that systemic immune-inflammation index and creatinine together play an important mediating effect throughout the process.

Methods: A total of 5578 women during 2007 to 2010 from the National Health and Nutrition Examination Survey was utilized in this study. Phenotypic age calculation, logistic regression analysis, restricted cubic spline model, and subgroup analysis were employed to investigate the association between daily sitting time and accelerated aging as well as its influencing factors.

PHLDA2 expression and promoter methylation in placental trophoblasts: Associations with preeclampsia development.

Objective: Preeclampsia (PE) is an idiopathic and life-threatening pregnancy-related disease. Alterations to DNA methylation in imprinted genes may play a crucial role in the dysfunction of trophoblast cells and PE.

Materials And Methods: Herein, we sought to elucidate the characteristics of PHLDA2 in placental trophoblasts and its underlying mechanisms in pregnant women with PE.

Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.

Aims/introduction: To investigate the expression of ATF2 in GDM patients and its impact on trophoblast viability and ferroptosis, as well as to explore the mechanism by which ATF2 regulates ferroptosis and affects trophoblast function in GDM.

Materials And Methods: Placental tissues from pregnant women with normal glucose levels and those with GDM were collected. The expression of ATF2 was detected using immunohistochemistry and western blot analysis, and its correlation with clinical maternal and neonatal outcomes was analyzed.

Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study.

Postpartum depression (PPD) remains a complex disorder with poorly understood genetic underpinnings. This study systematically evaluated the genetic susceptibility of PPD and identified potential therapeutic targets using Mendelian Randomization (MR) approach. Using a two-sample MR approach, the study assessed the causal effects of expression quantitative trait loci (eQTLs) of druggable genes in blood on PPD, which was sourced from the FinnGen.

Construction of psychosocial adaptation model for hysterectomy patient: hermeneutical phenomenological research.

Objective: To deeply explore the psychosocial adaptation experience of hysterectomy patients at various stages, with the aim of constructing a conceptual model to describe the complex experience of psychosocial adaptation.

Methods: Semi-structured in-depth interviews were conducted on twelve patients undergoing hysterectomy using hermeneutical phenomenological methods, and the data were analyzed using the Smith analysis method.

Results: were refined into four stages and ten sub-themes: (1) Shock and Confusion Stage: shock and unwillingness, fear and anxiety; (2) Physical and Mental Dilemma Stage: surgical trauma, self-cognitive impact, and increasing dependence on social support; (3) Adjustment and Exploration Stage: correcting self-efficacy, self-cognitive reconstruction, and exploring social boundaries; (4) Integration and Adaptation Stage: returning to social roles and achieving closed-loop psychosocial adaptation.

Mesenchymal stem cells derived from hPSC via neural crest attenuate chemotherapy-induced premature ovarian insufficiency by ameliorating apoptosis and oxidative stress in granulosa cells.

Background: Premature ovarian insufficiency (POI) poses a significant threat to female reproductive health and currently lacks effective interventions. Recent studies highlight the promising potential of human pluripotent stem cell-derived mesenchymal stem cells (hPSC-MSC) in regenerative medicine. However, research on hPSC-MSC-based treatments for POI remains limited, particularly in the characterization of the intermediate differentiation stages from hPSC to MSC.

Human milk composition in women with gestational diabetes mellitus: a systematic review and meta-analysis.

Background: Gestational diabetes mellitus (GDM) is a prevalent pregnancy disorder. In recent years, numerous studies have affirmed the augmented risk of obesity and diabetes mellitus in the offspring of affected individuals. Exclusive breastfeeding has been vigorously advocated as an infant feeding practice in various countries.

NCOA5 induces sorafenib resistance in hepatocellular carcinoma by inhibiting ferroptosis.

NCOA5 has been identified as a crucial factor in the progression of hepatocellular carcinoma (HCC). This study investigates the expression of NCOA5 in HCC, revealing its significant overexpression in tumor tissues compared to healthy liver tissues, as evidenced by analysis of the TCGA dataset and RT-qPCR in patient samples. Higher NCOA5 levels correlate with poor overall survival, highlighting its role as a prognostic indicator.

Effects of gestational diabetes mellitus with different birth weight on genetic metabolism of newborns. A retrospective cohort study.

Objectives: To investigate the effects of gestational diabetes mellitus (GDM) with different birth weights on neonatal genetic metabolism.

Material And Methods: 1252 patients with GDM diagnosed at Changzhou Maternal and Child Health Care Hospital from 2017 to 2021 were categorized into three groups: fetal growth restriction (G1), normal birth weight (G2), and macrosomia (G3). The levels of amino acids, free carnitine (CO) and acylcarnitine in neonates were detected using tandem mass spectrometry.

Role of the collagen scaffold in preventing intrauterine adhesion from recurrence after adhesiolysis: protocol for a multicentre, randomised, controlled, parallel-group, open-label, superiority clinical trial.

Introduction: Intrauterine adhesions (IUAs) are one of the most common causes of uterine infertility. Hysteroscopic adhesiolysis is the primary treatment for IUA, but the rate of IUA recurrence is high in moderate to severe cases. While traditional guidelines recommend placing a non-copper stainless steel intrauterine device (IUD) into the uterine cavity after adhesiolysis to prevent readhesion, the preventive effect is uncertain.

Fall Armyworm-Induced Secondary Metabolites in Sorghum Defend Against Its Attack.

The fall armyworm (FAW), , is one of the major agricultural pests that has invaded China. The FAW is a polyphagous insect with the gramineous crop sorghum being a key host plant. However, the basis of sorghum's chemical defense against FAW feeding is still unclear.

Research on digital empowerment, innovation vitality and manufacturing supply chain resilience mechanism.

As global manufacturing competition increasingly emphasizes supply chain resilience, enhancing the risk resistance of manufacturing supply chains through digital empowerment has become a critical priority. This study leverages the opportunities of the digital economy to deeply investigate the mechanisms that enhance supply chain resilience. Using data from China' s A-share listed manufacturing companies from 2012 to 2020, a research framework is constructed based on information asymmetry and transaction cost theories.

Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study.

Background: Human milk (HM) is considered a potential protective factor against bronchopulmonary dysplasia (BPD), but the specific volume needed for its protective effect in mixed feeding is unclear. This study aimed to investigate the impact of different HM volumes on BPD risk.

Methods: A retrospective cohort study examined the association between HM volume and BPD risk in very low birthweight (VLBW) infants.

Genetic association of lipid and lipid-lowing drug targets with uterine fibroids.

Objective: Observational studies suggest that blood lipids are a risk factor for uterine fibroids (UFs) and that lipid-lowering drugs are beneficial for the treatment and prevention of UF; however, the conclusions are inconsistent. We aimed to determine the causal effects of lipids and lipid-lowering drugs on UFs using Mendelian randomization (MR).

Methods: Genetic variants from genome-wide association studies (GWAS) of lipid traits and variants in genes encoding lipid-lowering drug targets were extracted, and two independent UF GWAS were set as the outcome.

Dietary Bacillus improves behavior, intestinal health, and growth of juvenile sea cucumbers Apostichopus japonicus at low temperature.

The traditional overwintering process of sea cucumbers (Apostichopus japonicus) requires burning a large amount of coal to raise the water temperature. It is useful but costly and not environmentally friendly. Bacillus is proposed as a cheap and green alternative.