Selectively Modulating the Donor and Acceptor Aggregation Behaviors Through Solid Additive Isomerization Engineering for Organic Solar Cells Exceeding 20% Efficiency.

Regulating the film morphology is essential for achieving high-performance organic solar cells (OSCs). Given the distinct features of donor and acceptor materials, designing solid additives to selectively control the aggregation behaviors of them represents a key strategy for further development of OSCs. Herein, a series of bithiophene isomers solid additives (2,2-TT, 2,3-TT, and 3,3-TT) are designed for film morphology regulation.

Medical Information Provided by Transgender and Gender-Diverse Content Creators on YouTube: Descriptive Content Analysis.

Background: Transgender and gender-diverse (TGD) individuals frequently turn to social media to find community, express their identities, and access essential information. These platforms are easily accessible to TGD people and enable health information-seeking in anonymous, identity-affirming spaces outside of traditional health care systems. As a result, social media has become a critical source of health information on topics like gender-affirming care for TGD individuals, specifically for TGD youth.

Pd Single-Atoms Doped CuP Quantum Dots with Moderately Optimized H* Sorption Behaviors for Actualizing the Multifunctional "Formaldehyde-Nitrate" Galvanic System.

Nitrate and formaldehyde, which are substantial wastes in industrial and agricultural effluents, pose significant hazards to the human health and ecosystem. Current purification technologies remain great challenges due to the unsatisfactory energy-intensive, time-consuming and noticeably costly reasons. Herein, a bifunctional electrocatalysts of Pd single-atoms doped CuP quantum dots (Pd-CuP SA-QDs) are reported to moderately optimize the H* sorption behaviors for accelerating the kinetics of nitrate reduction (NORR) and formaldehyde oxidation (FOR) reactions in a dual-directional way, thus realizing the high activity and selectivity for both cathodic ammonia (NH) synthesis and anodic H production concurrently.

Safety and efficacy of hypofractionated radiotherapy combined with tyrosine kinase inhibitors in patients with lung metastases after liver transplantation for hepatocellular carcinoma.

Background: Lung metastases often occur after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). This study aimed to evaluate the safety and efficacy of combining hypofractionated radiotherapy (HFRT) with tyrosine kinase inhibitors (TKIs) in patients with lung metastases from HCC following OLT.

Methods: We retrospectively analyzed forty-eight patients with lung metastases post-OLT for HCC, who underwent concurrent HFRT and TKIs between July 2011 and August 2022.

An easily overlooked cause of pulmonary arterial hypertension-thiamine deficiency.

Thiamine deficiency (TD), also known as vitamin B1 deficiency, is an often overlooked potential cause of pulmonary arterial hypertension (PAH). It may contribute to the pathological process of PAH through the deficiency of related coenzymes, thereby inhibiting the citric acid cycle. TD can manifest in various clinical forms, including dry beriberi and Shoshin beriberi, the latter characterized by high-output heart failure and lactic acidosis, which can lead to fatal outcomes if not promptly treated.

Factors Associated with Functional Outcome Following Acute Ischemic Stroke Due to M1 MCA/ICA Occlusion in the Extended Time Window.

A validated clinical decision tool predictive of favorable functional outcomes following endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) remains elusive. We performed a retrospective case series of patients at our regional Comprehensive Stroke Center, over a four-year period, who have undergone EVT to elucidate patient characteristics and factors associated with a favorable functional outcome after EVT. We reviewed all cases of EVT at our institution between February 2018 and February 2022 in the extended time window from 6-24 h.

JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance.

Adipose tissue inflammation contributes to obesity-induced insulin resistance. However, increasing evidence shows that high BMI (obesity) is not an accurate predictor of poor metabolic health in individuals. The molecular mechanisms regulating the metabolically activated M1 macrophage phenotype in the adipose tissues leading to insulin resistance remain largely unknown.

Gut Microbiota and Bacterial Extracellular Vesicles: Emerging Roles in Myocardial Remodelling and Cardiac Health.

The gut microbiota, a collection of microorganisms residing within the human gastrointestinal tract, exerts profound effects on the health of the host. In recent years, studies have revealed that the gut microbiota influences not only the function of the digestive system but also has close associations with various systemic diseases, including cardiovascular diseases. Myocardial remodelling refers to the structural, functional and molecular changes in the myocardium that occur in response to alterations in load.

ZEB1 Contributes to Drug Resistance Through Canonical Wnt Signaling in Lung Cancer.

Lung cancer is a severe malignant disease and causes plenty of deaths each year. The survival and prognosis are disappointing for patients with recurrence or metastasis. This is partially due to the lack of mechanisms underlying lung cancer.

Identification of NPR2 gene mutations affecting chondrocyte differentiation in short stature through JAK2-STAT5.

Background: Natriuretic peptide receptor 2 (NPR2) is a crucial regulator of endochondral bone growth. However, patients carrying heterozygous NPR2 gene mutations exhibit a wide range of clinical phenotypes, and evidence regarding treatment efficacy is limited, with the pathogenic mechanisms not yet fully understood. Therefore, the aim of this study is to analyze and identify the clinical phenotypes, treatment outcomes, and pathogenic molecular mechanisms associated with NPR2 gene mutations.

5G-remote radical prostatectomy under novel robotic systems: a prospective comparative cohort study with local surgeries.

Background: There is no report upon the remote surgery of radical prostatectomy and comparisons between local surgeries. This study aims to evaluate the feasibility and safety of the innovative remote tele-surgical robotic platforms in performing radical prostatectomy.

Methods: The study comprised 13 patients diagnosed with prostate cancer who underwent remote radical prostatectomy using a 5 G wireless network and the innovative remote robotic systems (Tele-RARP).

Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility.

Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE-associated infertility (OEI).

SePGRP-SA promotes antiviral immunity in Spodoptera exigua via Toll pathway activation.

Peptidoglycan recognition proteins (PGRPs) are essential components of innate immunity that are highly conserved in both insects and mammals. While their roles in antibacterial and antifungal defense have been extensively investigated, their contributions to antiviral immunity remain largely uncharacterized. Here, we show that SePGRP-SA is predominantly expressed in the fat body of Spodoptera exigua and is significantly upregulated following infection with Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV).

Using multiple criteria for redesigning habitat corridor plans for Giant Pandas.

One key factor to long-term success in conservation planning is to allocate limited resources to the most critical locations and ensure the effectiveness of contemporary management plans under future conditions. Here, we proposed an innovative framework to quantitatively prioritize conservation actions for a vulnerable species, giant panda (Ailuropoda melanoleuca), and use it to identify Priority Habitat Corridors (PHCs) to address the threat of habitat fragmentation. We focused on the newly established Giant Panda National Park (GPNP), and combined field data with remotely-sensed landscape and anthropogenic metrics to evaluate the feasibility and effectiveness of potential habitat corridors.

Robust and Versatile OPH-Cu Phosphate Hybrid Nanoflower for Organophosphorus Compound Degradation.

Organophosphorus hydrolase (OPH), a promising biocatalyst for the degradation of organophosphorus compounds, faces application limitations due to its structural fragility. To address this, we developed a novel bioinorganic hybrid nanoflowers (HNFs) system by integrating OPH with copper phosphate via a self-assembly strategy. The HNFs exhibited significant catalytic robustness across a broad pH and temperature range.

A federated vehicle re-identification benchmark and performance optimization using dual-phase contrastive dynamic aggregation.

Vehicle re-identification is pivotal in advancing intelligent transportation systems and smart city initiatives, but it faces privacy risks due to the central processing of extensive data. To address this, we introduce a federated vehicle re-identification (FV-REID) benchmark with a multi-domain dataset from five sources, evaluation protocols, and a baseline federated-averaging vehicle re-identification method (FVVR). Our studies show that FVVR underperforms compared to traditional models, especially under varied data distribution, and exhibits greater variability.

Integrating CT radiomics and clinical features using machine learning to predict post-COVID pulmonary fibrosis.

Background: The lack of reliable biomarkers for the early detection and risk stratification of post-COVID-19 pulmonary fibrosis (PCPF) underscores the urgency advanced predictive tools. This study aimed to develop a machine learning-based predictive model integrating quantitative CT (qCT) radiomics and clinical features to assess the risk of lung fibrosis in COVID-19 patients.

Methods: A total of 204 patients with confirmed COVID-19 pneumonia were included in the study.

Crystallinity-Directed In Situ Reconstruction of Cu-Al Oxides Yielding Tunable Cu Sites for Electrochemical CO-to-C Conversion.

During the electrochemical CO reduction reaction (CORR), copper catalysts continuously undergo structural evolution, which is less controllable, and its impact on the product distribution of CORR remains unclear. Here, crystallinity-tunable Cu-Al mixed metal oxide (CuAl-MMO-) precatalysts were first synthesized via layered double hydroxide calcination. These precatalysts subsequently underwent in situ electrochemical reconstruction to form active CuAl-MMO-R catalysts with tailored Cu valence states.

Pairing a Validated Alcohol Intervention With Social Media Alcohol Risk Identification: Impact on Alcohol Behaviors and Social Media Posts.

Purpose: Community college (CC) students are an at-risk population for binge drinking and its consequences. The Brief Alcohol Screening and Intervention for College Students (BASICS) is an evidence-based, feasible, and acceptable intervention to reduce risky drinking. Without a college health center, CC students may not have access to interventions like BASICS.

Construction of psychosocial adaptation model for hysterectomy patient: hermeneutical phenomenological research.

Objective: To deeply explore the psychosocial adaptation experience of hysterectomy patients at various stages, with the aim of constructing a conceptual model to describe the complex experience of psychosocial adaptation.

Methods: Semi-structured in-depth interviews were conducted on twelve patients undergoing hysterectomy using hermeneutical phenomenological methods, and the data were analyzed using the Smith analysis method.

Results: were refined into four stages and ten sub-themes: (1) Shock and Confusion Stage: shock and unwillingness, fear and anxiety; (2) Physical and Mental Dilemma Stage: surgical trauma, self-cognitive impact, and increasing dependence on social support; (3) Adjustment and Exploration Stage: correcting self-efficacy, self-cognitive reconstruction, and exploring social boundaries; (4) Integration and Adaptation Stage: returning to social roles and achieving closed-loop psychosocial adaptation.

Metformin reverses 5-FU resistance induced by radiotherapy through mediating folate metabolism in colorectal cancer.

Purpose: Radiation therapy has revolutionized the treatment of primary or liver metastases in colorectal cancer (CRC). In colorectal cancer, conventional fractionation (1.8 ~ 2.

Shape Alterations of Subcortical Nuclei Correlate With Amyotrophic Lateral Sclerosis Progression.

Background: Neuroimaging has been increasingly used to assess brain structural alterations in patients with amyotrophic lateral sclerosis (ALS). We aimed to investigate alterations in brain sub-cortical structures and to identify potential neuroimaging biomarkers for disease progression for patients with ALS.

Methods: A total of 61 patients with ALS were prospectively enrolled and were divided into three subgroups according to disease progression, i.

Enhanced stability and efficiency of enzyme-inorganic hybrid nanoflowers for organophosphate degradation.

Enzyme catalysis is characterized by high efficiency and selectivity; however, the natural enzymes are prone to inactivation once removed from their native environment. The immobilization of enzyme using solid-phase carriers presents an effective strategy to enhance the structural stability of natural enzymes. In this study, organophosphate hydrolase (OPH) was utilized as the organic component, while ferrous phosphate served as the inorganic component, leading to the synthesis of enzyme-inorganic hybrid nanoflower materials through biomimetic mineralization.

OTUD3 inhibits breast cancer cell metastasis by regulating TGF-β pathway through deubiquitinating SMAD7.

Background: Breast cancer (BRCA) is the most common malignant tumor in women, and distant metastasis is an important cause of death. Epithelial mesenchymal transition (EMT) is an important factor in tumor cell metastasis, in which TGF-β signaling pathway plays an important role. SMAD7 can inhibit TGF-β pathway.