Resorbable Bio-Inductive Collagen Implant for Rotator Cuff Repair: What We Know, What We Need to Know, and the Path Forward.

Objectives: Rotator cuff injuries are a leading cause of shoulder dysfunction, where bio-inductive collagen implants have demonstrated promising results in promoting tendon regeneration and reducing retear rates. However, existing evidence lacks consistent evaluation across varying follow-up durations, while the specific factors influencing their safety and effectiveness remain undetermined. This study aims to evaluate the quality of evidence regarding the safety, efficacy, and impact factors of applying the resorbable bio-inductive collagen implant clinically to repair rotator cuff injuries.

Intrinsic mechanical properties of two-dimensional covalent organic frameworks.

Understanding the mechanical properties of two-dimensional covalent organic frameworks (2D COFs) is critical to their design for flexible devices, energy storage and catalysis applications. To date, only a limited number of 2D COFs have been examined, leaving the material design principles largely undefined. Furthermore, the measured results are often complicated by various extrinsic factors, causing difficulties in deciphering the underlying relationships.

Genome-Wide Analysis of Gene Family in Maize Reveals Its Role in the Cadmium Stress Response.

Background: Phytoremediation is an efficient approach for remediating heavy metal-contaminated soils. Heavy metal-associated isoprenylated plant proteins (HIPPs)-crucial for metal ion homeostasis-are unique to vascular plants, featuring a heavy metal-associated (HMA) domain and an isoprenylated CaaX motif. However, genes have not been systematically or functionally characterized in maize.

Multimodal analysis of clinical characteristics associated with myopic retinoschisis.

Purpose: To analyse the clinical characteristics and risk factors associated with myopic retinoschisis (MR) and its severity.

Methods: In the case-control study, 200 highly myopic eyes with MR and 398 without MR were enrolled. All participants have recorded demographic characteristics and medical history.

The Ocular Parameter Changes Caused by Reading With Remote Image Optical Screen.

Purpose: This study aimed to analyze the differences in ocular parameter changes induced by reading with traditional electronic screens (TESs) compared with those associated with the remote image optical screen (RIOS), further evaluating the effects of RIOS on ocular parameters.

Methods: Thirty-five healthy participants (70 eyes) were enrolled in the prospective self-controlled study, completing two distinct reading tasks. Task A: near reading using TESs for 20 minutes; and task B: near reading with RIOS for an equivalent duration.

Integrating CT radiomics and clinical features using machine learning to predict post-COVID pulmonary fibrosis.

Background: The lack of reliable biomarkers for the early detection and risk stratification of post-COVID-19 pulmonary fibrosis (PCPF) underscores the urgency advanced predictive tools. This study aimed to develop a machine learning-based predictive model integrating quantitative CT (qCT) radiomics and clinical features to assess the risk of lung fibrosis in COVID-19 patients.

Methods: A total of 204 patients with confirmed COVID-19 pneumonia were included in the study.

Development of quantum dots-based immunochromatographic assay for the detection of infectious bronchitis virus.

Infectious bronchitis virus (IBV) is a significant pathogen threatening global poultry production, known for its rapid transmission and the continuous emergence of new variants. Here, a monoclonal antibody (mAb) which specifically recognizes IBV SABD domain of S1 protein, designated 5G4, was prepared. This mAb, along with a previously developed mouse mAb (N1) targeting the IBV N protein, was utilized as the conjugate and capture antibodies, respectively, to develop a quantum dot-based lateral flow assay for the rapid detection of IBV infections.

Comparative efficacy of Naringenin and Sinomenine in facilitating the differentiation of mouse hematopoietic stem cells into immature dendritic cells to promote transplantation immunological regulation.

Objective: Immature dendritic cells (imDC) are crucial in facilitating transplant immunological regulation. However, imDC is readily amenable to maturation. Sinomenine (Sin) naringin (Nar) are traditional Chinese medicine with immunoregulation and anti-inflammatory activities.

Quantifying natural and anthropogenic impacts on riverine total nitrogen concentration and load in the Yellow River Basin.

Understanding the spatiotemporal dynamics of riverine nitrogen and its responses to socioeconomic and hydroclimatic variability is crucial for sustainable water management, particularly in water-scarce basins facing increasing anthropogenic pressures. This study investigated multiple time-scale fluctuations in surface total nitrogen (TN) concentration and load in the Yellow River Basin (YRB) from 2019 to 2022, utilizing high-frequency water monitoring data. We compiled various anthropogenic pollution sources and natural factors, including climate, topography, and hydrology across sub-basins.

MlCOFSyn: A Machine Learning Framework To Facilitate the Synthesis of 2D Covalent Organic Frameworks.

Two-dimensional covalent organic frameworks (2D COFs) have been historically synthesized empirically, often resulting in uncontrolled crystallization and inferior crystal sizes, which limit their performance in various applications. Recently, crystallization models tailored for 2D COFs have been developed that demonstrate great potential in facilitating their rational synthesis. Nevertheless, effective strategies to leverage these models for 2D COF synthesis remain underdeveloped, and the specialized expertise required, combined with the high computational costs of exploring the vast chemical space, poses additional barriers to their practical application.

S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation.

The available therapeutic options for post-stroke depression patients are limited. Although SSRIs are the most commonly prescribed antidepressants, their slow onset of action and the higher risk of adverse effects or contraindications have led to an urgent need to develop fast-acting and highly specific antidepressants tailored to the needs of PSD patients. Therefore, ketamine has drawn attention.

[Textual research on Fuxiong].

Fuxiong has a long history of cultivation. Since its first record in the Beneficial Formulas from the Taiping Imperial Pharmacy of the Song Dynasty, Fuxiong had always been used by ancient physicians and became a preponderant variety for some reasons during the periods of the Ming Dynasty, Qing Dynasty, and Republic of China. However, as for modern use, only Chuanxiong Rhizoma is valued, and the medicinal value of Fuxiong is gradually being overlooked.

Effects of thinning on canopy structure, forest productivity, and productivity stability in mixed conifer-broadleaf forest: Insights from a LiDAR survey.

Understanding the mechanisms whereby harvesting disturbance influences canopy structural complexity, forest productivity, and the stability of productivity is essential for the effective management and conservation of natural secondary forests. Previous research has established significant positive correlations among biodiversity, forest productivity and stability. Nevertheless, less is known regarding the processes whereby stand and canopy structures influence forest productivity and stability following harvesting disturbance.

Exhaled volatile organic compounds as novel biomarkers for early detection of COPD, asthma, and PRISm: a cross-sectional study.

Background: Globally, chronic respiratory diseases have become the third leading cause of death, including chronic obstructive pulmonary disease (COPD) and asthma, and have been threatening human life for a long time. To alleviate the disease burden, it is crucial to develop rapid and convenient screening methods for COPD, preserved ratio impaired spirometry (PRISm), and asthma. Volatile organic compounds (VOCs) in breath can reflect the pathophysiological processes of disease, thereby having the potential to serve as a promising approach for diagnosing respiratory diseases.

An Artificial Metal-Free Peroxidase Designed Using a Ferritin Cage for Bioinspired Catalysis.

Developing artificial enzymes is challenging because it requires precise design of active sites with well-arranged amino acid residues. Histidine-rich oligopeptides have been recently shown to exhibit peroxidase-mimetic activities, but their catalytic function relies on maintaining unique supramolecular structures. This work demonstrates the design of a specific array of histidine residues on the internal surface of the ferritin cage to function as an active center for catalysis.

Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance.

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS). The groundbreaking application of multi-omics integration technologies has unveiled a novel role for lactate: lactylation, a unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function and gene expression, profoundly influencing the progression of various diseases.

Effects of Dietary Protein and Fat Levels on Growth Performance, Nutrient Digestibility, Serum Indexes, and Rectal Fecal Microbiota of Sika Deer () Fawns in Early Wintering Period.

This study examined the effects of dietary crude protein (CP: 18%, 15%) and crude fat (EE: 8%, 4%) levels, and their interactions, on growth performance, nutrient digestibility, serum indices, and rectal fecal microbiota in sika deer fawns during early wintering. A two-month 2 × 2 factorial experiment was conducted using 32 healthy five-month-old male fawns randomly assigned to four groups: P18E8 (18% CP, 8% EE), P18E4 (18% CP, 4% EE), P15E8 (15% CP, 8% EE), and P15E4 (15% CP, 4% EE). The P18E4 group showed the highest total weight gain and average daily gain ( < 0.

DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair.

Mammalian DNA double-strand breaks (DSBs) are repaired by homologous recombination (HR) and non-homologous end joining (NHEJ). HR occurs in the S/G2 phase, while NHEJ dominates in G1 phase. 53BP1 promotes NHEJ by recruiting RIF1 to DSBs in G1, but its inhibition during S/G2 remains unclear.

An odorant-binding protein functions in fire ant social immunity interfacing with innate immunity.

Social immunity-mediated sanitation behaviours occur in insects when microbially killed corpses are removed and/or dismembered by healthy nestmates. However, little is known concerning the chemical signals or receptor proteins that mediate these responses. Here, we identify cuticular components in the eusocial red important fire ant, : behenic acid, which induces dismemberment behaviour, and oleic and ,-9,12-linoleic acids, which inhibit dismemberment in a process mediated by odorant-binding protein-15 (SiOBP15).

The cytoplasmic tail of IBV spike mediates intracellular retention via interaction with COPI-coated vesicles in retrograde trafficking.

Coronaviruses are characterized by their progeny assembly and budding in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). Our previous studies demonstrated that truncation of 9 amino acids in the cytoplasmic tail (CT) of the infectious bronchitis virus (IBV) spike (S) protein impairs its localization to the ERGIC, resulting in increased expression at the plasma membrane. However, the precise mechanism underlying this phenomenon remained elusive.

[Textual research on Zitan].

In recent years, with the continuous deepening of the theory of Wu Yun Liu Qi, the application of Zitan in Shenping Decoction and Shengming Decoction has gradually become widespread. Because Zitan is an imported herbal medicine, it is not commonly used in modern medicine and known as an unusual medicinal material. The unclear original plants may affect the clinical application of this medicine.

The impact of sleep disturbances on treatment efficacy and prognosis in patients with depressive and anxiety disorders.

Introduction: Little was known about the relationship between sleep disturbances and depressive and anxiety disorders, as well as the efficacy of treatment regimens.

Methods: During 2021 to 2023, a total of 417 participants were screened by Hamilton Depression Rating Scale (HAMD-17) and Hamilton Anxiety Rating Scale (HAMA-14) for psychological status, and Pittsburgh sleep quality index (PSQI) assessment. 409 participants were finally enrolled, of which 188 (45.

Real-world clinical outcomes of tixagevimab/cilgavimab in the Omicron outbreak in China: baseline characteristics and interim analysis of the CLEAR study.

Purpose: This study aimed to investigate the real-world use and clinical outcomes of tixagevimab/cilgavimab in China during the Omicron outbreak in late 2022.

Methods: This observational, real-world study included patients who received tixagevimab/cilgavimab from July 9 to December 30, 2022, in Hainan, China. Here, we report the baseline and characteristics and interim analysis results of the clinical outcomes in those receiving at least one dose of tixagevimab/cilgavimab (300 mg) for pre-exposure prophylaxis.