Diet, genetic factors, and the risk of gastroesophageal reflux disease, Barrett's esophagus and esophageal adenocarcinoma.

: Diet has been recognized as the most pivotal modifiable lifestyle factor in the development of Gastroesophageal Reflux Disease (GERD), Barrett's Esophagus (BE) and Esophageal Adenocarcinoma (EA). However, the associations between dietary ingredients, patterns, and diet-gene interactions with the risk of GERD, BE and EA remain unclear. : The prospective cohort study included 502 412 participants from the UK Biobank.

Occurrence of fatal vertebrobasilar dolichoectasia after occlusion of unilateral internal carotid artery.

Background: Vertebrobasilar dolichoectasia (VBD) is a rare cerebrovascular disorder. The natural history of patients with VBD is generally poor, and current treatments do not appear to provide significant clinical benefit. Therefore, understanding the underlying mechanisms of VBD and implementing appropriate strategies in advance are particularly important.

Association between lncRNA H19 and osteoporosis in postmenopausal patients with type 2 diabetes mellitus.

Background: This study aimed to assess the expression level of long non-coding RNA H19 (lncRNA H19) in peripheral blood mononuclear cells (PBMCs) of postmenopausal patients with type 2 diabetes mellitus (T2DM) with comorbid osteoporosis (T2DM-OP), and to evaluate its diagnostic value and its role in the pathogenesis of T2DM-OP.

Methods: A total of 150 postmenopausal patients with T2DM were recruited from the First People's Hospital of Lianyungang City, China. Based on the bone mineral density (BMD) results measured by dual-energy X-ray absorptiometry (DXA), the patients were stratified into the T2DM-OP group (n = 108) and the T2DM group (n = 42).

DNase I-Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke.

The recruitment and formation of neutrophil extracellular traps (NETs) by neutrophils play an important role in reperfusion injury in ischemic stroke. Current nanosystem-based therapeutic strategies are mainly confined within the blood-brain barrier (BBB), ignoring the constant intrusion from external challenges. Here, considering the unique vascular localization of NETs, a DNase I-mediated NETs-targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and external microenvironment of the neurovascular unit (NVU).

Improved protection against H9N2 avian influenza virus challenge in chickens by the presence of LTB adjuvant on the 3M2e-NP nanoparticle vaccine delivered by sifA deficient Salmonella.

The H9N2 avian influenza virus is a still a great threat to poultry production and public health due to its variation. The highly conserved extracellular domain, M2 ion channel (M2e), and the nuclear protein (NP) are usually considered to be potential targets for a broad-spectrum influenza vaccine. In this study, we took use of a regulated delayed lysis Salmonella χYL56 lacking the sifA gene as a delivery vector to deliver a lumazine synthase (LS) based nanoparticle vaccine decorating with three copies of M2e (H9N2, H5N1 and H1N1 subtype, 3M2e) and NP protein, without or with LTB adjuvant, yielding S311 and S325, respectively.

Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance.

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of the central nervous system (CNS). The groundbreaking application of multi-omics integration technologies has unveiled a novel role for lactate: lactylation, a unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function and gene expression, profoundly influencing the progression of various diseases.

Effects of digital health on symptoms and health-related quality of life in children and adolescent cancer survivors: a meta-analysis and systematic review.

Objectives: To assess the effectiveness of digital health on symptoms and health-related quality of life in children and adolescent cancer survivors.

Methods: We searched PubMed, Embase, Web of Science, Cochrane Library, and CINAHL databases on July 11, 2024, to identify randomized controlled trials of the impact of digital health on children and adolescent cancer survivors aged 0-19 years. The Cochrane Risk of Bias Tool version 1.

Manganese-based virus-mimicking nanomedicine with triple immunomodulatory functions inhibits breast cancer brain metastasis.

Hindered by the challenges of blood-brain barrier (BBB) hindrance, tumor heterogeneity and immunosuppressive microenvironment, patients with breast cancer brain metastasis have yet to benefit from current clinical treatments, experiencing instead a decline in quality of life due to radiochemotherapy. While virus-mimicking nanosystems (VMN) mimicking viral infection processes show promise in treating peripheral tumors, the inability to modulate the immunosuppressive microenvironment limits the efficacy against brain metastasis. Accordingly, a VMN-based triple immunomodulatory strategy is initially proposed, aiming to activate innate and adaptive immune responses and reverse the immunosuppressive microenvironment.

A near-infrared emitting covalent organic framework with AIE characteristics for light-emitting diodes.

By incorporating methyl groups to introduce steric hindrance and utilizing hydroxyl groups to establish intramolecular hydrogen bonds, we synthesized a covalent organic framework (COF) with aggregation-induced emission (AIE) behavior and near-infrared (NIR) luminescence ( = 657 nm). The integration of the innovative COF with LED chips enabled the fabrication of high-quality red and white organic phosphor-converted light-emitting diodes (LEDs). This work provides a new way to explore COFs to construct low-cost, high-performance, and eco-friendly LED devices.

EX-Gaze: High-Frequency and Low-Latency Gaze Tracking with Hybrid Event-Frame Cameras for On-Device Extended Reality.

The integration of gaze/eye tracking into virtual and augmented reality devices has unlocked new possibilities, offering a novel human-computer interaction (HCI) modality for on-device extended reality (XR). Emerging applications in XR, such as low-effort user authentication, mental health diagnosis, and foveated rendering, demand real-time eye tracking at high frequencies, a capability that current solutions struggle to deliver. To address this challenge, we present EX-Gaze, an event-based real-time eye tracking system designed for on-device extended reality.

AirtypeLogger: How Short Keystrokes in Virtual Space Can Expose Your Semantic Input to Nearby Cameras.

Considering the issue of privacy leakage and motivating more sophisticated protection methods for air-typing with XR devices, in this paper, we propose AirtypeLogger, a new approach towards practical video-based attacks on the air-typing activities of XR users in virtual space. Different from the existing approaches, AirtypeLogger considers a scenario in which the users are typing a short text fragment with semantic meaning occasionally under the spy of video cameras. It detects and localizes the air-typing events in video streams and proposes the spatial-temporal representation to encode the keystrokes' relative positions and temporal order.

Multimodal assessment predicts cognitive impairment after aneurysmal subarachnoid hemorrhage: a prospective cohort study.

Background: Risk factors and mechanisms of cognitive impairment (CI) after aneurysmal subarachnoid hemorrhage (aSAH) are unclear. This study used a neuropsychological battery, MRI, ERP and CSF and plasma biomarkers to predict long-term cognitive impairment after aSAH.

Materials And Methods: 214 patients hospitalized with aSAH (n = 125) or unruptured intracranial aneurysms (UIA) (n = 89) were included in this prospective cohort study.

Development and validation of a novel artificial intelligence algorithm for precise prediction the postoperative prognosis of esophageal squamous cell carcinoma.

Background: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy, and current postoperative prognostic assessment methods remain unsatisfactory, underlining the urgent to develop a reliable approach for precision medicine. Given the similarities with gametogenesis, cancer/testis genes (CTGs) are acknowledged for regulation unrestrained multiplication and immune microenvironment during oncogenic processes. These processes are associated with advanced disease and poorer prognosis, indicating that CTGs could serve as ideal prognostic biomarkers in ESCC.

Alterations of oscillatory activity and cognitive function after aneurysmal subarachnoid hemorrhage.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) can lead to cognitive impairment (CI), but underlying neural mechanisms remain to be elucidated.

Materials And Methods: To predict long-term CI after aSAH, resting electroencephalography (EEG) was measured in 112 patients hospitalized with a diagnosis of aSAH ( n = 66) or unruptured intracranial aneurysms (controls) ( n = 46). A neuropsychological battery was administered 8-24 months after discharge.

Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus.

Avian influenza virus (AIV) subtype H9N2 still poses a great threat to the poultry farming industry and public health worldwide, and the development of a new influenza vaccine that is safe and conservative and able to address influenza virus mutations is highly promising for application. HA2, the neck of the HA protein, and M2e, the extracellular N-terminal structural domain of the M2 protein, are conserved and effective protective antigens. In this study, the HA2 sequences were fused with three M2e copies (H9N2, H1N1 and H5N1) to the norovirus VP1 protein via the SpyTag-SpyCatcher platform to form self-assembled nanoparticles and display antigenic proteins on its surface, yielding pYL262.

Super Tough PA6/PP/ABS/SEBS Blends Compatibilized by a Combination of Multi-Phase Compatibilizers.

Development of multi-component blends to prepare high-performance polymer materials is still challenging, and is a key technology for mechanical recycling of waste plastics. However, a multi-phase compatibilizer is prerequisite to create high-performance multi-component blends. In this study, POE--(MAH--St) and SEBS--(MAH--St) compatibilizers are prepared via melt-grafting of maleic anhydride (MAH) and styrene (St) dual monomers to polyolefin elastomer (POE) and poly [styrene-b-(ethylene-co-butylene)-b-styrene] (SEBS), respectively.

Preferences of Cancer Survivors for Follow-Up Care: A Systematic Review of Discrete Choice Experiments.

Background And Objective: Cancer survivors frequently encounter multiple challenges, including physical, psychological, social, emotional, and financial difficulties. These challenges significantly impact their quality of life and recovery process. This systematic review intends to delineate and assess the evidence gathered from discrete choice experiments, aiming to unravel the preferences of cancer survivors towards their follow-up care.

Effect of applying digital health in palliative care for patients with advanced cancer: a meta-analysis and systematic review.

Purpose: To assess the effectiveness of applying digital health palliative care to improve symptoms, mood, and quality of life in patients with advanced cancer.

Methods: We searched PubMed, Embase, Web of Science, Cochrane Library (CENTRAL), and CINAHL databases on November 16, 2023, to identify randomized controlled trials of the impact of palliative care applying digital health on patients with advanced cancer. The Cochrane Risk of Bias Tool version 1.

Identification of transcription factors in and analysis of their expression response to alkali stress response.

Breeding abiotic stress-tolerant varieties of Rosa chinensis is a paramount goal in horticulture. WRKY transcription factors, pivotal in plant responses to diverse stressors, offer potential targets for enhancing stress resilience in R. chinensis .

Effectiveness of e-health interventions for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis.

Introduction: The goal of this systematic review was to examine the effectiveness of e-health interventions for chemotherapy-induced nausea and vomiting (CINV).

Methods: A literature search was conducted across the databases of PubMed, Web of Science, Embase, CINAHL, and Cochrane Library from database establishment to 3 March 2024. We included randomized controlled trials in English where the intervention group was via e-health.

Development and validation of Social Support Needs Questionnaire (SSNQ) for the left-behind older adults in rural China.

This study compiled a Social Support Needs Questionnaire (SSNQ) for the left-behind older adults in rural China and assessed its psychometric properties. The formation of the SSNQ included three stages. First, item pool was established based on literature analysis.