Pleurotus citrinopileatus polysaccharides ameliorate DSS-induced ulcerative colitis by improving intestinal barrier and inflammation modulation via NF-κB pathway.

The aim was to investigate the pharmacological effects of a polysaccharide isolated from Pleurotus citrinopileatus on ulcerative colitis (UC). One polysaccharide, CP-2-2, was isolated and purified from P. citrinopileatus body fruit using chromatographic methods.

Curcumenol exerts anti-pulmonary fibrosis effects through modulation of the immune signature target SPP1: based on comprehensive bioinformatics and experiments validation.

Background: The efficacy of Curcuma wenyujin (C. wenyujin) volatile oil components in the treatment of lung diseases, including pulmonary fibrosis (PF), is gradually being recognized. However, the anti-PF potential and underlying mechanisms of curcumenol (Cur), one of the Q-markers of C.

[Varicocele ligation with mobile phone microscope: Report of 5 cases and literature review].

Objective: To investigate the feasibility of varicocele ligation with mobile phone microscope.

Methods: The high-performance mobile phone and mobile phone stand were combined to act as a mobile phone microscope. And the varicocele ligation was performed under the mobile phone microscope.

Axial engineering of bilayer single-atom catalysts for enhanced bifunctional oxygen electrocatalysis.

Axial ligand engineering is a promising strategy to enhance the performance of single-atom catalysts (SACs) in electrocatalysis. However, a single non-metallic axial coordination atom linked to monolayer SACs (MSACs) often exhibits insufficient stability. In this work, we designed a series of bilayer SACs (BSACs) with vertically stacked FeN and MN (M = Sc-Zn) layers bridged by axial non-metallic atoms (C, N, O, P, S, and Se).

Functional differentiation of industrial hemp rhizosphere microbiome along environmental gradients.

The southwestern, central, and northeastern regions of China are the primary cultivation areas for industrial hemp. Microorganisms within the soil-root continuum play a crucial role in plant health. However, the mechanisms by which these microbial communities respond to environmental gradients remain unclear.

Neurodegenerative Diseases in Male Former First-Class New Zealand Rugby Players.

Background: Growing concern surrounds the risk of neurodegenerative diseases in high-level collision sports, but research on Rugby Union's connection to these diseases is limited.

Objective: This study sought to examine the long-term neurodegenerative disease risk associated with participation in high-level Rugby Union ('rugby'), utilising whole-population administrative records.

Methods: This retrospective cohort study in New Zealand compared males born between 1920 and 1984 who were active in high-level (provincial or higher) rugby between 1950 and 2000 (n = 12,861) with males from the general population (n = 2,394,300), matched by age, ethnicity, and birthplace.

A lysosome-targetable fluorescent probe for monitoring peroxynitrite fluctuations and therapeutic evaluation in ferroptosis-induced cardiomyopathy.

Cardiomyopathy is a heterogeneous group of diseases, that has a wide range of etiologies and clinical symptoms, and in severe situations, it can result in severe complications such as heart failure and even death. Recent studies have suggested a close relationship between cardiomyopathy and ferroptosis, a type of cell death characterized by iron dependent lipid peroxides. During this process, reactive oxygen species (ROS) explode and oxidative stress levels sharply increase.

Prognostic relevance of the triglyceride-glucose index in patients after thrombectomy for acute anterior circulation occlusion.

Background: We aimed to investigate the relationship between the triglyceride-glucose (TyG) index and the 3-month prognosis after mechanical thrombectomy (MT) in patients with acute large-vessel occlusion in the anterior circulation.

Methods: We performed a retrospective analysis of data collected from 320 patients who underwent MT at our institution between May 2022 and January 2024. The main outcome measure was the modified Rankin Scale (mRS) score, with a score of ≤2 at 90 days post-treatment indicating a good prognosis.

Navigator motion-resolved MR fingerprinting using implicit neural representation: Feasibility for free-breathing three-dimensional whole-liver multiparametric mapping.

Purpose: To develop a multiparametric free-breathing three-dimensional, whole-liver quantitative maps of water T, water T, fat fraction (FF) and R*.

Methods: A multi-echo 3D stack-of-spiral gradient-echo sequence with inversion recovery and T-prep magnetization preparations was implemented for multiparametric MRI. Fingerprinting and a neural network based on implicit neural representation (FINR) were developed to simultaneously reconstruct the motion deformation fields, the static images, perform water-fat separation, and generate T, T, R*, and FF maps.

Detection of Microscopic Glioblastoma Infiltration in Peritumoral Edema Using Interactive Deep Learning With DTI Biomarkers: Testing via Stereotactic Biopsy.

Background: Microscopic tumor cell infiltration beyond contrast-enhancing regions influences glioblastoma prognosis but remains undetectable using conventional MRI.

Purpose: To develop and evaluate the glioblastoma infiltrating area interactive detection framework (GIAIDF), an interactive deep-learning framework that integrates diffusion tensor imaging (DTI) biomarkers for identifying microscopic infiltration within peritumoral edema.

Study Type: Retrospective.

Two-billion-year transitional oxygenation of the Earth's surface.

Earth's surface underwent stepwise oxygenation before persistently reaching modern levels late in its history, but the details of this transition remain unclear. Here we present a high-resolution 2.5-Gyr record of mass-independent oxygen isotopes in sedimentary sulfate (Δ'O), a proxy linked to the atmospheric partial pressure of O ( ).

A Review of Avian Influenza Virus Exposure Patterns and Risks Among Occupational Populations.

Avian influenza viruses (AIVs) pose significant risks to occupational populations engaged in poultry farming, livestock handling, and live poultry market operations due to frequent exposure to infected animals and contaminated environments. This review synthesizes evidence on AIV exposure patterns and risk factors through a comprehensive analysis of viral characteristics, host dynamics, environmental influences, and human behaviors. The main routes of transmission include direct animal contact, respiratory contact during slaughter/milking, and environmental contamination (aerosols, raw milk, shared equipment).

Secondary Metabolites from Protect Mitochondrial Function in LPS-Injured Endothelial Cells.

, a traditional Chinese herb, is commonly used to treat vascular-related disorders. Sepsis-associated vascular endothelial dysfunction is closely associated with mitochondrial damage. This study investigated the protective effects of secondary metabolites from against LPS-induced mitochondrial dysfunction in endothelial cells, providing potential therapeutic insights into sepsis-related vascular complications.

Development of a polydopamine‑graphene nanocomposite electrochemical aptasensor for sensitive detection of lung cancer biomarker VEGF165.

This study presents a novel electrochemical aptasensor utilizing polydopamine-graphene (PDA-G) nanocomposite for VEGF165 detection. The PDA-G nanocomposite was synthesized through a one-step self-polymerization process and characterized by SEM, XPS, and FTIR, confirming successful PDA coating on graphene sheets with 22.3% C-N bond incorporation.

Single-incision laparoscopic cholecystectomy with inflexible laparoscopic instruments and laparoscopy: a single-center experience of 533 cases.

Background: Laparoscopic cholecystectomy (LC) has been widely performed as the gold standard for BGDs. Single-incision laparoscopic cholecystectomy (SILC) was considered as an option for minimizing surgical injuries and improving outcomes. However, the benefit of this novel technique, especially with conventional and inflexible instruments and laparoscopy, is still controversial.

Virtual reality-based cue exposure therapy reduces psychological craving in men with methamphetamine use disorder: a randomized controlled trial.

Reducing psychological craving is critical for preventing relapse in methamphetamine use disorder (MUD). This study aimed to evaluate the efficacy of virtual reality (VR)-based cue exposure therapy (CET) and cue exposure with aversion therapy (CETA) in reducing methamphetamine craving in men with MUD. In this randomized controlled trial, 89 men with MUD were assigned to three groups: VR-based cue exposure therapy (CET, n = 30), VR-based cue exposure combined with aversion therapy (CETA, n = 29), and neutral scenes (NS, n = 30).

Association of Red Cell Distribution Width and Red-Cell-Distribution-Width-to-Albumin Ratio with Cardiovascular Diseases in Postmenopausal Women: A Cross-Sectional Study based on the National Health and Nutrition Examination Survey 2003-2016.

Background: Cardiovascular disease (CVD) significantly increases in postmenopausal women. This study aims to investigate the potential association between red cell distribution width (RDW), the RDW-to-albumin ratio (RAR), and the prevalence of CVD in postmenopausal women.

Methods: This study analyzed data extracted from the National Health and Nutrition Examination Survey (NHANES) database spanning the years 2003-2016.

Clinical Characteristics and Prognosis of Juvenile Idiopathic Arthritis-Associated Uveitis: A Single-Center Retrospective Study.

Objective: To characterize the clinical features, risk factors, and outcomes of juvenile idiopathic arthritis-associated uveitis (JIA-U), aiming to improve early detection and management strategies.

Methods: This study conducted a retrospective cohort analysis of JIA patients diagnosed and treated at the Department of Rheumatology at Beijing Children's Hospital (2016-2023), with subgroup evaluation of JIA-U cases.

Results: Among 1494 JIA patients, 72 (4.

ERBIN limits epithelial cell plasticity via suppression of TGF-β signaling.

ERBIN acts as a negative regulator of the epidermal growth factor receptor (EGFR) and transforming growth factor-β (TGF-β)/SMAD signaling pathways that play a role in epithelial-to-mesenchymal transition (EMT). However, the role of ERBIN in EMT is poorly understood. Our results show that ERBIN inhibits TGF-β-induced EMT in NMuMG breast and in A549 lung adenocarcinoma cell lines.

FAP deficiency attenuates T2DM-associated HFpEF by suppressing the CaMKIIδ-Calcineurin A-NFATc2 signaling pathway.

Heart failure with preserved ejection fraction (HFpEF) represents the initial phase of cardiac dysfunction associated with type 2 diabetes mellitus (T2DM). To date, the pathophysiological mechanisms underlying T2DM-induced HFpEF are complex and elusive. Fibroblast activation protein (FAP) is a prolyl-specific serine protease that its inhibition or vaccination has been shown to enhance cardiac repair following myocardial infarction (MI).

Spinal Cord-Like Scaffold with Rapid Tissue Integration Enhanced Spinal Cord Nerve Repair.

Spinal cord injury (SCI) repair represents an immense challenge globally. Despite various beneficial strategies having been attempted for SCI repair, the ideal therapy has not yet been achieved. In this study, a multidimensional biomimetic spinal cord-like scaffold (MBSLS) is designed with a hierarchical structure and embryonic neurogenetic microenvironment and neural regeneration in SCI repair.

Bacillus vallismortis LRB-5: a promising biocontrol agent for mitigating apple replant disease through pathogen suppression and growth promotion.

Apple replant disease (ARD) poses a serious threat to apple cultivation, primarily caused by the accumulation of Fusarium species. Bacillus species have demonstrated significant potential as microbial agents, with capabilities in promoting plant growth, suppressing soil-borne pathogens, and improving soil quality. Here in this study, strain LRB-5 was isolated from a healthy apple root system and identified as Bacillus vallismortis based on physiological and biochemical characterization and molecular sequencing analysis.